KEGG   PATHWAY: shr04062
Entry
shr04062                    Pathway                                
Name
Chemokine signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
shr04062  Chemokine signaling pathway
shr04062

Other DBs
GO: 0070098
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913351  [KO:K04180]
100913486  CCL21; C-C motif chemokine 21 [KO:K16062]
100913578  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
100913616  [KO:K04180]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100913731  [KO:K04345] [EC:2.7.11.11]
100913992  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
100914479  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100914558  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
100914706  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100914745  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100914747  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100914800  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
100914986  [KO:K05507]
100915231  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
100915281  GRK5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
100915440  [KO:K05505]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100915783  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100915784  [KO:K12964]
100916024  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
100916150  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100916183  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100916377  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100916478  [KO:K12964]
100916578  XCR1; chemokine XC receptor 1 [KO:K04193]
100916611  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
100916629  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100916737  [KO:K12964]
100916740  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
100916836  [KO:K04178]
100916865  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
100917003  [KO:K12964]
100917083  FOXO3; forkhead box protein O3 [KO:K09408]
100917237  PXN; paxillin [KO:K05760]
100917263  [KO:K12964]
100917513  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100917694  CCR10; C-C chemokine receptor type 10 [KO:K04185]
100917745  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100917781  [KO:K12964]
100917856  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100918041  [KO:K05408]
100918228  [KO:K04176]
100918370  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100918574  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100918907  [KO:K14624]
100918989  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
100919027  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
100919171  [KO:K05408]
100919206  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100919264  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100919435  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100920108  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100920135  RAP1B; ras-related protein Rap-1b [KO:K07836]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100920243  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100920266  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100920307  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100920537  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100920650  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100920700  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100920711  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100920799  [KO:K04546]
100921316  CCL19; C-C motif chemokine 19 [KO:K05512]
100921385  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
100921581  [KO:K16598]
100921741  CCL22; C-C motif chemokine 22 [KO:K21095]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100921906  GRK6; G protein-coupled receptor kinase 6 isoform X3 [KO:K08291] [EC:2.7.11.16]
100921931  RHOA; transforming protein RhoA [KO:K04513]
100921946  [KO:K04175]
100922003  CX3CL1; fractalkine [KO:K05508]
100922193  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100922206  [KO:K05050]
100922240  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100922264  CCL17; LOW QUALITY PROTEIN: C-C motif chemokine 17 [KO:K21083]
100922434  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100922938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100923119  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100923387  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
100923581  CRKL; crk-like protein [KO:K04438]
100923822  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100923926  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100924669  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100925102  [KO:K12964]
100925245  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925455  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100925657  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100925746  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
100926025  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100926184  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100926242  CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
100926362  CCL28; C-C motif chemokine 28 [KO:K05513]
100926507  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100926529  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100926770  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100926921  SHC1; SHC-transforming protein 1 isoform X4 [KO:K06279]
100927237  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100927252  [KO:K07827]
100927458  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100927581  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100928499  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
100928725  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100928883  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100928986  NRAS; GTPase NRas [KO:K07828]
100929015  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100929168  [KO:K02833]
100929196  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100929278  ADCY7; adenylate cyclase type 7 isoform X3 [KO:K08047] [EC:4.6.1.1]
100929360  [KO:K04345] [EC:2.7.11.11]
100929426  [KO:K07827]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100930507  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100930926  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100931079  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
100931224  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100931238  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100931703  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100932383  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100932473  RELA; transcription factor p65 [KO:K04735]
100932612  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100932634  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100933019  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
100933153  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100933167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100933581  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100933600  CXCL8; interleukin-8 [KO:K10030]
100933735  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100933888  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100934049  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100934222  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
100934273  [KO:K21096]
100934311  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100934336  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100934443  CCR7; C-C chemokine receptor type 7 [KO:K04182]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100934873  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100935403  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
105749426  CCL25; C-C motif chemokine 25 [KO:K13072]
105749862  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105750536  [KO:K05408]
105750580  [KO:K12964]
105750636  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
105750853  [KO:K12671]
105750855  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
105751035  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
111720800  [KO:K05514]
111720949  [KO:K05408]
111721298  [KO:K10032]
116419913  HRAS; GTPase HRas [KO:K02833]
116419978  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116419987  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116420004  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
116420956  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
116422421  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
116423442  [KO:K12964]
116423462  CRK; adapter molecule crk isoform X1 [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
shr04010  MAPK signaling pathway
shr04060  Cytokine-cytokine receptor interaction
shr04120  Ubiquitin mediated proteolysis
shr04630  JAK-STAT signaling pathway
shr04670  Leukocyte transendothelial migration
shr04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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