KEGG   PATHWAY: amex05132
Entry
amex05132                   Pathway                                
Name
Salmonella infection - Astyanax mexicanus (Mexican tetra)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
amex05132  Salmonella infection
amex05132

Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103038585  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
103027170  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
103034209  rab5b; ras-related protein Rab-5B [KO:K07888]
103045387  rab5c; ras-related protein Rab-5C [KO:K07889]
103035226  ras-related protein Rab-5C [KO:K07889]
103034827  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
103037857  ras-related protein rab7 [KO:K07897]
103043048  rab7a; ras-related protein Rab-7a [KO:K07897]
103042533  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
103037223  rab7b; ras-related protein Rab-7b [KO:K07897]
103022451  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
103044271  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
103028448  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
103029409  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
103022932  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
103044853  vps39; vam6/Vps39-like protein [KO:K20183]
103035288  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
103044209  rilp; RILP-like protein 1 isoform X1 [KO:K13883]
103041819  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
103040540  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
103032060  dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
103032145  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
103027766  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
103022543  dync1i2b; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
103045291  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
103024887  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
103032256  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
103041528  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
103028862  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
103025073  dynein light chain roadblock-type 2 [KO:K10419]
103024926  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
103040298  dynlt1b; dynein light chain Tctex-type 1 [KO:K10420]
103026579  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
103040401  dctn1b; dynactin subunit 1 isoform X1 [KO:K04648]
103029055  dctn1a; dynactin subunit 1a isoform X2 [KO:K04648]
103023724  dctn2; dynactin subunit 2 [KO:K10424]
103034730  dctn3; dynactin subunit 3 isoform X1 [KO:K10425]
103022004  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
103042460  dctn5; dynactin subunit 5 [KO:K10427]
103026360  dctn6; dynactin subunit 6 [KO:K10428]
103036907  actr1b; actin related protein 1B [KO:K16575]
103044751  actr10; actin-related protein 10 [KO:K16576]
103034569  tubulin alpha-1A chain-like [KO:K07374]
103037973  tubulin alpha chain isoform X1 [KO:K07374]
111195381  tubulin alpha-1B chain [KO:K07374]
103046666  tubulin alpha-1A chain [KO:K07374]
111195382  tubulin alpha-1C chain [KO:K07374]
103041851  tubulin alpha-8 chain [KO:K07374]
103034236  tubulin alpha-1A chain [KO:K07374]
111194076  tuba1a; tubulin alpha-1A chain [KO:K07374]
103042625  tuba8l2; tubulin alpha chain [KO:K07374]
103038315  tubulin alpha chain isoform X1 [KO:K07374]
103038928  tubulin alpha chain [KO:K07374]
103031418  tuba5; tubulin alpha 5 isoform X2 [KO:K07374]
125785677  tubulin alpha chain-like [KO:K07374]
103033696  tubulin alpha-8 chain-like [KO:K07374]
111194075  tubulin alpha chain-like [KO:K07374]
103022310  zgc:65894; tubulin beta-4B chain [KO:K07375]
103034833  tubb5; tubulin beta-5 chain [KO:K07375]
103024866  tubb2b; tubulin beta-2b chain [KO:K07375]
103035708  tubb1; tubulin beta-1 chain [KO:K07375]
103034970  tubb6; tubulin, beta 6 class V [KO:K07375]
103041736  tubulin beta-2A chain [KO:K07375]
103045037  tubb4b; tubulin beta-4b chain [KO:K07375]
103026320  tubb4bl; tubulin beta-4B chain [KO:K07375]
103024068  zgc:55461; beta-tubulin family protein [KO:K07375]
103045023  fyco1b; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
103039728  fyco1a; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
103036938  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
103032600  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
103033874  arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
103028132  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
103038215  kinesin-1 heavy chain [KO:K10396]
103025097  kif5ab; kinesin heavy chain [KO:K10396]
103036418  kif5bb; kinesin-1 heavy chain isoform X1 [KO:K10396]
111194328  kinesin light chain 2 isoform X2 [KO:K10407]
111194329  kinesin light chain 1-like [KO:K10407]
103044410  klc3; kinesin light chain 3 [KO:K10407]
103047573  klc1b; kinesin light chain 1b isoform X7 [KO:K10407]
103045712  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
125782228  kinesin light chain 1-like [KO:K10407]
111194330  LOW QUALITY PROTEIN: kinesin light chain 2 [KO:K10407]
103034545  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
103047560  zgc:162964; Golgi resident protein GCP60 isoform X1 [KO:K23935]
103028705  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
103027457  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
103031338  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
103035456  rhoca; ras homolog family member Ca [KO:K04513]
103029431  transforming protein RhoA [KO:K04513]
103031197  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
103024533  rab9a; ras-related protein Rab-9A [KO:K07899]
103025908  ras-related protein Rab-9A [KO:K07899]
103026314  rab9b; ras-related protein Rab-9B isoform X2 [KO:K07900]
103046118  GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
103033841  syntaxin-10 [KO:K23937]
103044322  pfn2a; profilin 2a isoform X1 [KO:K05759]
103026345  pfn2b; profilin-2 isoform X1 [KO:K05759]
103039434  pfn1; profilin-1 [KO:K05759]
103026913  flna; filamin-A isoform X1 [KO:K04437]
103034762  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
103029550  exoc4; exocyst complex component 4 isoform X1 [KO:K06111]
103032929  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
103038832  ralab; v-ral simian leukemia viral oncogene homolog Ab (ras related) [KO:K07834]
103042957  ralaa; ras-related protein Ral-A [KO:K07834]
103039558  actb1; actin, cytoplasmic 1 [KO:K05692]
103030443  actb2; actin, cytoplasmic 2 [KO:K05692]
103044950  s100a10a; protein S100-A10a [KO:K17274]
111193433  s100a10b; protein S100-A10b [KO:K17274]
103024979  annexin A2 [KO:K17092]
103044821  annexin A2 [KO:K17092]
103045718  anxa2b; annexin A2b [KO:K17092]
103044820  anxa14; annexin A2 [KO:K17092]
103025756  neuroblast differentiation-associated protein AHNAK-like isoform X1 [KO:K23934]
103027360  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
103045432  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
103032497  rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
103044275  rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744]
103045046  rhogd; ras homolog gene family, member Gd [KO:K07863]
103022922  rho-related GTP-binding protein RhoG [KO:K07863]
103046919  rhogc; ras homolog gene family, member Gc [KO:K07863]
103040355  rhogb; ras homolog family member Gb [KO:K07863]
125782580  rho-related GTP-binding protein RhoG-like [KO:K07863]
125782581  rho-related GTP-binding protein RhoG-like [KO:K07863]
103027251  ras-related C3 botulinum toxin substrate 1-like [KO:K07863]
103028188  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
103029920  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
103042784  rock2a; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.1]
103045824  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
103047490  myl2a; myosin regulatory light chain 2a [KO:K10351]
103044021  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X3 [KO:K10351]
111191483  myosin light chain 5-like [KO:K12753]
103025855  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103022187  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
103045271  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
103039046  myl10; myosin regulatory light chain 10 [KO:K12756]
103022780  myosin regulatory light chain 2B, cardiac muscle isoform isoform X1 [KO:K12756]
103037289  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
103039566  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
103045793  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
103046635  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
103022245  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
107197722  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 [KO:K23938]
103039613  cell division control protein 42 homolog [KO:K04393]
103046070  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103047218  cdc42l; cell division cycle 42, like [KO:K04393]
103034468  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
111194918  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111192975  rac1b; ras-related C3 botulinum toxin substrate 1b isoform X1 [KO:K04392]
103023232  ras-related protein Rac1-like [KO:K04392]
103034053  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103021823  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
103027489  nckap1l; nck-associated protein 1-like [KO:K05750]
103024370  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
103039807  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
111188844  abi1a; abl interactor 1a isoform X1 [KO:K23649]
103043517  abi1b; abl interactor 1b isoform X1 [KO:K23649]
103032283  brk1; probable protein BRICK1 [KO:K05752]
103035227  wasf3b; wiskott-Aldrich syndrome protein family member 3b isoform X1 [KO:K06083]
103028652  zgc:109889; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
103027289  si:ch73-362m14.4; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
103046612  wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
103038739  zgc:101810; actin-related protein 2-B [KO:K17260]
103042882  actr2b; actin-related protein 2-B [KO:K17260]
103025559  actr2a; actin-related protein 2-A [KO:K17260]
103045207  actr3; actin-related protein 3 [KO:K18584]
103033577  actr3b; actin-related protein 3B [KO:K18584]
103027593  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103027911  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103021341  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X2 [KO:K05757]
103022001  actin-related protein 2/3 complex subunit 2 [KO:K05758]
103022959  actin-related protein 2/3 complex subunit 2-A [KO:K05758]
103040148  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103038900  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103043660  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
103043418  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
103046792  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
103045524  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
103032016  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
103037975  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103043289  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103031958  myo6a; myosin VIa isoform X1 [KO:K10358]
103045863  myo6b; myosin VIb isoform X1 [KO:K10358]
103032909  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103045036  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103041606  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103022173  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103041836  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103035431  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103046979  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
103042558  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
111192911  cyth3b; cytohesin-3 [KO:K18441]
103022618  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
103032106  cyth4a; cytohesin-4 isoform X1 [KO:K18441]
103045162  cyth2; cytohesin-2 [KO:K18441]
103041062  cyth4b; cytohesin 4b [KO:K18441]
103025488  cyth3a; cytohesin-3 [KO:K18441]
111192981  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
103047706  arf6a; ADP-ribosylation factor 6a [KO:K07941]
103037751  arf6b; ADP-ribosylation factor 6b [KO:K07941]
103038497  arf1; ADP-ribosylation factor 1 [KO:K07937]
103047326  arf2b; ADP-ribosylation factor 2b [KO:K07937]
103045652  arf2a; ADP-ribosylation factor 2a [KO:K07937]
103035633  snx33; sorting nexin-33 [KO:K17923]
103024560  snx9b; sorting nexin-9b isoform X1 [KO:K17923]
103036978  snx18b; sorting nexin-18b [KO:K17923]
103026104  snx18a; sorting nexin-18a [KO:K17923]
103023149  snx9a; sorting nexin-9a isoform X3 [KO:K17923]
103034777  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
103023734  si:dkey-197j19.6; uncharacterized protein si:dkey-197j19.6 isoform X1 [KO:K23612]
103031973  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
111191899  dnm2a; dynamin-3 isoform X3 [KO:K23484] [EC:3.6.5.5]
103045101  toll-like receptor 2 type-2 [KO:K10159]
103044794  tlr2; toll-like receptor 2 [KO:K10159]
103042489  tlr18; toll-like receptor 18 [KO:K10159]
111190370  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
103044166  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111196020  toll-like receptor 4 [KO:K10160]
111196037  toll-like receptor 4 isoform X1 [KO:K10160]
111195965  toll-like receptor 4 [KO:K10160]
103047589  toll-like receptor 5 [KO:K10168]
103036522  tlr9; toll-like receptor 9 [KO:K10161]
103044222  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103046249  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103021325  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103039333  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103038577  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103032786  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103035047  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
103043929  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103033415  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103040024  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103038271  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
103043190  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
103038869  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103032041  rela; transcription factor p65 isoform X1 [KO:K04735]
103028111  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
103024454  hsp90aa1.1; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 [KO:K04079]
103047517  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
103024139  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
103043021  hsp90b1; endoplasmin [KO:K09487]
103022466  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
103040593  cse1l; exportin-2 [KO:K18423]
103044312  kpna1; importin subunit alpha-5 [KO:K23940]
103030092  importin subunit alpha-4 [KO:K23583]
103046682  kpna3; importin subunit alpha-4 [KO:K23583]
103046926  kpna4; importin subunit alpha-3 [KO:K23583]
103028699  rps3; 40S ribosomal protein S3 [KO:K02985]
103021516  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
103040103  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
103027930  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103025658  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103030512  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125782187  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
103041389  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111191499  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
103035641  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103035956  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
103046996  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103028137  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
103042110  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
103043112  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103040333  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103045018  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
103042940  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
103024363  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103040580  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103035319  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103034138  mapk8a; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
103036705  fosaa; protein c-Fos [KO:K04379]
103043278  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
107197750  fosl1b; protein c-Fos [KO:K04379]
103042954  si:ch211-153j24.3; protein c-Fos [KO:K04379]
103021920  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103026868  jun; transcription factor AP-1 [KO:K04448]
103032568  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
103026214  interleukin-1 beta [KO:K04519]
111194997  interleukin-1 beta-like [KO:K04519]
111191914  il6; interleukin-6 [KO:K05405]
103036120  interleukin-8-like [KO:K10030]
103026712  cxcl8a; interleukin-8 [KO:K10030]
103036419  interleukin-8 [KO:K10030]
103036716  interleukin-8-like [KO:K10030]
103029988  interleukin-8 [KO:K10030]
103034575  catenin beta-1 [KO:K02105]
103035854  ctnnb1; catenin beta-1 isoform X2 [KO:K02105]
103022374  tcf7l1b; transcription factor 7-like 1-B [KO:K04490]
103031257  tcf7l2; transcription factor 7-like 2 isoform X3 [KO:K04491]
103033630  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103038167  mycb; transcriptional regulator Myc-B [KO:K04377]
103033997  myca; transcriptional regulator Myc-A [KO:K04377]
103026918  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
103038057  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
103042658  fbxo22; F-box only protein 22 [KO:K10302]
103045526  skp1; S-phase kinase-associated protein 1 [KO:K03094]
103036375  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103028261  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103025481  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
103045920  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103027606  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103041091  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103022098  tnfsf10l4; tumor necrosis factor (ligand) superfamily, member 10 like 4 [KO:K04721]
103023521  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103030935  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
103025853  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
103022073  fadd; protein FADD [KO:K02373]
103036076  caspase-7 [KO:K04398] [EC:3.4.22.61]
103036379  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103037118  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103032582  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
103023787  apoptosis regulator BAX [KO:K02159]
103047816  zgc:153993; apoptosis regulator BAX [KO:K02159]
103025681  apoptosis regulator BAX isoform X1 [KO:K02159]
103042396  apoptosis regulator BAX [KO:K02159]
103040542  cytochrome c [KO:K08738]
103042278  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
103039548  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
103025383  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
103039001  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
103041716  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
103025336  rho-related GTP-binding protein RhoB [KO:K07856]
103045964  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
103040659  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103026930  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023390  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103040186  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103024575  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103030498  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
103028978  txn2; thioredoxin, mitochondrial [KO:K03671]
103040975  zgc:56493; thioredoxin [KO:K03671]
103039731  txn; thioredoxin [KO:K03671]
111188784  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111188786  uncharacterized protein LOC111188786 isoform X1 [KO:K12799]
125780425  LOW QUALITY PROTEIN: apoptosis-associated speck-like protein containing a CARD [KO:K12799]
125802086  uncharacterized protein LOC125802086 [KO:K12799]
111188785  caspase a-like [KO:K01370] [EC:3.4.22.36]
103039157  caspa; caspase a isoform X1 [KO:K01370] [EC:3.4.22.36]
103021832  casp23; LOW QUALITY PROTEIN: caspase-23 [KO:K01370] [EC:3.4.22.36]
125802140  caspase a-like [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
amex04010  MAPK signaling pathway
amex04210  Apoptosis
amex04217  Necroptosis
amex04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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