KEGG   PATHWAY: pprm05132
Entry
pprm05132                   Pathway                                
Name
Salmonella infection - Pimephales promelas (fathead minnow)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
pprm05132  Salmonella infection
pprm05132

Organism
Pimephales promelas (fathead minnow) [GN:pprm]
Gene
120476830  podxl; podocalyxin isoform X1 [KO:K06817]
120477222  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
120491156  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
120483794  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
120486535  rab5b; ras-related protein Rab-5B [KO:K07888]
120489695  rab5c; ras-related protein Rab-5C [KO:K07889]
120469838  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
120481340  ras-related protein rab7-like [KO:K07897]
120480617  rab7a; ras-related protein Rab-7a [KO:K07897]
120480718  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
120488221  zgc:100918; ras-related protein rab7 [KO:K07897]
120481206  ras-related protein rab7-like [KO:K07897]
120474443  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
120481997  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
120491558  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
120494141  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
120472093  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
120462371  vps39; vam6/Vps39-like protein [KO:K20183]
120475871  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
120472310  RILP-like protein 1 isoform X1 [KO:K13883]
120477692  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
120470698  cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
120459797  dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
120484643  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
120485146  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
120487028  dync1i2b; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
120483712  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
120480979  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
120479408  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
120489584  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
120490889  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
120479006  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
120460418  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
120480643  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
120471012  dynlt1b; dynein light chain Tctex-type 1 [KO:K10420]
120480830  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
120477349  dctn1a; dynactin subunit 1a isoform X1 [KO:K04648]
120479692  dctn1b; dynactin subunit 1 isoform X1 [KO:K04648]
120464585  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
120462714  dctn3; dynactin subunit 3 [KO:K10425]
120461037  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
120490042  dctn5; dynactin subunit 5 [KO:K10427]
120480157  dctn6; dynactin subunit 6 [KO:K10428]
120482114  actr1b; actin related protein 1B [KO:K16575]
120491984  actr10; actin-related protein 10 [KO:K16576]
120482207  tuba7l; LOW QUALITY PROTEIN: tubulin, alpha 7 like [KO:K07374]
120491473  tubulin alpha chain isoform X1 [KO:K07374]
120491474  tubulin alpha-1D chain-like [KO:K07374]
120484196  tuba5; tubulin alpha 5 [KO:K07374]
120492330  tubulin alpha-8 chain-like [KO:K07374]
120492333  tubulin alpha-8 chain-like [KO:K07374]
120487186  tuba8l3; tubulin, alpha 8 like 3 [KO:K07374]
120487337  tubulin alpha-1D chain-like [KO:K07374]
120463358  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
120463360  tubulin alpha chain-like [KO:K07374]
120473463  tubulin alpha-1A chain [KO:K07374]
120473464  tubulin alpha-1B chain [KO:K07374]
120484317  tubb5; tubulin beta-5 chain isoform X1 [KO:K07375]
120459965  zgc:65894; tubulin beta chain [KO:K07375]
120477300  tubulin beta chain-like [KO:K07375]
120492409  tubb6; tubulin beta-5 chain [KO:K07375]
120470110  zgc:55461; beta-tubulin family protein [KO:K07375]
120494273  tubb1; tubulin beta-1 chain [KO:K07375]
120473168  tubb4bl; tubulin beta-4 chain [KO:K07375]
120481079  tubb2; tubulin beta-2A chain [KO:K07375]
120481181  tubb2b; tubulin beta-2b chain [KO:K07375]
120482385  fyco1b; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
120463457  fyco1a; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
120491620  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
120486457  arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
120480288  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
120463467  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
120464564  kif5ab; kinesin heavy chain [KO:K10396]
120474750  kif5bb; kinesin-1 heavy chain [KO:K10396]
120475092  kif5aa; kinesin family member 5Aa [KO:K10396]
120467184  kif5c; kinesin heavy chain [KO:K10396]
120495478  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
120495479  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
120468662  klc4; kinesin light chain 4 isoform X1 [KO:K10407]
120460671  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
120469912  kinesin light chain 2-like [KO:K10407]
120469913  kinesin light chain 2-like [KO:K10407]
120478703  klc3; kinesin light chain 3 isoform X1 [KO:K10407]
120479762  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
120481790  zgc:162964; Golgi resident protein GCP60 [KO:K23935]
120493854  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
120473952  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
120473953  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
120483844  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120483860  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
120493692  rhoca; ras homolog family member Ca [KO:K04513]
120486480  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120495044  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
120478652  LOW QUALITY PROTEIN: ras-related protein Rab-9A-like [KO:K07899]
120478653  rab9a; ras-related protein Rab-9A [KO:K07899]
120495451  ras-related protein Rab-9A-like [KO:K07899]
120494791  rab9b; ras-related protein Rab-9B [KO:K07900]
120480582  GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
120480799  syntaxin-10 [KO:K23937]
120482427  pfn2l; profilin 2 like isoform X1 [KO:K05759]
120484093  pfn1; profilin-1 [KO:K05759]
120491867  pfn2; profilin-2 isoform X1 [KO:K05759]
120477520  pfn4; profilin-4 [KO:K05759]
120473355  flna; filamin-A [KO:K04437]
120461905  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
120475932  exoc5; exocyst complex component 5 [KO:K19984]
120476849  exoc4; exocyst complex component 4 [KO:K06111]
120493849  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
120482334  ralab; v-ral simian leukemia viral oncogene homolog Ab (ras related) isoform X1 [KO:K07834]
120492448  ralaa; ras-related protein Ral-A [KO:K07834]
120489986  actb2; actin, cytoplasmic 2 [KO:K05692]
120463340  actb1; actin, cytoplasmic 1 [KO:K05692]
120483693  s100a10a; protein S100-A10a [KO:K17274]
120484555  s100a10b; protein S100-A10b [KO:K17274]
120464754  anxa14; annexin A2 [KO:K17092]
120458987  anxa2a; annexin A2a [KO:K17092]
120473066  anxa2b; annexin A2b [KO:K17092]
120468918  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK [KO:K23934]
120460682  ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
120479747  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
120477784  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
120493915  rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
120485900  rho guanine nucleotide exchange factor 26-like [KO:K13744]
120486021  rho guanine nucleotide exchange factor 26-like isoform X1 [KO:K13744]
120478501  rhoga; ras homolog family member Ga [KO:K07863]
120461817  rhogc; ras homolog gene family, member Gc [KO:K07863]
120494540  rhogb; ras homolog family member Gb [KO:K07863]
120494840  rhogd; ras homolog gene family, member Gd [KO:K07863]
120485040  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
120461045  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
120493647  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
120479411  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
120471636  myl2a; myosin regulatory light chain 2a isoform X1 [KO:K10351]
120481296  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
120473556  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
120467926  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
120463800  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
120481944  myl10; myosin regulatory light chain 10 [KO:K12756]
120482763  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
120477405  myl12.1; myosin, light chain 12, genome duplicate 1 isoform X1 [KO:K12757]
120489373  mylpfa; LOW QUALITY PROTEIN: myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
120488829  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
120490989  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
120461216  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
120484761  cdc42l; cell division cycle 42, like [KO:K04393]
120463350  cdc42l2; cell division cycle 42 like 2 isoform X1 [KO:K04393]
120480475  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120463965  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120481534  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120490585  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120460263  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120467759  nckap1l; nck-associated protein 1-like [KO:K05750]
120487076  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
120474377  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
120491712  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog isoform X1 [KO:K05749]
120482180  abi1b; abl interactor 1b isoform X1 [KO:K23649]
120475786  abi1a; abl interactor 1a isoform X1 [KO:K23649]
120480523  brk1; probable protein BRICK1 [KO:K05752]
120476070  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
120462612  zgc:109889; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
120472392  wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
120473696  si:ch73-362m14.4; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
120489670  actr2a; actin-related protein 2-A [KO:K17260]
120492421  actr2b; actin-related protein 2-B [KO:K17260]
120469994  zgc:101810; actin-related protein 2-A [KO:K17260]
120475851  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
120487155  actr3; actin-related protein 3 [KO:K18584]
120489649  zgc:86896; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120490300  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120490301  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120487096  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
120490685  actin-related protein 2/3 complex subunit 3-B [KO:K05756]
120490756  actin-related protein 2/3 complex subunit 3-B [KO:K05756]
120491503  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
120480618  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
120482727  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
120469740  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
120494122  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
120473506  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
120473739  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120471754  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
120476627  myo6b; myosin VIb isoform X1 [KO:K10358]
120479250  myo6a; myosin VIa [KO:K10358]
120464703  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
120463328  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120463436  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120480566  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120470942  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
120462808  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
120459950  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
120487656  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
120495261  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
120481536  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
120474664  cyth1b; LOW QUALITY PROTEIN: cytohesin-1b [KO:K18441]
120490681  cyth3a; cytohesin-3 [KO:K18441]
120476202  cytohesin-1 isoform X1 [KO:K18441]
120476203  cytohesin-1-like [KO:K18441]
120467940  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
120462660  cyth2; cytohesin-2 isoform X1 [KO:K18441]
120489160  cyth4a; cytohesin-3 [KO:K18441]
120464082  arf6b; ADP-ribosylation factor 6b [KO:K07941]
120491988  arf6a; ADP-ribosylation factor 6a [KO:K07941]
120489401  arf2a; ADP-ribosylation factor 2a [KO:K07937]
120468718  arf1; ADP-ribosylation factor 1 [KO:K07937]
120488029  arf2b; ADP-ribosylation factor 2b [KO:K07937]
120481691  snx18b; sorting nexin-18b [KO:K17923]
120482372  snx9a; sorting nexin-9a [KO:K17923]
120477936  snx33; sorting nexin-33 [KO:K17923]
120493704  snx9b; sorting nexin-9b isoform X1 [KO:K17923]
120461762  snx18a; sorting nexin-18a [KO:K17923]
120469264  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
120489706  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
120487565  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
120476840  toll-like receptor 2 [KO:K10169]
120484621  tlr18; LOW QUALITY PROTEIN: toll-like receptor 18 [KO:K10159]
120463819  tlr2; toll-like receptor 2 [KO:K10159]
120460010  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
120476028  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120479739  tlr4bb; toll-like receptor 4b, duplicate b [KO:K10160]
120479740  toll-like receptor 4 [KO:K10160]
120479741  toll-like receptor 4 isoform X1 [KO:K10160]
120481298  tlr9; toll-like receptor 9 [KO:K10161]
120475052  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120460430  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120469276  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120493637  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120467961  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
120468311  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
120482437  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
120463432  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120479686  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
120489071  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120494118  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
120480064  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
120460868  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
120460975  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
120492169  rela; transcription factor p65 [KO:K04735]
120471170  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
120491962  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
120491995  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
120491996  heat shock protein HSP 90-alpha 1 [KO:K04079]
120476790  hsp90b1; endoplasmin [KO:K09487]
120471438  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
120467755  cse1l; LOW QUALITY PROTEIN: exportin-2 [KO:K18423]
120476049  kpna1; importin subunit alpha-5 [KO:K23940]
120464485  kpna4; importin subunit alpha-3 [KO:K23583]
120490553  kpna3; importin subunit alpha-4 [KO:K23583]
120473736  rps3; 40S ribosomal protein S3 [KO:K02985]
120464885  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
120473360  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
120460946  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120479037  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
120487665  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120471345  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
120495436  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
120469811  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120488967  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120474717  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
120474753  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
120476626  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
120476628  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120469059  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
120462104  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120473428  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
120464313  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
120466649  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
120490141  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120466717  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120479574  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120479828  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120494671  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120460309  si:ch211-153j24.3; proto-oncogene c-Fos isoform X1 [KO:K04379]
120460310  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
120462345  fosaa; proto-oncogene c-Fos [KO:K04379]
120493498  jun; transcription factor AP-1 [KO:K04448]
120471668  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
120485191  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120483159  il1b; interleukin-1 beta [KO:K04519]
120483438  interleukin-6-like [KO:K05405]
120483439  interleukin-6-like [KO:K05405]
120469433  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
120470323  cxcl8b.3; interleukin-8b.3 [KO:K10030]
120481204  cxcl8a; interleukin-8 [KO:K10030]
120465202  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
120483600  catenin beta-1-like [KO:K02105]
120473621  tcf7; transcription factor 7 isoform X1 [KO:K02620]
120474207  tcf7l1a; transcription factor 7-like 1-A [KO:K04490]
120481307  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
120474612  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120491182  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
120481646  mycb; transcriptional regulator Myc-B [KO:K04377]
120476017  myca; transcriptional regulator Myc-A [KO:K04377]
120481499  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
120490128  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
120473134  fbxo22; F-box only protein 22 [KO:K10302]
120473620  skp1; S-phase kinase-associated protein 1 [KO:K03094]
120495090  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120490283  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120469445  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120471951  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120473194  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120494429  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120470021  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
120495043  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
120488411  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
120470090  tnfsf10l4; tumor necrosis factor (ligand) superfamily, member 10 like 4 isoform X1 [KO:K04721]
120470427  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
120492744  fadd; protein FADD isoform X1 [KO:K02373]
120491686  caspase-8-like [KO:K04398] [EC:3.4.22.61]
120469557  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
120470089  casp22; caspase-22 [KO:K04398] [EC:3.4.22.61]
120477354  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
120489703  baxa; BCL2 associated X, apoptosis regulator a [KO:K02159]
120492712  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
120489578  baxb; BCL2 associated X, apoptosis regulator b isoform X1 [KO:K02159]
120491576  cytochrome c [KO:K08738]
120482147  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
120488185  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
120465362  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
120462979  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120488777  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
120474601  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
120491456  casp21; caspase 21, apoptosis-related cysteine peptidase [KO:K04397] [EC:3.4.22.60]
120476167  rho-related GTP-binding protein RhoB [KO:K07856]
120494387  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
120473888  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120476176  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120479738  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120473207  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120489082  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120473353  mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
120490154  txn2; thioredoxin, mitochondrial [KO:K03671]
120492649  zgc:56493; thioredoxin [KO:K03671]
120487823  txn; thioredoxin [KO:K03671]
120462223  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120462205  caspa; caspase a isoform X1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
pprm04010  MAPK signaling pathway
pprm04210  Apoptosis
pprm04217  Necroptosis
pprm04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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