KEGG   PATHWAY: prob05167
Entry
prob05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Phodopus roborovskii (desert hamster)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
prob05167  Kaposi sarcoma-associated herpesvirus infection
prob05167

Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127216803  C3; complement C3 [KO:K03990]
127220463  Tlr3; LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
127226543  toll-like receptor 3 [KO:K05401]
127216762  Ticam1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
127231159  Traf3; TNF receptor-associated factor 3 [KO:K03174]
127236377  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
127215702  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
127228535  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
127224801  interferon alpha-9-like [KO:K05414]
127224803  interferon alpha-12-like [KO:K05414]
127224841  interferon alpha-12 [KO:K05414]
127224844  interferon alpha-12 [KO:K05414]
127224845  interferon alpha-13-like [KO:K05414]
127224846  interferon alpha-12-like [KO:K05414]
127224847  interferon alpha-12-like [KO:K05414]
127224848  interferon alpha-12-like [KO:K05414]
127224849  interferon alpha-12-like [KO:K05414]
127213691  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
127219616  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
127225831  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127224840  Ifnb1; interferon beta [KO:K05415]
127227514  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
127227512  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
127224978  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
127231265  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
127226208  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
127215637  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
127230369  Irf9; interferon regulatory factor 9 [KO:K04693]
127217035  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
127224210  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
127224217  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
127225455  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
127225941  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127225942  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127236351  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
127218712  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
127238867  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
127235558  Il6; interleukin-6 [KO:K05405]
127219779  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
127234390  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
127234378  C-C chemokine receptor type 5 [KO:K04180]
127234401  C-C chemokine receptor type 1 [KO:K04176]
127213237  C-C chemokine receptor 1-like protein 1 [KO:K04176]
127234784  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
127213294  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
127233374  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
127228595  Fadd; FAS-associated death domain protein [KO:K02373]
127226337  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
127236186  Bid; BH3-interacting domain death agonist [KO:K04726]
127213848  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
127224244  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
127222385  cytochrome c, testis-specific [KO:K08738]
127235691  cytochrome c, somatic [KO:K08738]
127231040  cytochrome c, somatic-like [KO:K08738]
127231460  cytochrome c, somatic-like [KO:K08738]
127213328  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
127220536  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
127213032  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
127234649  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
127222603  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127233576  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
127220313  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
127217362  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
127230598  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
127222971  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127228707  Rela; transcription factor p65 isoform X1 [KO:K04735]
127219059  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
127231704  cellular tumor antigen p53-like [KO:K04451]
127224199  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
127215685  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
127216477  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127230188  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
127228116  E2f1; transcription factor E2F1 [KO:K17454]
127213278  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
127229376  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
127224265  H-2 class I histocompatibility antigen, D-D alpha chain isoform X1 [KO:K06751]
127224353  H-2 class I histocompatibility antigen, D-D alpha chain isoform X1 [KO:K06751]
127224384  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
127224388  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
127224389  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
127224404  H-2 class I histocompatibility antigen, D-37 alpha chain [KO:K06751]
127224408  popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
127224412  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
127224413  class I histocompatibility antigen, Gogo-A*0101 alpha chain [KO:K06751]
127224416  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
127224417  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
127224419  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
127215047  Ifngr1; interferon gamma receptor 1 [KO:K05132]
127231412  Icam1; intercellular adhesion molecule 1 [KO:K06490]
127227127  Cd86; T-lymphocyte activation antigen CD86 [KO:K05413]
127212884  C-type lectin domain family 2 member H-like [KO:K10071]
127217207  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
127225578  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
127238325  LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
127234025  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
127236973  Ubc; polyubiquitin-C isoform X1 [KO:K08770]
127219148  Ubb; polyubiquitin-B isoform X1 [KO:K08770]
127216630  Becn1; beclin-1 isoform X1 [KO:K08334]
127216426  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
127235104  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
127227210  Atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
127228212  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
127234628  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
127213531  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127237177  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
127212957  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
127223334  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
127231981  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
127228816  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
127229769  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
127216480  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
127228530  Hras; GTPase HRas [KO:K02833]
127213087  Kras; GTPase KRas isoform X1 [KO:K07827]
127233129  Nras; GTPase NRas [KO:K07828]
127236205  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127231875  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
127216563  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
127228340  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
127216731  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127226948  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127230692  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
127224952  Jun; transcription factor Jun [KO:K04448]
127230991  Fos; protein c-Fos [KO:K04379]
127214873  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
127219102  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
127219103  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
127223328  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127238024  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
127213428  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127217216  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127225197  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
127220972  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
127223664  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127231187  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127239025  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127213510  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
127223489  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
127237270  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
127235390  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127219360  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127232178  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127227203  Cd200r1; cell surface glycoprotein CD200 receptor 1 [KO:K21668]
127227205  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
127227266  cell surface glycoprotein CD200 receptor 5 [KO:K21668]
127229235  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
127224653  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127228521  Hck; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
127231840  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
127219129  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
127237193  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127234658  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
127224331  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
127236214  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127213143  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127224232  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
127223580  calmodulin-alpha-like [KO:K02183]
127229809  calmodulin-like protein 3 [KO:K02183]
127229810  Calml5; calmodulin-like protein 5 [KO:K02183]
127231063  Calm1; calmodulin-1 [KO:K02183]
127231862  Calml4; calmodulin-like protein 4 [KO:K02183]
127238587  Calm3; calmodulin-3 [KO:K02183]
127213474  Calml6; calmodulin-like protein 6 [KO:K02183]
127214928  Calm2; calmodulin-2 [KO:K02183]
127222969  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127230207  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127214138  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127224691  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
127233971  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
127235061  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
127223216  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
127225333  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
127234503  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127230357  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
127232097  C-X-C motif chemokine 15 [KO:K10030]
127223393  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
127232100  C-X-C motif chemokine 3 [KO:K05505]
127232102  growth-regulated alpha protein [KO:K05505]
127232104  C-X-C motif chemokine 2 [KO:K05505]
127227527  Rcan1; calcipressin-1 [KO:K17901]
127223306  Fgf2; fibroblast growth factor 2 [KO:K18497]
127236801  Vegfa; vascular endothelial growth factor A [KO:K05448]
127225799  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
127220306  Angpt2; angiopoietin-2 [KO:K05466]
127221151  Il6st; interleukin-6 receptor subunit beta [KO:K05060]
127233464  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
127216384  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
127227159  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127235353  Ctnnb1; catenin beta-1 [KO:K02105]
127219310  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
127235531  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
127233545  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
127223025  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
127226375  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
127228599  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
127235215  Myc; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
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Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
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Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
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PMID:11413168
  Authors
Coscoy L, Ganem D
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
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Pratt ZL, Sugden B
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How human tumor viruses make use of autophagy.
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Cells 1:617-30 (2012)
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Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
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PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
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Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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PMID:27518127
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Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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PMID:15573137
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Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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PMID:17329974
  Authors
Montaner S
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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PMID:23028325
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Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Reference
PMID:10318948
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Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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PMID:26192396
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Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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Reference
PMID:25187543
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
prob04010  MAPK signaling pathway
prob04064  NF-kappa B signaling pathway
prob04110  Cell cycle
prob04115  p53 signaling pathway
prob04140  Autophagy - animal
prob04144  Endocytosis
prob04151  PI3K-Akt signaling pathway
prob04210  Apoptosis
prob04310  Wnt signaling pathway
prob04610  Complement and coagulation cascades
prob04620  Toll-like receptor signaling pathway
prob04630  JAK-STAT signaling pathway
prob04650  Natural killer cell mediated cytotoxicity
prob04668  TNF signaling pathway
KO pathway
ko05167   
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