KEGG   PATHWAY: mze04010
Entry
mze04010                    Pathway                                
Name
MAPK signaling pathway - Maylandia zebra (zebra mbuna)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mze04010  MAPK signaling pathway
mze04010

Other DBs
GO: 0000165
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101484868  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101480217  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101480715  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101486272  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101471946  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101485620  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101474865  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101487658  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101485592  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101480057  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
101472797  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
101479737  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101485565  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
101477663  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101464297  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101479917  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101476728  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101486293  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101472221  voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
101483348  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101486968  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101467919  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860]
101471649  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101471517  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101472736  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101477065  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101472360  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
101483550  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101481806  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101466725  voltage-dependent L-type calcium channel subunit beta-4 isoform X3 [KO:K04865]
101487402  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101482453  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
101483772  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101463732  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101478451  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101465780  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101487690  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101482156  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
101463767  cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
101486527  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101471937  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101482520  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101474381  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101481740  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101482025  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
101473306  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
101482847  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101482575  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101470440  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101473852  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101487097  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101464257  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101465488  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101478005  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101481445  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
101473086  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101471056  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101473727  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
101470124  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112429968  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
101478346  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101470341  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101486266  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101465092  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101468521  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101465581  calcineurin subunit B type 1 [KO:K06268]
101487274  ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101468493  ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
101475482  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101486672  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101487894  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101480824  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
101472166  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101465816  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101478031  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101469290  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101469547  nf1; neurofibromin isoform X1 [KO:K08052]
101473967  rasa1; ras GTPase-activating protein 1 [KO:K04352]
101475471  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101466020  ras-related protein Rap-1A [KO:K04353]
101483640  ras-related protein Rap-1A [KO:K04353]
101471329  ras-related protein Rap-1b [KO:K07836]
101487082  egf; pro-epidermal growth factor [KO:K04357]
101486967  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
101481723  proepiregulin [KO:K09784]
101481239  proheparin-binding EGF-like growth factor [KO:K09782]
101468745  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
101481636  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101483487  fgf2; fibroblast growth factor 2 [KO:K18497]
101478433  fibroblast growth factor 20 [KO:K04358]
101472197  fibroblast growth factor 4-like [KO:K04358]
101473890  fgf6; fibroblast growth factor 6 [KO:K04358]
101484789  fgf3; fibroblast growth factor 3 [KO:K04358]
101486215  fgf4; fibroblast growth factor 4 [KO:K04358]
101475147  fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101471616  fgf16; fibroblast growth factor 16 [KO:K04358]
101474337  fibroblast growth factor 8b [KO:K04358]
101475610  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101466278  fibroblast growth factor 5 [KO:K04358]
101480132  fibroblast growth factor 20 [KO:K04358]
101473889  fibroblast growth factor 18 isoform X1 [KO:K04358]
101464481  fgf10; fibroblast growth factor 10 [KO:K04358]
101478942  fibroblast growth factor 6 [KO:K04358]
101487959  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101481167  fibroblast growth factor 18 isoform X1 [KO:K04358]
101467905  fibroblast growth factor 22 [KO:K04358]
101479827  fgf5; fibroblast growth factor 5 [KO:K04358]
101484510  fgf19; fibroblast growth factor 19 [KO:K22603]
101485258  fgf21; fibroblast growth factor 21 [KO:K22429]
101479227  fgf23; fibroblast growth factor 23 [KO:K22428]
101468558  nerve growth factor [KO:K02582]
101486340  nerve growth factor [KO:K02582]
101486366  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101473386  ntf3; neurotrophin-3 [KO:K04356]
101469513  insulin [KO:K04526]
101468103  ins; insulin [KO:K04526]
101476517  igf1; insulin-like growth factor I [KO:K05459]
101464291  insulin-like growth factor I [KO:K05459]
101468736  igf2; insulin-like growth factor II [KO:K13769]
101486854  platelet-derived growth factor subunit A [KO:K04359]
101486813  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
112432818  platelet-derived growth factor subunit A-like [KO:K04359]
101487929  mastermind-like domain-containing protein 1 [KO:K17386]
101473381  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101466155  pdgfc; platelet-derived growth factor C [KO:K05450]
101479983  uncharacterized protein LOC101479983 isoform X1 [KO:K05461]
101465508  kitlg; kit ligand [KO:K05461]
101480857  uncharacterized protein LOC101480857 [KO:K05461]
101472090  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101467969  vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448]
101474897  pgf; placenta growth factor isoform X1 [KO:K16859]
101480538  vascular endothelial growth factor A-A isoform X2 [KO:K16859]
101477124  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
101486579  vascular endothelial growth factor C [KO:K05449]
101479861  vegfd; vascular endothelial growth factor D [KO:K05449]
101486965  hepatocyte growth factor isoform X1 [KO:K05460]
101470516  hgf; hepatocyte growth factor [KO:K05460]
101488097  angpt1; angiopoietin-1 [KO:K05465]
101470933  angiopoietin-4 isoform X1 [KO:K05465]
101482218  angiopoietin-2 [KO:K05466]
101467910  angpt2; angiopoietin-2 [KO:K05466]
101475191  ephrin-A2 [KO:K05462]
101479095  ephrin-A1 [KO:K05462]
101479377  ephrin-A3 [KO:K05462]
101479854  ephrin-A4 isoform X2 [KO:K05462]
101487687  ephrin-A5b isoform X1 [KO:K05462]
101485854  ephrin-A2 isoform X1 [KO:K05462]
101485613  efna5; ephrin-A5 isoform X1 [KO:K05462]
101471458  ephrin-A1 isoform X2 [KO:K05462]
101471750  ephrin-A3 isoform X1 [KO:K05462]
101482940  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
101471543  glial cell line-derived neurotrophic factor-like [KO:K05452]
101472146  neurturin [KO:K25414]
101476374  artemin [KO:K25415]
101477281  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
101483528  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101482712  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101465105  receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
101469990  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101467929  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
101478875  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101480030  tyrosine-protein kinase SRK3 [KO:K04362] [EC:2.7.10.1]
101469987  fibroblast growth factor receptor 1-A isoform X3 [KO:K04362] [EC:2.7.10.1]
101470033  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
101463957  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101476450  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101477307  fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101487557  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101472190  tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
101487269  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101473195  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101477733  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101467169  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101480309  insulin receptor [KO:K04527] [EC:2.7.10.1]
101469999  insulin receptor [KO:K04527] [EC:2.7.10.1]
101469217  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101479543  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101471693  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101484671  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101466822  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101484032  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
101466356  macrophage colony-stimulating factor 1 receptor 2 isoform X1 [KO:K05090] [EC:2.7.10.1]
101477603  mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
101472356  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101480562  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101480071  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101479515  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101478748  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
101463681  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101472847  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101465566  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101485153  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
101464964  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
101475370  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112434355  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
101467818  grb2; growth factor receptor-bound protein 2 [KO:K04364]
101477192  GRB2-related adaptor protein 2 isoform X1 [KO:K04364]
101471030  sos2; son of sevenless homolog 2 [KO:K03099]
101471853  sos1; son of sevenless homolog 1 [KO:K03099]
101474892  hras; GTPase HRas [KO:K02833]
101465888  kras; GTPase KRas isoform X1 [KO:K07827]
101485266  GTPase HRas [KO:K07827]
101467469  ras-related protein R-Ras isoform X2 [KO:K07830]
101468923  rras2; ras-related protein R-Ras2 [KO:K07830]
101469336  mras; ras-related protein M-Ras [KO:K07831]
101471760  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101476445  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101470685  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101465184  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101484555  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101478402  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101469421  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
101486997  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101474234  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101465276  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101476821  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101466718  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101475486  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101485772  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101486250  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
101475680  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101464981  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101482089  ETS domain-containing protein Elk-1 [KO:K04375]
101467719  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
101464606  transcriptional regulator Myc-2 isoform X1 [KO:K04377]
101479046  transcriptional regulator Myc-A [KO:K04377]
101474120  myc; myc proto-oncogene protein [KO:K04377]
101469646  serum response factor [KO:K04378]
101469584  srf; serum response factor isoform X1 [KO:K04378]
101487312  proto-oncogene c-Fos [KO:K04379]
101487601  proto-oncogene c-Fos [KO:K04379]
101467033  proto-oncogene c-Fos [KO:K04379]
101463783  microtubule-associated protein tau isoform X1 [KO:K04380]
101481951  microtubule-associated protein tau [KO:K04380]
101477131  stathmin [KO:K04381]
101465203  stathmin [KO:K04381]
101466951  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
101477336  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101480888  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101469924  tumor necrosis factor [KO:K03156]
101467886  lymphotoxin-alpha [KO:K03156]
101472170  tumor necrosis factor [KO:K03156]
101472948  interleukin-1 beta-like [KO:K04519]
101473431  interleukin-1 beta-like [KO:K04519]
101485031  interleukin-1 beta isoform X1 [KO:K04519]
101481848  interleukin-1 beta [KO:K04519]
101473892  transforming growth factor beta-1 [KO:K13375]
101466107  transforming growth factor beta-2 [KO:K13376]
101469764  tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101467951  transforming growth factor beta-3 [KO:K13377]
101470853  transforming growth factor beta-3 [KO:K13377]
101476032  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K03158]
101479156  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
101470103  interleukin-1 receptor type 1 [KO:K04386]
101469783  interleukin-1 receptor accessory protein [KO:K04723]
101476087  interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
101479229  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101478446  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101465777  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101479131  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112430746  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
112435557  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
101467059  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101473046  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101463633  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101483895  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105941067  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101485378  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101485652  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101488012  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101467064  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101465436  cell division control protein 42 homolog [KO:K04393]
101466111  cell division control protein 42 homolog [KO:K04393]
101466863  cell division control protein 42 homolog [KO:K04393]
101480754  cell division control protein 42 homolog isoform X2 [KO:K04393]
101479607  cell division control protein 42 homolog [KO:K04393]
101472760  cell division control protein 42 homolog [KO:K04393]
112430189  cdc42 homolog [KO:K04393]
101483832  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101464077  caspase-3 [KO:K02187] [EC:3.4.22.56]
101463771  caspase-3 [KO:K02187] [EC:3.4.22.56]
101478576  caspase-3 [KO:K02187] [EC:3.4.22.56]
101467121  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101473415  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101472424  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101483949  death domain-associated protein 6 [KO:K02308]
101476408  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101465239  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101482950  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101469001  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101486438  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101471114  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101471410  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101471344  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101463564  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101463858  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101479184  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101486094  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101470608  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101484781  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101482482  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101475842  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101484057  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101476887  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101483446  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101482059  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101483196  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101482829  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101473947  serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101482544  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101476981  serine/threonine-protein kinase 3 [KO:K04412]
112431887  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
101481348  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101484222  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101463885  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101464541  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101475626  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
101468082  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101472971  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101477145  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101481641  mitogen-activated protein kinase kinase kinase 21 isoform X3 [KO:K17534] [EC:2.7.11.25]
101486282  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101478940  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101463743  map3k13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
101472093  mitogen-activated protein kinase kinase kinase 7 [KO:K04424] [EC:2.7.11.25]
101484425  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101482122  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101473117  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101484924  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101475992  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101485830  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101466358  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101482483  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101482619  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101482801  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101464345  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101478377  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101483027  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101475777  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101479195  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101473145  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101473047  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
101485749  C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101479729  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
101469207  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X5 [KO:K04436]
101465053  LOW QUALITY PROTEIN: filamin-A [KO:K04437]
101470907  adapter molecule crk [KO:K04438]
101472174  crkl; crk-like protein [KO:K04438]
101468680  adapter molecule crk [KO:K04438]
101482861  beta-arrestin-1 [KO:K04439]
101470144  arrb2; beta-arrestin-2 isoform X3 [KO:K04439]
101480702  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101486303  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101477577  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101476882  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101485680  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
101463712  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101484752  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101485563  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
101484250  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101484517  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101474406  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101472028  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101471444  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101473327  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
101466307  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04444] [EC:2.7.11.1]
101468435  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101464621  ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101482927  M-phase inducer phosphatase 1 isoform X1 [KO:K05866] [EC:3.1.3.48]
101479784  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101485322  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101469216  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101470988  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101463670  transcription factor AP-1 [KO:K04448]
101486839  jun; transcription factor AP-1 [KO:K04448]
101472459  transcription factor AP-1 [KO:K04448]
101484003  jund; transcription factor jun-D [KO:K04449]
101485682  transcription factor jun-D [KO:K04449]
101463949  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101480650  cellular tumor antigen p53 [KO:K04451]
112432676  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K04451]
101473986  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
101485218  protein max isoform X1 [KO:K04453]
101480189  max; protein max isoform X1 [KO:K04453]
101471731  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101479529  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101464631  heat shock protein beta-1-like [KO:K04455]
101481376  hspb1; heat shock protein beta-1 [KO:K04455]
101467814  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101480630  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101469973  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101476427  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101466452  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101485856  ppm1a; protein phosphatase 1A isoform X3 [KO:K04457] [EC:3.1.3.16]
101478948  protein phosphatase 1B isoform X1 [KO:K04457] [EC:3.1.3.16]
101469237  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101472981  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
101473792  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101482516  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101487702  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101466973  tyrosine-protein phosphatase vhp-1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101484664  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101473938  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101472860  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101463872  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101474655  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101481918  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101473092  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101468411  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101482904  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101469487  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101478841  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101474380  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101466509  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
101467207  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101464789  heat shock cognate 71 kDa protein [KO:K03283]
101484458  heat shock cognate 71 kDa protein [KO:K03283]
101486419  heat shock 70 kDa protein 1 [KO:K03283]
101481563  heat shock 70 kDa protein 1 [KO:K03283]
101480703  heat shock cognate 71 kDa protein [KO:K03283]
101468114  mecom; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
101486139  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101467194  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101463795  probable nuclear hormone receptor HR38 [KO:K04465]
101487394  probable nuclear hormone receptor HR38 [KO:K04465]
101468753  uncharacterized protein LOC101468753 [KO:K04466] [EC:2.7.11.25]
101468797  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
101486267  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101487089  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101472803  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101466977  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101464874  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101486522  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
101479063  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101474408  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
101487989  rela; transcription factor p65 isoform X1 [KO:K04735]
101474174  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mze04070  Phosphatidylinositol signaling system
mze04110  Cell cycle
mze04115  p53 signaling pathway
mze04210  Apoptosis
mze04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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