KEGG   PATHWAY: cjc05169
Entry
cjc05169                    Pathway                                
Name
Epstein-Barr virus infection - Callithrix jacchus (white-tufted-ear marmoset)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
cjc05169  Epstein-Barr virus infection
cjc05169

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
108587696  CR2; complement receptor type 2 isoform X2 [KO:K04012]
100402637  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
100386155  CAJA-DRB1; HLA class II histocompatibility antigen, DRB1-13 beta chain-like precursor [KO:K06752]
100397732  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
100386865  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100387227  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100405222  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100411388  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100412691  CAJA-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100408132  CAJA-DOA; HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100408503  CAJA-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain isoform X3 [KO:K06752]
100407771  CAJA-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
100413648  CAJA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100385427  CAJA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
128931734  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100404611  TLR2; toll-like receptor 2 [KO:K10159]
100413151  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100402978  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
100414273  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100395364  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
100398947  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100414129  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100403175  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100397484  TNF; tumor necrosis factor [KO:K03156]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100408692  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100410549  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100387401  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100392518  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100405036  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100414516  interferon alpha-1/13-like [KO:K05414]
100390201  interferon alpha-5-like [KO:K05414]
100406098  interferon alpha-5-like [KO:K05414]
100406466  interferon alpha-14 [KO:K05414]
100387372  interferon alpha-5-like [KO:K05414]
103793369  interferon alpha-5-like [KO:K05414]
128928158  interferon alpha-14-like [KO:K05414]
128932203  interferon alpha-5-like [KO:K05414]
100388391  IFNB1; interferon beta [KO:K05415]
100410306  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
128928024  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100405583  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100401630  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100393190  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100399251  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100385368  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
100392459  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
103795420  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100894965  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100384985  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100403496  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100399968  BCL2L11; bcl-2-like protein 11 isoform X16 [KO:K16341]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108593648  cytochrome c-like [KO:K08738]
108593819  cytochrome c-like [KO:K08738]
108593835  cytochrome c-like [KO:K08738]
108588095  cytochrome c-like [KO:K08738]
100406761  cytochrome c-like [KO:K08738]
100401718  cytochrome c [KO:K08738]
100413276  cytochrome c-like [KO:K08738]
108591937  cytochrome c-like [KO:K08738]
108592162  cytochrome c-like [KO:K08738]
108591932  cytochrome c, somatic-like [KO:K08738]
100403825  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100409044  T cell receptor alpha variable 8-6 [KO:K10784]
100896987  T cell receptor beta variable 7-2 [KO:K10785]
100896470  T cell receptor beta variable 7-9 [KO:K10785]
100403944  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
100404679  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
100404313  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
100896810  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
100400663  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100389462  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100387347  PSMC4; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6B [KO:K03063]
100395251  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100402042  26S proteasome regulatory subunit 10B-like [KO:K03064]
100391982  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
100392176  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
100399255  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100394142  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
100395546  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
100412477  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100403059  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
100387732  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
100386531  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100414464  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100406192  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100415274  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
100896765  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X5 [KO:K03029]
100394741  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
100404346  26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
100388798  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
100389162  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100400302  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
100407051  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100406316  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
100409944  TAPBP; tapasin isoform X1 [KO:K08058]
100395129  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100401971  CALR; calreticulin [KO:K08057]
100406240  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100398361  patr class I histocompatibility antigen, CH28 alpha chain isoform X3 [KO:K06751]
100405128  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100399078  patr class I histocompatibility antigen, A-126 alpha chain isoform X3 [KO:K06751]
100411069  patr class I histocompatibility antigen, A-126 alpha chain isoform X6 [KO:K06751]
100388209  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100387811  CAJA-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
118151094  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100404307  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
100405519  SNW1; SNW domain-containing protein 1 [KO:K06063]
100404916  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100402327  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100399690  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100401228  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
100388955  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
100386716  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
100401085  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
100392930  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
100400742  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
100403762  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
100398058  HES1; transcription factor HES-1 [KO:K06054]
100409349  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
100390885  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100410859  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
100415620  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100396301  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100390419  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100403269  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100388423  TRAF5; TNF receptor-associated factor 5 isoform X3 [KO:K09849]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100401112  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100403406  RELB; transcription factor RelB isoform X1 [KO:K09253]
100395882  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100401347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
100408512  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100393268  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
100386168  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100412930  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100415562  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100400411  JUN; transcription factor Jun [KO:K04448]
100386711  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X5 [KO:K01510] [EC:3.6.1.5]
100399270  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
100385800  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100390910  CD44; CD44 antigen isoform X17 [KO:K06256]
100390790  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100401521  CD58; lymphocyte function-associated antigen 3 isoform X3 [KO:K06492]
100393866  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100408168  VIM; vimentin [KO:K07606]
100397002  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
100397491  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100389282  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100390096  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100394657  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100386326  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X5 [KO:K10591] [EC:2.3.2.26]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103793556  immunoglobulin heavy variable 1-18 [KO:K06856]
100406337  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
100397439  BLNK; B-cell linker protein isoform X1 [KO:K07371]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100393248  SKP2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
100387508  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100388293  CCNA2; cyclin-A2 [KO:K06627]
100393051  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100398703  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100397928  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100414776  E2F2; transcription factor E2F2 [KO:K09389]
100390235  E2F3; transcription factor E2F3 isoform X4 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
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Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
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Nat Rev Cancer 4:757-68 (2004)
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Reference
PMID:21372216
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Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
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Reference
PMID:21429244
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  Title
Innate immune modulation in EBV infection.
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Herpesviridae 2:1 (2011)
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Reference
PMID:28408983
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Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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Reference
PMID:24586164
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van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
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PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
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Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
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Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
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J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
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Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
cjc03050  Proteasome
cjc04010  MAPK signaling pathway
cjc04020  Calcium signaling pathway
cjc04064  NF-kappa B signaling pathway
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04210  Apoptosis
cjc04612  Antigen processing and presentation
cjc04620  Toll-like receptor signaling pathway
cjc04622  RIG-I-like receptor signaling pathway
cjc04630  JAK-STAT signaling pathway
cjc04662  B cell receptor signaling pathway
KO pathway
ko05169   
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