KEGG   PATHWAY: psiu04015
Entry
psiu04015                   Pathway                                
Name
Rap1 signaling pathway - Phocoena sinus (vaquita)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
psiu04015  Rap1 signaling pathway
psiu04015

Other DBs
GO: 0007264
Organism
Phocoena sinus (vaquita) [GN:psiu]
Gene
116755898  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
116753261  ras-related protein Rap-1b-like isoform X1 [KO:K07836]
116760187  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
116757757  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
116753175  MRAS; ras-related protein M-Ras [KO:K07831]
116759780  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
116759546  DOCK4; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4 [KO:K17697]
116755534  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116740277  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
116760570  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116744236  CALM3; calmodulin-3 [KO:K02183]
116748386  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
116748713  CALM1; calmodulin-1 isoform X1 [KO:K02183]
116762110  calmodulin-1-like [KO:K02183]
116749119  calmodulin-like [KO:K02183]
116749952  calmodulin-like protein 3 [KO:K02183]
116764310  CALM2; calmodulin-2 [KO:K02183]
116751838  F2R; proteinase-activated receptor 1 [KO:K03914]
116750428  F2RL3; proteinase-activated receptor 4 [KO:K04236]
116753668  P2RY1; P2Y purinoceptor 1 [KO:K04270]
116756161  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116750439  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
116739667  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
116747722  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
116761044  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
116739170  ADORA2A; adenosine receptor A2a [KO:K04266]
116745445  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
116740990  neuroendocrine secretory protein 55-like [KO:K04632]
116740988  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
116759445  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116752275  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
116764233  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116749116  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116753224  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116760787  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
116744731  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
116742406  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116740403  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
116761070  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
116757044  RAPGEF4; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4 [KO:K04351]
116755414  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116749106  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116740640  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
116740954  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
116758215  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116764722  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116757885  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116754608  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116751451  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116753904  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
116758288  LOW QUALITY PROTEIN: fibroblast growth factor 2-like [KO:K18497]
116746806  FGF20; fibroblast growth factor 20 [KO:K04358]
116754298  FGF5; fibroblast growth factor 5 [KO:K04358]
116760979  FGF6; fibroblast growth factor 6 [KO:K04358]
116747847  FGF16; fibroblast growth factor 16 [KO:K04358]
116755801  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116749192  FGF7; fibroblast growth factor 7 [KO:K04358]
116750440  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116750545  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
116757391  FGF4; fibroblast growth factor 4 [KO:K04358]
116757392  FGF3; fibroblast growth factor 3 [KO:K04358]
116741677  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116751461  FGF10; fibroblast growth factor 10 [KO:K04358]
116758422  FGF19; fibroblast growth factor 19 [KO:K22603]
116744336  FGF21; fibroblast growth factor 21 [KO:K22429]
116761246  FGF23; fibroblast growth factor 23 [KO:K22428]
116754467  NGF; beta-nerve growth factor [KO:K02582]
116758168  insulin [KO:K04526]
116760902  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
116740378  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116761017  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116754109  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
116758674  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116756768  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116760722  KITLG; kit ligand isoform X1 [KO:K05461]
116762165  VEGFA; vascular endothelial growth factor A [KO:K05448]
116758090  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116749646  PGF; placenta growth factor isoform X1 [KO:K16859]
116746676  VEGFC; vascular endothelial growth factor C [KO:K05449]
116747916  VEGFD; vascular endothelial growth factor D [KO:K05449]
116759711  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
116742473  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
116746760  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116740279  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
116744243  EFNA3; ephrin-A3 [KO:K05462]
116744249  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116738713  EFNA1; ephrin-A1 [KO:K05462]
116752074  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116752293  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
116759758  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
116746732  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
116741579  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116754486  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116751966  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116745757  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116751331  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116748753  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116754045  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116751332  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116752024  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116754507  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116742893  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116752252  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116754436  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116759279  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116755617  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116756797  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116738862  CRKL; crk-like protein [KO:K04438]
116745432  CRK; adapter molecule crk isoform X1 [KO:K04438]
116755221  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
116744074  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116743680  CDH1; cadherin-1 [KO:K05689]
116761571  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
116762017  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116759043  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
116749377  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
116753860  RAPGEF2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
116750892  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
116740145  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
116751202  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
116752089  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
116745238  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
116740089  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116745476  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116739537  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116743766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116743898  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
116749291  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
116764371  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
116757987  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
116763575  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
116761812  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
116749946  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116759318  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116744142  guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
116741844  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
116748429  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
116757937  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
116741979  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
116743691  SIPA1L3; LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
116739487  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
116748587  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
116755498  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
116759480  RALA; ras-related protein Ral-A [KO:K07834]
116756440  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
116761737  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116739565  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116760236  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116745822  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116749595  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1 [KO:K17704]
116755317  TLN1; talin-1 isoform X1 [KO:K06271]
116749053  TLN2; talin-2 isoform X1 [KO:K06271]
116746301  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
116746035  ITGB3; integrin beta-3 [KO:K06493]
116747296  uncharacterized protein LOC116747296 [KO:K05759]
116764130  PFN4; profilin-4 [KO:K05759]
116751672  PFN3; profilin-3 [KO:K05759]
116752039  profilin-1-like [KO:K05759]
116745469  PFN1; profilin-1 [KO:K05759]
116752780  PFN2; profilin-2 isoform X1 [KO:K05759]
116743554  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116752948  ENAH; protein enabled homolog isoform X1 [KO:K05746]
116748467  EVL; LOW QUALITY PROTEIN: ena/VASP-like protein [KO:K23487]
116739532  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
116745324  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116751544  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
116762804  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
116740153  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
116757172  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
116752435  CDC42; cell division control protein 42 homolog [KO:K04393]
116755111  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116748371  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
116751236  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
116753482  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116748687  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116744257  LOW QUALITY PROTEIN: partitioning defective 6 homolog beta-like [KO:K06093]
116739184  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
116744548  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116740930  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
116752778  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116753166  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
116763385  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
116758714  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
116759086  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
116751607  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
116749631  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116739681  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
116740168  ITGAM; LOW QUALITY PROTEIN: integrin alpha-M [KO:K06461]
116753324  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
116748884  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
116759212  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116761625  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116747589  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116751189  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116738910  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116740620  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
116745655  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
116746300  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116760605  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116760782  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116762796  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
116762798  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116752953  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116752990  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116751286  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116750604  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116742613  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
116751944  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116743673  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116759669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116748950  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116741248  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116757893  HRAS; GTPase HRas isoform X1 [KO:K02833]
116751649  uncharacterized protein LOC116751649 [KO:K02833]
116760326  KRAS; GTPase KRas isoform X1 [KO:K07827]
116739088  NRAS; GTPase NRas [KO:K07828]
116743409  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
psiu04010  MAPK signaling pathway
psiu04014  Ras signaling pathway
psiu04020  Calcium signaling pathway
psiu04151  PI3K-Akt signaling pathway
psiu04510  Focal adhesion
psiu04520  Adherens junction
psiu04660  T cell receptor signaling pathway
psiu04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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