KEGG   PATHWAY: osa04120
Entry
osa04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Oryza sativa japonica (Japanese rice)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
osa04120  Ubiquitin mediated proteolysis
osa04120

Other DBs
GO: 0016567
Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
107275366  [KO:K03094]
107275430  [KO:K03094]
107275462  [KO:K03094]
107275506  [KO:K03094]
107275529  [KO:K03094]
107275695  [KO:K03094]
107275970  [KO:K03094]
107276398  [KO:K03094]
107276513  [KO:K10581] [EC:2.3.2.24]
107276545  [KO:K04506] [EC:2.3.2.27]
107277129  [KO:K03094]
107277317  [KO:K02927]
107277355  [KO:K03094]
107277614  [KO:K02977]
107278210  [KO:K03094]
107278737  [KO:K03094]
107279948  [KO:K10143] [EC:2.3.2.27]
107281645  [KO:K03094]
107282017  [KO:K03094]
112937424  [KO:K04506] [EC:2.3.2.27]
112937615  [KO:K04506] [EC:2.3.2.27]
136351794  [KO:K02927]
136351860  [KO:K03094]
136351892  [KO:K04506] [EC:2.3.2.27]
136356049  [KO:K06689] [EC:2.3.2.23]
136356056  [KO:K06689] [EC:2.3.2.23]
136356525  [KO:K04506] [EC:2.3.2.27]
136356526  [KO:K04506] [EC:2.3.2.27]
136356527  [KO:K04506] [EC:2.3.2.27]
4324280  [KO:K10581] [EC:2.3.2.24]
4324290  [KO:K10581] [EC:2.3.2.24]
4324695  [KO:K10144] [EC:2.3.2.27]
4324761  [KO:K10570]
4324993  [KO:K03875]
4325169  [KO:K10686] [EC:6.2.1.64]
4325174  [KO:K06688] [EC:2.3.2.23]
4325482  [KO:K10140]
4325735  [KO:K03347]
4325736  [KO:K03347]
4325904  [KO:K10580] [EC:2.3.2.23]
4326008  [KO:K10581] [EC:2.3.2.24]
4326047  [KO:K04506] [EC:2.3.2.27]
4326152  [KO:K03868] [EC:2.3.2.32]
4326296  [KO:K10571]
4326397  [KO:K03364]
4326977  OsJ_01558; ubiquitin-ribosomal protein eS31z fusion protein [KO:K02977]
4327162  OsJ_02884; ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
4327237  [KO:K04649] [EC:2.3.2.23]
4327386  P0408C03.9; ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
4327450  [KO:K06689] [EC:2.3.2.23]
4327451  [KO:K06689] [EC:2.3.2.23]
4327774  [KO:K04506] [EC:2.3.2.27]
4327983  [KO:K10590] [EC:2.3.2.26]
4328114  [KO:K06689] [EC:2.3.2.23]
4328179  [KO:K04506] [EC:2.3.2.27]
4328390  [KO:K08770]
4328940  OsJ_06152; ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
4329066  [KO:K04506] [EC:2.3.2.27]
4329118  [KO:K10570]
4330199  [KO:K03355]
4330430  [KO:K03363]
4330476  [KO:K03868] [EC:2.3.2.32]
4330720  [KO:K03869]
4330868  [KO:K10143] [EC:2.3.2.27]
4330947  [KO:K03351]
4331446  [KO:K10577]
4331448  [KO:K03364]
4331606  [KO:K10144] [EC:2.3.2.27]
4331972  [KO:K10598] [EC:5.2.1.8]
4332169  OJ1175C11.2; ubiquitin-ribosomal protein eL40z fusion protein [KO:K02927]
4332312  [KO:K02927]
4332529  [KO:K03178] [EC:6.2.1.45]
4332583  [KO:K03358]
4332614  [KO:K10578] [EC:2.3.2.23]
4332833  [KO:K10144] [EC:2.3.2.27]
4333165  [KO:K10597] [EC:2.3.2.27]
4333728  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
4333737  [KO:K10588] [EC:2.3.2.26]
4334354  [KO:K10609]
4334386  [KO:K10573] [EC:2.3.2.23]
4336204  [KO:K03349]
4336760  [KO:K10577]
4336870  [KO:K03363]
4337080  OsJ_16259; polyubiquitin 3 [KO:K08770]
4337175  [KO:K03869]
4337331  [KO:K06689] [EC:2.3.2.23]
4337553  [KO:K09561] [EC:2.3.2.27]
4337658  [KO:K10590] [EC:2.3.2.26]
4337820  [KO:K03347]
4337822  [KO:K03354]
4337836  [KO:K04506] [EC:2.3.2.27]
4337876  [KO:K10589] [EC:2.3.2.26]
4337883  OsJ_17209; ubiquitin-ribosomal protein eS31y fusion protein [KO:K02977]
4337993  [KO:K10573] [EC:2.3.2.23]
4338168  [KO:K10581] [EC:2.3.2.24]
4338181  [KO:K04506] [EC:2.3.2.27]
4338511  [KO:K03348]
4338850  [KO:K03875]
4339013  [KO:K10575] [EC:2.3.2.23]
4339037  [KO:K10590] [EC:2.3.2.26]
4339579  [KO:K10581] [EC:2.3.2.24]
4339716  [KO:K03357]
4339794  DBB1; DNA damage-binding protein 1 isoform 1 [KO:K10610]
4339908  [KO:K03094]
4340227  [KO:K04706] [EC:2.3.2.-]
4340379  [KO:K04554] [EC:2.3.2.23]
4340826  HRD1; eRAD-associated E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
4340862  [KO:K04506] [EC:2.3.2.27]
4341133  [KO:K06689] [EC:2.3.2.23]
4341553  [KO:K03350]
4341740  [KO:K10583] [EC:2.3.2.23]
4342488  [KO:K10573] [EC:2.3.2.23]
4343000  [KO:K03094]
4343261  [KO:K02927]
4343750  [KO:K10685] [EC:6.2.1.45]
4343962  [KO:K03094]
4343963  [KO:K03094]
4344013  [KO:K12456]
4344172  [KO:K04506] [EC:2.3.2.27]
4344380  [KO:K03178] [EC:6.2.1.45]
4344499  [KO:K09561] [EC:2.3.2.27]
4344771  [KO:K03869]
4345411  [KO:K10579] [EC:2.3.2.34]
4345419  [KO:K03094]
4346480  [KO:K03363]
4346522  [KO:K10592] [EC:2.3.2.26]
4346585  [KO:K03094]
4346586  [KO:K03094]
4346592  [KO:K03094]
4346639  [KO:K06689] [EC:2.3.2.23]
4346643  [KO:K10581] [EC:2.3.2.24]
4346713  [KO:K10579] [EC:2.3.2.34]
4347232  [KO:K02927]
4347411  [KO:K02927]
4347721  [KO:K03094]
4347896  UBQ2; ubiquitin-ribosomal protein eL40y fusion protein [KO:K02927]
4348232  [KO:K10579] [EC:2.3.2.34]
4348713  [KO:K03094]
4348755  [KO:K10576] [EC:2.3.2.23]
4348796  [KO:K10144] [EC:2.3.2.27]
4348844  OsJ_31829; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
4348886  [KO:K08770]
4349236  [KO:K10577]
4349557  [KO:K03178] [EC:6.2.1.45]
4350554  [KO:K10684] [EC:6.2.1.45]
4351227  [KO:K03872]
4352108  [KO:K10592] [EC:2.3.2.26]
4352424  [KO:K10144] [EC:2.3.2.27]
4352845  [KO:K03352]
4352894  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
9266295  [KO:K04506] [EC:2.3.2.27]
9267792  [KO:K03353]
9268150  [KO:K04506] [EC:2.3.2.27]
9269391  [KO:K04506] [EC:2.3.2.27]
9270098  OsJ_33809; SKP1-like protein 1 [KO:K03094]
9271171  [KO:K03178] [EC:6.2.1.45]
9272016  [KO:K08770]
9272104  [KO:K03358]
Reference
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
osa03050  Proteasome
KO pathway
ko04120   

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