KEGG   PATHWAY: pale05166
Entry
pale05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pteropus alecto (black flying fox)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
pale05166  Human T-cell leukemia virus 1 infection
pale05166

Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102885620  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
102894991  NRP1; neuropilin-1 isoform X2 [KO:K06724]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102898542  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
102887245  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
102892640  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102879417  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102896231  ITGB2; integrin beta-2 [KO:K06464]
102897326  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102886252  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
102894689  TLN2; talin-2 [KO:K06271]
102879371  RANBP3; ran-binding protein 3 isoform X4 [KO:K15304]
102893000  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102881186  XPO1; exportin-1 isoform X1 [KO:K14290]
102881831  CALR; calreticulin [KO:K08057]
102892219  CANX; calnexin [KO:K08054]
102880029  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102883156  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102898473  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102894471  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102895490  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102880857  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102886274  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102884312  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102888827  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102883396  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102888070  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102880365  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102898620  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102884638  signal transducer and activator of transcription 5A [KO:K11223]
102884882  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102895516  IL2; interleukin-2 [KO:K05429]
102885874  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
102887544  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
102898809  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102896885  B2M; beta-2-microglobulin [KO:K08055]
102888371  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102887036  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102897294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102878001  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102896364  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102896575  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102885895  ADP/ATP translocase 3-like [KO:K05863]
102898192  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102892527  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102882986  TSPO; translocator protein [KO:K05770]
102887146  TSPO2; translocator protein 2 [KO:K05770]
102894472  VAC14; protein VAC14 homolog [KO:K15305]
102889159  RANBP1; ran-specific GTPase-activating protein isoform X3 [KO:K15306]
102891468  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
102882657  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102894232  LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
102896980  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
102882717  BUB3; mitotic checkpoint protein BUB3 [KO:K02180]
102890060  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
102894926  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
102881017  CDC27; cell division cycle protein 27 homolog isoform X5 [KO:K03350]
102887771  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
102884397  ANAPC5; anaphase-promoting complex subunit 5 isoform X2 [KO:K03352]
102880240  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
102885734  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
102895279  CDC23; cell division cycle protein 23 homolog [KO:K03355]
102880062  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102881804  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102882912  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102885814  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102890991  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
102888011  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102880585  CDC20; cell division cycle protein 20 homolog [KO:K03363]
102885716  PTTG1; securin isoform X1 [KO:K06635]
102895542  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
102892539  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
102893142  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
102896422  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A [KO:K06621]
102894222  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102881884  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
102894049  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102890664  CCNA1; cyclin-A1 [KO:K06627]
102894080  CCNA2; cyclin-A2 [KO:K06627]
102882411  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102882260  CCNE1; LOW QUALITY PROTEIN: G1/S-specific cyclin-E1 [KO:K06626]
102893397  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102893019  RB1; retinoblastoma-associated protein [KO:K06618]
102895276  E2F1; transcription factor E2F1 [KO:K17454]
102884459  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
102887239  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102898588  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102889339  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102882405  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
102882358  CHEK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102891637  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102887557  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
102881949  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102887632  TNF; tumor necrosis factor [KO:K03156]
102885752  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102886741  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102894945  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
102885064  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
102890689  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102892777  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102896121  JUN; transcription factor AP-1 [KO:K04448]
102884900  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
102884439  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102884188  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102898423  T-cell receptor beta-2 chain C region [KO:K10785]
102891942  uncharacterized protein LOC102891942 [KO:K10785]
102894486  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
102894744  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102894240  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102889570  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102879469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102893261  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102880203  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102891056  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102880692  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102878395  RELA; transcription factor p65 [KO:K04735]
102882431  GPS2; G protein pathway suppressor 2 [KO:K15307]
102881387  LOW QUALITY PROTEIN: G protein pathway suppressor 2-like [KO:K15307]
102886421  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X3 [KO:K03159]
102890443  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102888839  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
102897751  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102886161  RELB; transcription factor RelB [KO:K09253]
102894780  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102895549  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
102891511  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102887558  IL15; interleukin-15 isoform X2 [KO:K05433]
102892156  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
102895746  IL6; interleukin-6 [KO:K05405]
102893042  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102887880  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
102887704  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102885349  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102884154  TGFB1; transforming growth factor beta-1 [KO:K13375]
102881295  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
102893304  TGFB3; transforming growth factor beta-3 [KO:K13377]
102880759  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
102889618  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102893928  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
102895268  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102886521  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
102887497  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102893265  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102886232  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102890575  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102897495  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102890588  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
102881535  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102896789  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102885676  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102887926  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
102890716  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102895822  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
102896083  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
102892493  HLA class II histocompatibility antigen, DM alpha chain isoform X3 [KO:K06752]
102894815  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102895566  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102883286  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
102883801  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
102884055  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102895309  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
102892903  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102897819  SRF; serum response factor isoform X1 [KO:K04378]
102892959  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102878877  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102880490  SPI1; transcription factor PU.1 [KO:K09438]
102893422  ETS1; protein C-ets-1 [KO:K02678]
102886586  ETS2; protein C-ets-2 isoform X2 [KO:K21932]
102898783  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
102892522  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
102883227  TBP; TATA-box-binding protein [KO:K03120]
102891428  FOS; proto-oncogene c-Fos [KO:K04379]
102892713  EGR1; early growth response protein 1 [KO:K09203]
102884316  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
102882726  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
102888198  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102878515  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
102894633  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102882888  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
102886510  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102879289  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
102889014  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102896553  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102884583  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102898128  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
102885130  CRTC1; CREB-regulated transcription coactivator 1 [KO:K15309]
102879203  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102884635  CRTC3; CREB-regulated transcription coactivator 3 [KO:K16334]
102886172  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102881042  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
102885647  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
102885891  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
102882010  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
102893018  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
102891182  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
102885135  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102878098  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
102895256  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
102888440  MSX1; homeobox protein MSX-1 [KO:K09341]
102897764  VENTX; homeobox protein VENTX [KO:K09341]
102897577  MSX2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
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Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
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Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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Nakano K, Watanabe T
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
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PMID:23248621
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Viruses 3:714-49 (2011)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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Oncogene 24:5952-64 (2005)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
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PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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PMID:11244044
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
pale03013  Nucleocytoplasmic transport
pale04010  MAPK signaling pathway
pale04064  NF-kappa B signaling pathway
pale04110  Cell cycle
pale04115  p53 signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04210  Apoptosis
pale04350  TGF-beta signaling pathway
pale04612  Antigen processing and presentation
pale04660  T cell receptor signaling pathway
pale04668  TNF signaling pathway
KO pathway
ko05166   
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