Entry
Name
MAPK signaling pathway - Pelodiscus sinensis (Chinese soft-shelled turtle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Pelodiscus sinensis (Chinese soft-shelled turtle) [GN:
pss ]
Gene
102452356 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
102451554 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
102447276 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
102444760 CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852 ]
102454148 CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854 ]
102461994 CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855 ]
102452855 CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856 ]
102453880 LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857 ]
102450076 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2 [KO:K04858 ]
102448752 CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859 ]
102448983 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
102451307 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
102445240 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862 ]
102445882 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
102449313 CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864 ]
102450169 CACNB4; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865 ]
102454085 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
102446638 CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867 ]
102453289 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
102453695 CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X2 [KO:K04869 ]
102453283 CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
102458365 CACNG7; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
102445616 GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346 ]
102449936 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
102445775 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102453558 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102457798 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102461251 RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349 ]
102458999 RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
102445100 RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361 ]
102457114 RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018 ]
102451145 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
102451139 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
102456411 VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448 ]
102448827 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448 ]
102457900 VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449 ]
102461533 GDNF; glial cell line-derived neurotrophic factor isoform X3 [KO:K05452 ]
102455379 NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
102462804 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
102463609 GRB2; growth factor receptor-bound protein 2 isoform X2 [KO:K04364 ]
102449551 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
102445357 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158 ]
102445541 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
102460695 FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
102463316 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
102447391 CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
102445228 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
102454616 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
102457123 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
102447859 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
102460773 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
102453103 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
102451479 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
102451433 ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
102451114 MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434 ]
102443920 MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436 ]
102452242 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
102447163 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
102460331 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
102460770 MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454 ]
102453141 LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A-like [KO:K03283 ]
102457132 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
pss04070 Phosphatidylinositol signaling system
KO pathway
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