KEGG   PATHWAY: hmh04621
Entry
hmh04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Hylobates moloch (silvery gibbon)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
hmh04621  NOD-like receptor signaling pathway
hmh04621

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116812602  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
116813394  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116480724  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116483283  IL1B; interleukin-1 beta [KO:K04519]
116476942  IL18; interleukin-18 [KO:K05482]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116467002  CXCL8; interleukin-8 [KO:K10030]
116466971  C-X-C motif chemokine 2 isoform X1 [KO:K05505]
116475080  C-X-C motif chemokine 3 [KO:K05505]
116475085  CXCL1; growth-regulated alpha protein [KO:K05505]
116474482  C-C motif chemokine 2 isoform X1 [KO:K14624]
116474527  CCL5; C-C motif chemokine 5 [KO:K12499]
116472331  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
116472391  defensin alpha 5-like [KO:K05230]
116472392  theta defensin subunit A-like [KO:K05230]
116472393  defensin alpha 4 [KO:K05230]
116472394  DEFA6; defensin-6 [KO:K05230]
116473839  neutrophil defensin 1-like [KO:K05230]
116470416  defensin beta 4A [KO:K21100]
116464371  beta-defensin 103A-like [KO:K23126]
116471250  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
116469793  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116458812  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
116463159  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116463202  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116811588  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116457363  JUN; transcription factor Jun [KO:K04448]
116810051  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
116470420  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
116470919  ATG12; ubiquitin-like protein ATG12 isoform X2 [KO:K08336]
116459322  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
116470809  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
116463324  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
116472669  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
116463648  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
116459062  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
116470731  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
116461498  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
116479655  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
116457645  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
116467322  SUGT1; protein SGT1 homolog [KO:K12795]
116813688  SHARPIN; sharpin isoform X1 [KO:K20894]
116461172  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
116484958  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
116484196  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116479588  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
116457076  CARD6; LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 6 [KO:K12797]
116463836  thyroid receptor-interacting protein 6 [KO:K12792]
116463863  thyroid receptor-interacting protein 6-like [KO:K12792]
116462762  ERBIN; erbin isoform X2 [KO:K12796]
116476859  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
116476860  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116457552  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116475862  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
116472893  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
116461432  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116480802  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
116457541  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116810749  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
116478197  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116466580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
116458330  interferon alpha-5 [KO:K05414]
116458331  interferon alpha-6 [KO:K05414]
116458332  interferon alpha-2 [KO:K05414]
116458527  interferon alpha-14 [KO:K05414]
116458611  interferon alpha-1/13 [KO:K05414]
116458660  interferon alpha-8 [KO:K05414]
116458843  IFNB1; interferon beta [KO:K05415]
116477052  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
116466466  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
116483057  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
116458363  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
116471192  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
116476876  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116461353  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
116473814  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
116457664  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
116476818  PANX1; pannexin-1 [KO:K03443]
116477795  P2RX7; P2X purinoceptor 7 [KO:K05220]
116482271  TRPM2; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
116481437  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X3 [KO:K04982] [EC:2.7.11.1]
116459027  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
116466872  CASR; extracellular calcium-sensing receptor isoform X1 [KO:K04612]
116475834  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116466681  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116472793  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116459671  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116811837  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
116471501  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116459956  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116461833  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116463675  calcium uniporter protein, mitochondrial [KO:K20858]
116463690  calcium uniporter protein, mitochondrial [KO:K20858]
116477889  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X2 [KO:K14216] [EC:2.7.7.84]
116477890  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
116477891  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
116457570  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
116458608  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
116468372  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX33-like [KO:K17820] [EC:5.6.2.6]
116812936  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
116459720  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
116484981  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
116472822  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
116814220  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
116811598  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
116470716  cytochrome b-245 light chain [KO:K08009]
116468014  TXNIP; thioredoxin-interacting protein [KO:K20910]
116475533  TXN; thioredoxin [KO:K03671]
116458929  TXN2; thioredoxin, mitochondrial [KO:K03671]
116485115  thioredoxin-like [KO:K03671]
116466686  thioredoxin-like [KO:K03671]
116482881  thioredoxin-like [KO:K03671]
116457548  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
116811225  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
116471919  LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
116485178  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
116460213  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
116478265  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
116460321  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
116471725  IRGM; immunity-related GTPase family M protein [KO:K14139] [EC:3.6.5.-]
116471194  PYDC1; LOW QUALITY PROTEIN: pyrin domain-containing protein 1 [KO:K12802]
116480131  PYDC2; LOW QUALITY PROTEIN: pyrin domain-containing protein 2 [KO:K20911]
116462414  MEFV; pyrin [KO:K12803]
116482563  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116476195  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
116466560  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
116479187  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform X1 [KO:K20864]
116479703  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X2 [KO:K20865]
116462608  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
116480547  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
116473376  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
116469799  GBP5; guanylate-binding protein 5 isoform X1 [KO:K20898]
116469241  AIM2; interferon-inducible protein AIM2 [KO:K12966]
116469242  gamma-interferon-inducible protein 16 isoform X1 [KO:K20914]
116482070  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
116467911  PYDC5; LOW QUALITY PROTEIN: pyrin domain-containing protein 5 [KO:K20916]
116469279  transforming protein RhoA-like [KO:K04513]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116479519  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
116467394  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
116467486  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
116464828  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
116465256  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
116469808  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
116458285  YWHAE; 14-3-3 protein epsilon [KO:K06630]
116469798  GBP4; guanylate-binding protein 4 [KO:K20899]
116469801  GBP7; guanylate-binding protein 7 [KO:K20899]
116469802  guanylate-binding protein 1-like [KO:K20899]
116469803  guanylate-binding protein 3 isoform X1 [KO:K20899]
116476875  caspase-5 isoform X1 [KO:K04395] [EC:3.4.22.58]
116476873  caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
116813661  GSDMD; gasdermin-D [KO:K20917]
116481707  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116482629  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116457829  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116478444  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
116810529  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116480910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
116484959  IRF9; interferon regulatory factor 9 [KO:K04693]
116475593  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
116457855  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
116483533  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
116473667  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116481090  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116471574  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
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Gasdermin D: the long-awaited executioner of pyroptosis.
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Cell Res 25:1183-4 (2015)
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PMID:22819539
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Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell 150:606-19 (2012)
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PMID:21575908
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Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
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Cell Host Microbe 9:363-75 (2011)
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PMID:29148036
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Heilig R, Broz P
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Function and mechanism of the pyrin inflammasome.
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Eur J Immunol 48:230-238 (2018)
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PMID:25816776
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RNase L activates the NLRP3 inflammasome during viral infections.
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Cell Host Microbe 17:466-77 (2015)
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pathway
hmh04010  MAPK signaling pathway
hmh04064  NF-kappa B signaling pathway
hmh04140  Autophagy - animal
hmh04620  Toll-like receptor signaling pathway
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ko04621   
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