KEGG   PATHWAY: rro05022
Entry
rro05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
rro05022  Pathways of neurodegeneration - multiple diseases
rro05022

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104678203  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
104682393  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
104672479  SNCA; alpha-synuclein isoform X2 [KO:K04528]
104654365  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
104661574  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
104664641  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
104674605  ATXN2; ataxin-2 isoform X1 [KO:K23625]
104682147  ATXN2L; ataxin-2-like protein isoform X2 [KO:K23625]
104678957  HTT; huntingtin isoform X1 [KO:K04533]
104672575  ATXN1; ataxin-1 [KO:K23616]
104654765  ATXN1L; ataxin-1-like [KO:K23616]
115893600  LOW QUALITY PROTEIN: ataxin-1-like [KO:K23616]
104669352  ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
104659431  ATXN3L; ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
104657643  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
104674584  PRNP; major prion protein [KO:K05634]
104672686  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
104679194  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104680382  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104664760  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
104653776  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
104657433  GRM5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
104663314  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104669996  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
104655777  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104673127  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
104668296  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
104659669  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
104672220  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
104675428  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104665907  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104676027  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
104661788  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
104680012  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
104664252  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104675331  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104658948  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104679962  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
104679189  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
104680383  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
104674637  PDYN; proenkephalin-B [KO:K15840]
104673336  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
104669771  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
104667722  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
104679865  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
104681333  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
104666582  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
104674106  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
104658112  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
104658627  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
104661942  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
104669605  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
104659017  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
104672388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104661816  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853]
104661868  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104681234  STX1A; syntaxin-1A [KO:K04560]
104668890  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
104682143  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
104677250  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104674813  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
104656202  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
104677021  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
104662779  DERL1; derlin-1 [KO:K11519]
104680029  VCP; transitional endoplasmic reticulum ATPase isoform X2 [KO:K13525]
104680628  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
104657521  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
115894892  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
104673976  ubiquitin-40S ribosomal protein S27a [KO:K02977]
104677290  RPS27A; LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a [KO:K02977]
115894201  ubiquitin-40S ribosomal protein S27a [KO:K02977]
104681436  UBB; polyubiquitin-B [KO:K04551]
104666337  UBC; polyubiquitin-C [KO:K08770]
104679823  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
104676695  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
104677978  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
104663887  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
104676060  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
104655901  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
104681941  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
115899063  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
104657815  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
104663088  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
104664369  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
104674874  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
104660141  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
104674143  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
104674403  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
104681040  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
104673545  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
104662043  26S proteasome regulatory subunit 4 [KO:K03062]
104670546  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
104682317  26S proteasome regulatory subunit 4 [KO:K03062]
104658905  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4 [KO:K03062]
104676129  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
104669166  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
104668413  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
104675461  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
104664628  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
104661392  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
104671873  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
104666289  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
104675424  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
104669328  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
104653845  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
104655883  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
104672642  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
104681047  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
104666029  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
104679956  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
104663820  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X5 [KO:K06691]
104656595  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
115893294  26S proteasome complex subunit SEM1 [KO:K10881]
104679224  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
104664586  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X2 [KO:K03178] [EC:6.2.1.45]
104667236  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
104676904  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
104665312  UBE2L5; ubiquitin-conjugating enzyme E2 L5 isoform X2 [KO:K04552] [EC:2.3.2.23]
104657843  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
115892152  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
104654284  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
104673216  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
104657898  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
104659957  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
104677222  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
104656222  GPR37; LOW QUALITY PROTEIN: prosaposin receptor GPR37 [KO:K04243]
104656681  SEPTIN5; septin-5 isoform X2 [KO:K04557]
104666988  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
104664383  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
104663791  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
104670391  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
104682361  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
104659033  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
104675499  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104669650  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
104675014  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
104679497  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104665278  LOW QUALITY PROTEIN: inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
104676124  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
104674177  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
104665027  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
104682563  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104668699  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
104663205  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
4171534  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4171535  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4171541  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4171543  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4171542  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4171544  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4171545  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
104664727  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
104670231  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
104674738  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
104678001  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
104668090  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
115898726  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
104681769  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
104681673  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
104676020  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
104682371  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
104655119  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
115898341  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115900323  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
104663455  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
104680801  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
104666007  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
104670246  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
115897013  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
104682265  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
104655854  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
104658990  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
104660451  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X6 [KO:K03954]
104658248  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
104665386  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
104678588  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
104680657  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
104679039  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
104659699  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
104671857  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
104666513  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
104680979  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
115898156  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
115894162  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
104670533  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
104656987  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
115894594  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
104655058  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
104661038  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
104682589  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
104656478  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
104662797  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
104681527  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
104664585  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
104653602  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
104664715  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
104665340  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
104668417  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
115891979  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
104672473  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
104681936  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104670266  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
104654148  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104653643  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
115898976  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
115896538  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104661530  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
104671414  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
104664718  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
104654339  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
104664308  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
104662045  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
104668708  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
104669912  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
104663917  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
104669001  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
104675621  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
104665348  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
104677354  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
104668069  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
104656160  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4171546  CYTB; cytochrome b [KO:K00412]
104671687  cytochrome c1, heme protein, mitochondrial [KO:K00413]
104667772  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
104682087  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
104662117  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
104671564  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
104659826  cytochrome b-c1 complex subunit 8 [KO:K00418]
104659363  cytochrome b-c1 complex subunit 9 isoform X2 [KO:K00419]
104671409  cytochrome b-c1 complex subunit 10 [KO:K00420]
104657632  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 10 [KO:K00420]
115897633  cytochrome b-c1 complex subunit 10 [KO:K00420]
4171540  COX3; cytochrome c oxidase subunit III [KO:K02262]
4171536  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4171537  COX2; cytochrome c oxidase subunit II [KO:K02261]
104653722  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
104656020  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
104672160  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
104661470  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
104661582  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
104666251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104670251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104660364  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104667089  cytochrome c oxidase subunit 6B1 [KO:K02267]
104682113  cytochrome c oxidase subunit 6B2 [KO:K02267]
104679876  cytochrome c oxidase subunit 6C [KO:K02268]
115894606  cytochrome c oxidase subunit 6C-like [KO:K02268]
115892804  cytochrome c oxidase subunit 6C [KO:K02268]
115893203  cytochrome c oxidase subunit 6C-like [KO:K02268]
115895267  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
104677541  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
104666288  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
104669287  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
104669550  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
104680071  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
104671254  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
115900678  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
104672609  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115897656  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899665  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115899666  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898290  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899930  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115892348  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898701  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899083  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898718  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115896572  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896575  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115894755  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896799  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115892928  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115897482  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115898761  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115893223  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115893945  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896524  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115897625  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115899181  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104672955  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
104679055  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
104680752  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
104673663  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
104682665  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
104671420  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
104663802  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
4171539  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
104658937  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
104659648  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
104672398  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
104670586  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
104659379  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
104658760  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
104678202  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
4171538  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
104682248  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104659812  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
115894591  voltage-dependent anion-selective channel protein 1 [KO:K05862]
115895711  voltage-dependent anion-selective channel protein 1 [KO:K05862]
104673506  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
104665346  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
104669950  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
104662055  calmodulin [KO:K02183]
104663170  CALM2; calmodulin-2 [KO:K02183]
104680741  calmodulin-alpha-like [KO:K02183]
104670544  CALM1; calmodulin-1 [KO:K02183]
104673406  CALM3; calmodulin-3 [KO:K02183]
104664834  CALML5; calmodulin-like protein 5 [KO:K02183]
104664835  CALML3; calmodulin-like protein 3 [KO:K02183]
104653554  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
104662590  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104674211  calmodulin-alpha-like [KO:K02183]
104656871  calmodulin-like [KO:K02183]
104663969  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104663623  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104669965  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104675975  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
104670806  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104653917  calcineurin subunit B type 1 [KO:K06268]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104669600  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104675147  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
104677132  FADD; FAS-associated death domain protein [KO:K02373]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104676299  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104664577  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
104674825  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
104672291  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
104671883  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
104666042  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104661254  LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
104663348  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
104673881  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
104673801  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
115899258  ADP/ATP translocase 2 [KO:K05863]
104662253  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
104661761  cytochrome c-like [KO:K08738]
104679886  cytochrome c [KO:K08738]
104672188  cytochrome c [KO:K08738]
104681924  cytochrome c-like [KO:K08738]
115898126  cytochrome c-like [KO:K08738]
115894533  cytochrome c-like [KO:K08738]
115893266  cytochrome c-like [KO:K08738]
115893541  cytochrome c-like [KO:K08738]
115899152  cytochrome c-like [KO:K08738]
104656342  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
104677696  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104681223  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
104680587  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
104663370  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
104678002  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
104676851  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
104657558  PARK7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
115896206  protein/nucleic acid deglycase DJ-1-like [KO:K05687] [EC:3.5.1.124]
115895970  protein/nucleic acid deglycase DJ-1-like [KO:K05687] [EC:3.5.1.124]
115895993  protein/nucleic acid deglycase DJ-1-like [KO:K05687] [EC:3.5.1.124]
104653720  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
104670591  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
104668934  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
104664454  OPTN; LOW QUALITY PROTEIN: optineurin [KO:K19946]
104676201  SQSTM1; sequestosome-1 [KO:K14381]
104665626  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
104679210  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
104680509  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
104656055  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
104680828  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
104666030  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
104656954  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
104665857  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
104679001  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
104661005  RAB8A; ras-related protein Rab-8A [KO:K07901]
104679603  RAB39B; ras-related protein Rab-39B [KO:K07925]
104656192  RAB1A; ras-related protein Rab-1A [KO:K07874]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104674321  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
104663276  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
104670650  ATG101; autophagy-related protein 101 [KO:K19730]
104668394  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
104666982  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
104668391  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X2 [KO:K17985]
104680067  BECN1; beclin-1 isoform X1 [KO:K08334]
104679208  BECN2; beclin-2 [KO:K08334]
104675724  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
104669140  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
104655659  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
115898785  nuclear receptor-binding factor 2 [KO:K21246]
104658709  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
104654479  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
104662842  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
104665223  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
104654030  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
104656183  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
104655524  ALS2; alsin isoform X1 [KO:K04575]
104665706  RAB5A; ras-related protein Rab-5A [KO:K07887]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104677664  CHMP2B; charged multivesicular body protein 2b isoform X2 [KO:K12192]
104664518  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
104679613  SPG11; spatacsin isoform X1 [KO:K19026]
104661913  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104680127  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104668929  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
104657969  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
104678467  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
104654038  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104675533  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
104664766  CCS; copper chaperone for superoxide dismutase [KO:K04569]
104669200  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
104667379  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
104673268  GPX6; LOW QUALITY PROTEIN: glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
104673269  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
104670427  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
104678431  GPX2; glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
104680491  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
104658349  CAT; catalase [KO:K03781] [EC:1.11.1.6]
104679719  PRPH; peripherin [KO:K07607]
104673963  NEFL; neurofilament light polypeptide [KO:K04572]
104673964  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
104659243  NEFH; neurofilament heavy polypeptide [KO:K04574]
104682357  KIF5A; kinesin heavy chain [KO:K10396]
104657263  KIF5B; kinesin-1 heavy chain [KO:K10396]
104658117  KIF5C; kinesin heavy chain [KO:K10396]
104673445  KLC3; kinesin light chain 3 [KO:K10407]
104664788  KLC2; kinesin light chain 2 [KO:K10407]
104667335  KLC4; kinesin light chain 4 [KO:K10407]
104654417  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
104676295  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
104676885  tubulin alpha-3 chain [KO:K07374]
104679720  TUBA1C; tubulin alpha-1C chain [KO:K07374]
104679721  tubulin alpha-1A chain [KO:K07374]
104679722  tubulin alpha-1B chain [KO:K07374]
104660054  tubulin alpha-4A chain isoform X1 [KO:K07374]
104664832  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
104682166  tubulin alpha-3 chain [KO:K07374]
115898194  tubulin alpha-3 chain-like [KO:K07374]
104666661  tubulin alpha-1B chain-like [KO:K07374]
104672253  tubulin alpha-3 chain [KO:K07374]
104672011  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
104674179  LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
104678490  tubulin beta-8 chain-like isoform X1 [KO:K07375]
104661226  tubulin beta-2B chain isoform X1 [KO:K07375]
104661227  TUBB2A; tubulin beta-2A chain [KO:K07375]
104663801  TUBB1; tubulin beta-1 chain [KO:K07375]
104666199  TUBB; tubulin beta chain [KO:K07375]
104671529  tubulin beta-8 chain-like [KO:K07375]
104665366  TUBB4A; tubulin beta-4A chain [KO:K07375]
104669623  TUBB4B; tubulin beta-4B chain [KO:K07375]
115896185  LOW QUALITY PROTEIN: tubulin beta-3 chain-like [KO:K07375]
104669765  tubulin beta-8 chain [KO:K07375]
115897019  tubulin beta-2 chain-like [KO:K07375]
115892025  tubulin beta-3 chain [KO:K07375]
115893883  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
115892049  tubulin beta-8 chain-like isoform X1 [KO:K07375]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104660810  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
104664070  CSNK2A2; casein kinase II subunit alpha' isoform X3 [KO:K03097] [EC:2.7.11.1]
104661923  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
104671126  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
104674809  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
104682359  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
104680010  DCTN3; dynactin subunit 3 [KO:K10425]
104670423  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
104658251  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
104668231  DCTN6; dynactin subunit 6 [KO:K10428]
115894814  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
104661471  ACTR1B; beta-centractin [KO:K16575]
104656522  ACTR1A; alpha-centractin [KO:K16575]
104657816  ACTR10; actin-related protein 10 [KO:K16576]
104680552  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
104662415  DNAH14; dynein heavy chain 14, axonemal isoform X3 [KO:K10408]
104663708  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
104672346  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
104672065  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
115894927  LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal-like [KO:K10408]
104660204  DNAH12; LOW QUALITY PROTEIN: dynein heavy chain 12, axonemal [KO:K10408]
104661666  DNAH2; LOW QUALITY PROTEIN: dynein heavy chain 2, axonemal [KO:K10408]
104677024  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
104682904  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
104682083  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
104670757  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
104674101  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
104666331  DNAH10; LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [KO:K10408]
104665047  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
104653621  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
104680004  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
104681351  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
104677551  DNAL1; dynein light chain 1, axonemal [KO:K10411]
104682548  DNAL4; dynein light chain 4, axonemal [KO:K10412]
104676623  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
104670410  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104671146  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
104669984  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104662820  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104677285  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104669329  CDK5R1; cyclin-dependent kinase 5 activator 1 isoform X1 [KO:K11716]
104675398  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
104662231  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
104669534  DKK2; dickkopf-related protein 2 isoform X1 [KO:K02165]
104676724  DKK1; dickkopf-related protein 1 [KO:K02165]
104666043  DKK4; dickkopf-related protein 4 [KO:K02165]
104679729  WNT1; proto-oncogene Wnt-1 [KO:K03209]
104682628  WNT2; protein Wnt-2 [KO:K00182]
104658925  WNT2B; protein Wnt-2b [KO:K00182]
104672034  WNT3A; protein Wnt-3a [KO:K00312]
104682399  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104663222  WNT4; protein Wnt-4 [KO:K00408]
104662531  WNT5B; protein Wnt-5b [KO:K00444]
104676516  WNT5A; protein Wnt-5a [KO:K00444]
104660036  WNT6; protein Wnt-6 [KO:K00445]
104676099  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104679020  WNT7A; protein Wnt-7a [KO:K00572]
104656476  WNT8B; protein Wnt-8b [KO:K00714]
104681717  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
104672033  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
104682400  WNT9B; protein Wnt-9b [KO:K01064]
104660037  WNT10A; protein Wnt-10a [KO:K01357]
104679730  WNT10B; protein Wnt-10b [KO:K01357]
104665095  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
104677318  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
104680806  FZD7; frizzled-7 [KO:K02432]
104655247  FZD1; frizzled-1 [KO:K02432]
104654721  FZD2; frizzled-2 [KO:K02235]
104668245  FZD3; frizzled-3 [KO:K02329]
104656419  FZD4; frizzled-4 isoform X2 [KO:K02354]
104680216  FZD5; frizzled-5 [KO:K02375]
104682682  FZD8; frizzled-8 [KO:K02375]
104655138  FZD6; frizzled-6 isoform X1 [KO:K02376]
104655547  FZD10; frizzled-10 [KO:K02842]
104681229  FZD9; frizzled-9 [KO:K02842]
104668335  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
104664820  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
104682535  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
104679742  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104673334  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
104664635  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
104682839  FRAT1; proto-oncogene FRAT1 [KO:K03069]
104682818  FRAT2; LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2 [KO:K03096]
104676962  AXIN1; axin-1 isoform X1 [KO:K02157]
104675432  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
104669245  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
104671452  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
104670934  CTNNB1; catenin beta-1 [KO:K02105]
104677933  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
104680771  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
104673948  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104664593  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104675589  NOX1; NADPH oxidase 1 [KO:K08008]
104658069  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104678914  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
104664815  RELA; transcription factor p65 [KO:K04735]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104669357  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
104664377  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104672546  IL1A; interleukin-1 alpha [KO:K04383]
104672547  IL1B; interleukin-1 beta [KO:K04519]
104680325  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
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Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Reference
PMID:28062563
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Dugger BN, Dickson DW
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Pathology of Neurodegenerative Diseases.
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
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Reference
PMID:20070435
  Authors
Jellinger KA
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Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
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Int J Mol Sci 20:E719 (2019)
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PMID:15272267
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Ross CA, Poirier MA
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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PMID:30250260
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Soto C, Pritzkow S
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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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PMID:25132814
  Authors
Dantuma NP, Bott LC
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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
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Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
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Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
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Reference
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Park H, Kang JH, Lee S
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Int J Mol Sci 21:E3369 (2020)
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Reference
PMID:31783880
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Malik BR, Maddison DC, Smith GA, Peters OM
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
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Mol Brain 12:100 (2019)
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Reference
PMID:29734735
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Metaxakis A, Ploumi C, Tavernarakis N
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Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
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Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Reference
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Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
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Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
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Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
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Reference
PMID:21722302
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
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PMID:28643372
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Halliday M, Hughes D, Mallucci GR
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Axonal transport deficits and neurodegenerative diseases.
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Nat Rev Neurosci 14:161-76 (2013)
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Axonal transport and neurological disease.
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Retrograde axonal transport: pathways to cell death?
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Trends Neurosci 33:335-44 (2010)
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Related
pathway
rro00190  Oxidative phosphorylation
rro03050  Proteasome
rro04020  Calcium signaling pathway
rro04120  Ubiquitin mediated proteolysis
rro04137  Mitophagy - animal
rro04140  Autophagy - animal
rro04141  Protein processing in endoplasmic reticulum
rro04142  Lysosome
rro04210  Apoptosis
rro04310  Wnt signaling pathway
rro04724  Glutamatergic synapse
rro04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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