KEGG   PATHWAY: csab05164
Entry
csab05164                   Pathway                                
Name
Influenza A - Chlorocebus sabaeus (green monkey)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
csab05164  Influenza A
csab05164

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103225829  tryptase alpha/beta-1 [KO:K01340] [EC:3.4.21.59]
103225859  tryptase delta [KO:K01340] [EC:3.4.21.59]
103240838  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
103227061  trypsin-1 [KO:K01312] [EC:3.4.21.4]
103227060  PRSS2; protease, serine 2 [KO:K01312] [EC:3.4.21.4]
103227062  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
103227063  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
103227064  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
103227334  trypsin-1-like [KO:K01312] [EC:3.4.21.4]
103227335  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
103247596  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
103219191  TMPRSS2; transmembrane protease, serine 2 [KO:K09633] [EC:3.4.21.122]
103248572  TMPRSS4; transmembrane protease, serine 4 [KO:K09635] [EC:3.4.21.-]
103235599  TMPRSS11D; transmembrane protease, serine 11D [KO:K09641] [EC:3.4.21.-]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103239154  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
103239155  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
103239156  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
103230468  RNASEL; ribonuclease L [KO:K01165]
103234043  DNAJB1; DnaJ heat shock protein family (Hsp40) member B1 [KO:K09507]
103214677  DNAJC3; DnaJ heat shock protein family (Hsp40) member C3 [KO:K09523]
103220482  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103229205  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
103242879  TRIM25; tripartite motif containing 25 [KO:K10652] [EC:2.3.2.27]
103219311  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:5.6.2.6]
103217190  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:5.6.2.6]
103248628  NLRX1; NLR family member X1 [KO:K12653]
103247611  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103234643  NFKBIB; NFKB inhibitor beta [KO:K02581]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103243627  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
103236634  TLR3; toll like receptor 3 [KO:K05401]
103233731  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
103229744  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103238638  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103230198  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103235050  IRF3; interferon regulatory factor 3 [KO:K05411]
103231770  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103223371  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103218937  TLR4; toll like receptor 4 [KO:K10160]
103231601  TLR7; toll like receptor 7 [KO:K05404]
103221064  MYD88; myeloid differentiation primary response 88 [KO:K04729]
103238180  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103226003  IRF7; interferon regulatory factor 7 [KO:K09447]
103241279  IL1A; interleukin 1 alpha [KO:K04383]
103241278  IL1B; interleukin 1 beta [KO:K04519]
103226390  IL6; interleukin 6 [KO:K05405]
103241402  IL12A; interleukin 12A [KO:K05406]
103244892  IL12B; interleukin 12B [KO:K05425]
103235786  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103242710  C-C motif chemokine 2 [KO:K14624]
103242750  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
103235824  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
103233893  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103219368  IFNA2; interferon alpha 2 [KO:K05414]
103219366  interferon alpha-1/13-like [KO:K05414]
103219367  IFNA8; interferon alpha 8 [KO:K05414]
103219370  interferon alpha-1/13 [KO:K05414]
103219372  interferon alpha-6 [KO:K05414]
103219377  interferon alpha-14 [KO:K05414]
103219378  interferon alpha-4-like [KO:K05414]
103219379  interferon alpha-4 [KO:K05414]
103219381  interferon alpha-17-like [KO:K05414]
103219383  IFNB1; interferon beta 1 [KO:K05415]
103216875  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103216889  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103224682  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103234360  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
103243658  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103217529  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103238525  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103228710  IRF9; interferon regulatory factor 9 [KO:K04693]
103219174  MX1; MX dynamin like GTPase 1 [KO:K14754]
103219159  MX2; MX dynamin like GTPase 2 [KO:K14754]
103223917  ADAR; adenosine deaminase, RNA specific [KO:K12968] [EC:3.5.4.37]
103245348  PML; promyelocytic leukemia [KO:K10054] [EC:2.3.2.-]
103238673  IFNG; interferon gamma [KO:K04687]
103240303  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103216867  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103219496  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103228144  CIITA; class II major histocompatibility complex transactivator [KO:K08060] [EC:2.7.11.1]
103221682  MHC-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
103221683  MHC-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
103221684  MHC-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
103221688  MHC-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103221689  MHC-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
103221695  MHC-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
103221696  MHC-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
103221698  MHC-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
103221700  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
103221702  HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
103221704  MHC-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
103247136  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
103247138  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
103247148  HLA class II histocompatibility antigen, DRB1-15 beta chain [KO:K06752]
103230928  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
103231357  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
103248363  caspase-1-like [KO:K01370] [EC:3.4.22.36]
103248365  CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
103248933  caspase-1-like [KO:K01370] [EC:3.4.22.36]
103248464  IL18; interleukin 18 [KO:K05482]
103219472  IL33; interleukin 33 [KO:K12967]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103221504  CCND3; cyclin D3 [KO:K10152]
103238589  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103226555  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103221246  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
103215472  TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
103215469  TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722]
103230577  FASLG; Fas ligand [KO:K04389]
103216224  FAS; Fas cell surface death receptor [KO:K04390]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103233291  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103245758  FADD; Fas associated via death domain [KO:K02373]
103217637  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103222876  BID; BH3 interacting domain death agonist [KO:K04726]
103235004  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103221651  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103244541  VDAC1; voltage dependent anion channel 1 [KO:K05862]
103236621  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
103236238  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
103247519  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
103247334  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
103220507  ADP/ATP translocase 2-like [KO:K05863]
103239827  cytochrome c [KO:K08738]
103225665  cytochrome c-like [KO:K08738]
103228018  cytochrome c-like [KO:K08738]
103244190  cytochrome c-like [KO:K08738]
103224843  cytochrome c-like [KO:K08738]
103240990  cytochrome c-like [KO:K08738]
103219556  cytochrome c-like [KO:K08738]
103238923  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
103225550  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103243113  CPSF4L; cleavage and polyadenylation specific factor 4 like [KO:K14404]
103246784  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
103231469  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
103233463  PABPN1L; poly(A) binding protein nuclear 1 like, cytoplasmic [KO:K14396]
103232947  polyadenylate-binding protein 2-like [KO:K14396]
103233854  NXF1; nuclear RNA export factor 1 [KO:K14284]
103232389  nuclear RNA export factor 2-like [KO:K14284]
103232394  nuclear RNA export factor 2 [KO:K14284]
103232396  NXF3; nuclear RNA export factor 3 [KO:K14284]
103232373  uncharacterized LOC103232373 [KO:K14284]
103232476  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
103215397  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
103234726  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U like 1 [KO:K15047]
103243755  RAE1; ribonucleic acid export 1 [KO:K14298]
103247974  NUP98; nucleoporin 98 [KO:K14297]
103220885  RSAD2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
103231848  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103223880  FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103243719  ACTG1; actin gamma 1 [KO:K05692]
103215020  actin, cytoplasmic 2-like [KO:K05692]
103246953  ACTB; actin beta [KO:K05692]
103217237  actin, cytoplasmic 2-like [KO:K05692]
103219323  actin, cytoplasmic 1 [KO:K05692]
103240948  actin, cytoplasmic 2-like [KO:K05692]
103245458  RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
103233840  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
103220190  XPO1; exportin 1 [KO:K14290]
103228184  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
103243153  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
103246786  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
103225204  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
103240502  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
csab00900  Terpenoid backbone biosynthesis
csab03013  Nucleocytoplasmic transport
csab03015  mRNA surveillance pathway
csab04010  MAPK signaling pathway
csab04110  Cell cycle
csab04144  Endocytosis
csab04210  Apoptosis
csab04620  Toll-like receptor signaling pathway
csab04621  NOD-like receptor signaling pathway
csab04622  RIG-I-like receptor signaling pathway
csab04630  JAK-STAT signaling pathway
csab05416  Viral myocarditis
KO pathway
ko05164   
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