KEGG   PATHWAY: pcoo05169
Entry
pcoo05169                   Pathway                                
Name
Epstein-Barr virus infection - Puma concolor (puma)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoo05169  Epstein-Barr virus infection
pcoo05169

Organism
Puma concolor (puma) [GN:pcoo]
Gene
112856966  CD19; B-lymphocyte antigen CD19 [KO:K06465]
112862042  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
112862071  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
112862094  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112862131  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
112862364  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
112862858  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
112862859  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
112862863  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112858853  toll-like receptor 2 [KO:K10159]
112850482  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112867801  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112870846  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
112865434  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112863443  TAB1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112862397  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112861992  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112854253  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112858003  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112871176  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112855073  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112858048  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112851941  RELA; transcription factor p65 [KO:K04735]
112853630  TNF; tumor necrosis factor [KO:K03156]
112866659  IL6; interleukin-6 [KO:K05405]
112864196  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
112869235  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
112855336  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112863806  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112857735  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
112852158  IRF7; interferon regulatory factor 7 [KO:K09447]
112851074  IRF3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
112849322  interferon alpha-2-like [KO:K05414]
112857196  interferon beta-like [KO:K05414]
112849621  IFNB1; interferon beta [KO:K05415]
112849641  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112849290  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112871857  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112852708  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
112869860  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112863559  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112855980  IRF9; interferon regulatory factor 9 [KO:K04693]
112864251  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112870096  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
112870260  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
112870493  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112858437  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
112848661  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
112851504  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112851989  FADD; FAS-associated death domain protein [KO:K02373]
112871959  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112867264  BID; BH3-interacting domain death agonist [KO:K04726]
112864201  BCL2L11; bcl-2-like protein 11 [KO:K16341]
112868295  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112861960  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
112870556  cytochrome c-like [KO:K08738]
112866368  cytochrome c, testis-specific-like [KO:K08738]
112866541  cytochrome c [KO:K08738]
112863492  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
112861739  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112870035  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112865851  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
112865849  CD3G; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
112865955  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
112863153  CD247; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
112866304  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
112856402  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112850709  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
112856484  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
112865190  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
112864552  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
112850215  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
112872149  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
112854113  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
112864467  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
112852693  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
112852521  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
112857328  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
112851991  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
112871860  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
112870755  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
112851286  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
112862736  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
112862344  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112862082  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112862480  TAPBP; tapasin [KO:K08058]
112854989  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112852509  CALR; calreticulin [KO:K08057]
112861479  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
112853671  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
112853699  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
112853701  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853765  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112853766  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853799  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
112855325  B2M; beta-2-microglobulin [KO:K08055]
112855423  SNW1; SNW domain-containing protein 1 [KO:K06063]
112855247  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
112868534  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
112862527  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112858888  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
112861246  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
112870670  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
112869488  RBPJL; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like protein [KO:K06053]
112858599  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
112862396  RUNX3; runt-related transcription factor 3 [KO:K09279]
112859511  MYC; myc proto-oncogene protein [KO:K04377]
112853157  USP7; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
112863934  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112856999  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
112862831  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112867941  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112866046  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112861098  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
112857763  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112849397  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112849524  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112848856  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112861619  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112868847  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112863208  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112851313  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112854134  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112850717  RELB; transcription factor RelB [KO:K09253]
112854307  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
112851076  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
112862790  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
112857039  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
112859092  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112854846  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112861322  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112860577  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112853514  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112857077  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112864599  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112862836  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112862837  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
112863384  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112872218  JUN; transcription factor AP-1 [KO:K04448]
112850063  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
112854532  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
112860798  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
112869205  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
112866089  CD44; CD44 antigen isoform X1 [KO:K06256]
112856284  ITGAL; integrin alpha-L [KO:K05718]
112872080  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
112852260  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
112867379  VIM; vimentin [KO:K07606]
112862294  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
112852387  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
112853996  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
112859429  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
112868539  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112855569  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
112859959  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112871134  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
112854330  BLNK; B-cell linker protein [KO:K07371]
112857487  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112861348  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
112867392  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112867915  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112862913  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112863780  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112866704  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112858444  CCNA2; cyclin-A2 [KO:K06627]
112861034  CCNA1; cyclin-A1 [KO:K06627]
112851063  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
112859481  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
112863472  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112860822  RB1; retinoblastoma-associated protein [KO:K06618]
112869529  E2F1; transcription factor E2F1 [KO:K17454]
112862285  E2F2; transcription factor E2F2 [KO:K09389]
112853567  E2F3; LOW QUALITY PROTEIN: transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
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Related
pathway
pcoo03050  Proteasome
pcoo04010  MAPK signaling pathway
pcoo04020  Calcium signaling pathway
pcoo04064  NF-kappa B signaling pathway
pcoo04110  Cell cycle
pcoo04115  p53 signaling pathway
pcoo04210  Apoptosis
pcoo04612  Antigen processing and presentation
pcoo04620  Toll-like receptor signaling pathway
pcoo04622  RIG-I-like receptor signaling pathway
pcoo04630  JAK-STAT signaling pathway
pcoo04662  B cell receptor signaling pathway
KO pathway
ko05169   
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