KEGG   PATHWAY: ppam05166
Entry
ppam05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ppam05166  Human T-cell leukemia virus 1 infection
ppam05166

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129069366  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
129077763  NRP1; neuropilin-1 isoform X1 [KO:K06724]
129084081  MYC; myc proto-oncogene protein [KO:K04377]
129066711  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
129068568  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
129074231  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129078038  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
129075119  ITGB2; integrin beta-2 [KO:K06464]
129061417  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129071444  T-cell surface glycoprotein CD4-like [KO:K06454]
129071445  CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454]
129064198  TLN2; talin-2 [KO:K06271]
129079428  TLN1; talin-1 isoform X1 [KO:K06271]
129061446  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
129087270  RAN; GTP-binding nuclear protein Ran [KO:K07936]
129072027  XPO1; exportin-1 isoform X1 [KO:K14290]
129062532  CALR; calreticulin [KO:K08057]
129064999  CANX; calnexin [KO:K08054]
129075010  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129069877  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129085325  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129079661  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129081330  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129078786  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129070613  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129075257  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129074067  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
129071253  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
129071133  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
129071023  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129074836  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
129087067  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
129086955  signal transducer and activator of transcription 5B [KO:K11224]
129061444  IL2; interleukin-2 [KO:K05429]
129082578  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
129082579  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
129082581  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
129082582  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
129082583  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
129082586  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129082587  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
129082589  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
129082590  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
129082591  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129082592  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
129082596  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129082597  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
129082598  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
129066830  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129073400  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
129067302  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129067380  LOW QUALITY PROTEIN: popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
129067407  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
129067534  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
129063934  B2M; beta-2-microglobulin [KO:K08055]
129062353  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
129076238  LOW QUALITY PROTEIN: farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
129066687  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129062855  ADP/ATP translocase 3-like [KO:K05863]
129076152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129069951  ADP/ATP translocase 2-like [KO:K05863]
129083503  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129064550  ADP/ATP translocase 2-like [KO:K05863]
129064887  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129085704  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129079754  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129061237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129069854  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129071050  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
129067084  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
129075491  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129075707  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129064788  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129077952  TSPO; translocator protein [KO:K05770]
129067026  TSPO2; translocator protein 2 [KO:K05770]
129075210  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
129086208  RANBP1; ran-specific GTPase-activating protein [KO:K15306]
129064221  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
129061363  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
129063039  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
129077238  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
129072136  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
129079145  ANAPC2; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2 [KO:K03349]
129071580  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
129077563  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
129087274  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
129064767  CDC16; cell division cycle protein 16 homolog [KO:K03353]
129087288  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
129066660  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
129062031  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
129086674  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
129079334  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
129088380  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
129079789  anaphase-promoting complex subunit 13-like [KO:K12456]
129072716  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
129069902  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
129069368  CDC20; cell division cycle protein 20 homolog [KO:K03363]
129084010  securin-like [KO:K06635]
129066355  PTTG1; securin [KO:K06635]
129084557  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
129063515  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
129083911  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
129082183  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
129075823  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129068523  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129067448  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
129067419  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129061281  CCNA2; cyclin-A2 [KO:K06627]
129081141  CCNA1; cyclin-A1 [KO:K06627]
129084214  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
129068119  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
129080865  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
129070474  E2F1; transcription factor E2F1 [KO:K17454]
129068981  E2F2; transcription factor E2F2 [KO:K09389]
129085787  E2F3; transcription factor E2F3 [KO:K06620]
129086012  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
129071778  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
129086390  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
129087453  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129071786  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
129069750  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129066972  TNF; tumor necrosis factor [KO:K03156]
129071418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129071974  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
129068797  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129070771  JUN; transcription factor Jun [KO:K04448]
129085867  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
129074255  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
129074243  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
129071919  T cell receptor alpha chain MC.7.G5-like [KO:K10784]
129071926  uncharacterized protein LOC129071926 [KO:K10784]
129086044  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
129086043  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
129085841  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
129070196  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
129077110  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129074378  IKBKG; NF-kappa-B essential modulator [KO:K07210]
129082066  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129068571  RELA; transcription factor p65 [KO:K04735]
129072304  GPS2; G protein pathway suppressor 2 [KO:K15307]
129071421  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
129070434  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
129077941  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
129086451  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
129082745  RELB; transcription factor RelB isoform X1 [KO:K09253]
129077297  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
129076694  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
129084544  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
129061104  IL15; interleukin-15 [KO:K05433]
129084554  IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074]
129063428  IL6; interleukin-6 [KO:K05405]
129066446  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
129067304  LTA; lymphotoxin-alpha [KO:K05468]
129070790  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
129073352  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
129076675  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
129072973  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129065729  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
129079398  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
129088202  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129078704  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
129064154  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
129078725  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
129068928  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129074539  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
129067273  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129074168  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
129071827  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129084881  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
129068161  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
129084082  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129083643  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129071369  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
129079989  nuclear transcription factor Y subunit beta-like [KO:K08065]
129073564  nuclear transcription factor Y subunit beta-like [KO:K08065]
129066985  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
129066987  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
129066989  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
129073401  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
129067350  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
129067351  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
129067352  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129067470  SRF; serum response factor [KO:K04378]
129062352  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
129065226  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
129081512  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
129075370  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
129074560  ETS2; protein C-ets-2 [KO:K21932]
129065775  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
129067790  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
129088077  TBP; TATA-box-binding protein [KO:K03120]
129065732  FOS; protein c-Fos [KO:K04379]
129066651  EGR1; early growth response protein 1 [KO:K09203]
129068385  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
129069795  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
129080390  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129081516  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129062388  CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
129062851  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
129078156  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
129079431  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129061773  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
129077836  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129063111  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
129067339  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
129074979  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
129062167  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
129083465  CRTC3; CREB-regulated transcription coactivator 3 [KO:K16334]
129083641  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
129077851  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
129087012  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
129088290  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
129081561  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
129064789  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
129069029  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
129082924  BAX; apoptosis regulator BAX [KO:K02159]
129069656  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
129074407  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
129077682  MSX1; homeobox protein MSX-1 [KO:K09341]
129079594  VENTX; homeobox protein VENTX [KO:K09341]
129067384  MSX2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
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Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
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Viruses 3:794-810 (2011)
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Current concepts regarding the HTLV-1 receptor complex.
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Retrovirology 7:99 (2010)
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Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
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Nat Rev Microbiol 6:815-26 (2008)
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Nat Rev Immunol 4:110-22 (2004)
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Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
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J Virol 90:7607-17 (2016)
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Front Microbiol 3:179 (2012)
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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HTLV-1 p13, a small protein with a busy agenda.
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Pathogens 5:E8 (2016)
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
ppam03013  Nucleocytoplasmic transport
ppam04010  MAPK signaling pathway
ppam04064  NF-kappa B signaling pathway
ppam04110  Cell cycle
ppam04115  p53 signaling pathway
ppam04151  PI3K-Akt signaling pathway
ppam04210  Apoptosis
ppam04350  TGF-beta signaling pathway
ppam04612  Antigen processing and presentation
ppam04660  T cell receptor signaling pathway
ppam04668  TNF signaling pathway
KO pathway
ko05166   
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