KEGG   PATHWAY: rfq04014
Entry
rfq04014                    Pathway                                
Name
Ras signaling pathway - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
rfq04014  Ras signaling pathway
rfq04014

Other DBs
GO: 0032318
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117021897  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117033382  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117016625  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117037862  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
117025364  FGF10; fibroblast growth factor 10 [KO:K04358]
117027635  FGF16; fibroblast growth factor 16 [KO:K04358]
117021496  FGF20; fibroblast growth factor 20 [KO:K04358]
117021758  FGF9; fibroblast growth factor 9 [KO:K04358]
117028974  FGF6; fibroblast growth factor 6 [KO:K04358]
117022308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117036181  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117030196  FGF3; fibroblast growth factor 3 [KO:K04358]
117030198  FGF4; fibroblast growth factor 4 [KO:K04358]
117023393  FGF7; fibroblast growth factor 7 [KO:K04358]
117016767  FGF18; fibroblast growth factor 18 [KO:K04358]
117038202  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117038267  FGF22; fibroblast growth factor 22 [KO:K04358]
117030197  FGF19; fibroblast growth factor 19 [KO:K22603]
117035017  FGF21; fibroblast growth factor 21 [KO:K22429]
117028661  FGF23; fibroblast growth factor 23 [KO:K22428]
117014821  NGF; beta-nerve growth factor [KO:K02582]
117029758  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
117028672  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117035029  NTF4; neurotrophin-4 [KO:K12457]
117030020  INS; insulin [KO:K04526]
117028523  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117030019  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
117016876  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117029043  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117031167  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117038535  PDGFC; platelet-derived growth factor C [KO:K05450]
117014994  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117029147  KITLG; kit ligand isoform X1 [KO:K05461]
117034353  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
117016780  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117031344  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117022809  PGF; placenta growth factor isoform X1 [KO:K16859]
117025800  VEGFD; vascular endothelial growth factor D [KO:K05449]
117021086  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
117012542  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117034118  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
117021387  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
117015886  ANGPT4; angiopoietin-4 [KO:K05467]
117014273  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
117014777  EFNA1; ephrin-A1 [KO:K05462]
117014844  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
117038068  ephrin-A2 isoform X1 [KO:K05462]
117025140  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
117012187  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117021283  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117035827  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117022243  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117017069  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117013914  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117014296  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117032168  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117037841  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117018797  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117022011  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117016666  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117016537  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117022389  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
117021070  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117026978  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117021297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117016973  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117022432  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117018153  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117032285  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117027437  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117013296  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117037725  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
117030648  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
117014851  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117037962  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
117031898  SHC3; SHC-transforming protein 3 [KO:K17448]
117023566  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
117017450  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
117026506  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
117032869  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117022939  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117015909  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
117034806  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117023358  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
117029919  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
117033403  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117034648  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
117017992  uncharacterized protein LOC117017992 [KO:K10785]
117019310  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
117019393  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
117035767  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
117026721  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
117025270  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
117028938  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
117014467  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
117023601  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
117023859  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
117030010  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
117018688  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
117026503  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
117013994  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
117037607  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117035136  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
117032086  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
117012111  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
117027381  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117038030  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
117019395  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
117012455  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
117013107  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
117027001  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117037860  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117018783  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117024869  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117031907  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117019640  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117029473  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117026472  CALML6; calmodulin-like protein 6 [KO:K02183]
117033010  CALM2; calmodulin-2 [KO:K02183]
117019182  calmodulin-like [KO:K02183]
117019237  calmodulin-like protein 3 [KO:K02183]
117013546  calmodulin-1-like [KO:K02183]
117034856  CALM3; calmodulin-3 [KO:K02183]
117022841  CALM1; calmodulin-1 [KO:K02183]
117023064  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117013636  GTPase HRas-like [KO:K02833]
117029835  HRAS; LOW QUALITY PROTEIN: GTPase HRas [KO:K02833]
117028978  KRAS; GTPase KRas isoform X1 [KO:K07827]
117014672  NRAS; GTPase NRas [KO:K07828]
117036845  MRAS; ras-related protein M-Ras [KO:K07831]
117034458  RRAS; ras-related protein R-Ras [KO:K07829]
117030046  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117013151  NF1; neurofibromin isoform X1 [KO:K08052]
117024549  RASA1; ras GTPase-activating protein 1 [KO:K04352]
117036947  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
117021458  RASA3; ras GTPase-activating protein 3 [KO:K12380]
117024728  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
117020320  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
117017453  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
117014527  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
117037443  RASAL3; RAS protein activator like-3 [KO:K17634]
117037216  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
117014861  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
117016094  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
117030926  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
117016447  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117029121  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117012711  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
117031245  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
117035676  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117026883  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
117034873  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117016309  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
117022765  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
117036663  RHOA; transforming protein RhoA [KO:K04513]
117027443  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117035064  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117037029  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117027160  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117024531  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117038261  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117018458  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117035083  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117023560  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117020791  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117036177  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117021384  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117022439  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117030742  RELA; transcription factor p65 isoform X1 [KO:K04735]
117030073  BAD; bcl2-associated agonist of cell death [KO:K02158]
117015788  BCL2L1; bcl-2-like protein 1 [KO:K04570]
117026694  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
117014309  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117022978  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
117015784  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
117015747  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
117032148  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
117014524  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
117017251  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
117012416  RALA; ras-related protein Ral-A [KO:K07834]
117026093  RALB; ras-related protein Ral-B [KO:K07835]
117034828  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
117013723  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
117026989  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
117028150  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
117033215  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
117026302  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
117035933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117022220  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117016634  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117011816  RALBP1; ralA-binding protein 1 [KO:K08773]
117026985  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117019071  AFDN; afadin isoform X1 [KO:K05702]
117036354  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
117037259  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117022968  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117037633  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117017296  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117037702  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
117017782  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117026522  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
117026523  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
117019496  group 10 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
117027236  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117027266  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
117027682  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117027837  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117022211  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117036414  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
117017628  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
117014282  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117022803  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
117022823  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
117023696  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
117029004  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
117030140  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
117025443  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
117017515  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
117034678  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
117017566  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
117012816  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
117017710  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
117012263  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
117014781  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
117028675  RAP1B; ras-related protein Rap-1b [KO:K07836]
117036083  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117012818  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117019414  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117035150  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117030344  RIN1; ras and Rab interactor 1 [KO:K17638]
117031775  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
117014852  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
117017475  ras-related protein Rab-5A-like [KO:K07887]
117036886  RAB5A; ras-related protein Rab-5A [KO:K07887]
117028351  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
117013111  RAB5C; ras-related protein Rab-5C [KO:K07889]
117023630  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
rfq04010  MAPK signaling pathway
rfq04015  Rap1 signaling pathway
rfq04020  Calcium signaling pathway
rfq04144  Endocytosis
rfq04151  PI3K-Akt signaling pathway
rfq04660  T cell receptor signaling pathway
rfq04720  Long-term potentiation
rfq04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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