KEGG   PATHWAY: vko04010
Entry
vko04010                    Pathway                                
Name
MAPK signaling pathway - Varanus komodoensis (Komodo dragon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
vko04010  MAPK signaling pathway
vko04010

Other DBs
GO: 0000165
Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123035671  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123028241  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
123016508  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
123034083  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123027874  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
123029960  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
123018180  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
123025136  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
123036269  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
123024268  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123020042  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
123034117  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
123034269  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
123016513  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
123031759  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
123020722  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
123019210  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
123017266  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
123033150  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
123028815  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
123034861  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
123033133  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123033140  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
123032289  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
123032293  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
123032236  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
123035427  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123024633  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123033095  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123034854  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123032105  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
123025206  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123028568  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123027009  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
123022492  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
123035980  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
123030750  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
123031590  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
123026763  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
123032547  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
123033808  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
123025952  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
123023712  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123023393  NF1; neurofibromin isoform X1 [KO:K08052]
123031220  RASA1; ras GTPase-activating protein 1 [KO:K04352]
123024676  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123031805  RAP1A; ras-related protein Rap-1A [KO:K04353]
123033326  RAP1B; ras-related protein Rap-1b [KO:K07836]
123022650  EGF; pro-epidermal growth factor [KO:K04357]
123016830  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123031864  AREG; amphiregulin [KO:K09782]
123035817  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123035357  FGF22; fibroblast growth factor 22 [KO:K04358]
123036193  FGF20; fibroblast growth factor 20 [KO:K04358]
123027283  fibroblast growth factor 16-like [KO:K04358]
123031411  FGF10; fibroblast growth factor 10 [KO:K04358]
123027620  FGF7; fibroblast growth factor 7 [KO:K04358]
123022990  FGF5; fibroblast growth factor 5 [KO:K04358]
123029399  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
123026259  FGF3; fibroblast growth factor 3 [KO:K04358]
123030391  FGF18; fibroblast growth factor 18 [KO:K04358]
123026852  FGF4; fibroblast growth factor 4 [KO:K04358]
123026897  FGF8; fibroblast growth factor 8 [KO:K04358]
123026257  FGF19; fibroblast growth factor 19 [KO:K22603]
123032192  fibroblast growth factor 21-like [KO:K22429]
123032092  fibroblast growth factor 21-like [KO:K22429]
123017019  FGF23; fibroblast growth factor 23 [KO:K22428]
123021257  NGF; beta-nerve growth factor [KO:K02582]
123021214  BDNF; brain-derived neurotrophic factor [KO:K04355]
123019419  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
123030566  NTF4; neurotrophin-4 [KO:K12457]
123030601  neurotrophin-4-like isoform X1 [KO:K12457]
123021294  INS; insulin [KO:K04526]
123028864  IGF1; insulin-like growth factor I [KO:K05459]
123021242  IGF2; insulin-like growth factor II [KO:K13769]
123025095  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123036177  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123023846  PDGFC; platelet-derived growth factor C [KO:K05450]
123029234  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123029887  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123036289  KITLG; kit ligand isoform X1 [KO:K05461]
123032337  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123032604  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
123031485  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
123026157  snake venom vascular endothelial growth factor toxin vammin-like [KO:K05448]
123026720  PGF; placenta growth factor isoform X1 [KO:K16859]
123023457  VEGFD; vascular endothelial growth factor D [KO:K05449]
123023707  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
123023708  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
123020075  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123019336  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123019340  ANGPT2; angiopoietin-2 [KO:K05466]
123020764  angiopoietin-2-like [KO:K05466]
123036119  ANGPT4; angiopoietin-4 [KO:K05467]
123036636  EFNA2; ephrin-A2 [KO:K05462]
123032502  EFNA1; ephrin-A1 [KO:K05462]
123032650  EFNA4; ephrin-A4 [KO:K05462]
123032658  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123031205  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123024062  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123017627  NRTN; neurturin [KO:K25414]
123033903  ARTN; artemin isoform X1 [KO:K25415]
123023248  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
123031797  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
123033111  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123024389  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123026996  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123028381  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123032384  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
123033991  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123030616  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
123020797  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
123031550  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123025167  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
123030778  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123016964  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123035769  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123035743  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123017038  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
123029521  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123021962  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
123028973  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123035695  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123017072  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123019909  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
123022419  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123018815  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123018201  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123035461  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123022594  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123026535  SOS2; son of sevenless homolog 2 [KO:K03099]
123021252  HRAS; GTPase HRas isoform X1 [KO:K02833]
123032158  GTPase HRas-like [KO:K07827]
123022284  KRAS; GTPase KRas isoform X1 [KO:K07827]
123032138  NRAS; GTPase NRas isoform X1 [KO:K07828]
123030473  RRAS; ras-related protein R-Ras [KO:K07830]
123021140  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123027312  MRAS; ras-related protein M-Ras [KO:K07831]
123024016  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
123028858  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123034069  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
123030795  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123017589  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
123023126  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123032171  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123028606  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123035346  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
123028985  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
123021971  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
123018864  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123029577  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
123025882  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123036185  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123023991  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123031269  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
123033703  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
123022960  SRF; serum response factor isoform X1 [KO:K04378]
123026796  FOS; proto-oncogene c-Fos [KO:K04379]
123031722  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123026004  STMN1; stathmin isoform X1 [KO:K04381]
123027870  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123026284  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026285  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026286  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026289  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026290  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026292  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026293  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026366  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123030607  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
123030608  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
123026805  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
123026807  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123026808  cytosolic phospholipase A2 delta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123018023  TNF; tumor necrosis factor [KO:K03156]
123016817  interleukin-1 beta-like isoform X1 [KO:K04519]
123025913  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123032486  transforming growth factor beta-2 proprotein-like [KO:K13376]
123021868  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123026416  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123033212  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
123025377  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
123025408  interleukin-1 receptor-like 2 [KO:K04386]
123036789  interleukin-1 receptor accessory protein [KO:K04723]
123034988  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123027347  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
123016834  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123028014  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123018472  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
123024904  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
123028894  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123018124  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
123030987  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123025496  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123033290  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123018020  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
123028318  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123023897  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
123020809  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
123029999  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
123019899  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123026693  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
123031599  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123028561  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
123018714  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123035987  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
123019868  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
123030038  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
123023219  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
123021941  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
123025358  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
123025845  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
123033528  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123024864  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123028451  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
123020535  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
123032552  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
123020769  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
123031252  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
123032609  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
123027569  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
123031851  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123020993  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
123026781  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
123018327  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
123029829  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
123025691  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
123017082  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
123020316  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123026039  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04426] [EC:2.7.11.25]
123022147  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123019057  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
123032749  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
123032109  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
123023653  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
123035486  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123035442  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123024965  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123020202  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123030154  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
123026265  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
123023809  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
123024989  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
123030057  FLNA; filamin-A isoform X1 [KO:K04437]
123032314  crk-like protein [KO:K04438]
123023691  CRK; adapter molecule crk [KO:K04438]
123030292  CRKL; crk-like protein isoform X1 [KO:K04438]
123016637  ARRB2; beta-arrestin-2 [KO:K04439]
123017290  ARRB1; beta-arrestin-1 [KO:K04439]
123032363  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123035762  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123022757  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123020010  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123020058  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
123024287  mitogen-activated protein kinase HOG1-like [KO:K04441] [EC:2.7.11.24]
123028758  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
123031422  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123034304  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
123026938  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
123032543  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
123022515  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
123021648  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123025522  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
123023503  JUN; transcription factor AP-1 [KO:K04448]
123036593  JUND; transcription factor jun-D [KO:K04449]
123021813  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123016682  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
123029780  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123027365  MAX; protein max isoform X1 [KO:K04453]
123031554  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123036736  HSPB1; heat shock protein beta-1 [KO:K04455]
123017919  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123026376  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123021030  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123026373  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
123033298  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
123021234  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
123031974  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
123035828  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123034159  DUSP7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123021185  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123027548  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123016766  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123017152  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123017525  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123036508  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123030060  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
123032720  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123023472  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123030629  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
123026126  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
123023214  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
123032880  heat shock 70 kDa protein II-like [KO:K03283]
123028093  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123025846  heat shock cognate 71 kDa protein-like [KO:K03283]
123025609  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
123030697  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123019595  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
123019242  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
123031703  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
123018301  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123027007  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123030004  IKBKG; NF-kappa-B essential modulator [KO:K07210]
123032152  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
123023451  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
123022802  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123018287  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123032554  RELA; transcription factor p65 isoform X1 [KO:K04735]
123025801  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
vko04070  Phosphatidylinositol signaling system
vko04110  Cell cycle
vko04115  p53 signaling pathway
vko04210  Apoptosis
vko04310  Wnt signaling pathway
KO pathway
ko04010   
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