KEGG   PATHWAY: oaa04014
Entry
oaa04014                    Pathway                                
Name
Ras signaling pathway - Ornithorhynchus anatinus (platypus)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
oaa04014  Ras signaling pathway
oaa04014

Other DBs
GO: 0032318
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100090413  TGFA; protransforming growth factor alpha [KO:K08774]
100078822  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100075228  FGF4; fibroblast growth factor 4 [KO:K04358]
100075300  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
100089319  FGF9; fibroblast growth factor 9 [KO:K04358]
100073730  FGF5; fibroblast growth factor 5 [KO:K04358]
100093377  FGF18; fibroblast growth factor 18 [KO:K04358]
100089414  FGF22; fibroblast growth factor 22 [KO:K04358]
100088500  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100089135  FGF20; fibroblast growth factor 20 [KO:K04358]
100080372  FGF8; fibroblast growth factor 8 [KO:K04358]
100075757  FGF10; fibroblast growth factor 10 [KO:K04358]
103165700  FGF6; fibroblast growth factor 6 [KO:K04358]
100084373  FGF16; fibroblast growth factor 16 [KO:K04358]
114813732  FGF7; fibroblast growth factor 7 [KO:K04358]
100075189  FGF19; fibroblast growth factor 19 [KO:K22603]
114807786  FGF23; fibroblast growth factor 23 [KO:K22428]
100074403  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
100081142  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
100081420  NTF3; neurotrophin-3 [KO:K04356]
114814648  NTF4; neurotrophin-4 [KO:K12457]
114810063  INS; insulin [KO:K04526]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
791102  IGF2; insulin-like growth factor II [KO:K13769]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100080577  KITLG; kit ligand isoform X1 [KO:K05461]
103165584  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100093060  PGF; placenta growth factor [KO:K16859]
100082290  VEGFD; vascular endothelial growth factor D [KO:K05449]
100084886  VEGFC; vascular endothelial growth factor C [KO:K05449]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100075440  ANGPT1; angiopoietin-1 [KO:K05465]
100073414  ANGPT2; angiopoietin-2 [KO:K05466]
100085755  EFNA1; ephrin-A1 [KO:K05462]
100082899  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100085461  EFNA2; ephrin-A2 [KO:K05462]
100086594  ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462]
114807932  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100084641  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100081967  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100091625  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114816147  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
103167743  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100080080  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100079104  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100079755  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100075317  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100090467  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090796  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100087557  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100074264  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100090952  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100082582  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
100079362  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
114808180  SHC1; SHC-transforming protein 1 [KO:K06279]
100081397  SHC2; SHC-transforming protein 2 [KO:K17447]
100089978  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100086381  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100089033  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
100090421  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
100080124  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100083583  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
114809080  LAT; linker for activation of T-cells family member 1 [KO:K07362]
100081612  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100077049  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114807890  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100090311  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100073829  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100081114  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100084993  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100082845  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114805646  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100092247  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100076953  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100088135  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100081252  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114813799  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
100078907  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100081920  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100085219  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100077961  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114815157  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100078846  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100088079  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100080490  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100077219  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
100082705  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100074436  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100090612  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100075369  CALM1; calmodulin-1 [KO:K02183]
100083509  CALM2; calmodulin-2 [KO:K02183]
100085837  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103165382  calmodulin-A-like [KO:K02183]
114812128  CALM3; calmodulin-3 [KO:K02183]
114816270  CALML3; calmodulin-like protein 3 [KO:K02183]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
103169212  MRAS; ras-related protein M-Ras [KO:K07831]
114814624  RRAS; ras-related protein R-Ras [KO:K07829]
100090494  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100074914  NF1; neurofibromin isoform X4 [KO:K08052]
100080153  RASA1; ras GTPase-activating protein 1 [KO:K04352]
100079072  RASA2; ras GTPase-activating protein 2 [KO:K08053]
100085335  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
100083784  ras GTPase-activating protein 4-like [KO:K17630]
100076661  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
100085253  RASAL2; ras GTPase-activating protein nGAP isoform X6 [KO:K17633]
100074609  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
100078239  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100092666  RASSF5; ras association domain-containing protein 5 [KO:K08015]
100088971  STK4; serine/threonine-protein kinase 4 [KO:K04411]
100088712  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100092844  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114808823  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100086384  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100075896  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100073584  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
103169124  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100084350  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100084781  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100073613  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100082351  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100078925  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
114810030  BAD; bcl2-associated agonist of cell death [KO:K02158]
107546921  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114812846  FOXO4; forkhead box protein O4 [KO:K12358]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100081034  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
100074294  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
100074004  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
100080818  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100082013  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
103168009  RGL2; LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
100075904  RALA; ras-related protein Ral-A [KO:K07834]
100087330  RALB; ras-related protein Ral-B [KO:K07835]
100083157  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103169305  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100079012  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
114808671  exocyst complex component 2-like [KO:K17637]
100076520  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100081576  REL; proto-oncogene c-Rel [KO:K09254]
100073424  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100076033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100082590  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100081456  RALBP1; ralA-binding protein 1 [KO:K08773]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100074808  AFDN; afadin isoform X1 [KO:K05702]
100082328  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103166923  collagen alpha-1(VIII) chain isoform X2 [KO:K13618] [EC:3.1.1.111]
100076775  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
100073869  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100079251  phospholipase A2, minor isoenzyme [KO:K01047] [EC:3.1.1.4]
100085458  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100081113  phospholipase A2 homolog sphenotoxin basic subunit B [KO:K01047] [EC:3.1.1.4]
100077303  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
103170804  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100681539  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
114809128  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100075836  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
114812284  phospholipase A2 homolog sphenotoxin basic subunit B-like [KO:K01047] [EC:3.1.1.4]
103166456  basic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]
114809084  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114812189  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
114818237  LOW QUALITY PROTEIN: phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
100086135  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100085563  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100088466  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100088450  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100086783  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100681775  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100090638  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
100083387  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
114809961  LOW QUALITY PROTEIN: phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100681469  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100073925  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
100079227  ETS2; protein C-ets-2 [KO:K21932]
100075845  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
100075310  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
100084431  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
100083319  RAPGEF5; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 5 [KO:K08019]
100076731  RAP1A; ras-related protein Rap-1A [KO:K04353]
100079331  RAP1B; ras-related protein Rap-1b [KO:K07836]
103169567  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100093582  RIN1; ras and Rab interactor 1 [KO:K17638]
100075676  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100081824  ABL2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
100076995  RAB5A; ras-related protein Rab-5A [KO:K07887]
114814513  RAB5B; ras-related protein Rab-5B [KO:K07888]
100085869  RAB5C; ras-related protein Rab-5C [KO:K07889]
100093050  ADP-ribosylation factor 6-like [KO:K07941]
100077992  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
oaa04010  MAPK signaling pathway
oaa04015  Rap1 signaling pathway
oaa04020  Calcium signaling pathway
oaa04144  Endocytosis
oaa04151  PI3K-Akt signaling pathway
oaa04660  T cell receptor signaling pathway
oaa04720  Long-term potentiation
oaa04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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