KEGG   PATHWAY: oga05169
Entry
oga05169                    Pathway                                
Name
Epstein-Barr virus infection - Otolemur garnettii (small-eared galago)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
oga05169  Epstein-Barr virus infection
oga05169

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100957344  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100960158  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100961105  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
105886937  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100940711  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100957117  HLA class II histocompatibility antigen, DRB1-1 beta chain isoform X1 [KO:K06752]
100957422  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100957736  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
100959019  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
100959331  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100966668  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
100956803  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
100964048  TLR2; toll-like receptor 2 [KO:K10159]
100948454  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100956612  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100951843  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100945817  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100949838  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100955970  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100962907  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100947991  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100963613  TNF; tumor necrosis factor [KO:K03156]
100949231  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
100964728  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
100945143  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100947925  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100940759  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100941040  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100950073  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100943304  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100962353  interferon alpha-10-like [KO:K05414]
100955951  interferon alpha-10-like isoform X2 [KO:K05414]
100945944  interferon alpha-4-like [KO:K05414]
100945309  interferon alpha-5-like [KO:K05414]
100956963  interferon alpha-5-like [KO:K05414]
100957574  interferon alpha-5-like [KO:K05414]
100958440  interferon alpha-5-like [KO:K05414]
100958763  interferon alpha-10-like [KO:K05414]
100959074  interferon alpha-5-like [KO:K05414]
100946255  interferon alpha-10-like [KO:K05414]
100959385  IFNB1; interferon beta [KO:K05415]
100958617  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100959248  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100955095  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100962299  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100956762  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100944401  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
100944155  IRF9; interferon regulatory factor 9 [KO:K04693]
100959776  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100951039  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
105887001  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105886995  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
100948306  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100966149  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100948662  ubiquitin-like protein ISG15 [KO:K12159]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100960309  FADD; FAS-associated death domain protein [KO:K02373]
100965468  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100960302  BID; BH3-interacting domain death agonist [KO:K04726]
100947708  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100955447  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100957285  BAX; apoptosis regulator BAX [KO:K02159]
100941755  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100952744  cytochrome c, somatic [KO:K08738]
100946237  cytochrome c [KO:K08738]
100961637  cytochrome c, testis-specific [KO:K08738]
100951508  cytochrome c-like [KO:K08738]
100959812  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100957904  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100966596  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100966280  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100953225  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
100957481  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100944801  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
100963717  PSMC1; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4 [KO:K03062]
100961600  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100963843  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
100965975  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
100943523  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
100945869  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100965008  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100952064  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100966239  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100950546  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100952591  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
100955990  26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
100951878  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100962652  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100944351  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
100941685  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100960187  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100947028  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
100961050  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100966979  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105886923  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100940392  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
100965502  TAPBP; tapasin isoform X2 [KO:K08058]
100944942  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100942739  CALR; calreticulin [KO:K08057]
100954043  calreticulin-like [KO:K08057]
100961793  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
100952503  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
100957517  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100956897  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
100959427  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100946825  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
100947452  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
100958806  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
100952177  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100952822  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
100954387  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100953138  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100943555  B2M; beta-2-microglobulin [KO:K08055]
100962550  SNW1; SNW domain-containing protein 1 [KO:K06063]
100940579  paired amphipathic helix protein Sin3a [KO:K11644]
100942963  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100965265  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100949586  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
100945492  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
100943919  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
100943659  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
100941141  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
100942402  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100961621  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100948316  HES1; transcription factor HES-1 [KO:K06054]
100941545  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
100963350  RUNX3; runt-related transcription factor 3 [KO:K09279]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100946169  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
100961605  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100947328  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100953808  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111727809  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100946928  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100950782  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100950842  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X2 [KO:K04402]
100962402  DDB2; DNA damage-binding protein 2 [KO:K10140]
100966233  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100957799  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100957606  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100962411  RELB; transcription factor RelB isoform X1 [KO:K09253]
100963289  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100952230  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100942572  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
100961213  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
100945898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
100966900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
100957169  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100967053  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100960275  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100966378  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100949124  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
100955929  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100962457  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100965098  JUN; transcription factor AP-1 [KO:K04448]
100942682  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
100965533  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
100959453  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
100943964  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
100943911  CD44; CD44 antigen isoform X1 [KO:K06256]
100963323  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100941780  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
100964084  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100950506  VIM; vimentin [KO:K07606]
100941032  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
100954742  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100958469  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100951050  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100949905  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100946994  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100956054  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
100941745  BLNK; B-cell linker protein [KO:K07371]
100948829  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100942708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100964179  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100962188  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100945148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100942167  CCNA1; cyclin-A1 [KO:K06627]
100966485  CCNA2; cyclin-A2 [KO:K06627]
100958215  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100959381  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100964880  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100951476  RB1; retinoblastoma-associated protein [KO:K06618]
100957114  E2F1; transcription factor E2F1 [KO:K17454]
100956861  E2F2; transcription factor E2F2 [KO:K09389]
100942819  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
oga03050  Proteasome
oga04010  MAPK signaling pathway
oga04020  Calcium signaling pathway
oga04064  NF-kappa B signaling pathway
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04210  Apoptosis
oga04612  Antigen processing and presentation
oga04620  Toll-like receptor signaling pathway
oga04622  RIG-I-like receptor signaling pathway
oga04630  JAK-STAT signaling pathway
oga04662  B cell receptor signaling pathway
KO pathway
ko05169   
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