KEGG   PATHWAY: tben04510
Entry
tben04510                   Pathway                                
Name
Focal adhesion - Trematomus bernacchii (emerald rockcod)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tben04510  Focal adhesion
tben04510

Other DBs
GO: 0005925
Organism
Trematomus bernacchii (emerald rockcod) [GN:tben]
Gene
117468664  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117468842  [KO:K06272] [EC:2.7.11.1]
117468868  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
117469598  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117469667  lamb4; laminin subunit beta-4 [KO:K06245]
117469673  [KO:K05636]
117469916  [KO:K05635]
117470004  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117470145  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117470147  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117470228  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117470321  vtna; vitronectin a isoform X1 [KO:K06251]
117470507  arhgap35a; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
117470767  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117470913  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117471076  [KO:K05699]
117471122  pak4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117471480  [KO:K04349]
117471585  [KO:K17449]
117471592  itga11a; integrin alpha-11a [KO:K06587]
117471614  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117471622  itgb6; integrin beta-6 isoform X1 [KO:K06589]
117471724  vegfd; vascular endothelial growth factor D [KO:K05449]
117471779  tln2a; talin-2a isoform X1 [KO:K06271]
117471879  fn1b; fibronectin 1b isoform X1 [KO:K05717]
117472181  [KO:K06274]
117472211  [KO:K00907] [EC:2.7.11.18]
117472213  [KO:K17386]
117472214  [KO:K05699]
117472631  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117472660  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117472793  [KO:K05760]
117472799  tnc; tenascin [KO:K06252]
117472925  itga2.2; integrin alpha-2 [KO:K06481]
117472990  [KO:K02649]
117472993  [KO:K05692]
117473304  itgb3b; integrin beta-3b isoform X1 [KO:K06493]
117473334  [KO:K04392]
117473443  [KO:K04659]
117473463  [KO:K00907] [EC:2.7.11.18]
117473547  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117473583  [KO:K06269] [EC:3.1.3.16]
117473611  [KO:K05700]
117473616  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
117473618  rac3b; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117473661  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117473708  itga3b; integrin alpha-3b [KO:K06482]
117473789  col1a1b; collagen, type I, alpha 1b [KO:K06236]
117473874  chad; chondroadherin [KO:K06248]
117474089  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117474460  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117474546  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117474903  [KO:K05449]
117474974  xiap; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117475117  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117475456  cdc42; cell division control protein 42 homolog [KO:K04393]
117475609  [KO:K06484]
117475715  [KO:K06277]
117475749  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117475878  [KO:K00922] [EC:2.7.1.153]
117475965  thbs4a; thrombospondin-4a [KO:K04659]
117476062  [KO:K00889] [EC:2.7.1.68]
117476209  [KO:K06238]
117476214  col6a4a; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
117476469  crkl; crk-like protein [KO:K04438]
117476544  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117476612  [KO:K16857]
117476613  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
117476691  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117476793  [KO:K06252]
117476810  shc3; SHC-transforming protein 3 [KO:K17448]
117476829  lamc3; laminin subunit gamma-3 [KO:K06247]
117477017  crk; adapter molecule crk [KO:K04438]
117477627  col9a2; collagen alpha-2(IX) chain [KO:K08131]
117477717  [KO:K06269] [EC:3.1.3.16]
117477721  col1a2; collagen alpha-2(I) chain [KO:K06236]
117477729  [KO:K00889] [EC:2.7.1.68]
117477806  [KO:K06252]
117477841  ptk2aa; LOW QUALITY PROTEIN: protein tyrosine kinase 2aa [KO:K05725] [EC:2.7.10.2]
117478019  [KO:K04393]
117478053  [KO:K05735] [EC:2.7.11.1]
117478211  [KO:K02105]
117478230  itgb8; integrin beta-8 [KO:K06591]
117478273  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
117478860  tln1; talin-1 [KO:K06271]
117478908  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117478923  pgfb; placenta growth factor [KO:K16859]
117478960  thbs4b; thrombospondin-4-B [KO:K04659]
117478991  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117479016  itga1; integrin alpha-1 [KO:K06480]
117479375  col2a1a; collagen, type II, alpha 1a [KO:K19719]
117479391  col9a3; collagen alpha-3(IX) chain [KO:K08131]
117479493  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117479541  [KO:K12329]
117479971  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117480017  [KO:K26255]
117480161  itga8; integrin alpha-8 [KO:K06584]
117480192  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117480198  ctnnb1; catenin beta-1 [KO:K02105]
117480205  [KO:K05719]
117480287  itga10; integrin alpha-10 [KO:K06586]
117480370  [KO:K00889] [EC:2.7.1.68]
117480431  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117480748  ptk2ab; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117481110  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117481148  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
117481187  itga4; integrin alpha-4 [KO:K06483]
117481352  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117481423  [KO:K05699]
117481439  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
117481440  col4a1; collagen alpha-1(IV) chain [KO:K06237]
117481558  actb1; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
117481636  [KO:K19662] [EC:2.7.11.13]
117481856  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117482152  emp1; epithelial membrane protein 1 [KO:K26255]
117482220  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
117482243  [KO:K05730]
117482399  ppp1r12c; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
117482537  [KO:K12757]
117482861  [KO:K08131]
117483159  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117483422  [KO:K04393]
117483447  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
117483562  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117483687  [KO:K04513]
117483773  [KO:K06482]
117483869  elk1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
117483944  [KO:K05730]
117483953  itgb1a; integrin beta-1a [KO:K05719]
117484380  itga5; integrin alpha-5 [KO:K06484]
117484386  [KO:K04359]
117484759  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
117484785  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117484918  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117484930  lamb1b; laminin subunit beta-1b [KO:K05636]
117484991  [KO:K10151]
117485067  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
117485078  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117485399  [KO:K05740]
117485577  [KO:K05717]
117485640  [KO:K06238]
117485843  col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238]
117486395  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117486491  pxna; paxillin a isoform X1 [KO:K05760]
117486518  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117486540  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117486666  [KO:K04361] [EC:2.7.10.1]
117486693  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117486932  [KO:K06269] [EC:3.1.3.16]
117486949  [KO:K05637]
117486952  thbs1b; thrombospondin-1 [KO:K16857]
117487131  [KO:K07836]
117487722  [KO:K06269] [EC:3.1.3.16]
117487811  badb; BCL2 associated agonist of cell death b [KO:K02158]
117488315  [KO:K00889] [EC:2.7.1.68]
117488326  tnn; tenascin-N [KO:K06252]
117488336  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117488347  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117488414  [KO:K02649]
117488448  col6a1; collagen alpha-1(VI) chain [KO:K06238]
117488453  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117488462  [KO:K06485]
117488538  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
117488567  [KO:K06237]
117488569  [KO:K06237]
117488629  [KO:K06240]
117488688  tnr; tenascin-R [KO:K06252]
117488699  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117488707  vegfba; vascular endothelial growth factor A [KO:K05448]
117488708  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117488737  [KO:K00922] [EC:2.7.1.153]
117488755  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117488775  [KO:K04448]
117489402  cav3; caveolin-3 [KO:K12959]
117489544  [KO:K04353]
117489626  col2a1b; LOW QUALITY PROTEIN: collagen, type II, alpha 1b [KO:K19719]
117489726  itga7; integrin alpha-7 isoform X1 [KO:K06583]
117489758  [KO:K12958]
117489773  zgc:172270; caveolin-2 [KO:K12958]
117489901  [KO:K05704] [EC:2.7.10.2]
117489997  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117490008  [KO:K04513]
117490067  [KO:K04438]
117490183  vtnb; vitronectin b [KO:K06251]
117490321  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117490365  birc2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
117490686  [KO:K05089] [EC:2.7.10.1]
117490720  [KO:K05733] [EC:2.7.11.1]
117490963  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117491207  [KO:K05460]
117491260  [KO:K04503]
117491364  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117491463  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117491568  egf; pro-epidermal growth factor [KO:K04357]
117491619  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117491646  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
117491654  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117491826  vwf; von Willebrand factor [KO:K03900]
117491847  parvaa; parvin, alpha a [KO:K06275]
117491867  tln2b; talin-2 [KO:K06271]
117491872  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
117491940  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
117492174  [KO:K05692]
117492175  [KO:K05692]
117492196  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117492288  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117492333  [KO:K19662] [EC:2.7.11.13]
117492347  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117492453  [KO:K17388] [EC:2.7.11.1]
117492572  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117492635  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117492701  itgb3a; integrin beta-3a [KO:K06493]
117492766  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117493088  ccndx; cyclin Dx [KO:K10151]
117493178  emp2; epithelial membrane protein 2 [KO:K26256]
117493310  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117493783  [KO:K04410] [EC:2.7.11.1]
117493794  si:ch1073-15f12.3; laminin subunit beta-3 [KO:K06244]
117494089  [KO:K04513]
117494090  [KO:K04513]
117494127  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117494238  lamb2l; laminin subunit beta-2 [KO:K06243]
117494257  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117494371  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
117494390  zgc:158296; caveolin-2 [KO:K12958]
117494692  flna; filamin-A isoform X1 [KO:K04437]
117494701  [KO:K05459]
117494758  zyx; LOW QUALITY PROTEIN: zyxin [KO:K06273]
117494784  cdc42l; cell division cycle 42, like [KO:K04393]
117495006  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117495114  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117495185  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117495196  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
117495269  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
117495272  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117495313  itgb5; integrin beta-5 [KO:K06588]
117495470  [KO:K02649]
117495829  comp; cartilage oligomeric matrix protein [KO:K04659]
117495884  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117495950  flt1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117496007  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117496095  jun; transcription factor AP-1 [KO:K04448]
117496176  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117496245  [KO:K02649]
117496376  lamc2; laminin subunit gamma-2 [KO:K06246]
117496418  [KO:K06587]
117496472  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117497008  [KO:K05087] [EC:2.7.10.1]
117497226  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117497255  cav1; caveolin-1 [KO:K06278]
117497331  cav2; caveolin-2 [KO:K12958]
117497477  parvb; beta-parvin isoform X1 [KO:K06275]
117497481  parvg; gamma-parvin [KO:K06275]
117497632  itgb4; integrin beta-4 [KO:K06525]
117497863  [KO:K27392]
117497934  col4a5; collagen alpha-5(IV) chain [KO:K06237]
117497945  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
117498264  itgav; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
117498342  pak7; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
117498357  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
117498500  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
117498536  lama4; laminin subunit alpha-4 [KO:K06241]
117498986  [KO:K04409] [EC:2.7.11.1]
117499053  [KO:K04659]
117499132  [KO:K05449]
117499163  [KO:K06237]
117499311  [KO:K03853] [EC:3.4.22.53]
117499313  [KO:K03853] [EC:3.4.22.53]
117499360  col1a1a; LOW QUALITY PROTEIN: collagen, type I, alpha 1a [KO:K06236]
117499454  [KO:K05700]
117499513  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
117499592  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117499673  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
117499674  [KO:K03853] [EC:3.4.22.53]
117499747  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117499769  itga9; integrin alpha-9 [KO:K06585]
117499856  thbs2a; thrombospondin-2 [KO:K04659]
117499934  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117500280  [KO:K05730]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
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Nat Rev Mol Cell Biol 5:816-26 (2004)
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Petit V, Thiery JP.
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Focal adhesions: structure and dynamics.
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Biol Cell 92:477-94 (2000)
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PMID:12235283
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Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
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J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
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PMID:12640026
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Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
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J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
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PMID:15688067
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Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
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Nat Rev Mol Cell Biol 6:56-68 (2005)
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PMID:14519391
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Interactions between growth factor receptors and adhesion molecules: breaking the rules.
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Curr Opin Cell Biol 15:565-71 (2003)
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PMID:15108811
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Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
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Curr Opin Genet Dev 14:92-101 (2004)
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PMID:14744429
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Burridge K, Wennerberg K.
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Rho and Rac take center stage.
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Cell 116:167-79 (2004)
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Rho GTPases: signaling, migration, and invasion.
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Exp Cell Res 261:1-12 (2000)
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Biochem J 346 Pt 3:561-76 (2000)
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Nicholson KM, Anderson NG.
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The protein kinase B/Akt signalling pathway in human malignancy.
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Cell Signal 14:381-95 (2002)
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Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
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Biochim Biophys Acta 1691:1-15 (2004)
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Nat Cell Biol 2:E231-6 (2000)
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The mechanism of action of the tumour suppressor gene PTEN.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
tben04010  MAPK signaling pathway
tben04060  Cytokine-cytokine receptor interaction
tben04070  Phosphatidylinositol signaling system
tben04110  Cell cycle
tben04310  Wnt signaling pathway
tben04512  ECM-receptor interaction
tben04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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