KEGG   PATHWAY: cjc05165
Entry
cjc05165                    Pathway                                
Name
Human papillomavirus infection - Callithrix jacchus (white-tufted-ear marmoset)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
cjc05165  Human papillomavirus infection
cjc05165

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100389319  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100395234  WNT2B; protein Wnt-2b [KO:K00182]
100411308  WNT2; protein Wnt-2 [KO:K00182]
100385309  WNT3A; protein Wnt-3a [KO:K00312]
100398579  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100387135  WNT4; protein Wnt-4 [KO:K00408]
100401066  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
100405273  WNT5B; protein Wnt-5b [KO:K00444]
100394855  WNT6; protein Wnt-6 [KO:K00445]
100414221  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
100387909  WNT7A; protein Wnt-7a [KO:K00572]
100414921  WNT8B; protein Wnt-8b [KO:K00714]
100402422  WNT8A; protein Wnt-8a [KO:K00714]
100397032  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
100393646  WNT9B; protein Wnt-9b [KO:K01064]
100395222  WNT10A; protein Wnt-10a [KO:K01357]
100388949  WNT10B; protein Wnt-10b [KO:K01357]
100398625  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
100387388  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100401631  FZD7; frizzled-7 [KO:K02432]
100404550  FZD1; frizzled-1 [KO:K02432]
100409481  FZD2; frizzled-2 [KO:K02235]
100396334  FZD3; frizzled-3 isoform X1 [KO:K02329]
100403228  FZD4; frizzled-4 isoform X1 [KO:K02354]
100410939  FZD5; frizzled-5 [KO:K02375]
100398598  FZD8; frizzled-8 [KO:K02375]
100387077  FZD6; frizzled-6 [KO:K02376]
100403975  FZD9; frizzled-9 [KO:K02842]
100398976  FZD10; frizzled-10 [KO:K02842]
100390081  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100398229  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100388569  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X3 [KO:K02353]
118154524  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100392475  AXIN1; axin-1 isoform X1 [KO:K02157]
100400518  AXIN2; axin-2 isoform X1 [KO:K04385]
100397972  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100385653  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100385646  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100407431  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
100894730  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
100399154  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100403963  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
100406757  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100385816  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
100409573  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
100405343  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100387401  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100392518  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100388391  IFNB1; interferon beta [KO:K05415]
100395278  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100405037  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100400105  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100403010  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100393064  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100403482  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100388182  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
100391194  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
100399514  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100394749  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
100404291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100407391  SCRIB; protein scribble homolog isoform X2 [KO:K16175]
100401687  DLG1; disks large homolog 1 isoform X23 [KO:K12076]
100414556  DLG2; disks large homolog 2 isoform X23 [KO:K12075]
100413310  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
100395080  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100389428  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
100414970  CRB3; protein crumbs homolog 3 isoform X2 [KO:K06090]
100409152  PATJ; inaD-like protein isoform X22 [KO:K06092]
100398752  PALS1; protein PALS1 isoform X1 [KO:K06091]
100396684  VWF; von Willebrand factor [KO:K03900]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100397101  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
100391690  COMP; cartilage oligomeric matrix protein [KO:K04659]
100391538  THBS4; thrombospondin-4 [KO:K04659]
100401976  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
100405983  FN1; fibronectin isoform X2 [KO:K05717]
100386176  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100411438  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
100400909  COL2A1; collagen alpha-1(II) chain [KO:K19719]
100405184  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100400812  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100388823  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
100388461  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100409842  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100394953  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100407758  collagen alpha-6(VI) chain [KO:K06238]
100413876  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
100408489  collagen alpha-4(VI) chain [KO:K06238]
100404862  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100408376  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100407319  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
100403902  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
100403892  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100405504  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
100403734  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
100405831  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100401798  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
103792989  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
100396274  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100400907  LAMB1; laminin subunit beta-1 [KO:K05636]
100389118  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100400492  LAMB3; laminin subunit beta-3 [KO:K06244]
100401649  LAMB4; laminin subunit beta-4 [KO:K06245]
100401710  LAMC1; laminin subunit gamma-1 [KO:K05635]
100401336  LAMC2; laminin subunit gamma-2 [KO:K06246]
100403136  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
100384970  CHAD; chondroadherin [KO:K06248]
100403212  RELN; reelin isoform X5 [KO:K06249] [EC:3.4.21.-]
100412217  SPP1; osteopontin [KO:K06250]
100401491  VTN; vitronectin [KO:K06251]
100414580  TNC; tenascin isoform X1 [KO:K06252]
100395051  TNR; tenascin-R isoform X1 [KO:K06252]
100395776  TNN; tenascin-N [KO:K06252]
100396269  TNXB; tenascin-X isoform X1 [KO:K06252]
100413274  IBSP; bone sialoprotein 2 [KO:K06253]
100404358  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
100403636  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
100408748  ITGA2B; integrin alpha-IIb [KO:K06476]
100386753  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100389291  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100386674  ITGA5; integrin alpha-5 [KO:K06484]
100403557  ITGA6; integrin alpha-6 isoform X7 [KO:K06485]
100401654  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
100404891  ITGA8; integrin alpha-8 [KO:K06584]
100399269  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100400720  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100397792  ITGA11; integrin alpha-11 [KO:K06587]
100389906  ITGAV; integrin alpha-V [KO:K06487]
100394145  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100398837  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100395279  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100401625  ITGB6; integrin beta-6 isoform X4 [KO:K06589]
100402863  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100401019  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100395283  PTK2; focal adhesion kinase 1 isoform X9 [KO:K05725] [EC:2.7.10.2]
103795442  PXN; paxillin isoform X1 [KO:K05760]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100401347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100415587  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X2 [KO:K13365]
100395261  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100398536  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100408674  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100413664  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100385385  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100407485  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
100407627  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
100386371  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
100399834  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100398540  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
100404394  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
128928017  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100415024  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100413827  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100407360  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100411858  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100414007  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100407741  TSC1; hamartin isoform X2 [KO:K07206]
100390664  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
100410955  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100386453  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100397180  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100409247  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100397393  FOXO1; forkhead box protein O1 [KO:K07201]
100387508  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100398703  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100397928  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100410315  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100410298  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100389462  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100388293  CCNA2; cyclin-A2 [KO:K06627]
100393051  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100412321  ATR; serine/threonine-protein kinase ATR isoform X4 [KO:K06640] [EC:2.7.11.1]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100415620  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100396301  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100399247  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
100402327  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100399690  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100401228  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
100412980  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
100407990  IRF1; interferon regulatory factor 1 [KO:K09444]
100410605  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
100401601  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
100405104  TBP; TATA-box-binding protein [KO:K03120]
100406240  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100398361  patr class I histocompatibility antigen, CH28 alpha chain isoform X3 [KO:K06751]
100405128  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100399078  patr class I histocompatibility antigen, A-126 alpha chain isoform X3 [KO:K06751]
100411069  patr class I histocompatibility antigen, A-126 alpha chain isoform X6 [KO:K06751]
100388209  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100387811  CAJA-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
118151094  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100409012  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
100411357  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100400819  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
100405540  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100402895  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X10 [KO:K02148]
100395645  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
100399709  ATP6V1D; V-type proton ATPase subunit D isoform X4 [KO:K02149]
100402779  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100396342  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100397160  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100415557  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
100396510  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
103795015  V-type proton ATPase subunit G 1-like [KO:K02152]
100408708  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100405532  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
100412131  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X5 [KO:K02154]
100406490  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
100896337  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
100400110  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100385552  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100393000  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100407218  V-type proton ATPase subunit e 2 [KO:K02153]
100397181  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
100414397  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X3 [KO:K03661]
100386892  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100407639  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100410649  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
103787209  neuroendocrine secretory protein 55 [KO:K04632]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100408115  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100409206  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
118151333  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100407681  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100394351  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100408954  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100406635  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100411140  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100409637  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100392579  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
100389671  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
100390134  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
100410082  LOW QUALITY PROTEIN: tubulin gamma-1 chain [KO:K10389]
100412392  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
100389879  pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
100414516  interferon alpha-1/13-like [KO:K05414]
100390201  interferon alpha-5-like [KO:K05414]
100406098  interferon alpha-5-like [KO:K05414]
100406466  interferon alpha-14 [KO:K05414]
100387372  interferon alpha-5-like [KO:K05414]
103793369  interferon alpha-5-like [KO:K05414]
128928158  interferon alpha-14-like [KO:K05414]
128932203  interferon alpha-5-like [KO:K05414]
100410306  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
128928024  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100405583  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100401630  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100393190  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100399251  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100401503  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
100405704  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
100407168  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
100384985  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100414977  JAG1; protein jagged-1 isoform X1 [KO:K06052]
103795708  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
100393852  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
100408994  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
108587674  NOTCH4; neurogenic locus notch homolog protein 4 isoform X4 [KO:K20996]
100401034  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
100397083  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X2 [KO:K05948] [EC:2.4.1.222]
100397710  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
100394244  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
100413881  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
100386797  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
100390939  MAML1; mastermind-like protein 1 [KO:K06061]
100400742  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
100403762  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
100398058  HES1; transcription factor HES-1 [KO:K06054]
100410578  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
100410555  HES7; transcription factor HES-7 isoform X3 [KO:K09087]
100409264  HES2; transcription factor HES-2 isoform X1 [KO:K09087]
100408172  HES3; transcription factor HES-3 [KO:K09088]
118155312  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
100397404  HES5; transcription factor HES-5 [KO:K06055]
100389602  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
100395441  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
100399453  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Viruses 7:2485-506 (2015)
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Reference
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Human papillomavirus proteins as prospective therapeutic targets.
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Reference
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Reference
PMID:11486705
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The molecular biology of cervical cancer.
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Reference
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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Reference
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Human papillomaviruses and cell signaling.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Human papillomaviruses, cervical cancer and cell polarity.
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Control of interferon signaling in human papillomavirus infection.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
cjc04064  NF-kappa B signaling pathway
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04150  mTOR signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
cjc04310  Wnt signaling pathway
cjc04330  Notch signaling pathway
cjc04510  Focal adhesion
cjc04520  Adherens junction
cjc04530  Tight junction
cjc04612  Antigen processing and presentation
cjc04620  Toll-like receptor signaling pathway
cjc04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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