KEGG   PATHWAY: mcc05168
Entry
mcc05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Macaca mulatta (rhesus monkey)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05168  Herpes simplex virus 1 infection
mcc05168

Disease
H00365  Herpes simplex virus infection
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100187576  MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]
100187587  MAMU-DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
100423877  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
100424348  [KO:K06751]
100425223  CYCS; cytochrome c [KO:K08738]
100426197  [KO:K06751]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100428228  MAMU-DRB5; LOW QUALITY PROTEIN: MHC class II antigen, Mamu-DRB5 [KO:K06752]
100428309  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
100428435  [KO:K06752]
100429857  MAMU-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
106992322  [KO:K05414]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106995371  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
106995399  [KO:K08738]
106995452  [KO:K06751]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
106996627  [KO:K06751]
106996676  [KO:K06751]
106997687  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 isoform X1 [KO:K28004]
106997893  [KO:K06751]
106997902  [KO:K06752]
114669761  PILRB; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
114669810  [KO:K06752]
114672113  [KO:K08056] [EC:5.3.4.1]
114672663  [KO:K05414]
114672664  [KO:K05414]
114675357  [KO:K06752]
114675515  [KO:K14021]
114676051  [KO:K06751]
114677644  [KO:K06751]
114680234  [KO:K12892]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
574138  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574178  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
574282  IFNG; interferon gamma precursor [KO:K04687]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574294  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574378  TLR3; toll-like receptor 3 precursor [KO:K05401]
574395  TLR9; toll-like receptor 9 precursor [KO:K10161]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
692100  MAMU-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
693880  [KO:K14284]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694184  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
694353  TMEM173; stimulator of interferon genes protein [KO:K12654]
694372  [KO:K06751]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694631  [KO:K05414]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
694965  TSC2; tuberin isoform X7 [KO:K07207]
695042  TNFRSF14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
695351  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
696054  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
696875  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
697191  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
698225  [KO:K08738]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699079  SRSF8; serine/arginine-rich splicing factor 8 [KO:K12891]
699243  MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
699489  IFNGR2; interferon gamma receptor 2 [KO:K05133]
699575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
699919  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
699951  [KO:K08738]
700316  HCFC2; host cell factor 2 [KO:K27390]
700322  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
700379  PML; protein PML [KO:K10054] [EC:2.3.2.-]
700467  C5; complement C5 isoform X1 [KO:K03994]
700530  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701246  [KO:K08738]
701360  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
701451  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
702024  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
702468  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
702488  [KO:K08738]
702592  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
703302  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
703325  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
703409  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
703613  C3; complement C3 [KO:K03990]
703628  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
703673  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
704638  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
705438  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
705449  [KO:K08738]
705819  IL6; interleukin-6 precursor [KO:K05405]
705862  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
706140  [KO:K14284]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
706835  POU2F2; POU domain, class 2, transcription factor 2 isoform X14 [KO:K09364]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707386  CFP; properdin [KO:K15412]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
708105  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
709076  MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709935  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710072  NECTIN1; nectin-1 [KO:K06081]
710150  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710485  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
710487  [KO:K05414]
710528  [KO:K05414]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710568  [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710751  [KO:K05414]
710820  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
710848  [KO:K05414]
711005  SP100; nuclear autoantigen Sp-100 isoform X8 [KO:K15413]
711029  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
711088  [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711309  [KO:K08738]
711414  IFNB1; interferon beta precursor [KO:K05415]
711532  MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]
711832  MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
711854  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
711879  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
712148  [KO:K08738]
712265  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
712342  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
712401  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
712428  B2M; beta-2-microglobulin precursor [KO:K08055]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
712867  SRSF5; serine/arginine-rich splicing factor 5 isoform X2 [KO:K12893]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
713229  NECTIN2; nectin-2 precursor [KO:K06531]
713388  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
713958  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
714645  TSC1; hamartin isoform X1 [KO:K07206]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714852  ALYREF; THO complex subunit 4 [KO:K12881]
714964  [KO:K06751]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
715378  RHEB; GTP-binding protein Rheb [KO:K07208]
715425  LTA; lymphotoxin-alpha precursor [KO:K05468]
715467  TNF; tumor necrosis factor [KO:K03156]
715647  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
715680  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716056  [KO:K08738]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716823  MAMU-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
716910  CALR; calreticulin precursor [KO:K08057]
717379  ITGB3; integrin beta-3 [KO:K06493]
717401  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717590  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
717665  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
717702  MAMU-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]
717726  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717742  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
717870  MAMU-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]
717947  MAMU-DOA; major histocompatibility complex, class II, DO alpha precursor [KO:K06752]
717969  MAMU-DPB; major histocompatibility complex, class II, DP beta [KO:K06752]
717992  MAMU-DPA; major histocompatibility complex, class II, DP alpha [KO:K06752]
718235  TAPBP; tapasin precursor [KO:K08058]
718420  NXF1; nuclear RNA export factor 1 [KO:K14284]
718948  BAX; apoptosis regulator BAX [KO:K02159]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
719039  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
719092  BST2; bone marrow stromal antigen 2 [KO:K06731]
719123  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
719250  [KO:K06751]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719702  [KO:K06751]
720132  [KO:K06751]
720582  MAMU-DQA1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]
721735  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
721913  PILRA; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
723473  [KO:K06751]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
mcc03040  Spliceosome
mcc03050  Proteasome
mcc04115  p53 signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04610  Complement and coagulation cascades
mcc04612  Antigen processing and presentation
mcc04620  Toll-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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