KEGG   PATHWAY: omm05168
Entry
omm05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Oncorhynchus masou masou (cherry salmon)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
omm05168  Herpes simplex virus 1 infection
omm05168

Disease
H00365  Herpes simplex virus infection
Organism
Oncorhynchus masou masou (cherry salmon) [GN:omm]
Gene
135503829  [KO:K07210]
135503853  hcfc1b; LOW QUALITY PROTEIN: host cell factor 1b [KO:K14966]
135503930  [KO:K05152]
135503931  [KO:K05152]
135503932  [KO:K05152]
135503933  [KO:K05152]
135503936  [KO:K05152]
135503937  [KO:K05152]
135503938  [KO:K05152]
135503939  [KO:K05152]
135503941  [KO:K05152]
135504098  [KO:K05704] [EC:2.7.10.2]
135504151  [KO:K06484]
135504357  [KO:K15412]
135504359  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
135504429  [KO:K04570]
135504499  [KO:K07293] [EC:3.1.3.48]
135504502  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
135504599  [KO:K12893]
135504732  [KO:K04467] [EC:2.7.11.10]
135504736  irf3; interferon regulatory factor 3 [KO:K05411]
135504751  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
135504806  ifnphi4; interferon phi 4 isoform X1 [KO:K05414]
135504838  [KO:K06493]
135504995  [KO:K04467] [EC:2.7.11.10]
135504999  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
135505102  [KO:K02159]
135505125  [KO:K02373]
135505128  [KO:K15409] [EC:2.7.11.1]
135505282  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
135505787  [KO:K06269] [EC:3.1.3.16]
135505817  [KO:K03237]
135505894  [KO:K04456] [EC:2.7.11.1]
135506037  [KO:K04404]
135506062  [KO:K04427] [EC:2.7.11.25]
135506121  [KO:K04734]
135506243  [KO:K03680]
135506246  [KO:K03754]
135506654  casp3a; caspase-3a isoform X1 [KO:K02187] [EC:3.4.22.56]
135506794  tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
135507823  [KO:K02187] [EC:3.4.22.56]
135507942  [KO:K03237]
135508003  [KO:K03174]
135508034  [KO:K04734]
135508265  [KO:K04456] [EC:2.7.11.1]
135508368  [KO:K04427] [EC:2.7.11.25]
135508530  srsf5a; serine and arginine rich splicing factor 5a isoform X1 [KO:K12893]
135508548  mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
135509121  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
135509147  bida; BH3 interacting domain death agonist [KO:K04726]
135509247  [KO:K09447]
135509388  calr3b; calreticulin 3b [KO:K08057]
135509503  [KO:K04733] [EC:2.7.11.1]
135509637  [KO:K08056] [EC:5.3.4.1]
135510120  cgasa; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
135510180  [KO:K12646] [EC:5.6.2.6]
135510255  badb; BCL2 associated agonist of cell death b [KO:K02158]
135510682  [KO:K04451]
135510692  [KO:K06269] [EC:3.1.3.16]
135510693  [KO:K04735]
135511032  [KO:K04390]
135511144  [KO:K04398] [EC:3.4.22.61]
135511536  [KO:K03990]
135511699  [KO:K02649]
135511959  [KO:K02649]
135512100  [KO:K12891]
135512110  [KO:K04696]
135512322  [KO:K04390]
135512339  [KO:K17834] [EC:2.7.7.86]
135512699  [KO:K08057]
135512926  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
135512956  [KO:K04389]
135513189  [KO:K02649]
135513224  [KO:K02161]
135513776  [KO:K04519]
135513966  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
135514046  [KO:K07205]
135514081  [KO:K03239]
135514215  [KO:K06269] [EC:3.1.3.16]
135514371  [KO:K12794]
135514877  [KO:K27390]
135515072  [KO:K02084]
135515449  [KO:K08057]
135515560  [KO:K08055]
135515565  [KO:K08055]
135515717  [KO:K02084]
135516146  [KO:K02649]
135516385  [KO:K04451]
135516395  [KO:K06269] [EC:3.1.3.16]
135516396  [KO:K04735]
135516505  tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
135516529  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
135516562  [KO:K08055]
135516563  [KO:K08055]
135516883  [KO:K11217] [EC:2.7.10.2]
135516918  il1b; LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
135517036  [KO:K03173] [EC:2.3.2.27]
135517100  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
135517190  [KO:K00922] [EC:2.7.1.153]
135517256  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
135517282  [KO:K02161]
135517606  [KO:K04447] [EC:2.7.10.2]
135517722  [KO:K07293] [EC:3.1.3.48]
135517812  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
135517927  [KO:K07206]
135517999  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
135518066  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
135518385  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
135518538  [KO:K07208]
135518930  crfb2; cytokine receptor family member b2 [KO:K05131]
135519005  [KO:K09364]
135519470  [KO:K04398] [EC:3.4.22.61]
135519482  [KO:K08738]
135519723  [KO:K11220]
135520095  [KO:K03990]
135520252  tlr18; toll-like receptor 18 [KO:K10159]
135520314  [KO:K08056] [EC:5.3.4.1]
135520362  [KO:K06531]
135520566  [KO:K09364]
135520591  [KO:K03158]
135520802  [KO:K06752]
135520864  [KO:K12896]
135521009  [KO:K09849]
135521250  [KO:K03156]
135521915  tapbpl; tapasin-related protein [KO:K28445]
135521919  [KO:K03158]
135521939  pou2f2b; POU class 2 homeobox 2a isoform X1 [KO:K09364]
135522092  [KO:K03990]
135522126  [KO:K06531]
135522243  [KO:K10159]
135522296  [KO:K05653] [EC:7.4.2.14]
135522397  [KO:K03990]
135522399  [KO:K03990]
135522408  [KO:K04456] [EC:2.7.11.1]
135522875  [KO:K02161]
135522890  [KO:K07208]
135522985  [KO:K12881]
135523118  [KO:K05468]
135523416  [KO:K12891]
135523536  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
135523550  ifngr1l; interferon gamma receptor 1-like isoform X1 [KO:K05132]
135523552  [KO:K05132]
135523687  [KO:K05132]
135523890  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
135524022  [KO:K04467] [EC:2.7.11.10]
135524282  [KO:K09447]
135524599  [KO:K08057]
135524650  [KO:K02649]
135525479  [KO:K12893]
135525619  eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237]
135525670  [KO:K03174]
135525697  [KO:K04734]
135525746  [KO:K05477]
135525926  [KO:K04456] [EC:2.7.11.1]
135526021  [KO:K04427] [EC:2.7.11.25]
135526233  cd74a; CD74 molecule, major histocompatibility complex, class II invariant chain a isoform X1 [KO:K06505]
135526301  [KO:K02580]
135526322  [KO:K04389]
135526598  [KO:K14284]
135527108  [KO:K12654]
135527281  [KO:K05425]
135527406  [KO:K07293] [EC:3.1.3.48]
135527673  [KO:K07210]
135527684  [KO:K14966]
135527685  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
135527749  [KO:K15409] [EC:2.7.11.1]
135527777  [KO:K04570]
135528047  [KO:K12893]
135528122  [KO:K15412]
135528205  [KO:K06752]
135528341  itga5; integrin alpha-5 [KO:K06484]
135528361  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
135528382  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
135528398  [KO:K05704] [EC:2.7.10.2]
135528647  [KO:K04687]
135528648  [KO:K04687]
135528649  [KO:K04687]
135529964  [KO:K07208]
135529967  [KO:K07208]
135531168  [KO:K06752]
135531402  [KO:K06752]
135532194  [KO:K06752]
135532195  [KO:K06752]
135532279  [KO:K08055]
135532584  [KO:K06081]
135533280  [KO:K05152]
135534575  [KO:K04729]
135534613  [KO:K06752]
135534614  [KO:K06752]
135536374  [KO:K07208]
135536480  [KO:K05414]
135536665  [KO:K04696]
135537042  [KO:K05414]
135537044  [KO:K05414]
135537527  [KO:K12890]
135537528  [KO:K12890]
135537766  [KO:K04687]
135537771  [KO:K04687]
135537772  [KO:K04687]
135537773  [KO:K04687]
135537777  [KO:K05410] [EC:2.7.11.10]
135537956  [KO:K07207]
135537959  [KO:K07207]
135538079  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
135538130  [KO:K06752]
135538354  [KO:K03754]
135538814  [KO:K05406]
135538815  [KO:K05406]
135538887  [KO:K12881]
135539368  [KO:K04456] [EC:2.7.11.1]
135539407  [KO:K03990]
135539451  [KO:K12896]
135539549  [KO:K05704] [EC:2.7.10.2]
135539603  [KO:K06484]
135539772  [KO:K12892]
135539925  [KO:K06269] [EC:3.1.3.16]
135539979  [KO:K07208]
135539986  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
135540016  [KO:K12892]
135540191  [KO:K04570]
135540194  [KO:K14966]
135540240  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
135540369  [KO:K15409] [EC:2.7.11.1]
135541363  [KO:K05704] [EC:2.7.10.2]
135541418  [KO:K06484]
135541678  [KO:K11220]
135541738  [KO:K12892]
135541934  [KO:K07208]
135541969  [KO:K12892]
135542104  [KO:K07205]
135542140  [KO:K04570]
135542142  [KO:K14966]
135542308  [KO:K15409] [EC:2.7.11.1]
135542375  [KO:K21123]
135542511  [KO:K11220]
135543283  [KO:K09364]
135543566  [KO:K11220]
135543794  [KO:K02187] [EC:3.4.22.56]
135543975  [KO:K16060]
135544085  [KO:K04456] [EC:2.7.11.1]
135544161  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
135544300  [KO:K14284]
135544309  [KO:K02158]
135544411  [KO:K07206]
135544487  [KO:K03173] [EC:2.3.2.27]
135544509  [KO:K07205]
135544652  [KO:K03173] [EC:2.3.2.27]
135544655  [KO:K02649]
135544705  [KO:K04519]
135544946  [KO:K05425]
135545190  [KO:K04389]
135545263  [KO:K05406]
135545264  [KO:K05406]
135545605  [KO:K12654]
135545623  [KO:K04519]
135545640  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
135545737  [KO:K06505]
135545799  [KO:K02580]
135545963  c5; complement C5 isoform X1 [KO:K03994]
135546035  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
135546237  [KO:K02649]
135546245  [KO:K12896]
135546622  [KO:K00922] [EC:2.7.1.153]
135546631  [KO:K04456] [EC:2.7.11.1]
135546635  [KO:K06751]
135547140  stat1b; signal transducer and activator of transcription 1b [KO:K11220]
135547150  fadd; protein FADD [KO:K02373]
135547166  [KO:K02159]
135547182  [KO:K12647] [EC:5.6.2.6]
135547328  [KO:K09364]
135547666  [KO:K06751]
135547684  [KO:K04398] [EC:3.4.22.61]
135547689  [KO:K08738]
135548127  [KO:K04447] [EC:2.7.10.2]
135548247  [KO:K03239]
135548248  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
135548318  [KO:K21123]
135548782  [KO:K05425]
135548875  [KO:K09364]
135548911  [KO:K12896]
135549026  [KO:K03156]
135549089  [KO:K09364]
135549437  [KO:K06081]
135549491  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
135549531  [KO:K12893]
135549561  [KO:K05405]
135549907  [KO:K08056] [EC:5.3.4.1]
135549969  [KO:K05654] [EC:7.4.2.14]
135549970  [KO:K06751]
135549984  [KO:K06531]
135550037  [KO:K17834] [EC:2.7.7.86]
135550215  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
135550226  [KO:K04456] [EC:2.7.11.1]
135550412  [KO:K14284]
135550436  [KO:K02158]
135550838  [KO:K12896]
135550888  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
135551001  [KO:K05425]
135551091  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
135551094  [KO:K12890]
135551344  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
135551422  [KO:K09364]
135551516  [KO:K05406]
135551710  [KO:K12893]
135551889  [KO:K08738]
135551931  il6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
135552157  [KO:K08056] [EC:5.3.4.1]
135552222  [KO:K05654] [EC:7.4.2.14]
135552227  [KO:K06751]
135552228  tapbp.1; TAP binding protein (tapasin), tandem duplicate 1 [KO:K08058]
135552231  daxx; death domain-associated protein 6 [KO:K02308]
135552237  pvrl2l; PVR cell adhesion molecule related 2 like isoform X1 [KO:K06531]
135552296  [KO:K17834] [EC:2.7.7.86]
135552731  [KO:K12896]
135552934  [KO:K12890]
135553111  [KO:K00922] [EC:2.7.1.153]
135553129  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
135553265  [KO:K06081]
135553653  [KO:K05414]
135553654  [KO:K05414]
135553655  [KO:K05414]
135553657  [KO:K05414]
135553658  [KO:K05414]
135553660  [KO:K05414]
135553661  [KO:K05414]
135553662  [KO:K05414]
135554012  [KO:K06493]
135554073  [KO:K02159]
135554074  [KO:K02159]
135554148  [KO:K11219] [EC:2.7.10.2]
135554353  [KO:K12881]
135554369  [KO:K12891]
135554428  [KO:K06269] [EC:3.1.3.16]
135554491  [KO:K05477]
135554855  [KO:K05414]
135555023  [KO:K05414]
135555025  [KO:K05414]
135555026  [KO:K05414]
135555028  [KO:K05414]
135555029  [KO:K05414]
135555031  [KO:K05414]
135555032  [KO:K05414]
135555034  [KO:K05414]
135555036  [KO:K05414]
135555037  [KO:K05414]
135555039  [KO:K05414]
135555041  [KO:K05414]
135555043  [KO:K05414]
135555044  [KO:K05414]
135555045  [KO:K05414]
135555046  [KO:K05414]
135555048  [KO:K05414]
135555049  [KO:K05414]
135555050  [KO:K05414]
135555051  [KO:K05414]
135555052  [KO:K05414]
135555053  [KO:K05414]
135555054  [KO:K05414]
135555055  [KO:K05414]
135555056  [KO:K05414]
135555118  [KO:K04389]
135555214  il12b2; interleukin-12 subunit beta isoform X1 [KO:K05425]
135555273  [KO:K05477]
135555291  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
135555338  [KO:K06269] [EC:3.1.3.16]
135555399  [KO:K12891]
135555409  [KO:K12881]
135555608  [KO:K11219] [EC:2.7.10.2]
135555686  [KO:K02159]
135555744  [KO:K06493]
135555837  [KO:K05414]
135555838  [KO:K05414]
135555954  [KO:K02159]
135556125  [KO:K02159]
135556158  [KO:K02649]
135556179  [KO:K11217] [EC:2.7.10.2]
135556407  calr; calreticulin [KO:K08057]
135556607  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
135556701  [KO:K08056] [EC:5.3.4.1]
135557457  [KO:K04734]
135557491  [KO:K04427] [EC:2.7.11.25]
135557522  [KO:K04404]
135557668  [KO:K04456] [EC:2.7.11.1]
135557860  [KO:K06269] [EC:3.1.3.16]
135557943  srsf5b; serine and arginine rich splicing factor 5b isoform X1 [KO:K12893]
135557980  [KO:K03754]
135557989  eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680]
135558085  [KO:K07208]
135558413  [KO:K11217] [EC:2.7.10.2]
135558441  [KO:K00922] [EC:2.7.1.153]
135558527  [KO:K02649]
135558554  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
135558588  [KO:K08057]
135558696  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
135558772  [KO:K02161]
135558893  [KO:K02649]
135558971  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
omm03040  Spliceosome
omm03050  Proteasome
omm04115  p53 signaling pathway
omm04210  Apoptosis
omm04620  Toll-like receptor signaling pathway
omm04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

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