KEGG   PATHWAY: rtp04010
Entry
rtp04010                    Pathway                                
Name
MAPK signaling pathway - Rhincodon typus (whale shark)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
rtp04010  MAPK signaling pathway
rtp04010

Other DBs
GO: 0000165
Organism
Rhincodon typus (whale shark) [GN:rtp]
Gene
109912552  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
109920177  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
109930589  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
109919653  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
109933425  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
109934787  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
109922317  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
109931996  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
109919291  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
109932632  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109930100  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
109931490  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109915985  voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
109915118  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
109921417  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109925470  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109936214  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109937782  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109927069  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109910402  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109937447  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
109917843  gna12a; guanine nucleotide-binding protein subunit alpha-12a isoform X2 [KO:K04346]
109931104  guanine nucleotide-binding protein subunit alpha-12-like isoform X1 [KO:K04346]
109911349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109928191  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109916628  protein phosphatase 3 catalytic subunit alpha-like [KO:K04348] [EC:3.1.3.16]
109917904  protein phosphatase 3 catalytic subunit alpha-like [KO:K04348] [EC:3.1.3.16]
109926132  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
109934526  ppp3r1b; calcineurin subunit B type 1b isoform X2 [KO:K06268]
109938076  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109938895  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
109917267  RAS guanyl-releasing protein 1 [KO:K04350]
125480966  rap guanine nucleotide exchange factor 2-like [KO:K08018]
109935321  nf1a; neurofibromin isoform X1 [KO:K08052]
109916106  ras GTPase-activating protein 1-like [KO:K04352]
109936745  LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
109924294  ras-related protein Rap-1b [KO:K07836]
109929559  egf; pro-epidermal growth factor [KO:K04357]
109925072  proepiregulin-like [KO:K09784]
109916803  fibroblast growth factor 1-like [KO:K18496]
109916889  fgf2; fibroblast growth factor 2 [KO:K18497]
109910616  fgf10a; fibroblast growth factor 10a [KO:K04358]
109912057  fgf5; fibroblast growth factor 5 [KO:K04358]
109934764  fibroblast growth factor 9-like [KO:K04358]
109938436  fgf16; fibroblast growth factor 16 [KO:K04358]
109918173  fgf24; fibroblast growth factor 24 [KO:K04358]
109925261  fgf4; fibroblast growth factor 4 [KO:K04358]
109931988  fgf22; fibroblast growth factor 22 [KO:K04358]
125487370  fgf17; fibroblast growth factor 17 [KO:K04358]
109920797  fibroblast growth factor 9 isoform X1 [KO:K04358]
125486788  fgf7; fibroblast growth factor 7 [KO:K04358]
109933756  fibroblast growth factor 4A-like [KO:K04358]
109917921  fgf19; fibroblast growth factor 19 [KO:K22603]
109920357  fibroblast growth factor 19-like [KO:K22428]
109934101  neurotrophin-7-like [KO:K02582]
109938236  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109930157  neurotrophin-3-like [KO:K04356]
109920487  neurotrophin-4-like [KO:K12457]
109921259  insulin [KO:K04526]
109914145  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
109927421  insulin-like growth factor II [KO:K13769]
109934227  insulin-like growth factor I [KO:K13769]
109916423  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109936774  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
109928695  platelet-derived growth factor subunit B-like [KO:K17386]
109915080  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
109938372  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
109921130  kit ligand-like isoform X1 [KO:K05461]
109922076  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
109920533  vegfc; vascular endothelial growth factor C [KO:K05449]
109923284  vascular endothelial growth factor D isoform X1 [KO:K05449]
109935795  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
109921451  hepatocyte growth factor isoform X1 [KO:K05460]
109913136  angiopoietin-1-like [KO:K05465]
109920264  angpt1; angiopoietin-1 [KO:K05465]
109931991  angiopoietin-2 [KO:K05466]
109927829  angiopoietin-2-like [KO:K05466]
109931882  ephrin-A5 [KO:K05462]
109920234  ephrin-A2-like [KO:K05462]
125484268  uncharacterized protein LOC125484268 [KO:K25415]
109920918  artemin [KO:K25416]
109927384  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109930473  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
109923881  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
109925871  fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
109910693  fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
109914322  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
109914800  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
109926902  ngfrb; nerve growth factor receptor b [KO:K02583]
109920280  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
109924711  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
109927411  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109928941  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
109913625  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109927631  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109932822  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
109927679  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
109928943  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109911784  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
109915196  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
109914722  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
109921507  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
109923392  sos2; son of sevenless homolog 2 [KO:K03099]
109915744  GTPase HRas [KO:K02833]
109919287  GTPase HRas [KO:K07827]
109931543  GTPase KRas isoform X1 [KO:K07827]
109917328  nras; GTPase NRas [KO:K07828]
109919272  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
109920125  ras-related protein R-Ras2-like isoform X1 [KO:K07830]
109932084  mrasa; ras-related protein M-Ras [KO:K07831]
109917885  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
109911534  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109922810  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109935274  lamtor3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
109918415  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109926722  MAP kinase-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K04372] [EC:2.7.11.1]
109922046  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
109923192  ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
109926959  ribosomal protein S6 kinase 2 alpha-like isoform X1 [KO:K04373] [EC:2.7.11.1]
109931386  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109912743  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
109919490  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109913007  ETS domain-containing protein Elk-4-like [KO:K04376]
109916636  myc proto-oncogene protein-like [KO:K04377]
109923817  mych; myelocytomatosis oncogene homolog [KO:K04377]
109923370  serum response factor-like isoform X1 [KO:K04378]
109925076  protein c-Fos-like [KO:K04379]
109934892  stathmin-like [KO:K04381]
109939126  stathmin-like [KO:K04381]
109933766  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109910851  tumor necrosis factor-like [KO:K03156]
109910853  tumor necrosis factor-like [KO:K03156]
109916901  lymphotoxin-alpha-like [KO:K03156]
125488288  tumor necrosis factor-like [KO:K03156]
109910852  tumor necrosis factor-like [KO:K03156]
109911779  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
109926035  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
109920170  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
109913741  interleukin-1 receptor accessory protein [KO:K04723]
125484712  interleukin-1 receptor accessory protein-like [KO:K04723]
109921531  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
109916891  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109926924  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
109930946  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109930951  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109930950  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109929457  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
109938489  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
109913495  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109924676  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109930936  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109936137  cdc42; cell division control protein 42 homolog [KO:K04393]
109922055  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109916783  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109936083  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109938698  death domain-associated protein 6-like isoform X1 [KO:K02308]
109927021  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109935969  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109936672  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109933624  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109926854  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109912678  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
109917334  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
109937967  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
109927177  mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
109919141  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
109939010  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
109911747  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109919516  stk3; serine/threonine-protein kinase 3/4 isoform X1 [KO:K04411]
109921319  serine/threonine-protein kinase 3-like [KO:K04412]
109916936  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
109913314  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
109921628  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109914330  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
109937616  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109938494  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
109919598  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109927672  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109926885  map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
109914179  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
109933638  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
109925823  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
109911816  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
109922694  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04432] [EC:2.7.12.2]
109935499  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
109928090  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
109913283  mapk8ip2; serine-rich adhesin for platelets [KO:K04435]
109915594  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
109923915  crkl; crk-like protein [KO:K04438]
109916685  crk; adapter molecule crk [KO:K04438]
109913604  S-arrestin-like [KO:K04439]
109916453  arrb1; beta-arrestin-1 [KO:K04439]
109925864  arrestin red cell isoform X1 [KO:K04439]
109927876  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109917844  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109917855  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109927220  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109932340  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109914201  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109936687  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109937784  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
109938878  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
109913209  ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
125484053  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
109911161  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
109933357  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109925743  jun; transcription factor AP-1 [KO:K04448]
109919401  transcription factor JunD [KO:K04449]
109929477  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
109925396  max; protein max isoform X1 [KO:K04453]
109918701  myocyte-specific enhancer factor 2C-like [KO:K04454]
109931290  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
109929983  si:dkey-1k23.3; heat shock protein beta-1 [KO:K04455]
125486164  hspb1; heat shock protein beta-1 [KO:K04455]
109931632  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109916533  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109918846  ppm1aa; protein phosphatase 1A isoform X4 [KO:K04457] [EC:3.1.3.16]
109937190  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
109916389  receptor-type tyrosine-protein phosphatase R-like [KO:K04458] [EC:3.1.3.48]
109930335  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
109924522  dual specificity protein phosphatase 1-B-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109914245  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109914607  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109923101  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109926768  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109918498  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109922272  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109918204  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109923680  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109932652  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109918758  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109915114  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109924758  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
109914616  heat shock cognate 71 kDa protein-like [KO:K03283]
109926956  heat shock cognate 71 kDa protein-like [KO:K03283]
109914620  heat shock 70 kDa protein [KO:K03283]
109935266  putative heat shock 70 kDa protein 7 [KO:K03283]
109921280  mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
109929473  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109925206  mapk7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
109910938  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
109918795  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
109927975  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109918515  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109917574  nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
109916823  transcription factor RelB-like [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
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KO pathway
ko04010   
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