Entry
Name
Salmonella infection - Hyaena hyaena (striped hyena)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Hyaena hyaena (striped hyena) [GN:
hhv ]
Gene
120237742 pleckstrin homology domain-containing family M member 1-like isoform X1 [KO:K23282 ]
120227153 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
120230009 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
120226046 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
120232286 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
120248056 VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
120224894 VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
120223082 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
120234434 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
120236414 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
120223967 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
120243614 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
120232013 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
120228570 DYNLRB2; LOW QUALITY PROTEIN: dynein light chain roadblock-type 2 [KO:K10419 ]
120229225 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
120228932 ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955 ]
120229774 PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
120223965 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
120249202 AHNAK; neuroblast differentiation-associated protein AHNAK [KO:K23934 ]
120236372 ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
120243290 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
120247408 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
120238920 MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
120242286 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
120223498 FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
120231260 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
120227958 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
120243327 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749 ]
120222422 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
120247427 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
120231303 ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755 ]
120236302 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
120233608 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
120220979 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
120246696 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
120241845 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
120224016 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923 ] [EC:2.7.1.154 ]
120228887 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
120234768 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
120247108 toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
120235110 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
120233644 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
120237570 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
120242823 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
120222817 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
120230296 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
120249038 LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094 ]
120221151 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
120223347 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
120219677 LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 3-like [KO:K16060 ]
120234588 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
120233928 tumor necrosis factor receptor superfamily member 25-like isoform X1 [KO:K04722 ]
120224242 LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738 ]
120221401 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
120247957 LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807 ]
120242234 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
hhv04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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