Entry
Name
Cytokine-cytokine receptor interaction - Oncorhynchus mykiss (rainbow trout)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
omy04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Oncorhynchus mykiss (rainbow trout) [GN:
omy ]
Gene
110534210 si:dkey-92i15.4; uncharacterized protein si:dkey-92i15.4 [KO:K22628 ]
118938165 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
118940077 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
110521615 tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389 ]
110524498 faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
110501712 tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
110520367 tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
110527377 tumor necrosis factor ligand superfamily member 10-like [KO:K05473 ]
100136706 tnfsf13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100136316 tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
110504548 tumor necrosis factor ligand superfamily member 13B-like [KO:K05476 ]
101268942 tgfb1a; transforming growth factor, beta 1a precursor [KO:K13375 ]
101268906 il2rb2; interleukin-2 receptor beta chain-2 precursor [KO:K05069 ]
101268908 il2rc2; interleukin-2 receptor gamma chain-2 precursor [KO:K05070 ]
110523781 il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
110486123 interleukin-3 receptor class 2 subunit beta isoform X2 [KO:K04738 ]
100136103 csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061 ]
101268915 gp130; interleukin 6 signal transducer GP130 protein precursor [KO:K05060 ]
110536851 il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
110524481 il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
118964552 ciliary neurotrophic factor receptor subunit alpha-like [KO:K05059 ]
118937616 cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
110529952 crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137 ]
110492428 wu:fl23c11; LOW QUALITY PROTEIN: interleukin-17 receptor C [KO:K05166 ]
110509537 tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
110527838 tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
110494628 tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
100305279 tnr5; tumor necrosis factor receptor superfamily member 5 [KO:K05152 ]
110532760 tumor necrosis factor receptor superfamily member 14 isoform X2 [KO:K05152 ]
110532762 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
110532768 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
110532769 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
110496258 tumor necrosis factor receptor superfamily member 11B [KO:K05143 ]
110488319 tumor necrosis factor receptor superfamily member 11B [KO:K05143 ]
110502471 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
110529004 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
110532217 tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
110509702 tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
110536280 tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
110523488 tnfrsfa; tumor necrosis factor receptor superfamily member 10B [KO:K04722 ]
110522289 tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
110529670 tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
110501718 tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
110520359 tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
110505609 nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583 ]
110538653 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
110520706 tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
110535418 tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
110489589 tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
101268950 cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
110527793 si:ch73-361p23.3; tumor necrosis factor receptor superfamily member 9 [KO:K05142 ]
110495196 tumor necrosis factor receptor superfamily member 10C-like [KO:K05142 ]
110491449 tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
110499048 tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
110504009 tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
110503477 tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
110508013 tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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