Entry
Name
Arachidonic acid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Ortholog table
Drug
D00118 Naproxen (JP18/USP/INN)
D00120 Sulindac (JP18/USP/INN)
D00126 Ibuprofen (JP18/USP/INN)
D00127 Piroxicam (JP18/USP/INN)
D00130 Diflunisal (JAN/USP/INN)
D00132 Ketoprofen (JP18/USP/INN)
D00151 Mefenamic acid (JP18/USP/INN)
D00158 Tolmetin sodium (JAN/USP)
D00169 Meclofenamate sodium (USP)
D00217 Acetaminophen (JP18/USP)
D00315 Etodolac (JP18/USP/INN)
D00330 Flurbiprofen (JP18/USP/INN)
D00425 Nabumetone (JP18/USP/INN)
D00463 Oxaprozin (JP18/USP/INN)
D00510 Phenylbutazone (JP18/USP/INN)
D00566 Sodium salicylate (JP18/USP)
D00567 Celecoxib (JP18/USP/INN)
D00568 Rofecoxib (JAN/USAN/INN)
D00810 Choline salicylate (JAN/USAN/INN)
D00813 Ketorolac tromethamine (USP)
D00827 Magnesium salicylate (USP)
D00903 Diclofenac potassium (USP)
D00904 Diclofenac sodium (JP18/USP)
D00968 Fenoprofen calcium (JAN/USP)
D00969 Meloxicam (JAN/USP/INN)
D01122 Ibuprofen piconol (JP18/USAN)
D01183 Tolfenamic acid (JAN/INN)
D01252 Alclofenac (JAN/USP/INN)
D01325 Tiaprofenic acid (JAN/INN)
D01344 Fenbufen (JP18/USAN/INN)
D01410 Benzydamine hydrochloride (JAN/USAN)
D01475 Flurbiprofen axetil (JAN)
D01513 Alminoprofen (JP18/INN)
D01527 Epidihydrocholesterin (JAN)
D01557 Glycol salicylate (JAN)
D01565 Indometacin farnesil (JAN)
D01581 Flufenamic acid (JAN/USAN/INN)
D01675 Felbinac (JP18/USAN/INN)
D01683 Ozagrel hydrochloride hydrate (JAN)
D01709 Loxoprofen sodium hydrate (JP18)
D01765 Proglumetacin maleate (JAN)
D01767 Tenoxicam (JAN/USAN/INN)
D01773 Oxatomide (JAN/USAN/INN)
D01811 Salicylamide (JAN/USP/INN)
D01866 Lornoxicam (JAN/USAN/INN)
D01974 Tilmacoxib (JAN/USAN/INN)
D02110 Indomethacin sodium (USP)
D02290 Flurbiprofen sodium (USP)
D02341 Meclofenamic acid (USAN/INN)
D03080 Benoxaprofen (USAN/INN)
D03163 Bromfenac sodium (USAN)
D03254 Flufenamate aluminum (JAN)
D03652 Darbufelone mesylate (USAN)
D03663 Dazoxiben hydrochloride (USAN)
D03715 Dexibuprofen (USAN/INN)
D03717 Parecoxib sodium (USAN)
D03718 Dexibuprofen lysine (USAN)
D03990 Enazadrem phosphate (USAN)
D04276 Furegrelate sodium (USAN)
D04490 Ibuprofen aluminum (USAN)
D05143 Nepafenac (JAN/USAN/INN)
D05181 Aspirin aluminum (JP18)
D05319 Oxyphenbutazone hydrate
D05451 Phenbutazone sodium glycerate (USAN)
D05499 Piriprost potassium (USAN)
D05511 Piroxicam betadex (USAN)
D05512 Piroxicam cinnamate (USAN)
D05513 Piroxicam olamine (USAN)
D05598 Pravadoline maleate (USAN)
D05791 Salicylate meglumine (USAN)
D06606 Ibuprofen lysine (USAN)
D07453 Amtolmetin guacil (INN)
D07580 Aspirin DL-lysine (JAN)
D07817 Diclofenac diethylamine
D08058 Ibuprofen arginine salt
D08375 Piketoprofen hydrochloride
D08434 Propacetamol hydrochloride
D08501 Trolamine salicylate (USP)
D09760 Ibuprofen sodium (USAN)
D10017 Naproxen etemesil (USAN)
D12510 Utreloxastat (USAN/INN)
D12595 Aspirin trelamine (USAN)
D12596 Aspirin trelamine hydrochloride (USAN)
D12597 Ibuprofen trelamine (USAN)
D12598 Ibuprofen trelamine hydrochloride (USAN)
Other DBs
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
1571 CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415 ] [EC:1.14.14.-]
242 ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021 ] [EC:1.13.11.-]
1555 CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709 ] [EC:1.14.14.-]
Compound
C03577 20-Hydroxyleukotriene E4
C04671 (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707 (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742 (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758 (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04835 (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C05958 Delta-12-Prostaglandin J2
C05959 11-epi-Prostaglandin F2alpha
C05960 15-Keto-prostaglandin F2alpha
C05961 6-Keto-prostaglandin F1alpha
C05962 6-Keto-prostaglandin E1
C05964 11-Dehydro-thromboxane B2
C13809 9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717 15-Deoxy-Delta12,14-PGJ2
C14794 2,3-Dinor-8-iso prostaglandin F2alpha
C14795 2,3-Dinor-8-iso prostaglandin F1alpha
Reference
Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
Journal
Reference
Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
Journal
Reference
Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Journal
Reference
Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
Journal
Reference
Authors
Sacerdoti D, Gatta A, McGiff JC.
Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
Journal
Reference
Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
Journal
Reference
Authors
Fleming I.
Title
Cytochrome p450 and vascular homeostasis.
Journal
Reference
Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
Journal
Reference
Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
Journal
Reference
Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
Journal
Related pathway
KO pathway
LinkDB
All DBs