KEGG   PATHWAY: ngi05010
Entry
ngi05010                    Pathway                                
Name
Alzheimer disease - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ngi05010  Alzheimer disease
ngi05010

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103737147  Adam10; ADAM metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
103747629  Adam17; ADAM metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
103745264  App; amyloid beta precursor protein [KO:K04520]
103744499  Nae1; NEDD8 activating enzyme E1 subunit 1 [KO:K04532]
103737561  Apbb1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
103737766  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103736085  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103734404  uncharacterized LOC103734404 [KO:K00134] [EC:1.2.1.12]
103746849  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
103727582  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103732150  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
103748314  Bace1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
103748454  Bace2; beta-site APP-cleaving enzyme 2 [KO:K07747] [EC:3.4.23.45]
103735071  Rtn3; reticulon 3 [KO:K20723]
103725778  Rtn4; reticulon 4 [KO:K20720]
103729935  Psenen; presenilin enhancer gamma-secretase subunit [KO:K06170]
103747390  Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
103725095  Psen2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
103740224  Ncstn; nicastrin [KO:K06171]
103742667  Aph1a; aph-1 homolog A, gamma-secretase subunit [KO:K06172]
103750079  Aph1b; aph-1 homolog B, gamma-secretase subunit [KO:K06172]
103747266  Ide; insulin degrading enzyme [KO:K01408] [EC:3.4.24.56]
103740089  Mme; membrane metallo-endopeptidase [KO:K01389] [EC:3.4.24.11]
103726236  neprilysin-like [KO:K01389] [EC:3.4.24.11]
103724766  Mapt; microtubule associated protein tau [KO:K04380]
15088436  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
15088424  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
15088430  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
15088432  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
15088431  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
15088433  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
15088434  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103725598  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
103740029  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
103735420  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
103743266  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
103729334  Ndufv3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103742966  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
103736048  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
103729672  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
103742923  Ndufa4l2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
103751157  Ndufa4; NDUFA4, mitochondrial complex associated [KO:K03948]
103727080  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
103743456  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
103743314  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
103734483  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
103727540  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
103730827  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
103742733  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
103737201  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
103733271  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
103726834  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
103726106  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
103738676  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
103741953  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
103738589  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
103748443  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
103751840  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
103743985  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
103743906  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
103752441  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
103726494  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
103744430  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
103745951  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
103742520  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
103734046  Ndufs4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
103747711  Ndufs5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
103749679  Ndufs6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
103737329  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
103744515  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
103742366  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
103742997  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
103749659  Sdha; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
103725310  Sdhb; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
103745944  Sdhc; succinate dehydrogenase complex subunit C [KO:K00236]
103733879  Sdhd; succinate dehydrogenase complex subunit D [KO:K00237]
103737005  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
15088435  CYTB; cytochrome b [KO:K00412]
103735265  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103750218  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
103742750  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
103730312  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
103745841  cytochrome b-c1 complex subunit 7 [KO:K00417]
103747034  cytochrome b-c1 complex subunit 8 [KO:K00418]
103740458  cytochrome b-c1 complex subunit 9 [KO:K00419]
103737315  cytochrome b-c1 complex subunit 10 [KO:K00420]
15088429  COX3; cytochrome c oxidase subunit III [KO:K02262]
15088425  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
15088426  COX2; cytochrome c oxidase subunit II [KO:K02261]
103731081  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
103729818  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
103736883  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103738129  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103740008  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
103726314  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
103744812  cytochrome c oxidase subunit 6B2 [KO:K02267]
103729930  cytochrome c oxidase subunit 6B1 [KO:K02267]
103732827  cytochrome c oxidase subunit 6C [KO:K02268]
103736386  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
103750679  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
103729087  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103737829  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103737882  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
103739114  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
103749033  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
103749082  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
103738810  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
103751059  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
108490133  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
103727847  Atp5a1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103730213  Atp5b; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
103727293  Atp5c1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
103737336  Atp5d; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
103741437  Atp5e; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
103728042  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
103731787  ATP synthase subunit epsilon-like protein, mitochondrial [KO:K02135]
15088428  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103734902  Atp5f1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
103738355  Atp5g1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
103738742  Atp5g2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
103751764  Atp5g3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
103732747  Atp5h; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
103736442  Atp5o; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
103745265  Atp5j; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
15088427  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103747316  Hsd17b10; hydroxysteroid 17-beta dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
103751014  Ppid; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
103729749  Vdac1; voltage dependent anion channel 1 [KO:K05862]
103747445  Vdac2; voltage dependent anion channel 2 [KO:K15040]
103747985  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
103726618  Vdac3; voltage dependent anion channel 3 [KO:K15041]
103750480  Slc25a4; solute carrier family 25 member 4 [KO:K05863]
103742868  Slc25a5; solute carrier family 25 member 5 [KO:K05863]
103750115  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
103726219  Slc25a31; solute carrier family 25 member 31 [KO:K05863]
103747430  Ppif; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
103747648  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103749170  Apoe; apolipoprotein E [KO:K04524]
103742926  Lrp1; LDL receptor related protein 1 [KO:K04550]
103738053  Fas; Fas cell surface death receptor [KO:K04390]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103751502  Fadd; Fas associated via death domain [KO:K02373]
103738672  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103745898  Bid; BH3 interacting domain death agonist [KO:K04726]
103737134  Calml3; calmodulin like 3 [KO:K02183]
103737133  Calml5; calmodulin like 5 [KO:K02183]
103749800  Calml6; calmodulin like 6 [KO:K02183]
103724616  Calm1; calmodulin 1 [KO:K02183]
103724738  Calm3; calmodulin 3 [KO:K02183]
103725745  Calm2; calmodulin 2 [KO:K02183]
103729208  calmodulin-alpha-like [KO:K02183]
103736816  Calml4; calmodulin like 4 [KO:K02183]
103736944  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103747869  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103728037  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103734750  Ppp3r1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103749104  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
103738795  Bad; BCL2 associated agonist of cell death [KO:K02158]
103740800  cytochrome c, somatic [KO:K08738]
103751785  cytochrome c, testis-specific [KO:K08738]
103733246  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
103725336  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103744668  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103750475  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103737656  Chrm1; cholinergic receptor muscarinic 1 [KO:K04129]
103740661  Chrm3; cholinergic receptor muscarinic 3 [KO:K04131]
103740509  Chrm5; cholinergic receptor muscarinic 5 [KO:K04133]
103742957  Grm5; glutamate metabotropic receptor 5 [KO:K04604]
103734421  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103735195  Plcb1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103738797  Plcb3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103741502  Plcb2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103732604  Grin1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
103731589  Grin2a; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
103737584  Grin2b; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
103732757  Grin2c; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
103743747  Grin2d; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
103739378  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103749025  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103741673  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103731814  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103748066  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
103736958  Mcu; mitochondrial calcium uniporter [KO:K20858]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103740528  Ryr3; ryanodine receptor 3 [KO:K04963]
103751203  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103739696  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103726408  Atp2a1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
103751990  Atp2a3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
103739078  Atp2a2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
103746777  Atf6; activating transcription factor 6 [KO:K09054]
103734968  Xbp1; X-box binding protein 1 [KO:K09027]
103742913  Ddit3; DNA damage inducible transcript 3 [KO:K04452]
103744745  Ern1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103740131  Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103741188  Traf2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103724902  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103726522  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103735023  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103748972  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103749366  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103749287  Eif2s1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
103748563  Atf4; activating transcription factor 4 [KO:K04374]
103734017  Psma6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
103736756  Psma2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
103726030  Psma4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
103742230  Psma7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
103745686  Psma8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
103747840  Psma5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
103750426  Psma1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
103739202  Psma3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
103752192  Psmb6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
103726882  Psmb7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
103743801  Psmb3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
103733306  Psmb2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
103739472  Psmb5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
103742346  Psmb1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
103730064  Psmb4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
103732200  Psmc2; proteasome 26S subunit, ATPase 2 [KO:K03061]
103724618  Psmc1; proteasome 26S subunit, ATPase 1 [KO:K03062]
103750750  Psmc4; proteasome 26S subunit, ATPase 4 [KO:K03063]
103739237  Psmc6; proteasome 26S subunit, ATPase 6 [KO:K03064]
103742513  Psmc3; proteasome 26S subunit, ATPase 3 [KO:K03065]
103744750  Psmc5; proteasome 26S subunit, ATPase 5 [KO:K03066]
103732654  Psmd2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
103738205  Psmd1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
103731110  Psmd3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
103739061  Psmd9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
103742194  Psmd12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
103746077  Psmd11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
103724479  Psmd6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
103734656  Psmd7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
103751058  Psmd13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
103730071  Psmd4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
103744087  Psmd14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
103750708  Psmd8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
103742236  Adrm1; adhesion regulating molecule 1 [KO:K06691]
103751713  Sem1; SEM1, 26S proteasome complex subunit [KO:K10881]
103745523  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
103724977  Capn1; calpain 1 [KO:K01367] [EC:3.4.22.52]
103726266  Capn2; calpain 2 [KO:K03853] [EC:3.4.22.53]
103746076  Cdk5r1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
103733655  Slc39a2; solute carrier family 39 member 2 [KO:K14709]
103737280  Slc39a3; solute carrier family 39 member 3 [KO:K14709]
103751706  Slc39a1; solute carrier family 39 member 1 [KO:K14709]
103735248  Slc39a4; solute carrier family 39 member 4 [KO:K14710]
103746513  Slc39a5; solute carrier family 39 member 5 [KO:K14711]
103733626  Slc39a6; solute carrier family 39 member 6 [KO:K14712]
103739715  Slc39a7; solute carrier family 39 member 7 [KO:K14713]
103728035  Slc39a8; solute carrier family 39 member 8 [KO:K14714]
103744211  Slc39a9; solute carrier family 39 member 9 [KO:K14715]
103736146  Slc39a10; solute carrier family 39 member 10 [KO:K14716]
103732777  Slc39a11; solute carrier family 39 member 11 [KO:K14717]
103726512  Slc39a12; solute carrier family 39 member 12 [KO:K14718]
103742514  Slc39a13; solute carrier family 39 member 13 [KO:K14719]
103747852  Slc39a14; solute carrier family 39 member 14 [KO:K14720]
103730627  Slc11a2; solute carrier family 11 member 2 [KO:K21398]
103745307  Cdk5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
103741948  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103731752  Casp7; caspase 7 [KO:K04397] [EC:3.4.22.60]
103732510  Dkk1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
103740598  Dkk2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
103726619  Dkk4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
103750567  Wnt1; Wnt family member 1 [KO:K03209]
103734912  Wnt2b; Wnt family member 2B [KO:K00182]
103737375  Wnt2; Wnt family member 2 [KO:K00182]
103739037  Wnt3a; Wnt family member 3A [KO:K00312]
103724772  Wnt3; Wnt family member 3 [KO:K00312]
103746395  Wnt4; Wnt family member 4 [KO:K00408]
103739374  Wnt5b; Wnt family member 5B [KO:K00444]
103749032  Wnt5a; Wnt family member 5A [KO:K00444]
103727729  Wnt6; Wnt family member 6 [KO:K00445]
103743417  Wnt7b; Wnt family member 7B [KO:K00572]
103730373  Wnt7a; Wnt family member 7A [KO:K00572]
103735176  Wnt8a; Wnt family member 8A [KO:K00714]
103743982  Wnt8b; Wnt family member 8B [KO:K00714]
103740409  Wnt9a; Wnt family member 9A [KO:K01064]
103724773  Wnt9b; Wnt family member 9B [KO:K01064]
103750565  Wnt10b; Wnt family member 10B [KO:K01357]
103727730  Wnt10a; Wnt family member 10A [KO:K01357]
103743015  Wnt11; Wnt family member 11 [KO:K01384]
103730604  Wnt16; Wnt family member 16 [KO:K01558]
103736031  Fzd7; frizzled class receptor 7 [KO:K02432]
103725249  Fzd1; frizzled class receptor 1 [KO:K02432]
103738297  Fzd2; frizzled class receptor 2 [KO:K02235]
103729990  Fzd3; frizzled class receptor 3 [KO:K02329]
103742963  Fzd4; frizzled class receptor 4 [KO:K02354]
103744444  Fzd5; frizzled class receptor 5 [KO:K02375]
103748031  Fzd8; frizzled class receptor 8 [KO:K02375]
103748769  Fzd6; frizzled class receptor 6 [KO:K02376]
103746251  Fzd9; frizzled class receptor 9 [KO:K02842]
103750619  Fzd10; frizzled class receptor 10 [KO:K02842]
103744519  Lrp5; LDL receptor related protein 5 [KO:K03068]
103737771  Lrp6; LDL receptor related protein 6 [KO:K03068]
103748588  Csnk1e; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
103732646  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
103749746  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
103752158  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
103733205  Frat1; FRAT1, WNT signaling pathway regulator [KO:K03069]
103733235  Frat2; FRAT2, WNT signaling pathway regulator [KO:K03096]
103735565  Csnk2a2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
103751629  Csnk2a1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
103724441  Csnk2b; casein kinase 2 beta [KO:K03115]
103748223  Axin1; axin 1 [KO:K02157]
103742203  Axin2; axin 2 [KO:K04385]
103737324  Apc2; APC2, WNT signaling pathway regulator [KO:K02085]
103735168  Apc; APC, WNT signaling pathway regulator [KO:K02085]
103747127  Ctnnb1; catenin beta 1 [KO:K02105]
103738092  Csnk1a1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
103742909  Kif5a; kinesin family member 5A [KO:K10396]
103748005  Kif5b; kinesin family member 5B [KO:K10396]
103727324  Kif5c; kinesin family member 5C [KO:K10396]
103749189  Klc3; kinesin light chain 3 [KO:K10407]
103725020  Klc2; kinesin light chain 2 [KO:K10407]
103727606  Klc1; kinesin light chain 1 [KO:K10407]
103730796  Klc4; kinesin light chain 4 [KO:K10407]
103733937  tubulin alpha-1B chain [KO:K07374]
108489984  tubulin alpha-1B chain-like [KO:K07374]
103745382  tubulin alpha-3 chain-like [KO:K07374]
108491798  tubulin alpha-3 chain [KO:K07374]
103745161  Tuba8; tubulin alpha 8 [KO:K07374]
103725897  Tubal3; tubulin alpha like 3 [KO:K07374]
103727749  Tuba4a; tubulin alpha 4a [KO:K07374]
103732935  tubulin beta-2A chain [KO:K07375]
103732934  Tubb2b; tubulin beta 2B class IIb [KO:K07375]
103737184  Tubb4a; tubulin beta 4A class IVa [KO:K07375]
103740575  Tubb; tubulin beta class I [KO:K07375]
103735435  Tubb6; tubulin beta 6 class V [KO:K07375]
103741388  Tubb3; tubulin beta 3 class III [KO:K07375]
103741445  Tubb1; tubulin beta 1 class VI [KO:K07375]
103732593  Tubb4b; tubulin beta 4B class IVb [KO:K07375]
103724405  Ager; advanced glycosylation end-product specific receptor [KO:K19722]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103741627  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103726107  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103746208  Nox1; NADPH oxidase 1 [KO:K08008]
103734151  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103750518  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
103724994  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103728077  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
103724501  Nos2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
103726651  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103740849  Il6; interleukin 6 [KO:K05405]
103739898  Il1a; interleukin 1 alpha [KO:K04383]
103739899  Il1b; interleukin 1 beta [KO:K04519]
103747824  Csf1; colony stimulating factor 1 [KO:K05453]
103743370  Snca; synuclein alpha [KO:K04528]
103725269  Eif2ak2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103731232  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103738986  Ins; insulin [KO:K04526]
103743312  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
103727788  Irs1; insulin receptor substrate 1 [KO:K16172]
103751690  Irs2; insulin receptor substrate 2 [KO:K07187]
103733517  insulin receptor substrate 1-like [KO:K17445]
103750027  Irs4; insulin receptor substrate 4 [KO:K17446]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103732897  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103750609  Ulk1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
103727512  Ulk2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
103739581  Atg101; autophagy related 101 [KO:K19730]
103742493  Atg13; autophagy related 13 [KO:K08331]
103740312  Rb1cc1; RB1 inducible coiled-coil 1 [KO:K17589]
103748789  Ambra1; autophagy and beclin 1 regulator 1 [KO:K17985]
103735917  Becn1; beclin 1 [KO:K08334]
103746908  Becn2; beclin 2 [KO:K08334]
103727284  Pik3r4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
103739217  Atg14; autophagy related 14 [KO:K17889]
103737478  Nrbf2; nuclear receptor binding factor 2 [KO:K21246]
103733619  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103738773  Atg2a; autophagy related 2A [KO:K17906]
103727665  Atg2b; autophagy related 2B [KO:K17906]
103742212  Wipi1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
103748663  Wipi2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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Related
pathway
ngi00190  Oxidative phosphorylation
ngi03050  Proteasome
ngi04020  Calcium signaling pathway
ngi04140  Autophagy - animal
ngi04141  Protein processing in endoplasmic reticulum
ngi04210  Apoptosis
ngi04310  Wnt signaling pathway
ngi04910  Insulin signaling pathway
ngi04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system