KEGG   PATHWAY: hmh05169
Entry
hmh05169                    Pathway                                
Name
Epstein-Barr virus infection - Hylobates moloch (silvery gibbon)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
hmh05169  Epstein-Barr virus infection
hmh05169

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116457505  CR2; complement receptor type 2 isoform X2 [KO:K04012]
116470199  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
116460144  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
116460248  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
116460249  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
116460315  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
116460316  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
116460317  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
116460318  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
116460319  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
116460327  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
116460329  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
116460331  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
116460420  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
116460328  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
116465400  TLR2; toll-like receptor 2 [KO:K10159]
116473667  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116481090  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116812171  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116458812  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
116463159  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116463202  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116469793  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116475391  RIGI; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
116461432  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116480802  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
116457541  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116466580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
116478197  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116458330  interferon alpha-5 [KO:K05414]
116458331  interferon alpha-6 [KO:K05414]
116458332  interferon alpha-2 [KO:K05414]
116458527  interferon alpha-14 [KO:K05414]
116458611  interferon alpha-1/13 [KO:K05414]
116458660  interferon alpha-8 [KO:K05414]
116458843  IFNB1; interferon beta [KO:K05415]
116481707  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116482629  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116457829  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116478444  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
116810529  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116480910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
116484959  IRF9; interferon regulatory factor 9 [KO:K04693]
116484273  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
116477889  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X2 [KO:K14216] [EC:2.7.7.84]
116477890  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
116477891  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
116466806  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
116812759  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116459453  BID; BH3-interacting domain death agonist [KO:K04726]
116483374  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116478225  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
116459971  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
116813623  LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer-like [KO:K14021]
116476907  cytochrome c-like [KO:K08738]
116809676  cytochrome c-like [KO:K08738]
116811446  cytochrome c-like [KO:K08738]
116471160  cytochrome c [KO:K08738]
116812987  cytochrome c isoform X2 [KO:K08738]
116479141  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116477006  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
116477007  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
116477008  T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
116472445  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
116461712  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7 [KO:K03061]
116814198  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
116809684  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
116471161  26S proteasome regulatory subunit 4-like [KO:K03062]
116456295  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
116480690  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
116813279  26S proteasome regulatory subunit 10B-like [KO:K03064]
116456332  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
116476272  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
116458738  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
116479902  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
116810091  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
116474767  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
116483230  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
116474472  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
116466621  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
116471451  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
116466559  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
116469451  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
116810748  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
116480744  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
116461465  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
116813839  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
116460421  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
116460419  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
116459839  TAPBP; tapasin isoform X1 [KO:K08058]
116464358  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
116464361  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
116478555  CALR; calreticulin [KO:K08057]
116459773  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
116460053  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
116460055  patr class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
116460058  patr class I histocompatibility antigen, CH28 alpha chain [KO:K06751]
116460103  class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
116482632  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
116456298  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
116482404  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
116471149  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116472879  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
116477712  NCOR2; nuclear receptor corepressor 2 isoform X7 [KO:K06065]
116471752  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
116466027  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
116810642  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
116460964  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
116457111  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
116479977  HES1; transcription factor HES-1 [KO:K06054]
116478365  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
116813088  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
116462225  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
116478988  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116460475  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116469918  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116483299  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116475228  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116476282  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
116462469  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
116457552  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116474979  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
116482928  RELB; transcription factor RelB isoform X1 [KO:K09253]
116484343  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116471376  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
116480724  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
116460215  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
116459332  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116459720  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
116483006  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116483711  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116457363  JUN; transcription factor Jun [KO:K04448]
116473631  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X2 [KO:K01510] [EC:3.6.1.5]
116456890  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
116475492  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
116461078  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
116476359  CD44; CD44 antigen isoform X2 [KO:K06256]
116470180  ITGAL; integrin alpha-L [KO:K05718]
116469554  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
116478438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
116475444  VIM; vimentin [KO:K07606]
116472893  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
116478681  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
116474863  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116813281  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
116475231  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
116481932  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116480287  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116811871  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
116456856  BLNK; B-cell linker protein isoform X1 [KO:K07371]
116470775  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116456910  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
116472702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116472548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
116460133  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116814109  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
116463537  CCNA2; cyclin-A2 [KO:K06627]
116467081  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
116478827  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
116813431  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116480938  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116467261  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
116461337  E2F1; transcription factor E2F1 [KO:K17454]
116813063  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
116459750  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
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  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
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Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
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Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
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Kang H, Kiess A, Chung CH
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Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
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Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
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Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Reference
PMID:25635182
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Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
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Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
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Future Virol 4:79-91 (2009)
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Reference
PMID:10818681
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Longnecker R
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Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
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Reference
PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
hmh03050  Proteasome
hmh04010  MAPK signaling pathway
hmh04020  Calcium signaling pathway
hmh04064  NF-kappa B signaling pathway
hmh04110  Cell cycle
hmh04115  p53 signaling pathway
hmh04210  Apoptosis
hmh04612  Antigen processing and presentation
hmh04620  Toll-like receptor signaling pathway
hmh04622  RIG-I-like receptor signaling pathway
hmh04630  JAK-STAT signaling pathway
hmh04662  B cell receptor signaling pathway
KO pathway
ko05169   
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