KEGG   PATHWAY: oga05167
Entry
oga05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Otolemur garnettii (small-eared galago)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
oga05167  Kaposi sarcoma-associated herpesvirus infection
oga05167

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100946120  C3; complement C3 [KO:K03990]
100956502  TLR3; toll-like receptor 3 [KO:K05401]
100961846  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100947925  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100941040  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100940759  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100950073  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100962353  interferon alpha-10-like [KO:K05414]
100955951  interferon alpha-10-like isoform X2 [KO:K05414]
100945944  interferon alpha-4-like [KO:K05414]
100945309  interferon alpha-5-like [KO:K05414]
100956963  interferon alpha-5-like [KO:K05414]
100957574  interferon alpha-5-like [KO:K05414]
100958440  interferon alpha-5-like [KO:K05414]
100958763  interferon alpha-10-like [KO:K05414]
100959074  interferon alpha-5-like [KO:K05414]
100946255  interferon alpha-10-like [KO:K05414]
100943304  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100943144  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100963040  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100959385  IFNB1; interferon beta [KO:K05415]
100958617  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100959248  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100955095  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100962299  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100956762  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100944401  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
100944155  IRF9; interferon regulatory factor 9 [KO:K04693]
100959776  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100966784  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100962457  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100965908  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
100949231  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
100958428  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100952202  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100953162  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100951890  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100965663  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100962281  CCR8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100960309  FADD; FAS-associated death domain protein [KO:K02373]
100965468  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100960302  BID; BH3-interacting domain death agonist [KO:K04726]
100957285  BAX; apoptosis regulator BAX [KO:K02159]
100941755  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100952744  cytochrome c, somatic [KO:K08738]
100946237  cytochrome c [KO:K08738]
100961637  cytochrome c, testis-specific [KO:K08738]
100951508  cytochrome c-like [KO:K08738]
100957904  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100955892  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100952230  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100966378  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100947991  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100951476  RB1; retinoblastoma-associated protein [KO:K06618]
100957114  E2F1; transcription factor E2F1 [KO:K17454]
100956861  E2F2; transcription factor E2F2 [KO:K09389]
100942819  E2F3; transcription factor E2F3 [KO:K06620]
100961793  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
100952503  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
100957517  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100956897  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
100959427  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100946825  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
100947452  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
100958806  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
100952177  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100952822  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
100954387  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100953138  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100960904  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
100964084  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100948329  CD86; T-lymphocyte activation antigen CD86 isoform X3 [KO:K05413]
100951863  MHC class I polypeptide-related sequence B isoform X1 [KO:K07985]
100941111  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
100960616  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
100944913  LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
100959324  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100953857  BECN1; beclin-1 [KO:K08334]
100963972  BECN2; beclin-2 [KO:K08334]
100953692  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100966217  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100955582  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
100963656  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
100956121  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100957512  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100964694  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100940763  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100950950  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100961335  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100954252  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111726116  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100947073  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100967014  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111723289  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111724938  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111728356  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111723667  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100954553  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111725594  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100954240  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111724020  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100941157  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100965098  JUN; transcription factor AP-1 [KO:K04448]
100953435  FOS; proto-oncogene c-Fos [KO:K04379]
100950470  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100950920  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
100951247  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100948506  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957169  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100967053  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100960275  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100940435  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
100966705  cell surface glycoprotein CD200 receptor 2 [KO:K21668]
100940752  cell surface glycoprotein CD200 receptor 1 [KO:K21668]
100949905  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100941865  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100954296  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
100951050  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100945898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
100966900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
100948829  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100948398  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100964437  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100954512  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100942290  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100952803  calmodulin-like [KO:K02183]
100956147  calmodulin-like [KO:K02183]
105887316  CALML6; calmodulin-like protein 6 [KO:K02183]
100942721  calmodulin-like [KO:K02183]
100941613  CALM3; calmodulin-3 [KO:K02183]
100964319  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100946498  CALM2; calmodulin-2 [KO:K02183]
100966114  CALML5; calmodulin-like protein 5 [KO:K02183]
100948288  CALM1; calmodulin-1 [KO:K02183]
100961754  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100961025  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100945846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
105886540  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105887331  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100955220  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100950273  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
111725388  CXCL8; interleukin-8 [KO:K10030]
100944482  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100952509  growth-regulated protein homolog gamma-like [KO:K05505]
100952827  growth-regulated alpha protein-like [KO:K05505]
100950823  growth-regulated protein homolog gamma-like [KO:K05505]
100941066  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100953177  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100958958  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
100948875  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100958469  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100966689  CTNNB1; catenin beta-1 [KO:K02105]
100947392  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100940553  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100943434  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100958411  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100964324  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
Reference
PMID:24710493
  Authors
Pratt ZL, Sugden B
  Title
How human tumor viruses make use of autophagy.
  Journal
Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
DOI:10.1128/JVI.78.14.7667-7676.2004
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
PMID:15573137
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
PMID:17329974
  Authors
Montaner S
  Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
  Journal
Cell Cycle 6:438-43 (2007)
DOI:10.4161/cc.6.4.3843
Reference
PMID:23028325
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
  Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
  Journal
Proc Natl Acad Sci U S A 96:5704-9 (1999)
DOI:10.1073/pnas.96.10.5704
Reference
PMID:26192396
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
PMID:25187543
  Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
PMID:16585191
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
  Authors
Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
oga04010  MAPK signaling pathway
oga04064  NF-kappa B signaling pathway
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04140  Autophagy - animal
oga04144  Endocytosis
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04310  Wnt signaling pathway
oga04610  Complement and coagulation cascades
oga04620  Toll-like receptor signaling pathway
oga04630  JAK-STAT signaling pathway
oga04650  Natural killer cell mediated cytotoxicity
oga04668  TNF signaling pathway
KO pathway
ko05167   
LinkDB

DBGET integrated database retrieval system