KEGG   PATHWAY: puc05169
Entry
puc05169                    Pathway                                
Name
Epstein-Barr virus infection - Panthera uncia (snow leopard)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
puc05169  Epstein-Barr virus infection
puc05169

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125925339  complement receptor type 2 isoform X1 [KO:K04012]
125928006  B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
125938154  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
125938382  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125938383  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
125938384  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
125938386  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
125938388  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
125938395  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
125938398  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
125938399  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
125938400  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
125923764  toll-like receptor 2 [KO:K10159]
125921434  myeloid differentiation primary response protein MyD88 [KO:K04729]
125918985  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125932080  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
125934537  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125919627  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
125938017  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125938695  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125932873  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125923306  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125932096  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125909567  NF-kappa-B inhibitor alpha [KO:K04734]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125912163  transcription factor p65 [KO:K04735]
125938466  tumor necrosis factor [KO:K03156]
125930836  interleukin-6 [KO:K05405]
125918656  antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
125936139  mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
125909139  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125919296  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125925487  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125937759  interferon regulatory factor 7 isoform X1 [KO:K09447]
125915966  interferon regulatory factor 3 isoform X1 [KO:K05411]
125925935  interferon beta-like [KO:K05414]
125925953  interferon alpha-2-like [KO:K05414]
125925944  interferon beta [KO:K05415]
125921711  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
125921705  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125913423  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125930538  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
125911435  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
125920249  signal transducer and activator of transcription 2 [KO:K11221]
125909651  interferon regulatory factor 9 [KO:K04693]
125937286  interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
125914169  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
125914170  2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
125914171  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
125922838  C-X-C motif chemokine 10 [KO:K12671]
125913254  ubiquitin-like protein ISG15 [KO:K12159]
125933220  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125929964  FAS-associated death domain protein [KO:K02373]
125911772  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
125918699  BH3-interacting domain death agonist [KO:K04726]
125937460  bcl-2-like protein 11 isoform X1 [KO:K16341]
125914709  apoptosis regulator Bcl-2 [KO:K02161]
125915138  apoptosis regulator BAX isoform X1 [KO:K02159]
125938359  bcl-2 homologous antagonist/killer [KO:K14021]
125929995  cytochrome c [KO:K08738]
125933126  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
125920151  cytochrome c-like [KO:K08738]
125920269  cytochrome c-like [KO:K08738]
125921158  cytochrome c-like [KO:K08738]
125919454  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
125913078  caspase-9 [KO:K04399] [EC:3.4.22.62]
125923904  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125909427  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
125909383  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
125909406  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
125925894  T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
125929844  26S proteasome regulatory subunit 7 [KO:K03061]
125909259  26S proteasome regulatory subunit 4 [KO:K03062]
125915899  26S proteasome regulatory subunit 6B [KO:K03063]
125908768  26S proteasome regulatory subunit 10B [KO:K03064]
125934056  26S proteasome regulatory subunit 6A [KO:K03065]
125926676  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
125921121  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
125931749  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
125911095  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
125926490  26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
125926687  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
125927487  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
125929542  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
125916298  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
125937741  26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
125912102  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
125911593  26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
125915784  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
125936430  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
125939091  26S proteasome complex subunit SEM1-like [KO:K10881]
125938390  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
125938391  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
125938368  LOW QUALITY PROTEIN: tapasin [KO:K08058]
125909939  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
125929051  calreticulin [KO:K08057]
125938453  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125938456  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
125938457  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
125938459  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
125938460  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-C*0201 alpha chain-like [KO:K06751]
125938463  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125938464  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125909955  beta-2-microglobulin [KO:K08055]
125909304  SNW domain-containing protein 1 [KO:K06063]
125910154  paired amphipathic helix protein Sin3a [KO:K11644]
125938817  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
125932228  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
125912823  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
125914361  nuclear receptor corepressor 2 [KO:K06065]
125923214  histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
125934516  histone deacetylase complex subunit SAP30L [KO:K19202]
125911828  corepressor interacting with RBPJ 1 [KO:K06066]
125923549  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
125936553  recombining binding protein suppressor of hairless-like protein [KO:K06053]
125921073  transcription factor HES-1 [KO:K06054]
125928973  low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
125912943  runt-related transcription factor 3 [KO:K09279]
125924410  myc proto-oncogene protein [KO:K04377]
125927866  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
125919324  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125927023  LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
125938307  cyclin-dependent kinase inhibitor 1 [KO:K06625]
125929753  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125930526  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
125912521  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125933993  DNA damage-binding protein 2 isoform X1 [KO:K10140]
125935748  DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
125925301  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125926656  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
125915169  transcription factor RelB [KO:K09253]
125932909  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
125916585  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125915462  NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
125911398  LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta-like [KO:K02581]
125937893  NF-kappa-B inhibitor epsilon [KO:K05872]
125927589  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
125928966  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125916877  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
125917114  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
125933328  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125935352  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125923516  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125939602  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
125926929  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125926707  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
125937867  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125937868  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125919741  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125919935  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125912547  transcription factor Jun [KO:K04448]
125923918  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
125932830  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
125921406  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
125936517  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
125934691  CD44 antigen isoform X1 [KO:K06256]
125928080  integrin alpha-L isoform X1 [KO:K05718]
125913288  lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
125930551  intercellular adhesion molecule 1 isoform X1 [KO:K06490]
125919995  vimentin isoform X1 [KO:K07606]
125938952  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
125929213  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125926571  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125924861  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
125924291  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125917249  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
125917260  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
125928294  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125931830  tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
125933413  B-cell linker protein isoform X1 [KO:K07371]
125916347  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
125934645  S-phase kinase-associated protein 2 [KO:K03875]
125918841  cyclin-dependent kinase inhibitor 1B [KO:K06624]
125930010  G1/S-specific cyclin-D1 [KO:K04503]
125917183  G1/S-specific cyclin-D2 [KO:K10151]
125918030  G1/S-specific cyclin-D2 [KO:K10151]
125938244  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125919257  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125930419  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125918223  cyclin-A2 [KO:K06627]
125918226  cyclin-A2 [KO:K06627]
125933710  cyclin-A1 [KO:K06627]
125924535  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125917277  G1/S-specific cyclin-E1 [KO:K06626]
125917289  G1/S-specific cyclin-E1 [KO:K06626]
125919210  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125933773  retinoblastoma-associated protein isoform X1 [KO:K06618]
125936106  transcription factor E2F1 [KO:K17454]
125912975  transcription factor E2F2 [KO:K09389]
125908499  transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
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PMID:11905817
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Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
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PMID:25403939
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Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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PMID:29932446
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Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
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Cancers (Basel) 10:E213 (2018)
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PMID:19649319
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
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PMID:19244339
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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PMID:19394062
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Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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PMID:25635182
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Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
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Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
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Future Virol 4:79-91 (2009)
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PMID:10818681
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Longnecker R
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Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
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PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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PMID:12811813
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Dolcetti R, Masucci MG
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
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Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
puc03050  Proteasome
puc04010  MAPK signaling pathway
puc04020  Calcium signaling pathway
puc04064  NF-kappa B signaling pathway
puc04110  Cell cycle
puc04115  p53 signaling pathway
puc04210  Apoptosis
puc04612  Antigen processing and presentation
puc04620  Toll-like receptor signaling pathway
puc04622  RIG-I-like receptor signaling pathway
puc04630  JAK-STAT signaling pathway
puc04662  B cell receptor signaling pathway
KO pathway
ko05169   
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