KEGG   PATHWAY: ptex04010
Entry
ptex04010                   Pathway                                
Name
MAPK signaling pathway - Pseudonaja textilis (eastern brown snake)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptex04010  MAPK signaling pathway
ptex04010

Other DBs
GO: 0000165
Organism
Pseudonaja textilis (eastern brown snake) [GN:ptex]
Gene
113433536  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
113443835  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
113447447  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
113449745  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
113438079  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
113443408  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
113436966  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
113438860  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
113433807  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
113446940  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
113447751  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
113436564  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
113453910  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
113449736  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
113437976  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
113447383  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
113446447  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
113445485  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
113434160  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
113443116  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
113435837  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
113438992  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
113443141  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
113443187  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
113443683  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
113450906  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
113443650  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
113443633  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
113433613  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113436070  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113443192  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113438611  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113443569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
113438808  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113436029  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113445606  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113445645  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113434821  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113444200  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113442027  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
113448038  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
113442707  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
113447484  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
113433142  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
113446037  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
113435947  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
113442596  NF1; neurofibromin isoform X1 [KO:K08052]
113445028  RASA1; ras GTPase-activating protein 1 [KO:K04352]
113436863  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
113444272  RAP1A; ras-related protein Rap-1A [KO:K04353]
113435814  RAP1B; ras-related protein Rap-1b [KO:K07836]
113434620  EGF; pro-epidermal growth factor [KO:K04357]
113445878  TGFA; protransforming growth factor alpha [KO:K08774]
113447269  proepiregulin-like [KO:K09784]
113447268  AREG; amphiregulin [KO:K09782]
113433550  FGF1; fibroblast growth factor 1 [KO:K18496]
113434610  FGF2; fibroblast growth factor 2 [KO:K18497]
113438930  FGF4; fibroblast growth factor 4 [KO:K04358]
113438941  FGF3; fibroblast growth factor 3 [KO:K04358]
113434575  FGF20; fibroblast growth factor 20 [KO:K04358]
113435243  FGF22; fibroblast growth factor 22 [KO:K04358]
113446612  FGF10; fibroblast growth factor 10 [KO:K04358]
113441710  FGF9; fibroblast growth factor 9 [KO:K04358]
113436608  FGF8; fibroblast growth factor 8 [KO:K04358]
113442346  FGF7; fibroblast growth factor 7 [KO:K04358]
113442671  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
113448288  FGF5; fibroblast growth factor 5 [KO:K04358]
113437951  FGF16; fibroblast growth factor 16 [KO:K04358]
113438920  FGF19; fibroblast growth factor 19 [KO:K22603]
113443668  FGF21; fibroblast growth factor 21 [KO:K22429]
113433020  fibroblast growth factor 23-like [KO:K22428]
113433118  fibroblast growth factor 23-like [KO:K22428]
113433182  fibroblast growth factor 23-like [KO:K22428]
113444273  NGF; beta-nerve growth factor [KO:K02582]
113438878  BDNF; brain-derived neurotrophic factor [KO:K04355]
113437121  NTF3; neurotrophin-3 [KO:K04356]
113442917  NTF4; neurotrophin-4 [KO:K12457]
113440221  INS; insulin [KO:K04526]
113455259  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
113440276  IGF2; insulin-like growth factor II [KO:K13769]
113438773  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113433737  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
113440508  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
113435877  PDGFC; platelet-derived growth factor C [KO:K05450]
113440646  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
113435258  KITLG; kit ligand isoform X1 [KO:K05461]
113443652  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
113450301  snake venom vascular endothelial growth factor toxin HF-like [KO:K05448]
113453194  vascular endothelial growth factor A-like [KO:K05448]
113453195  vascular endothelial growth factor A-like [KO:K05448]
113433163  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
113439386  PGF; placenta growth factor isoform X1 [KO:K16859]
113435705  VEGFC; vascular endothelial growth factor C [KO:K05449]
113436578  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113438254  ANGPT1; angiopoietin-1 [KO:K05465]
113437585  angiopoietin-2-like [KO:K05466]
113432934  ANGPT2; angiopoietin-2 [KO:K05466]
113450131  ANGPT4; angiopoietin-4 [KO:K05467]
113435329  EFNA2; ephrin-A2 [KO:K05462]
113446663  EFNA1; ephrin-A1 [KO:K05462]
113446669  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
113446715  EFNA4; ephrin-A4 [KO:K05462]
113448853  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
113445192  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
113451103  NRTN; neurturin [KO:K25414]
113437354  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113447396  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113443089  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
113440942  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
113445594  fibroblast growth factor receptor 1-like isoform X1 [KO:K04362] [EC:2.7.10.1]
113445646  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
113439153  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113449380  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113455189  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113451676  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
113442961  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113449167  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
113438479  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113435201  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
113442022  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113435807  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113433810  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113433809  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
113435806  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
113441673  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
113441696  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
113437917  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
113433804  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
113435930  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
113444350  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113444605  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
113446251  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
113445411  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
113437138  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113433387  SOS1; son of sevenless homolog 1 [KO:K03099]
113435148  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113440320  HRAS; GTPase HRas [KO:K02833]
113441228  KRAS; GTPase KRas isoform X1 [KO:K07827]
113443525  GTPase HRas isoform X1 [KO:K07827]
113444286  NRAS; GTPase NRas [KO:K07828]
113440235  RRAS2; ras-related protein R-Ras2 [KO:K07830]
113442894  RRAS; ras-related protein R-Ras [KO:K07830]
113441159  MRAS; ras-related protein M-Ras [KO:K07831]
113443282  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
113451893  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
113452732  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113442026  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113450336  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113434827  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
113446490  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113443485  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113435269  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
113440693  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
113439301  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
113445233  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113437513  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
113437847  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
113433792  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113443232  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
113446148  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
113438317  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
113433345  SRF; serum response factor isoform X1 [KO:K04378]
113443590  FOS; proto-oncogene c-Fos [KO:K04379]
113447380  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113437530  STMN1; stathmin [KO:K04381]
113439154  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113451488  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
113442223  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113442234  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113438047  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
113438524  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113438533  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113438543  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113438555  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113438568  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113438574  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113438593  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
113449096  TNF; tumor necrosis factor [KO:K03156]
113445875  IL1B; interleukin-1 beta [KO:K04519]
113445961  TGFB1; transforming growth factor beta-1 [KO:K13375]
113433267  TGFB2; transforming growth factor beta-2 [KO:K13376]
113443688  TGFB3; transforming growth factor beta-3 [KO:K13377]
113444433  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113440769  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
113451499  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
113437392  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
113441236  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113441269  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113438172  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113452963  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
113438763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113433327  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113437082  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113451601  CDC42; cell division control protein 42 homolog [KO:K04393]
113445309  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113434641  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113443864  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
113447969  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113443218  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
113447567  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
113440701  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113451154  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113436028  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
113438516  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113433754  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113439674  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113446880  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
113433384  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
113440767  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
113437755  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
113445953  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
113440497  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113436796  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
113434402  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
113439872  STK3; serine/threonine-protein kinase 3 [KO:K04412]
113447459  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
113442468  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
113446900  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
113447461  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
113441211  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
113447218  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
113447966  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
113438496  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
113439361  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
113445523  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
113436766  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
113434068  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
113437497  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
113439618  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
113455385  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113439289  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
113451306  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
113451391  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
113443571  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
113437210  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
113433617  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113438784  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
113436987  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113438415  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
113450640  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
113438711  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
113443323  FLNA; filamin-A isoform X1 [KO:K04437]
113447037  CRKL; crk-like protein [KO:K04438]
113443596  crk-like protein [KO:K04438]
113449997  CRK; adapter molecule crk [KO:K04438]
113451258  beta-arrestin-1-like [KO:K04439]
113453780  ARRB2; beta-arrestin-2 [KO:K04439]
113433784  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113434600  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113449402  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113445070  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
113445079  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113446951  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113446987  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113447763  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113447794  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113448708  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
113446087  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
113453848  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
113444322  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
113446631  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
113451716  M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
113435562  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113445107  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
113440637  JUN; transcription factor AP-1 [KO:K04448]
113435225  JUND; transcription factor jun-D [KO:K04449]
113434057  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113451334  TP53; cellular tumor antigen p53 [KO:K04451]
113444919  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
113441118  MAX; protein max isoform X1 [KO:K04453]
113448256  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
113441584  HSPB1; heat shock protein beta-1 [KO:K04455]
113450329  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113439387  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113435046  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113435083  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
113436652  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
113440211  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
113444269  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
113433686  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113439097  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113445825  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113440370  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113453525  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113437289  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113444117  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113435250  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
113433252  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113442897  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
113446063  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
113433321  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
113451409  heat shock cognate 71 kDa protein-like [KO:K03283]
113441797  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113449161  heat shock 70 kDa protein II-like [KO:K03283]
113449210  heat shock 70 kDa protein-like [KO:K03283]
113439707  MDS1 and EVI1 complex locus protein-like [KO:K04462] [EC:2.1.1.367]
113439788  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
113442010  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
113449965  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
113447350  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
113447838  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
113449389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113445889  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113443435  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113442555  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
113443577  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
113434817  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
113445367  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
113446671  RELA; transcription factor p65 isoform X1 [KO:K04735]
113445963  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ptex04070  Phosphatidylinositol signaling system
ptex04110  Cell cycle
ptex04115  p53 signaling pathway
ptex04210  Apoptosis
ptex04310  Wnt signaling pathway
KO pathway
ko04010   
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