KEGG   PATHWAY: ngi05170
Entry
ngi05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
ngi05170  Human immunodeficiency virus 1 infection
ngi05170

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103727506  Cd4; CD4 molecule [KO:K06454]
103744000  Btrc; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
103748186  Fbxw11; F-box and WD repeat domain containing 11 [KO:K03362]
103729775  Skp1; S-phase kinase associated protein 1 [KO:K03094]
103731381  Cul1; cullin 1 [KO:K03347]
103743488  Rbx1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
103734615  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
103728841  Ccr5; C-C motif chemokine receptor 5 [KO:K04180]
103747835  Gnai3; G protein subunit alpha i3 [KO:K04630]
103750163  Gnai2; G protein subunit alpha i2 [KO:K04630]
103724646  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
103732220  Gnai1; G protein subunit alpha i1 [KO:K04630]
103749858  Gnao1; G protein subunit alpha o1 [KO:K04534]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103748419  Ptk2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103730003  Ptk2b; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
103739977  Pxn; paxillin [KO:K05760]
103741458  Crkl; CRK like proto-oncogene, adaptor protein [KO:K04438]
103730505  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103732897  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103741760  Rps6kb1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103725586  Rps6kb2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103728077  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
103724994  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103747342  Fos; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103737138  Jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103738795  Bad; BCL2 associated agonist of cell death [KO:K02158]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103734421  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103737243  Gna11; G protein subunit alpha 11 [KO:K04635]
103747244  Plcg1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103748739  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103725694  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
103751203  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103739696  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103737134  Calml3; calmodulin like 3 [KO:K02183]
103737133  Calml5; calmodulin like 5 [KO:K02183]
103749800  Calml6; calmodulin like 6 [KO:K02183]
103724616  Calm1; calmodulin 1 [KO:K02183]
103724738  Calm3; calmodulin 3 [KO:K02183]
103725745  Calm2; calmodulin 2 [KO:K02183]
103729208  calmodulin-alpha-like [KO:K02183]
103736816  Calml4; calmodulin like 4 [KO:K02183]
103736944  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103747869  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103728037  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103734750  Ppp3r1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103749104  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
103748128  Nfatc1; nuclear factor of activated T-cells 1 [KO:K04446]
103735763  Nfatc2; nuclear factor of activated T-cells 2 [KO:K17332]
103734978  Nfatc3; nuclear factor of activated T-cells 3 [KO:K17333]
103739410  Nfatc4; nuclear factor of activated T-cells 4 [KO:K17334]
103742202  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103746928  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103729666  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103749764  Gnb1; G protein subunit beta 1 [KO:K04536]
103733509  Gnb2; G protein subunit beta 2 [KO:K04537]
103727502  Gnb3; G protein subunit beta 3 [KO:K07825]
103738592  Gnb4; G protein subunit beta 4 [KO:K04538]
103731407  Gnb5; G protein subunit beta 5 [KO:K04539]
103739246  Gng2; G protein subunit gamma 2 [KO:K07826]
103737671  Gng3; G protein subunit gamma 3 [KO:K04540]
103745125  Gng4; G protein subunit gamma 4 [KO:K04541]
103728101  Gng5; G protein subunit gamma 5 [KO:K04542]
103737284  Gng7; G protein subunit gamma 7 [KO:K04543]
103724710  Gng8; G protein subunit gamma 8 [KO:K04544]
108490535  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
103732533  Gng10; G protein subunit gamma 10 [KO:K04545]
103725218  Gng11; G protein subunit gamma 11 [KO:K04546]
103743355  Gng12; G protein subunit gamma 12 [KO:K04347]
103751889  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
103752404  Gng13; G protein subunit gamma 13 [KO:K04547]
103725217  Gngt1; G protein subunit gamma transducin 1 [KO:K04548]
103738360  Gngt2; G protein subunit gamma transducin 2 [KO:K04549]
103726484  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103748617  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103743005  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103738502  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103750017  Pak3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
103750732  Pak4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
103729196  Pak5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
103741500  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103748493  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103740428  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103731431  Cfl2; cofilin 2 [KO:K05765]
103725002  Cfl1; cofilin 1 [KO:K05765]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103747487  Tnfrsf1b; TNF receptor superfamily member 1B [KO:K05141]
103731080  Bcl2l1; BCL2 like 1 [KO:K04570]
103750991  Tlr2; toll like receptor 2 [KO:K10159]
103734505  Tlr4; toll like receptor 4 [KO:K10160]
103744662  Myd88; myeloid differentiation primary response 88 [KO:K04729]
103728592  Irak4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103731212  Irak1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103749513  Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103748567  Tab1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103731917  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103739547  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103731232  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103734016  Nfkbia; NFKB inhibitor alpha [KO:K04734]
103736148  interferon alpha-12-like [KO:K05414]
103746654  interferon alpha-1-like [KO:K05414]
103746653  interferon alpha-12-like [KO:K05414]
103731654  interferon alpha-13-like [KO:K05414]
103732546  interferon alpha-13-like [KO:K05414]
103743951  Ifnb1; interferon beta 1 [KO:K05415]
103746144  interferon beta-like [KO:K05415]
103739660  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103739659  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103735473  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103735474  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103735023  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103748972  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103749366  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103744364  Mb21d1; Mab-21 domain containing 1 [KO:K17834] [EC:2.7.7.86]
103743083  Tmem173; transmembrane protein 173 [KO:K12654]
103730726  Tbk1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103743674  Irf3; interferon regulatory factor 3 [KO:K05411]
103748572  DNA dC->dU-editing enzyme APOBEC-3-like [KO:K18750] [EC:3.5.4.-]
103726195  deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [KO:K22544] [EC:3.1.5.-]
103736931  deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [KO:K22544] [EC:3.1.5.-]
103732121  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
103732077  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
103732120  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
103726899  Bst2; bone marrow stromal cell antigen 2 [KO:K06731]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103732937  Ripk1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
103738912  Tradd; TNFRSF1A associated via death domain [KO:K03171]
103727039  Traf5; TNF receptor associated factor 5 [KO:K09849]
103741188  Traf2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103724822  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103742218  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103726522  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103740694  Faslg; Fas ligand [KO:K04389]
103738053  Fas; Fas cell surface death receptor [KO:K04390]
103751502  Fadd; Fas associated via death domain [KO:K02373]
103738672  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103745898  Bid; BH3 interacting domain death agonist [KO:K04726]
103743639  Bax; BCL2 associated X, apoptosis regulator [KO:K02159]
103739733  Bak1; BCL2 antagonist/killer 1 [KO:K14021]
103740099  Bcl2; BCL2, apoptosis regulator [KO:K02161]
103740800  cytochrome c, somatic [KO:K08738]
103751785  cytochrome c, testis-specific [KO:K08738]
103725336  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103744668  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103750475  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103728619  Cd3e; CD3e molecule [KO:K06451]
103748301  Cd3g; CD3g molecule [KO:K06452]
103748303  Cd3d; CD3d molecule [KO:K06450]
103739902  Cd247; CD247 molecule [KO:K06453]
103748644  Tap1; transporter 1, ATP binding cassette subfamily B member [KO:K05653] [EC:7.4.2.14]
103748319  Tap2; transporter 2, ATP binding cassette subfamily B member [KO:K05654] [EC:7.4.2.14]
103739704  Tapbp; TAP binding protein [KO:K08058]
103746706  Pdia3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
103751874  Calr; calreticulin [KO:K08057]
103730262  calreticulin-like [KO:K08057]
103738688  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103740578  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
103739356  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
103744250  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
103747894  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103725555  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752329  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103752528  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752527  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103724463  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
103731142  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729790  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729781  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729792  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729784  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103729783  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
103740468  Ap1b1; adaptor related protein complex 1 beta 1 subunit [KO:K12392]
103739448  Ap1g2; adaptor related protein complex 1 gamma 2 subunit [KO:K12391]
103735624  Ap1g1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
103747553  Ap1m2; adaptor related protein complex 1 mu 2 subunit [KO:K12393]
103726925  Ap1m1; adaptor related protein complex 1 mu 1 subunit [KO:K12393]
103733495  Ap1s1; adaptor related protein complex 1 sigma 1 subunit [KO:K12394]
103731382  AP-1 complex subunit sigma-2 [KO:K12394]
103749350  Ap1s2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394]
103729132  AP-1 complex subunit sigma-1A-like [KO:K12394]
103727779  Ap1s3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
103746859  B2m; beta-2-microglobulin [KO:K08055]
103744009  Elob; elongin B [KO:K03873]
103746623  Eloc; elongin C [KO:K03872]
103731332  Cul5; cullin 5 [KO:K10612]
103748287  Rnf7; ring finger protein 7 [KO:K10611]
103747256  Dcaf1; DDB1 and CUL4 associated factor 1 [KO:K11789] [EC:2.7.11.1]
103725009  Ddb1; damage specific DNA binding protein 1 [KO:K10610]
103734860  Cul4b; cullin 4B [KO:K10609]
103746287  Cul4a; cullin 4A [KO:K10609]
103731335  Atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
103752518  Atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
103735579  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
103735158  Cdc25c; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
103750397  Wee1; WEE1 G2 checkpoint kinase [KO:K06632] [EC:2.7.11.1]
103726112  Wee2; WEE1 homolog 2 [KO:K06632] [EC:2.7.11.1]
103738717  Ccnb1; cyclin B1 [KO:K05868]
103737154  Ccnb2; cyclin B2 [KO:K21770]
103726150  G2/mitotic-specific cyclin-B3-like [KO:K21771]
103736117  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
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Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
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Related
pathway
ngi03050  Proteasome
ngi04010  MAPK signaling pathway
ngi04020  Calcium signaling pathway
ngi04064  NF-kappa B signaling pathway
ngi04110  Cell cycle
ngi04141  Protein processing in endoplasmic reticulum
ngi04142  Lysosome
ngi04150  mTOR signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04612  Antigen processing and presentation
ngi04620  Toll-like receptor signaling pathway
ngi04623  Cytosolic DNA-sensing pathway
ngi04668  TNF signaling pathway
ngi04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
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