KEGG   PATHWAY: tben04510
Entry
tben04510                   Pathway                                
Name
Focal adhesion - Trematomus bernacchii (emerald rockcod)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tben04510  Focal adhesion
tben04510

Other DBs
GO: 0005925
Organism
Trematomus bernacchii (emerald rockcod) [GN:tben]
Gene
117473789  col1a1b; collagen, type I, alpha 1b [KO:K06236]
117499360  col1a1a; LOW QUALITY PROTEIN: collagen, type I, alpha 1a [KO:K06236]
117477721  col1a2; collagen alpha-2(I) chain [KO:K06236]
117489626  col2a1b; LOW QUALITY PROTEIN: collagen, type II, alpha 1b [KO:K19719]
117479375  col2a1a; collagen, type II, alpha 1a [KO:K19719]
117497934  col4a5; collagen alpha-5(IV) chain [KO:K06237]
117497945  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
117481439  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
117481440  col4a1; collagen alpha-1(IV) chain [KO:K06237]
117499163  collagen alpha-5(IV) chain-like [KO:K06237]
117488567  collagen alpha-5(IV) chain-like [KO:K06237]
117488569  collagen alpha-4(IV) chain-like [KO:K06237]
117485640  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
117488448  col6a1; collagen alpha-1(VI) chain [KO:K06238]
117476209  collagen alpha-6(VI) chain-like [KO:K06238]
117476214  col6a4a; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
117488538  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
117485843  col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238]
117479391  col9a3; collagen alpha-3(IX) chain [KO:K08131]
117499513  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
117482220  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
117482861  collagen alpha-1(IX) chain-like [KO:K08131]
117477627  col9a2; collagen alpha-2(IX) chain [KO:K08131]
117486949  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
117488629  laminin subunit alpha-3-like isoform X1 [KO:K06240]
117483447  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
117498536  lama4; laminin subunit alpha-4 [KO:K06241]
117484930  lamb1b; laminin subunit beta-1b [KO:K05636]
117469673  laminin subunit beta-1-like [KO:K05636]
117494238  lamb2l; laminin subunit beta-2 [KO:K06243]
117494371  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
117493794  si:ch1073-15f12.3; laminin subunit beta-3 [KO:K06244]
117469667  lamb4; laminin subunit beta-4 [KO:K06245]
117469916  laminin subunit gamma-1-like [KO:K05635]
117496376  lamc2; laminin subunit gamma-2 [KO:K06246]
117476829  lamc3; laminin subunit gamma-3 [KO:K06247]
117473874  chad; chondroadherin [KO:K06248]
117495006  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117486952  thbs1b; thrombospondin-1 [KO:K16857]
117476612  thrombospondin-1-like isoform X1 [KO:K16857]
117478960  thbs4b; thrombospondin-4-B [KO:K04659]
117495829  comp; cartilage oligomeric matrix protein [KO:K04659]
117473443  thrombospondin-2-like [KO:K04659]
117499053  thrombospondin-3a-like [KO:K04659]
117475965  thbs4a; thrombospondin-4a [KO:K04659]
117499856  thbs2a; thrombospondin-2 [KO:K04659]
117471879  fn1b; fibronectin 1b isoform X1 [KO:K05717]
117485577  LOW QUALITY PROTEIN: fibronectin-like [KO:K05717]
117490183  vtnb; vitronectin b [KO:K06251]
117470321  vtna; vitronectin a isoform X1 [KO:K06251]
117472799  tnc; tenascin [KO:K06252]
117488326  tnn; tenascin-N [KO:K06252]
117476793  tenascin-like isoform X1 [KO:K06252]
117488688  tnr; tenascin-R [KO:K06252]
117477806  tenascin [KO:K06252]
117491826  vwf; von Willebrand factor [KO:K03900]
117479016  itga1; integrin alpha-1 [KO:K06480]
117472925  itga2.2; integrin alpha-2 [KO:K06481]
117483773  integrin alpha-3-like [KO:K06482]
117473708  itga3b; integrin alpha-3b [KO:K06482]
117481187  itga4; integrin alpha-4 [KO:K06483]
117484380  itga5; integrin alpha-5 [KO:K06484]
117475609  integrin alpha-5-like [KO:K06484]
117481148  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
117488462  integrin alpha-6-like [KO:K06485]
117489726  itga7; integrin alpha-7 isoform X1 [KO:K06583]
117480161  itga8; integrin alpha-8 [KO:K06584]
117499769  itga9; integrin alpha-9 [KO:K06585]
117480287  itga10; integrin alpha-10 [KO:K06586]
117496418  LOW QUALITY PROTEIN: integrin alpha-11-like [KO:K06587]
117471592  itga11a; integrin alpha-11a [KO:K06587]
117498264  itgav; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
117483953  itgb1a; integrin beta-1a [KO:K05719]
117480205  integrin beta-1-like [KO:K05719]
117473304  itgb3b; integrin beta-3b isoform X1 [KO:K06493]
117492701  itgb3a; integrin beta-3a [KO:K06493]
117497632  itgb4; integrin beta-4 [KO:K06525]
117495313  itgb5; integrin beta-5 [KO:K06588]
117471622  itgb6; integrin beta-6 isoform X1 [KO:K06589]
117478230  itgb8; integrin beta-8 [KO:K06591]
117493178  emp2; epithelial membrane protein 2 [KO:K26256]
117484386  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
117492572  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117472213  uncharacterized protein LOC117472213 [KO:K17386]
117490963  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117470228  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117491568  egf; pro-epidermal growth factor [KO:K04357]
117485067  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
117494701  insulin-like growth factor I [KO:K05459]
117492288  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117470767  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117488707  vegfba; vascular endothelial growth factor A [KO:K05448]
117478923  pgfb; placenta growth factor [KO:K16859]
117498500  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
117474903  LOW QUALITY PROTEIN: vascular endothelial growth factor C-like [KO:K05449]
117499132  vascular endothelial growth factor C-like [KO:K05449]
117471724  vegfd; vascular endothelial growth factor D [KO:K05449]
117485078  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117491207  hepatocyte growth factor [KO:K05460]
117495114  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117490686  LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
117470913  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117497008  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117491654  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117496176  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117486666  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
117488453  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117495950  flt1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117488699  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117475117  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117497226  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117473547  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117480017  epithelial membrane protein 2-like [KO:K26255]
117482152  emp1; epithelial membrane protein 1 [KO:K26255]
117489901  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117483562  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117468868  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
117470507  arhgap35a; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
117483687  rho-related GTP-binding protein RhoA-C [KO:K04513]
117490008  rho-related GTP-binding protein RhoA-B [KO:K04513]
117494089  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117494090  rho-related GTP-binding protein RhoA-D [KO:K04513]
117494127  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117485399  LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
117488708  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117486693  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117492453  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
117484785  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117486540  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117472660  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117486518  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117482537  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
117495185  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117474089  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117492766  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117484759  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
117473583  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117486932  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117492347  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117487722  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117477717  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117484918  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117479541  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
117491940  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
117482399  ppp1r12c; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
117472211  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
117473463  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117488336  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117493310  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117495269  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
117478991  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117496007  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117480370  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117488315  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
117476062  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117477729  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117492174  actin, cytoplasmic 1 [KO:K05692]
117492175  actin, cytoplasmic 1-like [KO:K05692]
117481558  actb1; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
117491364  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117471480  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
117499311  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117499313  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117499673  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
117499674  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117472214  alpha-actinin-4-like [KO:K05699]
117481423  alpha-actinin-1 isoform X1 [KO:K05699]
117471076  alpha-actinin-4-like isoform X1 [KO:K05699]
117478860  tln1; talin-1 [KO:K06271]
117491867  tln2b; talin-2 [KO:K06271]
117471779  tln2a; talin-2a isoform X1 [KO:K06271]
117494692  flna; filamin-A isoform X1 [KO:K04437]
117497863  LOW QUALITY PROTEIN: filamin-B [KO:K27392]
117472793  paxillin-like isoform X1 [KO:K05760]
117486491  pxna; paxillin a isoform X1 [KO:K05760]
117490321  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117468842  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117494758  zyx; LOW QUALITY PROTEIN: zyxin [KO:K06273]
117472181  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
117470145  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117473611  vinculin [KO:K05700]
117499454  vinculin-like isoform X1 [KO:K05700]
117497477  parvb; beta-parvin isoform X1 [KO:K06275]
117497481  parvg; gamma-parvin [KO:K06275]
117491847  parvaa; parvin, alpha a [KO:K06275]
117473661  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117481856  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117499747  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117469598  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117470147  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117481110  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117478211  catenin beta-1-like [KO:K02105]
117480198  ctnnb1; catenin beta-1 [KO:K02105]
117474546  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117492635  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117481636  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117492333  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
117480431  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117480748  ptk2ab; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117477841  ptk2aa; LOW QUALITY PROTEIN: protein tyrosine kinase 2aa [KO:K05725] [EC:2.7.10.2]
117495884  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117475878  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117470004  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117494257  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117488737  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117495470  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117496245  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117472990  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
117488414  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117476544  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117488755  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117468664  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117499934  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117483944  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
117478908  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117500280  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3-like [KO:K05730]
117482243  proto-oncogene vav-like isoform X1 [KO:K05730]
117473334  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117471614  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117473618  rac3b; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117498986  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
117493783  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
117495272  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117490720  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
117471122  pak4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117498342  pak7; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
117478053  serine/threonine-protein kinase PAK 4 [KO:K05735] [EC:2.7.11.1]
117475456  cdc42; cell division control protein 42 homolog [KO:K04393]
117494784  cdc42l; cell division cycle 42, like [KO:K04393]
117483422  cell division control protein 42 homolog isoform X1 [KO:K04393]
117478019  cell division control protein 42 homolog [KO:K04393]
117491646  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
117490067  adapter molecule crk-like [KO:K04438]
117476469  crkl; crk-like protein [KO:K04438]
117477017  crk; adapter molecule crk [KO:K04438]
117473616  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
117475715  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1-like [KO:K06277]
117476613  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
117489544  ras-related protein Rap-1A [KO:K04353]
117487131  ras-related protein Rap-1b [KO:K07836]
117486395  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117499592  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117475749  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117476691  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117496095  jun; transcription factor AP-1 [KO:K04448]
117474460  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117488775  transcription factor AP-1-like [KO:K04448]
117483159  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117497255  cav1; caveolin-1 [KO:K06278]
117489758  caveolin-2-like [KO:K12958]
117489773  zgc:172270; caveolin-2 [KO:K12958]
117497331  cav2; caveolin-2 [KO:K12958]
117494390  zgc:158296; caveolin-2 [KO:K12958]
117489402  cav3; caveolin-3 [KO:K12959]
117478273  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
117498357  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
117480192  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117495196  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
117476810  shc3; SHC-transforming protein 3 [KO:K17448]
117471585  SHC-transforming protein 3-like [KO:K17449]
117479971  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117481352  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117491619  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117479493  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117491463  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117472631  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117492196  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117483869  elk1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
117496472  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117491260  G1/S-specific cyclin-D1-like [KO:K04503]
117484991  G1/S-specific cyclin-D2-like [KO:K10151]
117491872  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
117493088  ccndx; cyclin Dx [KO:K10151]
117489997  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117490365  birc2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
117474974  xiap; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117487811  badb; BCL2 associated agonist of cell death b [KO:K02158]
117488347  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
tben04010  MAPK signaling pathway
tben04060  Cytokine-cytokine receptor interaction
tben04070  Phosphatidylinositol signaling system
tben04110  Cell cycle
tben04310  Wnt signaling pathway
tben04512  ECM-receptor interaction
tben04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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