KEGG   PATHWAY: ptao04010
Entry
ptao04010                   Pathway                                
Name
MAPK signaling pathway - Phyllopteryx taeniolatus (common seadragon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptao04010  MAPK signaling pathway
ptao04010

Other DBs
GO: 0000165
Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133476798  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
133466040  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
133489951  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
133471941  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
133483429  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
133474397  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
133488846  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
133480287  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
133476776  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
133485243  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
133469006  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
133465679  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
133476813  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
133466011  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
133483173  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
133478597  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
133477886  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
133471884  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
133482993  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
133483884  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
133489155  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
133483919  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
133478678  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
133471942  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
133465810  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
133470143  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
133477431  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
133487974  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
133490252  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
133486884  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
133477532  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
133465939  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
133476688  voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
133465426  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
133477262  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
133466312  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
133477531  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
133465569  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
133477530  voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
133470993  voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871]
133480116  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
133470992  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
133480084  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
133470989  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
133480083  cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873]
133488854  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
133465732  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
133481437  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
133476315  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
133477529  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
133466213  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
133477257  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
133466239  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
133480082  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
133477245  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
133488978  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
133466119  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like isoform X1 [KO:K04347]
133465017  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133484850  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133472445  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
133467303  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133474756  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
133476565  ppp3r1b; calcineurin subunit B type 1b isoform X1 [KO:K06268]
133485508  calcineurin subunit B type 1-like [KO:K06268]
133478345  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
133474247  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
133464953  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
133475174  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
133481959  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
133487972  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
133472924  RAS guanyl-releasing protein 2-like isoform X1 [KO:K12361]
133485385  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
133484376  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
133482727  neurofibromin isoform X1 [KO:K08052]
133474970  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
133482620  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
133483430  ras-related protein Rap-1A isoform X1 [KO:K04353]
133477705  rap1aa; RAP1A, member of RAS oncogene family a isoform X1 [KO:K04353]
133472202  ras-related protein Rap-1b isoform X1 [KO:K07836]
133485125  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
133483544  tgfa; protransforming growth factor alpha [KO:K08774]
133475092  proepiregulin-like isoform X1 [KO:K09784]
133484434  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
133467603  putative fibroblast growth factor 1 [KO:K18496]
133484625  fgf2; fibroblast growth factor 2 [KO:K18497]
133476431  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
133477318  fibroblast growth factor 20-like [KO:K04358]
133465173  fgf10a; fibroblast growth factor 10a [KO:K04358]
133484689  fgf20b; fibroblast growth factor 20b [KO:K04358]
133484811  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
133478674  fgf6a; fibroblast growth factor 6a [KO:K04358]
133485111  fgf16; fibroblast growth factor 16 [KO:K04358]
133472097  fibroblast growth factor 6-like [KO:K04358]
133467056  fgf7; fibroblast growth factor 7 [KO:K04358]
133486171  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
133480764  fgf22; fibroblast growth factor 22 [KO:K04358]
133475857  fgf5; fibroblast growth factor 5 [KO:K04358]
133475871  fibroblast growth factor 10-like [KO:K04358]
133470008  fgf19; fibroblast growth factor 19 isoform X1 [KO:K22603]
133469281  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
133478673  uncharacterized protein LOC133478673 [KO:K22428]
133472096  fgf23; fibroblast growth factor 23 [KO:K22428]
133483201  ngfb; nerve growth factor [KO:K02582]
133487867  ngfa; neurotrophin-7 [KO:K02582]
133470388  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
133472012  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
133485005  insulin-like [KO:K04526]
133467054  ins; insulin [KO:K04526]
133467349  insulin-like [KO:K04526]
133472083  igf1; insulin-like growth factor I [KO:K05459]
133486846  igf3; insulin-like growth factor 3 [KO:K05459]
133477991  igf2b; insulin-like growth factor 2b [KO:K13769]
133477294  platelet-derived growth factor subunit A-like [KO:K04359]
133466036  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
133476822  pdgfba; platelet-derived growth factor beta polypeptide a isoform X1 [KO:K17386]
133484834  pdgfc; platelet-derived growth factor C [KO:K05450]
133482593  pdgfd; platelet-derived growth factor D [KO:K05450]
133478168  kitlga; kit ligand a [KO:K05461]
133472257  uncharacterized protein LOC133472257 isoform X1 [KO:K05461]
133484770  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
133479747  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
133468282  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
133488236  pgfb; vascular endothelial growth factor A [KO:K16859]
133473425  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
133467658  vegfd; vascular endothelial growth factor D [KO:K05449]
133477888  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
133472086  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
133471357  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
133471261  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
133485967  angpt2a; angiopoietin-2a [KO:K05466]
133465074  ephrin-A5b-like [KO:K05462]
133471310  efna1a; ephrin-A1a isoform X1 [KO:K05462]
133471311  efna3a; ephrin-A3 [KO:K05462]
133479375  efna1b; ephrin-A1b [KO:K05462]
133479535  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
133480021  efna3b; ephrin-A3b isoform X1 [KO:K05462]
133475226  efna5b; ephrin-A5b isoform X1 [KO:K05462]
133487919  efna2a; ephrin-A2 isoform X1 [KO:K05462]
133490156  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
133475310  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
133489245  neurturin isoform X1 [KO:K25414]
133489345  glial cell line-derived neurotrophic factor [KO:K25415]
133481349  artemin [KO:K25415]
133488957  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
133470267  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
133468974  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
133483342  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
133478381  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
133480110  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133486824  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133489921  fibroblast growth factor receptor 1-like isoform X1 [KO:K04362] [EC:2.7.10.1]
133474608  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
133485443  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
133488274  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
133466939  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
133469414  ngfrb; nerve growth factor receptor b [KO:K02583]
133466016  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
133479117  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
133480037  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
133489820  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
133475300  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
133489349  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
133481278  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
133478285  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
133474106  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
133480405  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
133484435  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
133467039  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
133484436  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
133467614  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
133477078  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
133480406  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
133470079  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
133470077  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
133484726  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
133484316  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
133481404  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
133478154  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
133483042  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
133484763  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
133485353  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
133466512  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
133476943  son of sevenless homolog 1-like isoform X1 [KO:K03099]
133487316  sos2; son of sevenless homolog 2 [KO:K03099]
133477792  GTPase HRas [KO:K02833]
133477772  kras; GTPase KRas isoform X1 [KO:K07827]
133465751  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
133465888  rras; ras-related protein R-Ras [KO:K07830]
133466875  rras2; ras-related protein R-Ras2 [KO:K07830]
133486660  ras-related protein M-Ras isoform X1 [KO:K07831]
133474590  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
133472286  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
133487624  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
133478460  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
133481008  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
133487657  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
133466092  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133474857  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133480810  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
133481365  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
133469922  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
133485040  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
133474364  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
133487408  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
133476684  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
133465798  atf4b; activating transcription factor 4b [KO:K04374]
133485270  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
133469959  myca; transcriptional regulator Myc-A [KO:K04377]
133476957  serum response factor-like isoform X1 [KO:K04378]
133486162  srfb; serum response factor b isoform X1 [KO:K04378]
133468338  protein c-Fos-like isoform X1 [KO:K04379]
133468339  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
133487442  fosaa; protein c-Fos [KO:K04379]
133469141  microtubule-associated protein tau-like isoform X1 [KO:K04380]
133471394  stmn1a; stathmin 1a [KO:K04381]
133480006  stathmin-like [KO:K04381]
133485567  pla2g4f.1; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
133485850  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
133480602  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
133470890  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
133474935  il1b; interleukin-1 beta [KO:K04519]
133482292  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
133484883  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
133479548  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
133487708  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
133468619  transforming growth factor beta-3 proprotein-like [KO:K13377]
133479490  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
133482633  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
133487202  interleukin-1 receptor type 1 [KO:K04386]
133482600  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
133470130  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
133470860  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
133486353  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
133483714  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
133484977  cd40lg; CD40 ligand isoform X1 [KO:K04389]
133485405  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
133466372  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
133469308  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
133476693  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
133469626  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
133483015  cell division control protein 42 homolog isoform X1 [KO:K04393]
133477984  cell division control protein 42 homolog isoform X1 [KO:K04393]
133471519  cell division control protein 42 homolog [KO:K04393]
133479196  cdc42l; cell division cycle 42, like [KO:K04393]
133474429  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
133476745  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
133484344  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
133490230  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
133490304  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
133474596  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
133470813  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
133470416  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
133465152  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
133478109  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
133471939  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
133489269  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
133490052  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
133490053  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
133475230  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
133488156  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
133476686  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
133468019  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
133472403  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
133485447  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
133489872  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
133484537  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
133487196  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
133482042  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
133480564  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
133487857  serine/threonine-protein kinase PAK 2-like isoform X1 [KO:K04410] [EC:2.7.11.1]
133483396  serine/threonine-protein kinase 4-like isoform X1 [KO:K04411]
133471260  stk3; serine/threonine-protein kinase 3 [KO:K04412]
133472447  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
133470340  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
133472481  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
133478744  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
133470061  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
133466645  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
133487796  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
133482173  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
133486148  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
133483878  mitogen-activated protein kinase kinase kinase 12-like isoform X1 [KO:K04423] [EC:2.7.11.25]
133488109  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
133486639  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
133488789  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
133486748  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
133479543  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133467900  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133468076  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
133485895  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
133469770  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
133490145  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
133466031  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
133467038  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
133481852  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
133475658  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
133465762  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
133468876  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
133477200  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
133465694  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
133468948  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
133478265  C-Jun-amino-terminal kinase-interacting protein 1-like isoform X1 [KO:K04434]
133472066  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
133477981  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
133466037  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
133486974  flna; filamin-A isoform X1 [KO:K04437]
133467709  adapter molecule crk-like isoform X1 [KO:K04438]
133482413  crk; adapter molecule crk isoform X1 [KO:K04438]
133467093  arrestin red cell [KO:K04439]
133482157  beta-arrestin-1-like [KO:K04439]
133484364  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133490325  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
133485601  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133469052  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133483087  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
133477578  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
133485215  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
133474919  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
133481934  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
133475202  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
133483357  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
133483280  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04444] [EC:2.7.11.1]
133483348  mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
133487741  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
133466952  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
133487771  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
133470717  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
133480004  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
133474265  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
133488582  transcription factor Jun-like [KO:K04448]
133465148  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
133481114  jun; transcription factor AP-1 [KO:K04448]
133488758  jund; transcription factor jun-D [KO:K04449]
133480318  transcription factor JunD-like isoform X1 [KO:K04449]
133486594  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
133472385  tp53; cellular tumor antigen p53 [KO:K04451]
133468655  cellular tumor antigen p53-like [KO:K04451]
133484120  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
133468135  max; protein max isoform X1 [KO:K04453]
133488055  protein max-like isoform X1 [KO:K04453]
133474827  mef2cb; myocyte enhancer factor 2cb [KO:K04454]
133467071  hspb1; heat shock protein beta-1 [KO:K04455]
133476580  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133482790  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133486243  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133487385  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133467664  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) isoform X1 [KO:K04457] [EC:3.1.3.16]
133482103  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
133488327  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
133471789  ptprr; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K04458] [EC:3.1.3.48]
133477657  tyrosine-protein phosphatase non-receptor type 5-like isoform X1 [KO:K18018] [EC:3.1.3.48]
133465322  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
133484927  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
133483095  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133477656  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133464945  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133472185  dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133466504  si:ch211-195b15.8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133475171  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133487660  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133476268  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133478162  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
133468481  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
133465826  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
133482515  ppp5c; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
133486181  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
133469044  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
133484862  heat shock 70 kDa protein 1-like [KO:K03283]
133479267  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
133466732  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
133481947  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
133468728  heat shock 70 kDa protein 1 [KO:K03283]
133481964  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
133470969  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
133469690  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
133476933  probable nuclear hormone receptor HR38 [KO:K04465]
133483980  probable nuclear hormone receptor HR38 [KO:K04465]
133469725  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
133465930  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
133485849  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
133469133  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
133475135  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
133487166  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
133466032  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
133481781  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
133484904  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
133485712  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
133472326  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
133482762  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ptao04070  Phosphatidylinositol signaling system
ptao04110  Cell cycle
ptao04115  p53 signaling pathway
ptao04210  Apoptosis
ptao04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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