KEGG   PATHWAY: srx04510
Entry
srx04510                    Pathway                                
Name
Focal adhesion - Sinocyclocheilus rhinocerous
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
srx04510  Focal adhesion
srx04510

Other DBs
GO: 0005925
Organism
Sinocyclocheilus rhinocerous [GN:srx]
Gene
107722140  collagen alpha-2(I) chain-like [KO:K06236]
107708989  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
107717204  collagen alpha-1(I) chain-like [KO:K06236]
107720033  collagen alpha-1(I) chain-like [KO:K06236]
107731699  collagen alpha-2(I) chain-like [KO:K06236]
107740634  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
107731244  collagen alpha-1(II) chain-like [KO:K19719]
107742021  collagen alpha-1(II) chain isoform X1 [KO:K19719]
107715436  collagen alpha-1(II) chain-like isoform X1 [KO:K19719]
107730819  LOW QUALITY PROTEIN: collagen alpha-4(IV) chain-like [KO:K06237]
107711567  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107711551  collagen alpha-6(IV) chain-like [KO:K06237]
107715897  collagen alpha-2(IV) chain-like [KO:K06237]
107715912  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
107721566  collagen alpha-2(IV) chain-like [KO:K06237]
107721605  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
107707901  collagen alpha-5(IV) chain-like [KO:K06237]
107739767  collagen alpha-5(IV) chain-like [KO:K06237]
107750310  collagen alpha-6(IV) chain-like [KO:K06237]
107755689  collagen alpha-6(VI) chain-like [KO:K06238]
107725234  collagen alpha-3(VI) chain-like [KO:K06238]
107723650  collagen alpha-3(VI) chain-like [KO:K06238]
107705786  collagen alpha-6(VI) chain-like [KO:K06238]
107715812  collagen alpha-1(VI) chain-like [KO:K06238]
107715814  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
107718214  collagen alpha-1(VI) chain-like isoform X1 [KO:K06238]
107718216  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
107734282  collagen alpha-6(VI) chain-like [KO:K06238]
107734283  collagen alpha-6(VI) chain-like [KO:K06238]
107722164  collagen alpha-2(IX) chain-like [KO:K08131]
107718896  collagen alpha-1(IX) chain-like [KO:K08131]
107719903  collagen alpha-3(IX) chain-like [KO:K08131]
107713563  collagen alpha-3(IX) chain-like isoform X1 [KO:K08131]
107712764  collagen alpha-2(IX) chain-like [KO:K08131]
107753862  collagen alpha-1(IX) chain-like [KO:K08131]
107747272  collagen alpha-1(IX) chain-like [KO:K08131]
107736861  collagen alpha-1(IX) chain-like [KO:K08131]
107727315  collagen alpha-2(IX) chain-like [KO:K08131]
107711612  lama2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
107740527  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
107747483  laminin subunit alpha-1-like [KO:K05637]
107743991  laminin subunit alpha-1-like [KO:K05637]
107705144  laminin subunit alpha-3-like [KO:K06240]
107708592  laminin subunit alpha-3-like [KO:K06240]
107727012  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
107705651  laminin subunit alpha-5-like [KO:K06240]
107715692  lama4; laminin subunit alpha-4 [KO:K06241]
107712496  lamb1; laminin subunit beta-1 [KO:K05636]
107739090  laminin subunit beta-1-like [KO:K05636]
107755155  laminin subunit beta-1-like [KO:K05636]
107737682  laminin subunit beta-2-like [KO:K06243]
107712697  laminin subunit beta-2-like [KO:K06243]
107737594  laminin subunit beta-2-like isoform X1 [KO:K06243]
107712713  laminin subunit beta-1-like [KO:K06243]
107710800  lamb3; laminin subunit beta-3 [KO:K06244]
107712510  laminin subunit beta-4-like [KO:K06245]
107722047  laminin subunit gamma-1 [KO:K05635]
107726890  laminin subunit gamma-1-like [KO:K05635]
107722066  laminin subunit gamma-2-like [KO:K06246]
107726891  LOW QUALITY PROTEIN: laminin subunit gamma-2-like [KO:K06246]
107757520  laminin subunit gamma-3-like [KO:K06247]
107718641  laminin subunit gamma-3-like [KO:K06247]
107706882  chondroadherin-like [KO:K06248]
107727306  chondroadherin-like [KO:K06248]
107728186  reelin-like [KO:K06249] [EC:3.4.21.-]
107711363  reln; reelin [KO:K06249] [EC:3.4.21.-]
107719693  thrombospondin-1-like [KO:K16857]
107721311  thrombospondin-1-like [KO:K16857]
107743901  thrombospondin-1-like isoform X1 [KO:K16857]
107756566  thrombospondin-1-like [KO:K16857]
107756306  thrombospondin-4-B-like isoform X1 [KO:K04659]
107755534  thrombospondin-2-like isoform X1 [KO:K04659]
107719129  thrombospondin-3a [KO:K04659]
107705413  thrombospondin-2-like [KO:K04659]
107720209  thrombospondin-4-B-like [KO:K04659]
107705968  thrombospondin-4-B-like [KO:K04659]
107714313  thrombospondin-3a-like [KO:K04659]
107731553  thrombospondin-3b-like [KO:K04659]
107707836  thrombospondin-2-like [KO:K04659]
107739867  thrombospondin-2-like isoform X1 [KO:K04659]
107747026  thrombospondin-4-like [KO:K04659]
107738600  thrombospondin-3b [KO:K04659]
107733073  thrombospondin-4-like [KO:K04659]
107737158  thrombospondin-4-B [KO:K04659]
107721590  fibronectin-like [KO:K05717]
107716781  fibronectin-like [KO:K05717]
107731971  vitronectin-like [KO:K06251]
107725145  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
107709842  tenascin-like [KO:K06252]
107715756  tenascin-like [KO:K06252]
107724633  tenascin-like [KO:K06252]
107722078  tenascin-N-like isoform X1 [KO:K06252]
107726886  LOW QUALITY PROTEIN: tenascin-R-like [KO:K06252]
107722042  tenascin-R-like [KO:K06252]
107726927  tenascin-N-like isoform X1 [KO:K06252]
107757727  tenascin-X-like isoform X1 [KO:K06252]
107715542  tenascin-like [KO:K06252]
107736173  vwf; von Willebrand factor [KO:K03900]
107713335  itga1; integrin alpha-1 isoform X1 [KO:K06480]
107713336  integrin alpha-2-like [KO:K06481]
107713338  integrin alpha-2-like [KO:K06481]
107744091  integrin alpha-2-like [KO:K06481]
107744146  integrin alpha-2-like [KO:K06481]
107725055  integrin alpha-8-like [KO:K06476]
107708875  LOW QUALITY PROTEIN: integrin alpha-3-like [KO:K06482]
107709989  integrin alpha-3-like [KO:K06482]
107739753  itga3; integrin alpha-3 [KO:K06482]
107755364  itga4; integrin alpha-4 [KO:K06483]
107717001  integrin alpha-4-like isoform X1 [KO:K06483]
107756357  itga5; integrin alpha-5 [KO:K06484]
107723722  integrin alpha-5-like [KO:K06484]
107740164  integrin alpha-6-like isoform X1 [KO:K06485]
107738477  integrin alpha-6-like [KO:K06485]
107745248  LOW QUALITY PROTEIN: integrin alpha-6-like [KO:K06485]
107708686  integrin alpha-6-like [KO:K06485]
107742949  integrin alpha-6-like [KO:K06485]
107713863  integrin alpha-7-like [KO:K06583]
107713866  integrin alpha-7-like isoform X1 [KO:K06583]
107717802  integrin alpha-8-like [KO:K06584]
107738861  itga8; integrin alpha-8 [KO:K06584]
107733329  itga9; integrin alpha-9 [KO:K06585]
107754575  integrin alpha-9-like [KO:K06585]
107707172  integrin alpha-10-like [KO:K06586]
107743189  integrin alpha-10-like [KO:K06586]
107745098  integrin alpha-11-like isoform X1 [KO:K06587]
107738627  integrin alpha-11-like [KO:K06587]
107740496  integrin alpha-11-like [KO:K06587]
107755089  integrin alpha-11-like [KO:K06587]
107749889  itgav; integrin alpha-V [KO:K06487]
107752904  integrin alpha-V-like [KO:K06487]
107749113  integrin beta-1-A-like [KO:K05719]
107734314  integrin beta-1-like [KO:K05719]
107713907  integrin beta-1-like [KO:K05719]
107721734  integrin beta-1-like [KO:K05719]
107727289  integrin beta-3-like [KO:K06493]
107706862  integrin beta-3-like [KO:K06493]
107754700  integrin beta-3-like isoform X1 [KO:K06493]
107725294  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
107758026  integrin beta-4-like isoform X1 [KO:K06525]
107725247  integrin beta-5-like isoform X1 [KO:K06588]
107723672  integrin beta-5-like [KO:K06588]
107718899  integrin beta-6-like [KO:K06589]
107747010  integrin beta-6-like [KO:K06589]
107711053  integrin beta-7-like [KO:K06590]
107740576  integrin beta-7-like [KO:K06590]
107709728  integrin beta-8-like [KO:K06591]
107755959  itgb8; integrin beta-8 isoform X1 [KO:K06591]
107733858  epithelial membrane protein 2-like [KO:K26256]
107732522  peripheral myelin protein 22-like [KO:K26256]
107716808  epithelial membrane protein 2-like isoform X1 [KO:K26256]
107715705  platelet-derived growth factor subunit A-like [KO:K04359]
107716439  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
107740670  uncharacterized protein LOC107740670 [KO:K04359]
107710051  uncharacterized protein LOC107710051 [KO:K04359]
107718638  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
107753752  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
107720370  adenylate cyclase, terminal-differentiation specific-like [KO:K17386]
107717652  platelet-derived growth factor subunit B-like [KO:K17386]
107736246  putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 [KO:K17386]
107756229  platelet-derived growth factor D-like isoform X1 [KO:K05450]
107725770  platelet-derived growth factor D-like isoform X1 [KO:K05450]
107740106  platelet-derived growth factor C-like isoform X1 [KO:K05450]
107723796  platelet-derived growth factor C-like [KO:K05450]
107740113  pro-epidermal growth factor-like isoform X1 [KO:K04357]
107723791  pro-epidermal growth factor-like [KO:K04357]
107755307  insulin-like growth factor I [KO:K05459]
107744912  insulin-like growth factor I, adult form [KO:K05459]
107725558  insulin-like growth factor I, adult form isoform X1 [KO:K05459]
107725277  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
107726022  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
107715260  vascular endothelial growth factor A-like [KO:K05448]
107710132  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
107737030  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
107732225  placenta growth factor-like [KO:K16859]
107712199  placenta growth factor-like [KO:K16859]
107739261  placenta growth factor-like [KO:K16859]
107752233  vascular endothelial growth factor C-like [KO:K05449]
107737103  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
107737256  vascular endothelial growth factor D-like isoform X1 [KO:K05449]
107751140  vascular endothelial growth factor D-like isoform X1 [KO:K05449]
107723941  hepatocyte growth factor-like [KO:K05460]
107732993  hepatocyte growth factor-like [KO:K05460]
107738418  hepatocyte growth factor-like [KO:K05460]
107738831  hepatocyte growth factor-like [KO:K05460]
107718396  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107755213  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
107754478  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
107747104  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
107706937  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107708213  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107741044  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107738680  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107755244  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
107718422  vascular endothelial growth factor receptor 2-like [KO:K05098] [EC:2.7.10.1]
107732093  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
107708546  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
107731792  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
107747514  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
107716416  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
107705214  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
107744528  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
107751995  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
107712307  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107706735  vascular endothelial growth factor receptor 3-like [KO:K05097] [EC:2.7.10.1]
107716667  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
107753308  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107751707  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107718756  epithelial membrane protein 2-like [KO:K26255]
107712235  epithelial membrane protein 2-like isoform X1 [KO:K26255]
107754892  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
107738191  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107724951  rho GTPase-activating protein 35-like isoform X1 [KO:K05732]
107726507  rho GTPase-activating protein 35-like isoform X1 [KO:K05732]
107734134  rho GTPase-activating protein 35-like [KO:K05732]
107746386  rho GTPase-activating protein 35-like [KO:K05732]
107719447  rho GTPase-activating protein 5-like [KO:K13709]
107733129  rho GTPase-activating protein 5-like [KO:K13709]
107708160  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107719044  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107709246  transforming protein RhoA-like [KO:K04513]
107748433  ras-like GTP-binding protein O-RHO [KO:K04513]
107755302  rho-related GTP-binding protein RhoA-A [KO:K04513]
107737929  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107711944  rho-related GTP-binding protein RhoA-D [KO:K04513]
107707673  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107729745  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107758012  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107711976  rho-related GTP-binding protein RhoA-B [KO:K04513]
107754500  LOW QUALITY PROTEIN: protein diaphanous homolog 1-like [KO:K05740]
107747105  protein diaphanous homolog 1-like [KO:K05740]
107711696  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
107727500  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
107707968  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
107726463  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
107726633  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
107757116  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
107714591  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107720970  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
107743076  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
107712465  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
107753162  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
107711796  myosin regulatory light polypeptide 9 [KO:K12755]
107705895  myosin regulatory light polypeptide 9-like [KO:K12755]
107737046  myosin regulatory light polypeptide 9-like [KO:K12755]
107752860  myosin regulatory light polypeptide 9-like [KO:K12755]
107734439  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
107728843  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
107745301  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
107746904  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
107732590  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
107728660  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
107708280  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
107756198  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
107729469  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107737758  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107721356  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107724005  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107716016  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107716473  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107720972  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
107752675  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107732870  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107729511  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107727958  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107749073  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
107755884  protein phosphatase 1 regulatory subunit 12A-like [KO:K06270]
107726853  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
107746501  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
107716886  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
107710164  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
107748549  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107756349  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
107721383  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107734487  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107757773  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107711643  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
107732064  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107708588  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
107721964  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107729567  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107745269  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107717461  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107724086  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
107719627  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107748713  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107749098  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107726562  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107725287  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107739532  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107741984  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107743110  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107728534  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
107734539  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107725373  actin, cytoplasmic 1 [KO:K05692]
107725374  actin, cytoplasmic 1 [KO:K05692]
107722944  actin, cytoplasmic 1 [KO:K05692]
107709805  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
107715192  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
107755343  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755344  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755345  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755925  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107724584  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722658  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722663  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722669  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
107734257  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107731818  alpha-actinin-4-like [KO:K05699]
107705429  alpha-actinin-1-like isoform X1 [KO:K05699]
107739883  alpha-actinin-1 isoform X1 [KO:K05699]
107737420  alpha-actinin-4 isoform X1 [KO:K05699]
107715875  talin-1-like isoform X1 [KO:K06271]
107712503  talin-2-like [KO:K06271]
107741407  talin-2-like [KO:K06271]
107739102  talin-2 [KO:K06271]
107737170  talin-1-like [KO:K06271]
107712729  filamin-A-like isoform X1 [KO:K04437]
107737611  filamin-A-like [KO:K04437]
107712990  filamin-B-like isoform X1 [KO:K27392]
107747421  flnb; filamin-B isoform X1 [KO:K27392]
107737717  filamin-A-like [KO:K27392]
107724377  paxillin-like [KO:K05760]
107725082  paxillin-like [KO:K05760]
107753001  paxillin [KO:K05760]
107754409  paxillin-like isoform X1 [KO:K05760]
107748058  proteoglycan 4-like [KO:K05760]
107718724  integrin-linked protein kinase-like isoform X1 [KO:K06272] [EC:2.7.11.1]
107720653  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
107744703  zyxin-like [KO:K06273]
107748852  zyxin-like [KO:K06273]
107710968  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
107714454  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
107726962  vinculin isoform X1 [KO:K05700]
107718685  vinculin-like [KO:K05700]
107743588  vinculin-like [KO:K05700]
107748304  vinculin-like [KO:K05700]
107744221  parvg; gamma-parvin isoform X1 [KO:K06275]
107744231  beta-parvin-like isoform X1 [KO:K06275]
107754387  beta-parvin-like [KO:K06275]
107707483  alpha-parvin-like isoform X1 [KO:K06275]
107730072  alpha-parvin [KO:K06275]
107727093  alpha-parvin-like [KO:K06275]
107718133  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
107741790  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107747865  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
107722100  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107716055  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107726567  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107715681  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107729704  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107714435  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107714796  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107747540  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107711004  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107733672  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107746086  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107715908  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107721573  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
107729358  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107710337  catenin beta-1-like [KO:K02105]
107751892  catenin beta-1-like isoform X1 [KO:K02105]
107748497  catenin beta-1 [KO:K02105]
107706261  catenin beta-1-like [KO:K02105]
107710161  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107710697  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107716883  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107725358  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107722959  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107710001  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107752983  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107741772  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
107718208  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107718809  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107719529  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107726123  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
107708832  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107747314  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107717145  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107730332  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107722495  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
107731623  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107709897  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107727530  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107738919  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
107711700  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107716233  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107715959  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107724682  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107744570  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107753428  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107708338  guanine nucleotide exchange factor VAV2-like [KO:K05730]
107722824  guanine nucleotide exchange factor VAV2-like [KO:K05730]
107712784  guanine nucleotide exchange factor VAV3-like [KO:K05730]
107722334  proto-oncogene vav-like [KO:K05730]
107727171  vav1; proto-oncogene vav [KO:K05730]
107739004  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
107732951  guanine nucleotide exchange factor VAV3-like [KO:K05730]
107736604  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107752410  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107745654  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107729213  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107733870  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
107732889  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
107720282  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
107719987  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107721474  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107708991  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
107735921  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
107706409  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107744645  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107738196  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107741800  serine/threonine-protein kinase PAK 2-like isoform X1 [KO:K04410] [EC:2.7.11.1]
107712492  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
107743662  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05734] [EC:2.7.11.1]
107744790  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05734] [EC:2.7.11.1]
107712195  serine/threonine-protein kinase PAK 7-like [KO:K05736] [EC:2.7.11.1]
107731598  serine/threonine-protein kinase PAK 7-like [KO:K05736] [EC:2.7.11.1]
107716049  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
107726570  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
107738886  serine/threonine-protein kinase PAK 6-like isoform X1 [KO:K05735] [EC:2.7.11.1]
107728109  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
107707751  cell division control protein 42 homolog isoform X1 [KO:K04393]
107714605  cell division control protein 42 homolog [KO:K04393]
107751216  cell division control protein 42 homolog [KO:K04393]
107756639  cell division control protein 42 homolog isoform X1 [KO:K04393]
107724785  cell division control protein 42 homolog [KO:K04393]
107726155  bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
107706473  crk-like protein [KO:K04438]
107722822  crk-like protein [KO:K04438]
107743676  adapter molecule crk-like [KO:K04438]
107744771  adapter molecule crk-like [KO:K04438]
107711371  dedicator of cytokinesis protein 1-like [KO:K13708]
107740868  dedicator of cytokinesis protein 1-like [KO:K13708]
107705978  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
107725290  rap guanine nucleotide exchange factor 1-like [KO:K06277]
107757300  rap guanine nucleotide exchange factor 1-like [KO:K06277]
107737187  rap guanine nucleotide exchange factor 1-like [KO:K06277]
107711849  ras-related protein Rap-1A [KO:K04353]
107742898  ras-related protein Rap-1A-like [KO:K04353]
107751450  ras-related protein Rap-1A-like [KO:K04353]
107745329  ras-related protein Rap-1b-like [KO:K04353]
107732995  rap1b; ras-related protein Rap-1b [KO:K07836]
107725524  ras-related protein Rap-1b-like [KO:K07836]
107707207  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107719076  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107720002  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107749917  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107749009  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107756804  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107709004  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107721038  transcription factor AP-1-like isoform X1 [KO:K04448]
107712863  transcription factor AP-1-like [KO:K04448]
107739852  transcription factor AP-1-like [KO:K04448]
107735627  transcription factor AP-1-like [KO:K04448]
107725591  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
107757253  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107716666  caveolin-1-like isoform X1 [KO:K06278]
107753536  caveolin-1 [KO:K06278]
107716639  caveolin-2-like [KO:K12958]
107737724  caveolin-2-like [KO:K12958]
107741322  caveolin-2-like [KO:K12958]
107753679  caveolin-2-like [KO:K12958]
107750272  caveolin-2-like [KO:K12958]
107715787  caveolin-2-like [KO:K12958]
107749619  caveolin-3-like [KO:K12959]
107750282  caveolin-3-like [KO:K12959]
107755790  tyrosine-protein kinase fyna-like isoform X1 [KO:K05703] [EC:2.7.10.2]
107755004  tyrosine-protein kinase fynb-like [KO:K05703] [EC:2.7.10.2]
107750405  tyrosine-protein kinase fynb [KO:K05703] [EC:2.7.10.2]
107751750  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
107723450  SHC-transforming protein 1-like [KO:K06279]
107714692  SHC-transforming protein 1-like isoform X1 [KO:K06279]
107719564  SHC-transforming protein 2-like isoform X1 [KO:K17447]
107729700  SHC-transforming protein 2-like isoform X1 [KO:K17447]
107731079  SHC-transforming protein 3-like [KO:K17448]
107713521  shc3; SHC-transforming protein 3 [KO:K17448]
107719324  growth factor receptor-bound protein 2 [KO:K04364]
107733915  growth factor receptor-bound protein 2-like [KO:K04364]
107728184  growth factor receptor-bound protein 2-like [KO:K04364]
107723603  growth factor receptor-bound protein 2-like [KO:K04364]
107705364  son of sevenless homolog 2-like [KO:K03099]
107712562  son of sevenless homolog 1-like [KO:K03099]
107727064  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
107736529  son of sevenless homolog 2-like [KO:K03099]
107757516  GTPase HRas-like [KO:K02833]
107707549  GTPase HRas [KO:K02833]
107709950  GTPase HRas [KO:K02833]
107735603  GTPase HRas-like [KO:K02833]
107713759  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107742031  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107758125  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107738719  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107741490  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107755584  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107755839  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107729189  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
107743099  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
107734500  ETS domain-containing protein Elk-1-like [KO:K04375]
107730086  G1/S-specific cyclin-D1 [KO:K04503]
107727103  G1/S-specific cyclin-D1-like [KO:K04503]
107732799  G1/S-specific cyclin-D2-like [KO:K10151]
107725932  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
107707471  G1/S-specific cyclin-D2-like [KO:K10151]
107729433  G1/S-specific cyclin-D2-like [KO:K10151]
107732861  G1/S-specific cyclin-D2-like [KO:K10151]
107710106  G1/S-specific cyclin-D2-like [KO:K10151]
107723118  G1/S-specific cyclin-D2-like isoform X1 [KO:K10152]
107718959  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
107731450  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
107751921  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
107756098  bcl2-associated agonist of cell death-like [KO:K02158]
107750664  bcl2-associated agonist of cell death-like [KO:K02158]
107715303  bcl2-associated agonist of cell death-like [KO:K02158]
107749804  uncharacterized protein LOC107749804 isoform X1 [KO:K02158]
107711715  apoptosis regulator Bcl-2-like [KO:K02161]
107757715  apoptosis regulator Bcl-2-like [KO:K02161]
107729657  apoptosis regulator Bcl-2-like [KO:K02161]
107727540  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
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Exp Cell Res 261:1-12 (2000)
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The PI3K-PDK1 connection: more than just a road to PKB.
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Biochem J 346 Pt 3:561-76 (2000)
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PMID:11882383
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Nicholson KM, Anderson NG.
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The protein kinase B/Akt signalling pathway in human malignancy.
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Cell Signal 14:381-95 (2002)
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PMID:15053919
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Oloumi A, McPhee T, Dedhar S.
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Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
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Biochim Biophys Acta 1691:1-15 (2004)
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PMID:11146675
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Turner CE.
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Paxillin and focal adhesion signalling.
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Nat Cell Biol 2:E231-6 (2000)
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The mechanism of action of the tumour suppressor gene PTEN.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
srx04010  MAPK signaling pathway
srx04060  Cytokine-cytokine receptor interaction
srx04070  Phosphatidylinositol signaling system
srx04110  Cell cycle
srx04310  Wnt signaling pathway
srx04512  ECM-receptor interaction
srx04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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