KEGG   PATHWAY: pyu04024
Entry
pyu04024                    Pathway                                
Name
cAMP signaling pathway - Herpailurus yagouaroundi (jaguarundi)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04024  cAMP signaling pathway
pyu04024

Other DBs
GO: 0019933
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010149  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
121010340  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121010378  [KO:K08402]
121010380  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
121010452  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121010462  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011007  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
121011198  RHOA; transforming protein RhoA [KO:K04513]
121011233  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121011250  DRD1; D(1A) dopamine receptor isoform X1 [KO:K04144]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011569  FFAR2; free fatty acid receptor 2 [KO:K04328]
121011570  [KO:K04328]
121011587  FXYD1; phospholemman [KO:K13360]
121011790  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
121012085  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
121012246  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
121012424  OXT; oxytocin-neurophysin 1 [KO:K05243]
121013296  [KO:K05264]
121013486  AFDN; afadin [KO:K05702]
121013975  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014117  VAV1; proto-oncogene vav [KO:K05730]
121014183  [KO:K06225]
121014270  [KO:K03914]
121014870  [KO:K02183]
121014873  [KO:K02183]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015055  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
121015072  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015334  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
121015362  SOX9; transcription factor SOX-9 [KO:K18435]
121015368  SSTR2; somatostatin receptor type 2 [KO:K04218]
121015507  [KO:K01539] [EC:7.2.2.13]
121015508  [KO:K01539] [EC:7.2.2.13]
121015563  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
121015682  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
121015696  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
121015983  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
121016054  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
121016232  FSHR; follicle-stimulating hormone receptor [KO:K04247]
121016305  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
121016318  CALM2; calmodulin-2 [KO:K02183]
121016395  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
121016641  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121016945  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121016977  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121017370  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017884  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
121017941  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
121018087  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121018096  NPPA; natriuretic peptides A [KO:K12334]
121018174  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
121018181  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121018400  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
121018485  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
121018625  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
121018659  CALM3; calmodulin-3 isoform X1 [KO:K02183]
121018786  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
121018883  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
121018886  [KO:K08521]
121019338  CALML6; calmodulin-like protein 6 [KO:K02183]
121019534  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121019600  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121019602  [KO:K04498] [EC:2.3.1.48]
121019744  SSTR5; somatostatin receptor type 5 [KO:K04221]
121019926  EDN3; endothelin-3 [KO:K05227]
121019943  [KO:K04632]
121019944  [KO:K04632]
121020148  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
121020230  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121020445  EDN1; endothelin-1 [KO:K16366]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020805  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
121021133  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
121021239  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
121021362  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121021379  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
121021387  AMH; muellerian-inhibiting factor [KO:K04665]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021567  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
121021623  ADORA1; adenosine receptor A1 [KO:K04265]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121021888  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022470  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121022967  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
121022981  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023156  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
121023342  TNNI3; troponin I, cardiac muscle [KO:K12044]
121023688  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121023725  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121023818  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023959  RELA; transcription factor p65 [KO:K04735]
121023973  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
121025006  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
121025071  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
121025392  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
121025419  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
121025596  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121026946  EDN2; endothelin-2 [KO:K16367]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121027265  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
121027308  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027595  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
121027636  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121027674  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
121027680  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
121027745  TSHB; thyrotropin subunit beta [KO:K05251]
121027760  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
121028050  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028276  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
121028280  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
121028439  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
121028520  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
121028523  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
121028557  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121028615  NPY; pro-neuropeptide Y [KO:K05232]
121028803  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121028820  EDNRA; endothelin-1 receptor [KO:K04197]
121028935  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
121029109  [KO:K06231]
121029152  CGA; glycoprotein hormones alpha chain [KO:K08522]
121029240  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
121029418  [KO:K11265] [EC:4.6.1.1]
121029688  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
121029748  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
121029836  BVES; blood vessel epicardial substance [KO:K21108]
121029837  POPDC3; popeye domain-containing protein 3 [KO:K26207]
121029977  PLN; cardiac phospholamban [KO:K05852]
121030619  GCG; pro-glucagon isoform X1 [KO:K05259]
121030635  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121030705  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
121030974  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121031569  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
121031656  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
121031678  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
121031765  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121031881  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
121032071  FOS; proto-oncogene c-Fos [KO:K04379]
121032135  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
121032181  CALM1; calmodulin-1 [KO:K02183]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032683  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033118  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
121033130  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262]
121033234  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
121033362  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121033760  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
121033854  SUCNR1; succinate receptor 1 [KO:K10042]
121033993  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034136  SST; somatostatin [KO:K05237]
121034643  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121034724  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
121034768  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
121035401  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
121035451  [KO:K01538]
121036015  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
121036108  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
121036160  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
121036280  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
121036524  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121036802  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121037018  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
121037793  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
121038024  CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X1 [KO:K04953]
121038177  CRH; corticoliberin [KO:K05256]
121038444  DRD5; D(1B) dopamine receptor [KO:K05840]
121038647  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121038668  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
121038849  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
121038896  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121038903  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
121039327  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121040167  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
121040286  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
121040395  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121040647  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
121040701  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121040776  RAP1B; ras-related protein Rap-1b [KO:K07836]
121040874  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041261  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
121041265  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
121041310  OXTR; oxytocin receptor [KO:K04229]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041895  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
121041964  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
121042416  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
121042990  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121043476  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121043615  FSHB; follitropin subunit beta [KO:K05250]
121043625  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
121044101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121044199  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121044205  POMC; pro-opiomelanocortin [KO:K05228]
121044291  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121044748  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
121044775  ADRB2; beta-2 adrenergic receptor [KO:K04142]
121044827  [KO:K05258]
121044909  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
121045049  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121045271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
121045367  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
121045437  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
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Related
pathway
pyu00071  Fatty acid degradation
pyu04015  Rap1 signaling pathway
pyu04020  Calcium signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04210  Apoptosis
pyu04260  Cardiac muscle contraction
pyu04340  Hedgehog signaling pathway
pyu04720  Long-term potentiation
pyu04740  Olfactory transduction
pyu04972  Pancreatic secretion
pyu04976  Bile secretion
KO pathway
ko04024   

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