KEGG   PATHWAY: nsu05169
Entry
nsu05169                    Pathway                                
Name
Epstein-Barr virus infection - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
nsu05169  Epstein-Barr virus infection
nsu05169

Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110573896  CR2; complement receptor type 2 [KO:K04012]
110589861  CD19; B-lymphocyte antigen CD19 [KO:K06465]
110575638  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
110575636  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
123325484  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
110575557  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
110575559  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
110575560  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
110575567  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
110575569  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
110575634  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
110586717  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
110586769  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
110588386  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
110588474  TLR2; toll-like receptor 2 [KO:K10159]
110569660  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
110593539  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
110574588  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110576276  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110577941  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110583336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
110583654  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
110589216  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110573165  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110574194  IKBKG; NF-kappa-B essential modulator [KO:K07210]
110585142  NFKBIA; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110575986  RELA; transcription factor p65 [KO:K04735]
110586713  TNF; tumor necrosis factor [KO:K03156]
110580018  IL6; interleukin-6 isoform X1 [KO:K05405]
110581392  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
110579411  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
110571685  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
110570585  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
110577285  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
110582214  IRF7; interferon regulatory factor 7 [KO:K09447]
110572882  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
123326492  interferon alpha-1/2-like [KO:K05414]
123326498  interferon alpha-like [KO:K05414]
110587126  LOW QUALITY PROTEIN: interferon alpha [KO:K05414]
110587131  interferon alpha-16-like [KO:K05414]
110587130  IFNB1; interferon beta [KO:K05415]
110570024  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
110570027  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
110571840  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110593684  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X3 [KO:K11219] [EC:2.7.10.2]
110592138  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
110577818  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110585591  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110587259  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
110588261  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
110588238  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
110588305  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
110591475  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
110574584  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
110585971  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110576065  FADD; FAS-associated death domain protein [KO:K02373]
110592166  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110580739  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
110587324  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110577152  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
110572854  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
110575593  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110579961  cytochrome c [KO:K08738]
110575385  cytochrome c-like [KO:K08738]
110592054  cytochrome c, testis-specific [KO:K08738]
110594255  cytochrome c-like [KO:K08738]
110574689  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
110584089  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123325714  uncharacterized protein LOC123325714 [KO:K10784]
110586253  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
110586250  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
110586281  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
110574045  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
110580165  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
110570779  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7-like [KO:K03061]
110583235  26S proteasome regulatory subunit 4-like [KO:K03062]
110571657  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
110590075  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
110578730  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
110590601  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
110575776  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
110570464  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
110582721  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
110580709  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
110593153  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
110570406  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
110593275  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
110589248  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6-like [KO:K03037]
110584781  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
110592293  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
110582255  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
110578588  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
110591941  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
110590347  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
110569906  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
110583668  26S proteasome complex subunit SEM1 [KO:K10881]
110580054  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
110575563  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
110575561  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
110575580  tapasin isoform X1 [KO:K08058]
110585149  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
110593665  CALR; calreticulin [KO:K08057]
110580263  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
110575688  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
110586919  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A alpha chain [KO:K06751]
110581264  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
110585197  B2M; beta-2-microglobulin [KO:K08055]
110589396  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
110571481  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
110584035  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
110578860  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
110575214  HDAC1; LOW QUALITY PROTEIN: histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110583689  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110588284  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
110588524  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
110590285  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
110591812  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
110571350  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
110579345  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
110582442  HES1; transcription factor HES-1 [KO:K06054]
110593971  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
110583349  RUNX3; runt-related transcription factor 3 [KO:K09279]
110578930  MYC; myc proto-oncogene protein [KO:K04377]
110588043  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
110570608  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
110575681  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110584301  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
110571814  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
110593844  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
110575769  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
110587463  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
110573917  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110573171  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110572759  RELB; transcription factor RelB [KO:K09253]
110589069  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110592808  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
110590277  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
110582095  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
110584510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
110593849  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110591392  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110589690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110580283  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
110581233  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110586632  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
110584435  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110570428  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
110575614  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575674  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578302  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578303  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575086  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
110589266  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
110581299  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
110594311  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
110579528  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110576273  CD44; CD44 antigen isoform X1 [KO:K06256]
110589962  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
110580352  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
110593812  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
110586538  VIM; vimentin [KO:K07606]
110583100  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
110574431  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110573316  STAT3; signal transducer and activator of transcription 3 isoform X5 [KO:K04692]
110579039  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
110584304  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
110583798  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
110572663  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110585603  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
110589462  BLNK; B-cell linker protein isoform X1 [KO:K07371]
110593864  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110586053  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110580846  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110580853  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110582036  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110577858  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110579972  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110575554  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
110570307  CCNA1; cyclin-A1 [KO:K06627]
110573041  CCNA2; cyclin-A2 [KO:K06627]
110590303  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
110579138  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
110577806  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
110579773  RB1; retinoblastoma-associated protein [KO:K06618]
110579642  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
110574749  E2F2; transcription factor E2F2 [KO:K09389]
110586656  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
nsu03050  Proteasome
nsu04010  MAPK signaling pathway
nsu04020  Calcium signaling pathway
nsu04064  NF-kappa B signaling pathway
nsu04110  Cell cycle
nsu04115  p53 signaling pathway
nsu04210  Apoptosis
nsu04612  Antigen processing and presentation
nsu04620  Toll-like receptor signaling pathway
nsu04622  RIG-I-like receptor signaling pathway
nsu04630  JAK-STAT signaling pathway
nsu04662  B cell receptor signaling pathway
KO pathway
ko05169   
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