KEGG   PATHWAY: hmh05167
Entry
hmh05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Hylobates moloch (silvery gibbon)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
hmh05167  Kaposi sarcoma-associated herpesvirus infection
hmh05167

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116478338  C3; complement C3 [KO:K03990]
116466084  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
116457855  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
116483533  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116457541  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116480802  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
116466580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
116458330  interferon alpha-5 [KO:K05414]
116458331  interferon alpha-6 [KO:K05414]
116458332  interferon alpha-2 [KO:K05414]
116458527  interferon alpha-14 [KO:K05414]
116458611  interferon alpha-1/13 [KO:K05414]
116458660  interferon alpha-8 [KO:K05414]
116478197  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116458301  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
116462715  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116458843  IFNB1; interferon beta [KO:K05415]
116481707  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116482629  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116457829  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116478444  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
116810529  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116480910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
116484959  IRF9; interferon regulatory factor 9 [KO:K04693]
116484273  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116457332  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
116483711  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116480712  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116470324  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
116473551  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
116472337  CCR5; C-C chemokine receptor type 5 [KO:K04180]
116473553  CCR1; C-C chemokine receptor type 1 [KO:K04176]
116472356  CCR4; C-C chemokine receptor type 4 [KO:K04179]
116473640  CCR8; C-C chemokine receptor type 8 [KO:K04183]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116459453  BID; BH3-interacting domain death agonist [KO:K04726]
116478225  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
116459971  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
116813623  LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer-like [KO:K14021]
116476907  cytochrome c-like [KO:K08738]
116809676  cytochrome c-like [KO:K08738]
116811446  cytochrome c-like [KO:K08738]
116471160  cytochrome c [KO:K08738]
116812987  cytochrome c isoform X2 [KO:K08738]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116471376  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116460475  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116814109  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
116467261  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
116461337  E2F1; transcription factor E2F1 [KO:K17454]
116813063  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
116459750  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
116459773  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
116460053  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
116460055  patr class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
116460058  patr class I histocompatibility antigen, CH28 alpha chain [KO:K06751]
116460103  class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
116472865  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
116478438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
116466874  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
116460109  MICB; MHC class I polypeptide-related sequence B [KO:K07985]
116472227  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
116477709  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K02927]
116484892  ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
116478712  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
116471270  ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
116483828  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
116460223  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
116460384  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
116475790  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
116481186  ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
116474889  BECN1; beclin-1 isoform X1 [KO:K08334]
116457644  BECN2; beclin-2 [KO:K08334]
116484834  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
116468590  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
116466953  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
116459062  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
116470731  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
116461498  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
116479655  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
116457645  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
116812793  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116463853  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
116463857  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
116472600  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
116481481  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116484566  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X3 [KO:K07826]
116468899  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116457634  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116476763  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116457866  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
116469841  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116811956  GNG5B; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B [KO:K04542]
116477213  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
116483152  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116478306  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
116475542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116814102  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116469917  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116462301  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116814103  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116474673  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116469568  NRAS; GTPase NRas [KO:K07828]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116814342  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116456139  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
116457363  JUN; transcription factor Jun [KO:K04448]
116456218  FOS; protein c-Fos [KO:K04379]
116814224  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
116458584  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
116458845  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116812918  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116461374  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
116480287  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116467420  CD200R1L; LOW QUALITY PROTEIN: cell surface glycoprotein CD200 receptor 2 [KO:K21668]
116466949  CD200R1; cell surface glycoprotein CD200 receptor 1 [KO:K21668]
116475231  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
116461023  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116461143  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
116813281  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
116459332  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116470775  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116461010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116466681  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116472793  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116459671  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116467516  uncharacterized protein LOC116467516 [KO:K02183]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116478308  CALM3; calmodulin-3 [KO:K02183]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116466871  calmodulin-1-like [KO:K02183]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116483814  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
116459475  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116461844  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116483520  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
116475348  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116468452  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116461045  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116471414  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
116484619  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
116467002  CXCL8; interleukin-8 [KO:K10030]
116457725  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116466971  C-X-C motif chemokine 2 isoform X1 [KO:K05505]
116475080  C-X-C motif chemokine 3 [KO:K05505]
116475085  CXCL1; growth-regulated alpha protein [KO:K05505]
116481465  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
116463600  FGF2; fibroblast growth factor 2 [KO:K18497]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116473842  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116463892  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
116458453  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
116474863  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116473623  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
116471505  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
116483590  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
116483446  TCF7L2; transcription factor 7-like 2 isoform X12 [KO:K04491]
116479176  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116810385  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
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pathway
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hmh04144  Endocytosis
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KO pathway
ko05167   
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