KEGG   PATHWAY: pteh04151
Entry
pteh04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pteh04151  PI3K-Akt signaling pathway
pteh04151

Other DBs
GO: 0043491
Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111547933  EGF; pro-epidermal growth factor [KO:K04357]
111550529  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
111524571  EREG; proepiregulin [KO:K09784]
111524578  AREG; amphiregulin [KO:K09782]
111523283  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111546245  FGF2; fibroblast growth factor 2 [KO:K18497]
111528737  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
111534218  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111552814  FGF7; fibroblast growth factor 7 [KO:K04358]
111522276  FGF3; fibroblast growth factor 3 [KO:K04358]
111522486  FGF4; fibroblast growth factor 4 [KO:K04358]
111535838  FGF6; fibroblast growth factor 6 [KO:K04358]
111536051  FGF16; fibroblast growth factor 16 [KO:K04358]
111525307  FGF9; fibroblast growth factor 9 [KO:K04358]
111547150  FGF18; fibroblast growth factor 18 [KO:K04358]
111547417  FGF20; fibroblast growth factor 20 [KO:K04358]
111538699  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
111549401  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
111522468  FGF19; fibroblast growth factor 19 [KO:K22603]
111519986  FGF21; fibroblast growth factor 21 [KO:K22429]
111535828  FGF23; fibroblast growth factor 23 [KO:K22428]
111549636  NGF; beta-nerve growth factor [KO:K02582]
111554690  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
111555967  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
113223046  neurotrophin-4 [KO:K12457]
111520090  neurotrophin-4 [KO:K12457]
111520623  INS; insulin isoform X1 [KO:K04526]
111523785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111520622  IGF2; insulin-like growth factor II [KO:K13769]
111523727  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111549133  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111553384  PDGFC; platelet-derived growth factor C [KO:K05450]
111540080  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111556006  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111538065  KITLG; kit ligand isoform X1 [KO:K05461]
113219545  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
111520142  fms-related tyrosine kinase 3 ligand [KO:K05454]
111543089  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111522374  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
111520971  PGF; placenta growth factor isoform X1 [KO:K16859]
111531650  VEGFD; vascular endothelial growth factor D [KO:K05449]
111554086  VEGFC; vascular endothelial growth factor C [KO:K05449]
111552446  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
111551202  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
111547381  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
111548219  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
111542672  EFNA5; ephrin-A5 [KO:K05462]
111543743  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
111543744  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
111543746  EFNA1; ephrin-A1 [KO:K05462]
111526782  EFNA2; ephrin-A2 [KO:K05462]
111545603  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
111530846  NRTN; neurturin [KO:K25414]
111548823  ARTN; artemin isoform X1 [KO:K25415]
111522639  PSPN; persephin [KO:K25416]
111555709  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111537465  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111541863  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111548039  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
111544121  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111550787  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111539069  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111521629  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111537554  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111543817  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111554169  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111522649  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
111548389  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111520430  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111552670  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111552684  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111520450  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
111540451  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
111540453  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111527329  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111526494  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111553422  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111537223  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
111527303  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
111531334  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111542428  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111545353  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111549528  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111540622  KRAS; GTPase KRas isoform X1 [KO:K07827]
111549619  NRAS; GTPase NRas [KO:K07828]
111546904  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111548354  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111521954  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111527547  IRS1; insulin receptor substrate 1 [KO:K16172]
111553190  TLR2; toll-like receptor 2 [KO:K10159]
111550322  TLR4; toll-like receptor 4 [KO:K10160]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111528531  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111526920  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
111538748  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
113224568  somatotropin-like [KO:K05438]
111532415  somatotropin-like [KO:K05438]
111532246  somatotropin-like [KO:K05438]
113224570  somatotropin-like [KO:K05438]
113224571  somatotropin-like [KO:K05438]
113224572  somatotropin-like [KO:K05438]
111532431  somatotropin-like [KO:K05438]
111533513  somatotropin isoform X1 [KO:K05438]
111541106  PRL; prolactin isoform X1 [KO:K05439]
111525348  OSM; oncostatin-M [KO:K05418]
111546287  IL2; interleukin-2 [KO:K05429]
111527574  IL3; interleukin-3 [KO:K04736]
111545050  IL6; interleukin-6 isoform X1 [KO:K05405]
111529515  IL4; interleukin-4 [KO:K05430]
111553128  IL7; interleukin-7 isoform X1 [KO:K05431]
111537187  interferon alpha-14 [KO:K05414]
111537188  interferon alpha-6 [KO:K05414]
111537189  interferon alpha-2 [KO:K05414]
111537190  interferon alpha-8 [KO:K05414]
111537191  interferon alpha-1/13 [KO:K05414]
111526141  interferon alpha-10 [KO:K05414]
111526147  IFNB1; interferon beta [KO:K05415]
111530173  EPO; erythropoietin isoform X1 [KO:K05437]
111537268  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
111545572  GHR; growth hormone receptor isoform X1 [KO:K05080]
111545527  PRLR; prolactin receptor isoform X1 [KO:K05081]
111545500  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
111554868  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
111549045  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111533635  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
111535429  interleukin-3 receptor subunit alpha-like [KO:K04737]
111543722  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
111526911  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
111545525  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
111525309  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
111525288  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111534401  EPOR; erythropoietin receptor [KO:K05079]
111555820  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
111541367  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
111543300  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
111554242  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111552480  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111537568  COL1A1; collagen alpha-1(I) chain [KO:K06236]
111555277  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
111536673  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
111546314  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
111546316  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
111527511  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111527529  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111536655  collagen alpha-6(IV) chain-like [KO:K06237]
111539443  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
111553748  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111527942  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111527947  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111539442  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
111539510  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
111520484  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111554646  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
111548837  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
111554928  LAMA2; laminin subunit alpha-2 [KO:K05637]
111553579  LAMA1; laminin subunit alpha-1 [KO:K05637]
111520480  laminin subunit alpha-5 [KO:K06240]
111539764  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111547317  LAMA4; laminin subunit alpha-4 [KO:K06241]
111520373  LAMB1; laminin subunit beta-1 [KO:K05636]
111555391  LAMB2; laminin subunit beta-2 [KO:K06243]
111531101  LAMB3; laminin subunit beta-3 [KO:K06244]
111520401  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
111536950  LAMC1; laminin subunit gamma-1 [KO:K05635]
111536949  LAMC2; laminin subunit gamma-2 [KO:K06246]
111545964  LAMC3; laminin subunit gamma-3 [KO:K06247]
111537574  CHAD; chondroadherin [KO:K06248]
111526701  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111524230  THBS1; thrombospondin-1 [KO:K16857]
111530915  THBS2; thrombospondin-2 [KO:K04659]
111544433  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
111554211  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
111548154  FN1; fibronectin isoform X1 [KO:K05717]
111530883  SPP1; osteopontin isoform X1 [KO:K06250]
111520771  VTN; vitronectin isoform X1 [KO:K06251]
111550356  TNC; tenascin isoform X1 [KO:K06252]
111528966  TNXB; tenascin-X [KO:K06252]
111539366  TNR; tenascin-R isoform X1 [KO:K06252]
111539367  TNN; tenascin-N [KO:K06252]
111555950  VWF; von Willebrand factor [KO:K03900]
111530880  IBSP; bone sialoprotein 2 [KO:K06253]
111541654  ITGA1; integrin alpha-1 [KO:K06480]
111541653  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
111525821  ITGA2B; integrin alpha-IIb [KO:K06476]
111537562  ITGA3; integrin alpha-3 [KO:K06482]
111542790  ITGA4; integrin alpha-4 [KO:K06483]
111541902  ITGA5; integrin alpha-5 [KO:K06484]
111522158  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111541886  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
111550012  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
111523197  ITGA9; integrin alpha-9 [KO:K06585]
111531387  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
111548412  ITGA11; integrin alpha-11 [KO:K06587]
111542813  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111546659  ITGB1; integrin beta-1 [KO:K05719]
111526557  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111542414  ITGB4; integrin beta-4 [KO:K06525]
111544514  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
111546158  ITGB6; integrin beta-6 [KO:K06589]
111541940  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
111545093  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
111553372  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111521403  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111544647  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111523340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111554247  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111539891  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111548774  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111529547  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
111522344  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
111524771  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
111535768  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
111554350  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
111539505  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
111536060  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
111555936  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
111523079  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
111544570  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111530203  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
111555925  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
111521415  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
111552767  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
111549428  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
111522414  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113224997  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111540329  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111534550  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111535694  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111551379  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111552373  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111541090  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111524122  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111537549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111520385  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111525462  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
111525465  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
111526789  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
111523274  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
111545491  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
111537873  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
111523975  TSC1; hamartin isoform X1 [KO:K07206]
111524144  TSC2; tuberin isoform X1 [KO:K07207]
111551439  RHEB; GTP-binding protein Rheb [KO:K07208]
111524124  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
111526309  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111542542  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111544131  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
111521587  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
111523750  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111525509  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
111522215  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
111541948  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111524736  40S ribosomal protein S6 [KO:K02991]
111546440  40S ribosomal protein S6 [KO:K02991]
111542503  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111554279  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
111540096  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
111532946  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
111554889  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
111553249  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
111549202  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111533609  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
111527272  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
111551321  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111543666  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
111529155  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111544152  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111530328  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
111540119  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
111522076  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113223584  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like isoform X1 [KO:K04354]
113219540  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like isoform X1 [KO:K04354]
111552590  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113219537  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like isoform X1 [KO:K04354]
111545723  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111539127  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
111534796  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
111524445  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113223920  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
116418599  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
113223918  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
111523337  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
111538309  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111543057  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
111522311  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
111537149  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
111555700  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111543094  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
111538310  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
111549509  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
111524308  HSP90B1; endoplasmin [KO:K09487]
111527733  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
111543705  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
111528447  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
111541481  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
111538269  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
111527391  MTCP1; protein p13 MTCP-1 [KO:K16837]
111551457  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
111537329  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
111543871  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111520086  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
111540567  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
111552909  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
111555669  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
111524520  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
111537261  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
111525832  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
111550563  MYC; myc proto-oncogene protein [KO:K04377]
111522272  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111542983  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111552085  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
111541872  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111541790  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111552475  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111535839  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111543039  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111553938  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111549709  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
111538546  FOXO3; forkhead box protein O3 [KO:K09408]
111541247  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111539343  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111524280  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
111520900  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
111531828  YWHAQ; 14-3-3 protein theta [KO:K16197]
111553214  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
111530644  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
111521815  YWHAH; 14-3-3 protein eta [KO:K16198]
113219724  14-3-3 protein eta [KO:K16198]
111547068  YWHAG; 14-3-3 protein gamma [KO:K16198]
111522294  BAD; bcl2-associated agonist of cell death [KO:K02158]
111548123  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
111528437  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
111527287  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111547676  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111542753  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111548140  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111548991  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111521981  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
111543707  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
111544982  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111536760  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111524755  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111551841  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
111528965  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111543617  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
111523996  photoreceptor-specific nuclear receptor-like [KO:K08524]
111534772  retinoic acid receptor RXR-alpha [KO:K08524]
111541979  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111538794  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111544093  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111554962  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
111528609  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111527100  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pteh00010  Glycolysis / Gluconeogenesis
pteh04010  MAPK signaling pathway
pteh04012  ErbB signaling pathway
pteh04062  Chemokine signaling pathway
pteh04064  NF-kappa B signaling pathway
pteh04068  FoxO signaling pathway
pteh04110  Cell cycle
pteh04115  p53 signaling pathway
pteh04150  mTOR signaling pathway
pteh04210  Apoptosis
pteh04370  VEGF signaling pathway
pteh04510  Focal adhesion
pteh04620  Toll-like receptor signaling pathway
pteh04630  JAK-STAT signaling pathway
pteh04662  B cell receptor signaling pathway
pteh04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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