KEGG   PATHWAY: rbb05161
Entry
rbb05161                    Pathway                                
Name
Hepatitis B - Rhinopithecus bieti (black snub-nosed monkey)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
rbb05161  Hepatitis B
rbb05161

Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108538399  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
108520275  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
108536158  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
108528282  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
108534939  TGFB3; transforming growth factor beta-3 [KO:K13377]
108512466  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108516558  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108514714  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
108528336  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108517508  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108528761  MYC; myc proto-oncogene protein [KO:K04377]
108533155  EGR2; LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2 [KO:K12496]
108540793  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
108538320  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108528445  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108526259  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108533616  DDB1; DNA damage-binding protein 1 [KO:K10610]
108521962  DDB2; DNA damage-binding protein 2 [KO:K10140]
108530959  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
108533372  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108544549  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
108516257  YWHAQ; 14-3-3 protein theta [KO:K16197]
108520193  YWHAZ; LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta [KO:K16197]
108517313  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108535077  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108540719  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108518784  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108519636  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108532817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108543519  RELA; transcription factor p65 [KO:K04735]
108533326  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
108526412  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108542734  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108526609  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
108538801  FADD; FAS-associated death domain protein [KO:K02373]
108532002  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108532107  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
108541711  BID; BH3-interacting domain death agonist [KO:K04726]
108523624  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
108543462  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
108530087  cytochrome c-like [KO:K08738]
108532915  cytochrome c [KO:K08738]
108535521  cytochrome c [KO:K08738]
108524009  cytochrome c [KO:K08738]
108538827  cytochrome c-like [KO:K08738]
108536287  cytochrome c-like [KO:K08738]
108524923  cytochrome c-like [KO:K08738]
108523439  cytochrome c-like [KO:K08738]
108533297  cytochrome c-like [KO:K08738]
108524269  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
108512689  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
108513174  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
108534183  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
108514363  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108516606  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
108515587  CCNA2; cyclin-A2 [KO:K06627]
108516053  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108539896  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
108530611  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108530701  RB1; retinoblastoma-associated protein [KO:K06618]
108533038  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
108538448  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
108522131  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
108518773  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108538857  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
108529452  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108525049  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108539466  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108515354  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
108540953  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108520255  TNF; tumor necrosis factor isoform X1 [KO:K03156]
108532886  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
108523026  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
108534230  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108517816  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
108518318  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
108527866  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108516059  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
108527864  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
108518319  STAT5A; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A [KO:K11223]
108518352  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B-like [KO:K11224]
108519693  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
108540717  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108537591  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108519844  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108537414  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108513636  SOS2; son of sevenless homolog 2 [KO:K03099]
108520869  SOS1; son of sevenless homolog 1 [KO:K03099]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108528122  NRAS; GTPase NRas [KO:K07828]
108532921  JUN; transcription factor AP-1 [KO:K04448]
108533135  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
108527163  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
108540349  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108519245  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108518996  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108542557  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108512141  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108518846  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108520463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108535460  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108519898  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108523449  CXCL8; interleukin-8 [KO:K10030]
108533343  PCNA; proliferating cell nuclear antigen [KO:K04802]
108530908  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
108541537  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108534930  FOS; proto-oncogene c-Fos [KO:K04379]
108530915  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
108529041  TLR2; toll-like receptor 2 [KO:K10159]
108512239  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
108542317  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
108530054  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108539989  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108535063  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
108535559  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108520466  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108536673  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
108539499  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108529326  IL6; interleukin-6 isoform X1 [KO:K05405]
108521513  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
108523215  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108528326  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108528327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108539403  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108539422  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108534524  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108540015  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
108522436  TLR3; LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
108512106  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
108529797  DDX58; LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
108541427  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
108533499  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
108514953  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
108535149  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
108529966  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108544916  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3Y-like [KO:K11594] [EC:5.6.2.7]
108531457  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
108525954  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3Y-like [KO:K11594] [EC:5.6.2.7]
108535826  IRF3; interferon regulatory factor 3 [KO:K05411]
108543524  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108525122  interferon alpha-10 [KO:K05414]
108538560  interferon alpha-4-like [KO:K05414]
108525752  LOW QUALITY PROTEIN: interferon alpha-21-like [KO:K05414]
108536968  IFNA8; LOW QUALITY PROTEIN: interferon alpha-8 [KO:K05414]
108536996  interferon alpha-14 [KO:K05414]
108537115  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
108537124  IFNA6; interferon alpha-6 [KO:K05414]
108538565  IFNB1; interferon beta [KO:K05415]
108536856  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
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Schadler S, Hildt E
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HBV life cycle: entry and morphogenesis.
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Viruses 1:185-209 (2009)
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Ortega-Prieto AM, Dorner M
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Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
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Vaccines (Basel) 5:E24 (2017)
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PMID:28704708
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Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
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Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
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Mol Immunol 90:64-73 (2017)
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PMID:24530748
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Bagheri V, Askari A, Arababadi MK, Kennedy D
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Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
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Hum Immunol 75:549-54 (2014)
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PMID:25550115
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Zhang E, Lu M
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Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
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Med Microbiol Immunol 204:11-20 (2015)
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Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
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Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
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J Gen Virol 91:2080-90 (2010)
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Revill P, Yuan Z
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New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
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Antivir Ther 18:1-15 (2013)
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Tumour viruses and innate immunity.
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Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
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New insight in the pathobiology of hepatitis B virus infection.
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Gut 61 Suppl 1:i6-17 (2012)
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Related
pathway
rbb04010  MAPK signaling pathway
rbb04064  NF-kappa B signaling pathway
rbb04110  Cell cycle
rbb04115  p53 signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04210  Apoptosis
rbb04620  Toll-like receptor signaling pathway
rbb04622  RIG-I-like receptor signaling pathway
rbb04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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