KEGG   PATHWAY: ptg05010
Entry
ptg05010                    Pathway                                
Name
Alzheimer disease - Panthera tigris altaica (Amur tiger)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ptg05010  Alzheimer disease
ptg05010

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102950285  ADAM10; ADAM metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
102948618  ADAM17; ADAM metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
102960478  APP; amyloid beta precursor protein [KO:K04520]
102951299  NAE1; NEDD8 activating enzyme E1 subunit 1 [KO:K04532]
102964621  APBB1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
102972075  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102956216  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102952748  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102969425  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
107180331  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102961605  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102949291  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
102955826  BACE2; beta-site APP-cleaving enzyme 2 [KO:K07747] [EC:3.4.23.45]
102963980  RTN3; reticulon 3 [KO:K20723]
102950135  RTN4; reticulon 4 [KO:K20720]
102961369  PSENEN; presenilin enhancer gamma-secretase subunit [KO:K06170]
102966511  PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
102972248  PSEN2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
102954118  NCSTN; nicastrin [KO:K06171]
102958827  APH1B; aph-1 homolog B, gamma-secretase subunit [KO:K06172]
102961126  APH1A; aph-1 homolog A, gamma-secretase subunit [KO:K06172]
102971779  IDE; insulin degrading enzyme [KO:K01408] [EC:3.4.24.56]
102956005  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
102967519  MAPT; microtubule associated protein tau [KO:K04380]
102964581  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102966551  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102965900  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102960858  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
102964097  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102950382  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
102955496  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102957607  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102961267  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102951077  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102962666  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
102963930  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102963683  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102966891  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102958206  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102962736  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102953991  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102972128  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102956958  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102966469  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102970864  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102968764  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102964265  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102960332  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102962692  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102951920  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102951766  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102953273  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102968755  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102964329  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102951216  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102956606  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102967222  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102954909  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102967539  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
102967094  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
107179064  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102972527  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102950278  NADH-quinone oxidoreductase subunit I-like [KO:K03941] [EC:7.1.1.2]
102963800  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102953727  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102966043  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102949810  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102961107  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102958685  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102952867  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102964791  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102954021  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102967145  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102961769  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102972429  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102958491  cytochrome b-c1 complex subunit 7 [KO:K00417]
102961512  cytochrome b-c1 complex subunit 8 [KO:K00418]
107179658  cytochrome b-c1 complex subunit 9 [KO:K00419]
102953539  cytochrome b-c1 complex subunit 10 [KO:K00420]
102949741  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102968374  COX4; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102965948  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
102972662  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102970017  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102954128  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102959733  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102969700  cytochrome c oxidase subunit 6B1-like [KO:K02267]
102959649  cytochrome c oxidase subunit 6B1 [KO:K02267]
107181236  cytochrome c oxidase subunit 6B1-like [KO:K02267]
102964462  cytochrome c oxidase subunit 6C [KO:K02268]
102967026  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102955153  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102969642  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102951800  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102970291  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102967492  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102954518  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102960097  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102953511  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102970698  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102972172  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102948494  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
107179784  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
102964967  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102954327  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102957105  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102965976  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102968775  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102966183  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102959044  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102959999  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
102956982  HSD17B10; hydroxysteroid 17-beta dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102950091  PPID; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
102959401  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102951163  VDAC2; voltage dependent anion channel 2 [KO:K15040]
102962706  VDAC3; voltage dependent anion channel 3 [KO:K15041]
102960718  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
102966182  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
102972215  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
102971432  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
102962163  ADP/ATP translocase 2-like [KO:K05863]
102969541  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
102967736  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
102951269  LRP1; LDL receptor related protein 1 [KO:K04550]
102958442  FAS; Fas cell surface death receptor [KO:K04390]
102956793  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102962460  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102951809  BID; BH3 interacting domain death agonist [KO:K04726]
102953457  CALM3; calmodulin 3 [KO:K02183]
102963939  calmodulin-like [KO:K02183]
102964234  CALML3; calmodulin-like protein 3 [KO:K02183]
102954552  CALM2; calmodulin 2 [KO:K02183]
102960923  calmodulin-like [KO:K02183]
102950842  CALML6; calmodulin like 6 [KO:K02183]
102951822  CALM1; calmodulin 1 [KO:K02183]
102971520  calmodulin-alpha-like [KO:K02183]
102950182  CALML4; calmodulin like 4 [KO:K02183]
102952632  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102949359  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102963447  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102965200  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102967427  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102956027  BAD; BCL2 associated agonist of cell death [KO:K02158]
102966744  cytochrome c 2-like [KO:K08738]
102952864  cytochrome c-like [KO:K08738]
102960081  cytochrome c [KO:K08738]
102964536  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102967404  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102954729  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102964850  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102953867  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102965519  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102954227  GNAQ; G protein subunit alpha q [KO:K04634]
102959485  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102961437  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102960646  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102961121  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102949242  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102969126  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102962401  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102959236  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102960299  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102956322  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102958456  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102950547  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102949808  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102955772  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
102969716  MCU; mitochondrial calcium uniporter [KO:K20858]
102964841  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102960964  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102961931  RYR3; ryanodine receptor 3 [KO:K04963]
102963245  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102971840  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102967639  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102953307  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102962973  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102972450  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102967171  ATF6; activating transcription factor 6 [KO:K09054]
102961098  XBP1; X-box binding protein 1 [KO:K09027]
102965918  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102955540  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102963843  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102966802  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102960317  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102949140  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102959159  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102950880  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102963096  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102962011  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102950077  ATF4; activating transcription factor 4 [KO:K04374]
102956413  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
102959910  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
102964813  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
102960768  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
102961604  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
102953650  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
102967599  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
102957937  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
102971535  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
102950937  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
102954945  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
102956128  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
102967110  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
102973035  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
102956212  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
102972186  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102952413  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102952740  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102963735  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102964237  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102951790  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102970133  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102968765  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102965316  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102971583  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
102960839  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102969027  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
102966651  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102957237  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102949162  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
102952652  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
102972721  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102962507  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102961319  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102970278  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102968230  caspase-12-like [KO:K04741] [EC:3.4.22.-]
102962715  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
102955453  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
102968232  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
102963052  SLC39A3; solute carrier family 39 member 3 [KO:K14709]
102952470  SLC39A2; solute carrier family 39 member 2 [KO:K14709]
102952829  SLC39A1; solute carrier family 39 member 1 [KO:K14709]
102950811  SLC39A4; solute carrier family 39 member 4 [KO:K14710]
102965391  SLC39A5; solute carrier family 39 member 5 [KO:K14711]
102961332  SLC39A6; solute carrier family 39 member 6 [KO:K14712]
102953347  SLC39A7; solute carrier family 39 member 7 [KO:K14713]
102951767  SLC39A8; solute carrier family 39 member 8 [KO:K14714]
102954991  SLC39A9; solute carrier family 39 member 9 [KO:K14715]
102957075  SLC39A10; solute carrier family 39 member 10 [KO:K14716]
102968504  SLC39A11; solute carrier family 39 member 11 [KO:K14717]
102965007  SLC39A12; solute carrier family 39 member 12 [KO:K14718]
102951950  SLC39A13; solute carrier family 39 member 13 [KO:K14719]
102948590  SLC39A14; solute carrier family 39 member 14 [KO:K14720]
102965906  SLC11A2; solute carrier family 11 member 2 [KO:K21398]
102956209  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
102961382  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102951959  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
102971689  DKK2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
102963169  DKK4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
102962277  WNT1; Wnt family member 1 [KO:K03209]
102963336  WNT2B; Wnt family member 2B [KO:K00182]
102954954  WNT2; Wnt family member 2 [KO:K00182]
102950040  WNT3A; Wnt family member 3A [KO:K00312]
102962551  WNT3; Wnt family member 3 [KO:K00312]
102965201  WNT5A; Wnt family member 5A [KO:K00444]
102958778  WNT5B; Wnt family member 5B [KO:K00444]
102972888  WNT7A; Wnt family member 7A [KO:K00572]
102966525  WNT8A; Wnt family member 8A [KO:K00714]
102956179  WNT8B; Wnt family member 8B [KO:K00714]
102950323  WNT9A; Wnt family member 9A [KO:K01064]
102962257  WNT9B; Wnt family member 9B [KO:K01064]
102961987  WNT10B; Wnt family member 10B [KO:K01357]
102956294  WNT10A; Wnt family member 10A [KO:K01357]
102971675  WNT11; Wnt family member 11 [KO:K01384]
102959880  WNT16; Wnt family member 16 [KO:K01558]
102968815  FZD1; frizzled class receptor 1 [KO:K02432]
102948653  FZD7; frizzled class receptor 7 [KO:K02432]
102962395  FZD2; frizzled class receptor 2 [KO:K02235]
102961371  FZD3; frizzled class receptor 3 [KO:K02329]
102952336  FZD4; frizzled class receptor 4 [KO:K02354]
102953646  FZD6; frizzled class receptor 6 [KO:K02376]
102970273  FZD9; frizzled class receptor 9 [KO:K02842]
102953438  FZD10; frizzled class receptor 10 [KO:K02842]
102968327  LRP5; LDL receptor related protein 5 [KO:K03068]
102968142  LRP6; LDL receptor related protein 6 [KO:K03068]
102969346  CSNK1E; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
102954084  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102967723  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102957003  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102969391  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
102963968  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
102953509  CSNK2B; casein kinase 2 beta [KO:K03115]
102951323  AXIN1; axin 1 [KO:K02157]
102967280  AXIN2; axin 2 [KO:K04385]
102948725  APC; APC, WNT signaling pathway regulator [KO:K02085]
102959570  CTNNB1; catenin beta 1 [KO:K02105]
102949834  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102967932  KIF5A; kinesin family member 5A [KO:K10396]
102971278  KIF5C; kinesin family member 5C [KO:K10396]
102965837  KIF5B; kinesin family member 5B [KO:K10396]
102966188  KLC2; kinesin light chain 2 [KO:K10407]
102970489  KLC1; kinesin light chain 1 [KO:K10407]
102971570  KLC3; kinesin light chain 3 [KO:K10407]
102962356  KLC4; kinesin light chain 4 [KO:K10407]
102969257  TUBAL3; tubulin alpha like 3 [KO:K07374]
102953141  tubulin alpha-1A chain [KO:K07374]
102954023  tubulin alpha-1A chain-like [KO:K07374]
102953725  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102950928  TUBA8; tubulin alpha 8 [KO:K07374]
102962068  TUBA4A; tubulin alpha 4a [KO:K07374]
102951399  tubulin alpha-8 chain [KO:K07374]
102969214  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102963137  tubulin beta-2B chain-like [KO:K07375]
102963413  tubulin beta-2B chain-like [KO:K07375]
102963307  TUBB; tubulin beta class I [KO:K07375]
102971239  uncharacterized LOC102971239 [KO:K07375]
102971736  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
102955872  tubulin beta chain-like [KO:K07375]
102949211  TUBB6; tubulin beta 6 class V [KO:K07375]
102963427  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
102952119  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102957350  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102952980  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102956086  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102951082  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102955852  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102969757  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102956808  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102971358  NOX1; NADPH oxidase 1 [KO:K08008]
102950901  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102952905  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
102951132  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102964232  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102950049  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
102948685  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102958919  TNF; tumor necrosis factor [KO:K03156]
102968780  IL6; interleukin 6 [KO:K05405]
102951574  IL1A; interleukin 1 alpha [KO:K04383]
102951272  IL1B; interleukin 1 beta [KO:K04519]
102972710  CSF1; colony stimulating factor 1 [KO:K05453]
102948486  SNCA; synuclein alpha [KO:K04528]
102951575  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
102949289  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102963734  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102967156  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102965599  IRS1; insulin receptor substrate 1 [KO:K16172]
102952104  uncharacterized LOC102952104 [KO:K17445]
102952189  IRS4; insulin receptor substrate 4 [KO:K17446]
102949853  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102952993  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102967709  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102953082  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102965070  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102972487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102952603  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102954757  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102967196  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102952269  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102952805  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102948940  ATG101; autophagy related 101 [KO:K19730]
102956276  ATG13; autophagy related 13 [KO:K08331]
102951720  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102950173  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102970579  BECN2; beclin 2 [KO:K08334]
102962656  BECN1; beclin 1 [KO:K08334]
102954950  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102951862  ATG14; autophagy related 14 [KO:K17889]
102966800  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102971493  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102957143  ATG2A; autophagy related 2A [KO:K17906]
102971657  ATG2B; autophagy related 2B [KO:K17906]
102967857  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102954818  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
ptg00190  Oxidative phosphorylation
ptg03050  Proteasome
ptg04020  Calcium signaling pathway
ptg04140  Autophagy - animal
ptg04141  Protein processing in endoplasmic reticulum
ptg04210  Apoptosis
ptg04310  Wnt signaling pathway
ptg04910  Insulin signaling pathway
ptg04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system