KEGG   PATHWAY: osa04120
osa04120                    Pathway                                
Ubiquitin mediated proteolysis - Oryza sativa japonica (Japanese rice) (RefSeq)
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Genetic Information Processing; Folding, sorting and degradation
Pathway map
osa04120  Ubiquitin mediated proteolysis

Other DBs
GO: 0016567
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
4328390  polyubiquitin [KO:K08770]
9272016  polyubiquitin [KO:K08770]
4337080  polyubiquitin 3 [KO:K08770]
4341860  polyubiquitin [KO:K08770]
4348886  polyubiquitin 12 [KO:K08770]
4332169  ubiquitin-60S ribosomal protein L40-2 [KO:K02927]
4332312  ubiquitin [KO:K02927]
4347409  ubiquitin [KO:K02927]
4343261  ubiquitin [KO:K02927]
4347232  ubiquitin [KO:K02927]
4347411  ubiquitin-60S ribosomal protein L40 [KO:K02927]
4347896  ubiquitin-60S ribosomal protein L40-2 [KO:K02927]
107277317  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
4326977  ubiquitin-40S ribosomal protein S27a-1 [KO:K02977]
4337883  ubiquitin-40S ribosomal protein S27a-2 [KO:K02977]
107277614  ubiquitin-like [KO:K02977]
4349557  ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:]
4332529  ubiquitin-activating enzyme E1 3 [KO:K03178] [EC:]
4344380  ubiquitin-activating enzyme E1 3 isoform X1 [KO:K03178] [EC:]
9271171  LOW QUALITY PROTEIN: ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:]
4350554  SUMO-activating enzyme subunit 1A [KO:K10684] [EC:]
4343750  SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:]
4325169  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:]
4342488  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:]
4334386  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:]
4337993  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:]
4325174  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:]
4327450  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K06689] [EC:]
4337331  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:]
4346639  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:]
4327162  ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:]
4328940  ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:]
4341133  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:]
4327451  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:]
4343707  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:]
4339013  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:]
4327386  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:]
4348755  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:]
4331446  SUMO-conjugating enzyme SCE1 [KO:K10577]
4349236  SUMO-conjugating enzyme SCE1 [KO:K10577]
4336760  SUMO-conjugating enzyme SCE1 [KO:K10577]
4332614  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:]
4340379  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:]
4327237  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:]
4345411  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:]
4346713  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:]
4348232  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:]
4325905  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:]
4326008  probable ubiquitin-conjugating enzyme E2 23 isoform X1 [KO:K10581] [EC:]
4324280  baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10581] [EC:]
4338168  probable ubiquitin-conjugating enzyme E2 26 [KO:K10581] [EC:]
4324290  putative ubiquitin-conjugating enzyme E2 39 isoform X1 [KO:K10581] [EC:]
4339578  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:]
4346643  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:]
107277097  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:]
4339579  probable ubiquitin-conjugating enzyme E2 24 isoform X1 [KO:K10581] [EC:]
107276513  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:]
4341740  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:]
4333728  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:]
4352894  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:]
4333737  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:]
4337876  E3 ubiquitin-protein ligase UPL6 isoform X1 [KO:K10589] [EC:]
4327983  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:]
4337658  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:]
4339037  E3 ubiquitin-protein ligase UPL4 isoform X1 [KO:K10590] [EC:]
4352108  E3 ubiquitin-protein ligase UPL2 [KO:K10592] [EC:]
4333165  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:]
4337553  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:]
4344499  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:]
4331972  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:]
4348844  pre-mRNA-processing factor 19 [KO:K10599] [EC:]
4328179  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:]
4344172  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:]
4329066  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:]
4327774  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:]
4340862  putative E3 ubiquitin-protein ligase SINA-like 9 isoform X1 [KO:K04506] [EC:]
9266295  E3 ubiquitin-protein ligase SINAT5 isoform X1 [KO:K04506] [EC:]
9269391  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:]
107278743  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:]
107276545  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:]
107278300  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:]
107280903  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:]
4326047  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:]
4337836  E3 ubiquitin-protein ligase SINA-like 5 [KO:K04506] [EC:]
9268150  uncharacterized protein LOC9268150 [KO:K04506] [EC:]
4330868  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:]
107279948  WD repeat-containing protein RUP2-like [KO:K10143] [EC:]
4348796  E3 ubiquitin-protein ligase MIEL1 isoform X1 [KO:K10144] [EC:]
4352424  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:]
4332833  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:]
4324695  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:]
4331606  E3 ubiquitin-protein ligase MIEL1 isoform X1 [KO:K10144] [EC:]
4340227  E4 SUMO-protein ligase PIAL1 [KO:K04706] [EC:2.3.2.-]
4340826  ERAD-associated E3 ubiquitin-protein ligase HRD1 isoform X1 [KO:K10601] [EC:]
4326152  RING-box protein 1a [KO:K03868] [EC:]
4330476  RING-box protein 1 [KO:K03868] [EC:]
4325735  cullin-1 [KO:K03347]
4337820  cullin-1 [KO:K03347]
4325736  cullin-1 [KO:K03347]
4347721  SKP1-like protein 1A [KO:K03094]
4345419  SKP1-like protein 1A [KO:K03094]
4346586  SKP1-like protein 1A [KO:K03094]
4343963  SKP1-like protein 11 [KO:K03094]
4346592  SKP1-like protein 4 [KO:K03094]
4343000  SKP1-like protein 1B [KO:K03094]
4348713  SKP1-like protein 11 [KO:K03094]
4343962  SKP1-like protein 14 [KO:K03094]
4339908  SKP1-like protein 13 [KO:K03094]
4346585  probable disease resistance protein At1g61300 isoform X1 [KO:K03094]
9270098  SKP1-like protein 1A [KO:K03094]
107275366  SKP1-like protein 11 [KO:K03094]
107275430  SKP1-like protein 1A [KO:K03094]
107275462  SKP1-like protein 1B [KO:K03094]
107275506  SKP1-like protein 1A [KO:K03094]
107275529  SKP1-like protein 11 [KO:K03094]
107275695  SKP1-like protein 1A [KO:K03094]
107275970  SKP1-like protein 1A [KO:K03094]
107276398  SKP1-like protein 11 [KO:K03094]
107277355  SKP1-like protein 11 [KO:K03094]
107278210  SKP1-like protein 13 [KO:K03094]
107278737  SKP1-like protein 11 [KO:K03094]
107281645  SKP1-like protein 11 [KO:K03094]
107281670  SKP1-like protein 11 [KO:K03094]
107282017  SKP1-like protein 1B [KO:K03094]
4324993  F-box protein SKP2A [KO:K03875]
4338850  F-box protein SKP2A [KO:K03875]
4351227  transcription elongation factor B polypeptide 1 [KO:K03872]
4330720  cullin-3A [KO:K03869]
4337175  cullin-3B [KO:K03869]
4344771  cullin-3A [KO:K03869]
4334354  cullin-4 [KO:K10609]
4339794  DNA damage-binding protein 1a isoform X1 [KO:K10610]
4325482  protein DAMAGED DNA-BINDING 2 [KO:K10140]
4329118  DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
4324761  DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
4326296  light-mediated development protein DET1 isoform X1 [KO:K10571]
4332583  anaphase-promoting complex subunit 11 [KO:K03358]
9272104  anaphase-promoting complex subunit 11 [KO:K03358]
4336204  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
4330430  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
4346480  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
4336870  cell division cycle 20.2, cofactor of APC complex isoform X1 [KO:K03363]
4331448  protein FIZZY-RELATED 2 [KO:K03364]
4326397  protein FIZZY-RELATED 3 [KO:K03364]
4338511  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
4341553  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
4330947  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
4352845  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
9267792  anaphase-promoting complex subunit 6 [KO:K03353]
4337822  anaphase-promoting complex subunit 7 [KO:K03354]
4330199  anaphase-promoting complex subunit 8 [KO:K03355]
4339716  anaphase-promoting complex subunit 10 [KO:K03357]
4344013  uncharacterized protein LOC4344013 isoform X1 [KO:K12456]
Kamura T.
[Cullin-based E3 family]
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Matsuda N.
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Tokunaga F.
[E2 ubiquitin-conjugating enzymes: structures and functions]
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Nalepa G, Rolfe M, Harper JW.
Drug discovery in the ubiquitin-proteasome system.
Nat Rev Drug Discov 5:596-613 (2006)
Hsu YJ, Goodman SR.
Spectrin and ubiquitination: a review.
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Hatakeyama S, Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J Biochem 134:1-8 (2003)
Lee J, Zhou P.
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Mol Cell 26:775-80 (2007)
osa03050  Proteasome
KO pathway

DBGET integrated database retrieval system