KEGG   PATHWAY: cbai05163
Entry
cbai05163                   Pathway                                
Name
Human cytomegalovirus infection - Camelus bactrianus (Bactrian camel)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
cbai05163  Human cytomegalovirus infection
cbai05163

Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105077672  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105063312  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105071167  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105066839  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105082679  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105064416  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105065663  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105079975  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105083596  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105062855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105069721  TSC1; hamartin [KO:K07206]
105064853  TSC2; tuberin [KO:K07207]
105067026  RHEB; GTP-binding protein Rheb [KO:K07208]
105070974  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105070333  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105065845  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105081887  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105071245  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105076053  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105076396  NF-kappa-B essential modulator-like [KO:K07210]
105067913  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105070689  RELA; transcription factor p65 [KO:K04735]
105067674  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105065653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105078489  SOS2; son of sevenless homolog 2 [KO:K03099]
105078987  SOS1; son of sevenless homolog 1 [KO:K03099]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105062297  KRAS; GTPase KRas [KO:K07827]
105079555  NRAS; GTPase NRas [KO:K07828]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105078209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105079378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105076285  SP1; transcription factor Sp1 [KO:K04684]
105072910  ITGAV; integrin alpha-V [KO:K06487]
105069802  ITGB3; integrin beta-3 [KO:K06493]
105073493  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105077365  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105073153  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105065540  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105080261  RHOA; transforming protein RhoA [KO:K04513]
105064893  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105082187  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
105081359  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105062642  IRF3; interferon regulatory factor 3 [KO:K05411]
105061913  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
105082393  interferon alpha-1-like [KO:K05414]
105061875  interferon alpha-1-like [KO:K05414]
105061876  interferon alpha-1-like [KO:K05414]
105061880  interferon alpha-14-like [KO:K05414]
105061881  IFNB1; interferon beta [KO:K05415]
105074074  TNF; tumor necrosis factor [KO:K03156]
105071112  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105079771  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105074812  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105064517  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
105068625  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105072137  IL1B; interleukin-1 beta [KO:K04519]
105072217  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105079152  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105081283  CCL2; C-C motif chemokine 2 [KO:K14624]
105064286  CCL5; C-C motif chemokine 5 [KO:K12499]
105080383  CXCL8; interleukin-8 [KO:K10030]
105079801  IL6; interleukin-6 [KO:K05405]
105071051  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105067755  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105071086  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105063316  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105080494  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105070137  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105075111  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105069319  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
105062549  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
105082939  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105068344  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
105065706  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105082944  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105067298  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105078179  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105077045  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105082996  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105082997  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105070632  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105074761  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105062304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105064212  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105074723  calmodulin-like [KO:K02183]
105079857  CALM1; calmodulin [KO:K02183]
105079032  CALM2; calmodulin [KO:K02183]
105062547  CALM3; calmodulin [KO:K02183]
105069522  CALML4; calmodulin-like protein 4 [KO:K02183]
105071194  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105075369  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105067906  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105068979  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105069046  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105071843  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
105074856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105068820  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105083396  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105078712  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105080525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105081234  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105063873  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105068818  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105076187  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105074271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105082946  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105064797  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105064291  regakine-1-like [KO:K05408]
105064292  C-C motif chemokine 3-like [KO:K05408]
105064293  C-C motif chemokine 4 [KO:K12964]
105078688  CX3CL1; fractalkine isoform X1 [KO:K05508]
105078210  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105067606  LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
105063934  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105062465  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105068229  ARHGEF11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
105067864  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
105075203  AKAP13; LOW QUALITY PROTEIN: A-kinase anchor protein 13 [KO:K16529]
105071393  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
105076019  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105061760  CTNNB1; catenin beta-1 [KO:K02105]
105074575  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
105075540  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105070771  PTGER4; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP4 subtype [KO:K04261]
105071802  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
105071803  neuroendocrine secretory protein 55 [KO:K04632]
105081598  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105070367  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105082940  MYC; myc proto-oncogene protein [KO:K04377]
105068250  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105064618  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105080116  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
105083818  VEGFA; vascular endothelial growth factor A [KO:K05448]
105063918  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105064175  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105064176  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070806  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070807  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105072963  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105073454  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105073101  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105076770  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105078379  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105068196  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105063046  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105067333  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105082021  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105074031  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
105078516  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105083390  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105063850  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105074777  focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105078652  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
105070566  CRKL; crk-like protein [KO:K04438]
105071519  CRK; adapter molecule crk [KO:K04438]
105080562  paxillin isoform X1 [KO:K05760]
105067828  IL10RA; LOW QUALITY PROTEIN: interleukin-10 receptor subunit alpha [KO:K05134]
105070235  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
105064000  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050]
105061818  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105078726  CCR3; LOW QUALITY PROTEIN: C-C chemokine receptor type 3 [KO:K04178]
105078728  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105064241  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105064243  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105064223  TAPBP; tapasin [KO:K08058]
105076963  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105068326  CALR; calreticulin [KO:K08057]
105074080  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
105074082  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
105074083  LOW QUALITY PROTEIN: histocompatibility antigen-related [KO:K06751]
105074084  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
105074117  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
105065248  HLA class I histocompatibility antigen, Cw-8 alpha chain-like [KO:K06751]
105061640  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
105076977  B2M; beta-2-microglobulin [KO:K08055]
105081337  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105077515  TP53; cellular tumor antigen p53 [KO:K04451]
105064166  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105062140  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105083000  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105066145  RB1; retinoblastoma-associated protein [KO:K06618]
105073627  E2F1; transcription factor E2F1 [KO:K17454]
105071122  E2F2; transcription factor E2F2 [KO:K09389]
105061681  E2F3; transcription factor E2F3 [KO:K06620]
105070302  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105081852  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105070436  FADD; FAS-associated death domain protein [KO:K02373]
105082299  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105076073  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105062612  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105064215  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105079817  cytochrome c [KO:K08738]
105065989  cytochrome c [KO:K08738]
105070945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105067685  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
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Biomol Ther (Seoul) 25:69-79 (2017)
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Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
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PLoS One 7:e48935 (2012)
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G-protein-coupled receptors encoded by human herpesviruses.
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Trends Pharmacol Sci 26:405-11 (2005)
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Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
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Human cytomegalovirus gene expression in long-term infected glioma stem cells.
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PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
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PMID:24445563
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Vischer HF, Siderius M, Leurs R, Smit MJ
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Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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Nat Rev Drug Discov 13:123-39 (2014)
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PMID:20398729
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Mol Cell Endocrinol 331:179-84 (2011)
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Nat Immunol 2:116-22 (2001)
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PMID:16352349
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Vischer HF, Leurs R, Smit MJ
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HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
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Trends Pharmacol Sci 27:56-63 (2006)
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PMID:25805993
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de Munnik SM, Smit MJ, Leurs R, Vischer HF
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Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
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Front Pharmacol 6:40 (2015)
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Hum Immunol 65:465-75 (2004)
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Tu CC, Arnolds KL, O'Connor CM, Spencer JV
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J Virol 92:e01981-17 (2018)
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Biochim Biophys Acta 1768:952-63 (2007)
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Adv Immunol 92:225-305 (2006)
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Trends Microbiol 8:111-9 (2000)
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Med Res Rev 25:167-85 (2005)
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FEMS Microbiol Rev 28:59-77 (2004)
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Gene 290:19-34 (2002)
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Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
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J Cell Biochem 93:37-45 (2004)
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Brune W
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Virus Res 157:144-50 (2011)
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Brune W, Andoniou CE
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Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
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Viruses 9:E249 (2017)
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Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
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HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
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Cell Rep 15:1542-1553 (2016)
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Wang X, Sanchez J, Stone MJ, Payne RJ
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Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
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Angew Chem Int Ed Engl 56:8490-8494 (2017)
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Related
pathway
cbai00590  Arachidonic acid metabolism
cbai03050  Proteasome
cbai04010  MAPK signaling pathway
cbai04064  NF-kappa B signaling pathway
cbai04110  Cell cycle
cbai04150  mTOR signaling pathway
cbai04151  PI3K-Akt signaling pathway
cbai04210  Apoptosis
cbai04612  Antigen processing and presentation
cbai04623  Cytosolic DNA-sensing pathway
cbai04630  JAK-STAT signaling pathway
cbai04668  TNF signaling pathway
cbai04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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