KEGG PATHWAY: xhe04514

KEGG

PATHWAY: xhe04514

Entry

xhe04514                    Pathway

Name

Cell adhesion molecules - Xiphophorus hellerii (green swordtail)

Description

Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

Cell adhesion molecules

Other DBs

GO:

Organism

Xiphophorus hellerii (green swordtail) [GN:xhe]

Gene

slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]

nectin1; nectin-1 isoform X1 [KO:K06081]

jam3; junctional adhesion molecule C [KO:K06785]

nrxn3; neurexin 3 isoform X1 [KO:K07377]

lrrc4c; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4C [KO:K07523]

cldn11; claudin-11 [KO:K06087]

cldn20; claudin-20 [KO:K06087]

nfasc; neurofascin isoform X1 [KO:K06757]

cntn2; contactin-2 [KO:K06760]

cldn19; claudin-19 isoform X1 [KO:K06087]

sdc4; syndecan-4 isoform X1 [KO:K16338]

[KO:K05695] [EC:3.1.3.48]

cd8a; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]

itgb1; integrin beta-1 isoform X1 [KO:K05719]

ntng1; netrin-G1 isoform X1 [KO:K07522]

cd226; CD226 antigen isoform X1 [KO:K06567]

[KO:K05693] [EC:3.1.3.48]

cntnap2; contactin-associated protein-like 2 isoform X1 [KO:K07380]

vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]

nrxn1; neurexin-1 isoform X1 [KO:K07377]

itga9; integrin alpha-9 [KO:K06585]

itga8; integrin alpha-8 [KO:K06584]

nectin2; nectin-2 isoform X1 [KO:K06531]

slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]

slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]

slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]

slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]

slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]

cldn12; claudin-12 [KO:K06087]

ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03160]

neo1; neogenin isoform X1 [KO:K06766]

cdh15; cadherin-15 [KO:K06809]

cd276; CD276 antigen [KO:K06746]

[KO:K06777] [EC:3.1.3.48]

[KO:K06778] [EC:3.1.3.48]

cadm3; cell adhesion molecule 3 isoform X1 [KO:K06780]

cdh2; cadherin-2 [KO:K06736]

ptprm; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]

[KO:K05695] [EC:3.1.3.48]

mpz; myelin protein P0 isoform X1 [KO:K06770]

itgav; integrin alpha-V [KO:K06487]

cldn10; claudin-10 isoform X1 [KO:K06087]

itga4; integrin alpha-4 [KO:K06483]

cldn14; claudin-14 [KO:K06087]

cd274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]

cldn34; claudin-34 [KO:K06087]

[KO:K06778] [EC:3.1.3.48]

negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]

ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]

nlgn1; neuroligin-1 isoform X1 [KO:K07378]

sele; E-selectin [KO:K06496]

l1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]

cadm1; cell adhesion molecule 1 isoform X1 [KO:K06781]

esam; endothelial cell-selective adhesion molecule [KO:K06787]

cxadr; coxsackievirus and adenovirus receptor [KO:K06788]

cldn5; claudin-5 [KO:K06087]

ntng2; netrin-G2 [KO:K16359]

vcan; LOW QUALITY PROTEIN: versican core protein [KO:K06793]

sdc3; syndecan-3 [KO:K16337]

itgb8; integrin beta-8 [KO:K06591]

cd99l2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]

ptprd; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]

cldn15; claudin-15 [KO:K06087]

cntnap1; contactin-associated protein 1 [KO:K07379]

lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]

lrrc4; leucine-rich repeat-containing protein 4 [KO:K16351]

cntn1; contactin-1 [KO:K06759]

ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]

alcam; CD166 antigen isoform X1 [KO:K06547]

Reference

Authors

Barclay AN.

Title

Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.

Journal

Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2

Reference

Authors

Sharpe AH, Freeman GJ.

Title

The B7-CD28 superfamily.

Journal

Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727

Reference

Authors

Grewal IS, Flavell RA.

Title

CD40 and CD154 in cell-mediated immunity.

Journal

Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111

Reference

Authors

Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.

Title

CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.

Journal

J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558

Reference

Authors

Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.

Title

Cell adhesion and polarity during immune interactions.

Journal

Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x

Reference

Authors

Dejana E.

Title

Endothelial cell-cell junctions: happy together.

Journal

Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357

Reference

Authors

Bazzoni G.

Title

The JAM family of junctional adhesion molecules.

Journal

Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2

Reference

Authors

Becker BF, Heindl B, Kupatt C, Zahler S.

Title

Endothelial function and hemostasis.

Journal

Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320

Reference

Authors

Elangbam CS, Qualls CW Jr, Dahlgren RR.

Title

Cell adhesion molecules--update.

Journal

Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113

Reference

Authors

Muller WA.

Title

Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

Journal

Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0

Reference

Authors

Yamagata M, Sanes JR, Weiner JA.

Title

Synaptic adhesion molecules.

Journal

Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8

Reference

Authors

Ethell IM, Pasquale EB.

Title

Molecular mechanisms of dendritic spine development and remodeling.

Journal

Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003

Reference

Authors

Benson DL, Schnapp LM, Shapiro L, Huntley GW.

Title

Making memories stick: cell-adhesion molecules in synaptic plasticity.

Journal

Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9

Reference

Authors

Rosdahl JA, Mourton TL, Brady-Kalnay SM.

Title

Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.

Journal

Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071

Reference

Authors

Dunican DJ, Doherty P.

Title

The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.

Journal

Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225

Reference

Authors

Girault JA, Peles E.

Title

Development of nodes of Ranvier.

Journal

Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7

Reference

Authors

Arroyo EJ, Scherer SS.

Title

On the molecular architecture of myelinated fibers.

Journal

Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001

Reference

Authors

Salzer JL.

Title

Polarized domains of myelinated axons.

Journal

Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7

Reference

Authors

Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.

Title

Roles and modes of action of nectins in cell-cell adhesion.

Journal

Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002

Reference

Authors

Nakanishi H, Takai Y.

Title

Roles of nectins in cell adhesion, migration and polarization.

Journal

Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116

Reference

Authors

Siu MK, Cheng CY.

Title

Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.

Journal

Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225

Reference

Authors

Lee NP, Cheng CY.

Title

Adaptors, junction dynamics, and spermatogenesis.

Journal

Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268

Reference

Authors

Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.

Title

Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.

Journal

Development 132:1525-37 (2005)
DOI:10.1242/dev.01697

Reference

Authors

Marthiens V, Gavard J, Lambert M, Mege RM.

Title

Cadherin-based cell adhesion in neuromuscular development.

Journal

Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9

Reference

Authors

Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.

Title

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.

Journal

J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397

Related
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Adherens junction

Tight junction

KO pathway

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