KEGG   PATHWAY: csab05010
Entry
csab05010                   Pathway                                
Name
Alzheimer disease - Chlorocebus sabaeus (green monkey)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
csab05010  Alzheimer disease
csab05010

Disease
H00056  Alzheimer disease
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214298  CSNK1A1L; casein kinase 1 alpha 1 like [KO:K08957] [EC:2.7.11.1]
103214788  IRS2; insulin receptor substrate 2 [KO:K07187]
103214791  LRP5; LDL receptor related protein 5 [KO:K03068]
103214808  [KO:K02128]
103214941  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
103215231  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
103215235  [KO:K00234] [EC:1.3.5.1]
103215415  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103215453  SLC39A14; solute carrier family 39 member 14 [KO:K14720]
103215459  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103215545  FZD3; frizzled class receptor 3 [KO:K02329]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103215690  DKK4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
103215691  VDAC3; voltage dependent anion channel 3 [KO:K15041]
103215835  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103215933  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
103215964  VDAC2; voltage dependent anion channel 2 [KO:K15040]
103215997  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103216000  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
103216021  MCU; mitochondrial calcium uniporter [KO:K20858]
103216125  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
103216187  DKK1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
103216224  FAS; Fas cell surface death receptor [KO:K04390]
103216264  IDE; insulin degrading enzyme [KO:K01408] [EC:3.4.24.56]
103216335  FRAT1; FRAT1, WNT signaling pathway regulator [KO:K03069]
103216336  FRAT2; FRAT2, WNT signaling pathway regulator [KO:K03096]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103216388  WNT8B; Wnt family member 8B [KO:K00714]
103216390  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
103216537  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
103216555  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
103216644  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
103216844  TUBA3E; tubulin alpha 3e [KO:K07374]
103216985  [KO:K00236]
103217064  KIF5C; kinesin family member 5C [KO:K10396]
103217175  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
103217364  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
103217563  SLC39A10; solute carrier family 39 member 10 [KO:K14716]
103217629  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
103217637  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103217660  FZD7; frizzled class receptor 7 [KO:K02432]
103217702  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
103217720  FZD5; frizzled class receptor 5 [KO:K02375]
103217727  APP; amyloid beta precursor protein [KO:K04520]
103217773  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
103217884  WNT6; Wnt family member 6 [KO:K00445]
103217886  WNT10A; Wnt family member 10A [KO:K01357]
103217904  TUBA4A; tubulin alpha 4a [KO:K07374]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103218204  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
103218332  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
103218369  WNT5B; Wnt family member 5B [KO:K00444]
103218385  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103218424  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103218453  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103218639  LRP6; LDL receptor related protein 6 [KO:K03068]
103218664  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103218776  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103218895  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
103218927  [KO:K00416]
103219106  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103219113  BACE2; beta-site APP-cleaving enzyme 2 [KO:K07747] [EC:3.4.23.45]
103219306  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
103219478  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103219556  [KO:K08738]
103219624  GNAQ; G protein subunit alpha q [KO:K04634]
103219870  [KO:K03949]
103220127  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103220251  RTN4; reticulon 4 [KO:K20720]
103220326  CALM2; calmodulin 2 [KO:K02183]
103220405  COX7A2L; cytochrome c oxidase subunit 7A2 like [KO:K02270]
103220482  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103220507  [KO:K05863]
103220846  ADAM17; ADAM metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
103221134  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
103221145  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
103221202  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103221350  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
103221478  KLC4; kinesin light chain 4 [KO:K10407]
103221654  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103221676  SLC39A7; solute carrier family 39 member 7 [KO:K14713]
103221709  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
103221761  CSNK2B; casein kinase 2 beta [KO:K03115]
103221819  TUBB; tubulin beta class I [KO:K07375]
103222274  [KO:K07375]
103222280  [KO:K07375]
103222477  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103222505  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103222529  SLC39A6; solute carrier family 39 member 6 [KO:K14712]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222611  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
103222752  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
103222808  TUBB6; tubulin beta 6 class V [KO:K07375]
103222876  BID; BH3 interacting domain death agonist [KO:K04726]
103222884  TUBA8; tubulin alpha 8 [KO:K07374]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103223125  XBP1; X-box binding protein 1 [KO:K09027]
103223148  UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
103223312  CSNK1E; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
103223345  ATF4; activating transcription factor 4 [KO:K04374]
103223414  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
103223483  WNT7B; Wnt family member 7B [KO:K00572]
103223664  ATF6; activating transcription factor 6 [KO:K09054]
103223678  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
103223688  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
103223723  NCSTN; nicastrin [KO:K06171]
103223878  [KO:K03038]
103223940  SLC39A1; solute carrier family 39 member 1 [KO:K14709]
103224033  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
103224043  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224193  KLC2; kinesin light chain 2 [KO:K10407]
103224207  WNT2B; Wnt family member 2B [KO:K00182]
103224226  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
103224269  CSF1; colony stimulating factor 1 [KO:K05453]
103224293  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
103224843  [KO:K08738]
103224893  UQCRH; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103225005  [KO:K00236]
103225129  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
103225216  AXIN1; axin 1 [KO:K02157]
103225256  [KO:K03950]
103225420  WNT4; Wnt family member 4 [KO:K00408]
103225507  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
103225550  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103225665  [KO:K08738]
103225806  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
103226162  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
103226390  IL6; interleukin 6 [KO:K05405]
103226429  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
103226480  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
103226516  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
103226575  FZD1; frizzled class receptor 1 [KO:K02432]
103226684  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
103226775  WNT2; Wnt family member 2 [KO:K00182]
103226795  WNT16; Wnt family member 16 [KO:K01558]
103226813  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
103227022  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103227023  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
103227238  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103227444  CTNNB1; catenin beta 1 [KO:K02105]
103227597  UQCRC1; ubiquinol-cytochrome c reductase core protein I [KO:K00414]
103227762  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103227777  WNT5A; Wnt family member 5A [KO:K00444]
103227837  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103228018  [KO:K08738]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103228043  WNT7A; Wnt family member 7A [KO:K00572]
103228072  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
103228104  [KO:K03960]
103228205  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103228810  [KO:K03938]
103228819  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
103228995  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
103229035  ATG14; autophagy related 14 [KO:K17889]
103229087  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
103229205  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
103229245  SLC39A9; solute carrier family 39 member 9 [KO:K14715]
103229302  PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
103229536  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
103229541  CALM1; calmodulin 1 [KO:K02183]
103229564  UQCR2; ubiquinol-cytochrome c reductase core protein II [KO:K00415]
103229567  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
103229590  COX8C; cytochrome c oxidase subunit 8C [KO:K02273]
103229646  ATG2B; autophagy related 2B [KO:K17906]
103229745  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103229927  [KO:K10407]
103229967  WNT3A; Wnt family member 3A [KO:K00312]
103229968  WNT9A; Wnt family member 9A [KO:K01064]
103229985  PSEN2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
103230023  CAPN2; calpain 2 [KO:K03853] [EC:3.4.22.53]
103230269  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
103230332  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
103230339  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103230420  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103230829  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
103230857  [KO:K08334]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103231367  SLC39A2; solute carrier family 39 member 2 [KO:K14709]
103231423  COX6A2; cytochrome c oxidase subunit 6A2 [KO:K02266]
103231457  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
103231597  [KO:K02272]
103231882  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
103231895  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103231971  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103232017  HSD17B10; hydroxysteroid 17-beta dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
103232235  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103232344  NOX1; NADPH oxidase 1 [KO:K08008]
103232472  IRS4; insulin receptor substrate 4 [KO:K17446]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103232842  ATG2A; autophagy related 2A [KO:K17906]
103233082  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
103233130  NAE1; NEDD8 activating enzyme E1 subunit 1 [KO:K04532]
103233205  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103233412  [KO:K02263]
103233496  [KO:K07375]
103233597  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
103233605  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
103233614  [KO:K00420]
103233656  SLC39A3; solute carrier family 39 member 3 [KO:K14709]
103233675  RTN3; reticulon 3 [KO:K20723]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103233757  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
103233760  [KO:K02128]
103233776  [KO:K07375]
103233777  [KO:K07375]
103233802  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
103233823  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103233836  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
103234046  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
103234228  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
103234321  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
103234346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234417  [KO:K00411] [EC:7.1.1.8]
103234532  PSENEN; presenilin enhancer gamma-secretase subunit [KO:K06170]
103234629  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
103234690  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103234841  APOE; apolipoprotein E [KO:K04524]
103234862  KLC3; kinesin light chain 3 [KO:K10407]
103234915  CALM3; calmodulin 3 [KO:K02183]
103234973  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
103235239  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
103235309  [KO:K02267]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103235974  SNCA; synuclein alpha [KO:K04528]
103236018  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
103236040  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103236046  SLC39A8; solute carrier family 39 member 8 [KO:K14714]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103236081  DKK2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
103236098  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
103236141  SLC39A13; solute carrier family 39 member 13 [KO:K14719]
103236222  [KO:K02138]
103236238  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
103236278  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
103236386  ATG13; autophagy related 13 [KO:K08331]
103236448  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
103236450  PPID; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
103236524  [KO:K03938]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103236621  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
103236790  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
103237165  [KO:K00417]
103237200  [KO:K02268]
103237249  FZD6; frizzled class receptor 6 [KO:K02376]
103237406  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
103237609  [KO:K00413]
103237625  SLC39A4; solute carrier family 39 member 4 [KO:K14710]
103237818  TUBAL3; tubulin alpha like 3 [KO:K07374]
103237820  CALML5; calmodulin like 5 [KO:K02183]
103237822  CALML3; calmodulin like 3 [KO:K02183]
103237855  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
103237963  SLC39A12; solute carrier family 39 member 12 [KO:K14718]
103238089  KIF5B; kinesin family member 5B [KO:K10396]
103238123  FZD8; frizzled class receptor 8 [KO:K02375]
103238251  WNT1; Wnt family member 1 [KO:K03209]
103238252  WNT10B; Wnt family member 10B [KO:K01357]
103238260  TUBA1B; tubulin alpha 1b [KO:K07374]
103238261  TUBA1A; tubulin alpha 1a [KO:K07374]
103238262  [KO:K07374]
103238312  SLC11A2; solute carrier family 11 member 2 [KO:K21398]
103238337  ATG101; autophagy related 101 [KO:K19730]
103238407  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
103238515  SLC39A5; solute carrier family 39 member 5 [KO:K14711]
103238538  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
103238555  LRP1; LDL receptor related protein 1 [KO:K04550]
103238561  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
103238566  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
103238888  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
103238923  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
103239029  INS; insulin [KO:K04526]
103239106  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
103239250  COX6A1; cytochrome c oxidase subunit 6A1 [KO:K02266]
103239294  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
103239400  FZD10; frizzled class receptor 10 [KO:K02842]
103239428  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
103239501  KIF5A; kinesin family member 5A [KO:K10396]
103239540  [KO:K07375]
103239564  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
103239575  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
103239600  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103239807  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
103239827  [KO:K08738]
103239889  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
103240310  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103240581  [KO:K00237]
103240980  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
103240990  [KO:K08738]
103241089  COX5B; cytochrome c oxidase subunit 5B [KO:K02265]
103241278  IL1B; interleukin 1 beta [KO:K04519]
103241279  IL1A; interleukin 1 alpha [KO:K04383]
103241350  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103241443  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
103241488  APBB1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103241695  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
103241732  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
103242172  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
103242203  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
103242279  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
103242353  [KO:K02267]
103242520  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
103242598  [KO:K13241] [EC:1.14.13.39]
103242600  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
103242697  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
103242698  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
103243059  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
103243074  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
103243081  ADRM1; adhesion regulating molecule 1 [KO:K06691]
103243105  SLC39A11; solute carrier family 39 member 11 [KO:K14717]
103243135  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
103243149  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
103243162  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
103243176  AXIN2; axin 2 [KO:K04385]
103243204  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103243218  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
103243254  WNT9B; Wnt family member 9B [KO:K01064]
103243255  WNT3; Wnt family member 3 [KO:K00312]
103243264  MAPT; microtubule associated protein tau [KO:K04380]
103243320  FZD2; frizzled class receptor 2 [KO:K02235]
103243387  BECN1; beclin 1 [KO:K08334]
103243426  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
103243432  TUBB1; tubulin beta 1 class VI [KO:K07375]
103243526  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
103243561  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
103243629  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
103243885  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103244129  [KO:K03948]
103244190  [KO:K08738]
103244309  [KO:K03947]
103244338  APC; APC, WNT signaling pathway regulator [KO:K02085]
103244527  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII [KO:K00418]
103244541  VDAC1; voltage dependent anion channel 1 [KO:K05862]
103244620  WNT8A; Wnt family member 8A [KO:K00714]
103244665  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
103244781  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103245250  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
103245320  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103245424  CALML4; calmodulin like 4 [KO:K02183]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103245510  APH1B; aph-1 homolog B, gamma-secretase subunit [KO:K06172]
103245557  ADAM10; ADAM metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
103245758  FADD; Fas associated via death domain [KO:K02373]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103245911  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
103245932  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
103246111  RYR3; ryanodine receptor 3 [KO:K04963]
103246147  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246638  FZD9; frizzled class receptor 9 [KO:K02842]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103246841  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
103247187  APH1A; aph-1 homolog A, gamma-secretase subunit [KO:K06172]
103247334  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
103247345  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
103247465  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103247519  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
103247857  [KO:K07374]
103248003  COX4I2; cytochrome c oxidase subunit 4I2 [KO:K02263]
103248071  WNT11; Wnt family member 11 [KO:K01384]
103248104  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
103248178  FZD4; frizzled class receptor 4 [KO:K02354]
103248193  GRM5; glutamate metabotropic receptor 5 [KO:K04604]
103248196  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
103248368  [KO:K04741] [EC:3.4.22.-]
103248461  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
103248553  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
4097488  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4097489  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4097490  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4097491  COX2; cytochrome c oxidase subunit II [KO:K02261]
4097492  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
4097493  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
4097494  COX3; cytochrome c oxidase subunit III [KO:K02262]
4097495  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4097496  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4097497  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4097498  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4097499  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
4097500  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
csab00190  Oxidative phosphorylation
csab03050  Proteasome
csab04020  Calcium signaling pathway
csab04140  Autophagy - animal
csab04141  Protein processing in endoplasmic reticulum
csab04210  Apoptosis
csab04310  Wnt signaling pathway
csab04910  Insulin signaling pathway
csab04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system