KEGG   PATHWAY: lruf05161
Entry
lruf05161                   Pathway                                
Name
Hepatitis B - Lynx rufus (bobcat)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
lruf05161  Hepatitis B
lruf05161

Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124514397  basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
124512072  sodium/bile acid cotransporter-like [KO:K14341]
124511094  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
124510378  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
124512625  transforming growth factor beta-3 proprotein [KO:K13377]
124502313  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
124526598  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
124508465  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
124528296  cyclin-dependent kinase inhibitor 1 [KO:K06625]
124520648  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124506951  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124514653  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124507805  myc proto-oncogene protein [KO:K04377]
124506841  E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
124521014  early growth response protein 3 [KO:K12497]
124517735  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
124501617  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
124510216  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
124505109  DNA damage-binding protein 1 [KO:K10610]
124504922  DNA damage-binding protein 2 isoform X1 [KO:K10140]
124517338  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
124503145  14-3-3 protein beta/alpha [KO:K16197]
124503513  14-3-3 protein theta [KO:K16197]
124518954  14-3-3 protein zeta/delta [KO:K16197]
124512264  LOW QUALITY PROTEIN: 14-3-3 protein theta-like [KO:K16197]
124517052  14-3-3 protein zeta/delta-like [KO:K16197]
124519495  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
124525968  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124527077  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124514827  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124517840  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124514527  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
124523730  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124510270  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
124511119  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124512474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124507057  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124521298  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124525847  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124508912  NF-kappa-B inhibitor alpha [KO:K04734]
124520800  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124504954  transcription factor p65 [KO:K04735]
124503402  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
124517105  apoptosis regulator Bcl-2 [KO:K02161]
124505120  bcl2-associated agonist of cell death-like [KO:K02158]
124518681  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
124505197  FAS-associated death domain protein-like [KO:K02373]
124515468  caspase-8-like [KO:K04398] [EC:3.4.22.61]
124515024  caspase-10-like isoform X1 [KO:K04400] [EC:3.4.22.63]
124501306  BH3-interacting domain death agonist-like [KO:K04726]
124510927  apoptosis regulator BAX isoform X1 [KO:K02159]
124502711  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
124524650  cytochrome c [KO:K08738]
124526642  cytochrome c-like [KO:K08738]
124526919  cytochrome c-like [KO:K08738]
124514186  cytochrome c, testis-specific-like [KO:K08738]
124501505  cytochrome c-like [KO:K08738]
124502126  cytochrome c-like [KO:K08738]
124514692  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124520277  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124504970  caspase-12-like [KO:K04741] [EC:3.4.22.-]
124513356  baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
124519563  cellular tumor antigen p53 isoform X1 [KO:K04451]
124520480  cyclin-A2 [KO:K06627]
124509481  cyclin-A1 [KO:K06627]
124502320  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
124511276  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
124518951  G1/S-specific cyclin-E2 [KO:K06626]
124512196  retinoblastoma-associated protein isoform X1 [KO:K06618]
124503500  transcription factor E2F1 [KO:K17454]
124515072  transcription factor E2F2 isoform X1 [KO:K09389]
124528848  transcription factor E2F3 isoform X1 [KO:K06620]
124525823  V-type proton ATPase subunit S1 [KO:K03662]
124513500  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124517730  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124527789  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124516980  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
124502945  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
124511421  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
124508199  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
124528979  tumor necrosis factor [KO:K03156]
124515396  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
124527989  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
124523034  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
124524613  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
124522098  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
124515343  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
124501367  signal transducer and activator of transcription 2-like [KO:K11221]
124515342  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
124522097  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
124522246  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
124501154  signal transducer and activator of transcription 6 [KO:K11225]
124520533  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
124520193  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
124504000  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
124513422  growth factor receptor-bound protein 2 [KO:K04364]
124504040  son of sevenless homolog 1 isoform X1 [KO:K03099]
124512209  son of sevenless homolog 2 isoform X1 [KO:K03099]
124527565  GTPase HRas isoform X1 [KO:K02833]
124502703  GTPase KRas isoform X1 [KO:K07827]
124516245  GTPase NRas [KO:K07828]
124516273  transcription factor Jun [KO:K04448]
124516988  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
124514138  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
124516566  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
124524408  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
124506275  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
124521809  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
124501745  cyclic AMP-responsive element-binding protein 3-like isoform X1 [KO:K09048]
124523866  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
124502100  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124524308  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
124528650  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
124520198  interleukin-8 [KO:K10030]
124503991  proliferating cell nuclear antigen [KO:K04802]
124509491  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124524722  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124523760  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124508471  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124524782  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
124517731  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
124519861  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124512631  protein c-Fos [KO:K04379]
124509494  ETS domain-containing protein Elk-1 [KO:K04375]
124520186  toll-like receptor 2 [KO:K10159]
124526006  myeloid differentiation primary response protein MyD88 [KO:K04729]
124505835  toll/interleukin-1 receptor domain-containing adapter protein-like isoform X1 [KO:K05403]
124503507  toll-like receptor 4 [KO:K10160]
124501320  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
124525860  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
124505383  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
124501060  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
124528760  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
124528290  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
124524718  interleukin-6 [KO:K05405]
124519494  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
124513476  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
124528014  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124528088  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
124501588  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
124502315  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
124523965  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124515056  TIR domain-containing adapter molecule 2-like [KO:K05409]
124520581  toll-like receptor 3 [KO:K05401]
124524270  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
124501213  antiviral innate immune response receptor RIG-I-like isoform X1 [KO:K12646] [EC:5.6.2.6]
124514967  interferon-induced helicase C domain-containing protein 1-like isoform X1 [KO:K12647] [EC:5.6.2.6]
124503382  mitochondrial antiviral-signaling protein-like [KO:K12648]
124512500  TNF receptor-associated factor 3 [KO:K03174]
124509964  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
124501448  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
124509460  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
124510901  interferon regulatory factor 3-like isoform X1 [KO:K05411]
124527563  interferon regulatory factor 7-like isoform X1 [KO:K09447]
124524295  interferon alpha-like [KO:K05414]
124525665  interferon alpha-2-like [KO:K05414]
124525682  interferon alpha-2-like [KO:K05414]
124525697  interferon alpha [KO:K05414]
124525706  interferon alpha-like [KO:K05414]
124525727  interferon alpha-like [KO:K05414]
124525672  interferon beta [KO:K05415]
124527044  interferon alpha/beta receptor 1-like [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
lruf04010  MAPK signaling pathway
lruf04064  NF-kappa B signaling pathway
lruf04110  Cell cycle
lruf04115  p53 signaling pathway
lruf04151  PI3K-Akt signaling pathway
lruf04210  Apoptosis
lruf04620  Toll-like receptor signaling pathway
lruf04622  RIG-I-like receptor signaling pathway
lruf04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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