KEGG   PATHWAY: pvp05010
Entry
pvp05010                    Pathway                                
Name
Alzheimer disease - Pteropus vampyrus (large flying fox)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pvp05010  Alzheimer disease
pvp05010

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105294280  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
105295437  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
105290808  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
105305691  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
105309093  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
105306877  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105294854  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105301553  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105295969  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105307615  BACE1; beta-secretase 1 isoform X2 [KO:K04521] [EC:3.4.23.46]
105300589  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
105297830  RTN3; reticulon-3 [KO:K20723]
105294680  RTN4; reticulon-4 [KO:K20720]
105306650  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
105299254  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
105292607  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
105300707  NCSTN; nicastrin isoform X1 [KO:K06171]
105308697  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
105294256  APH1B; gamma-secretase subunit APH-1B isoform X3 [KO:K06172]
105293081  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
105305828  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
105303449  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105306559  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105296192  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105305394  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
111742157  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
105305558  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105306976  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105309466  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105294061  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105302549  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
105290165  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X2 [KO:K03949]
105298025  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105307710  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105292672  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105293278  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105305214  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105311066  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
105301667  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105301070  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105295986  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105296558  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X2 [KO:K11353]
105300789  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X2 [KO:K03957]
105291606  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105298131  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
105300868  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105307507  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105306407  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105308512  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105304627  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105292546  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105303324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
105305449  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105298415  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105303396  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105290042  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
105305799  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
105306380  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
111734519  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
105301308  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105302238  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
105306564  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105297603  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X2 [KO:K03968]
105301309  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105294330  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105303403  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105295633  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105301194  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
105301970  cytochrome c1, heme protein, mitochondrial [KO:K00413]
105302414  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105306053  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
105297147  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
105300597  cytochrome b-c1 complex subunit 7 [KO:K00417]
105311019  cytochrome b-c1 complex subunit 8 [KO:K00418]
105300922  cytochrome b-c1 complex subunit 9 [KO:K00419]
105302219  cytochrome b-c1 complex subunit 10 [KO:K00420]
105305502  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
105298839  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
105306845  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105306783  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105289274  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105304499  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105304910  cytochrome c oxidase subunit 6B2 isoform X2 [KO:K02267]
105306643  cytochrome c oxidase subunit 6B1 [KO:K02267]
105302898  cytochrome c oxidase subunit 6C isoform X1 [KO:K02268]
105307875  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105307890  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105292938  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
105308883  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
105293916  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105294928  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
105303918  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105297836  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105292810  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105302566  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105291714  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105296096  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105296904  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105290188  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105307242  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105302646  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105293340  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105295843  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105290810  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105307806  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
105294477  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105293648  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105288878  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105300538  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105305546  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105308002  ADP/ATP translocase 3 [KO:K05863]
105293469  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105294703  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105295516  ADP/ATP translocase 3-like [KO:K05863]
105288974  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105296666  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
105297354  APOE; apolipoprotein E isoform X2 [KO:K04524]
105302691  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105307475  FADD; FAS-associated death domain protein [KO:K02373]
105298127  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105297238  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
105297322  CALM3; calmodulin-3 [KO:K02183]
105290127  CALM1; calmodulin-1 [KO:K02183]
105299180  calmodulin [KO:K02183]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105293163  cytochrome c [KO:K08738]
105288270  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105297824  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105311212  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105288600  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105294211  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
105302452  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105298564  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105290959  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105302783  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105293418  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105304199  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105297298  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105309056  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105296936  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105307287  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105288836  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105288773  RYR3; ryanodine receptor 3 [KO:K04963]
105295171  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105294112  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105301042  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105289209  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105304583  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105291989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105303424  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
105300938  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105307377  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105297760  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105302307  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105298613  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105308244  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105303190  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105303219  PSMA2; proteasome subunit alpha type-2 isoform X1 [KO:K02726] [EC:3.4.25.1]
105307329  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105292262  PSMA8; proteasome subunit alpha type-7-like isoform X2 [KO:K02731] [EC:3.4.25.1]
105307466  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105297267  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105301482  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105308921  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105291754  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105294870  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105308386  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105290624  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105300529  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105303717  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105303843  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105295499  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
105290124  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
105300217  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
105309288  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
105290037  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
105297724  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
105307005  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105306136  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105307510  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105289192  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
105297704  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
105291960  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105290990  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
105307210  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105309810  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105303837  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105291055  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105300193  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X2 [KO:K03031]
105301411  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105294208  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
105297472  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
105289401  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105297886  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105292618  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105291961  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
105296391  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
105307294  SLC39A2; zinc transporter ZIP2 [KO:K14709]
105300427  SLC39A3; zinc transporter ZIP3 [KO:K14709]
105302750  zinc transporter ZIP2-like isoform X1 [KO:K14709]
105301959  SLC39A4; zinc transporter ZIP4 [KO:K14710]
105302581  SLC39A5; zinc transporter ZIP5 isoform X2 [KO:K14711]
105292995  SLC39A6; zinc transporter ZIP6 [KO:K14712]
105300977  SLC39A7; zinc transporter SLC39A7 isoform X2 [KO:K14713]
105293030  SLC39A8; zinc transporter ZIP8 [KO:K14714]
105308001  SLC39A9; zinc transporter ZIP9 isoform X2 [KO:K14715]
105291791  zinc transporter ZIP10-like [KO:K14716]
105293409  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
105294915  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
105290036  SLC39A13; zinc transporter ZIP13 isoform X3 [KO:K14719]
105296534  SLC39A14; zinc transporter ZIP14 [KO:K14720]
105297565  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105303753  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105291475  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105293010  DKK2; dickkopf-related protein 2 [KO:K02165]
105293123  DKK1; dickkopf-related protein 1 [KO:K02165]
105300530  DKK4; dickkopf-related protein 4 [KO:K02165]
105297529  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105296814  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105308466  WNT2; protein Wnt-2 [KO:K00182]
105299958  WNT3A; protein Wnt-3a [KO:K00312]
105303453  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105290434  WNT4; protein Wnt-4 [KO:K00408]
105297256  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105299863  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
105291052  WNT6; protein Wnt-6 isoform X2 [KO:K00445]
105302044  WNT7B; protein Wnt-7b [KO:K00572]
105294978  WNT7A; protein Wnt-7a [KO:K00572]
105304667  WNT8B; protein Wnt-8b [KO:K00714]
105293607  WNT8A; protein Wnt-8a [KO:K00714]
105300002  WNT9A; protein Wnt-9a [KO:K01064]
105303454  WNT9B; protein Wnt-9b [KO:K01064]
105297527  WNT10B; protein Wnt-10b [KO:K01357]
105291051  WNT10A; protein Wnt-10a [KO:K01357]
105297627  WNT11; protein Wnt-11 [KO:K01384]
105290156  WNT16; protein Wnt-16 [KO:K01558]
105298116  FZD7; frizzled-7 [KO:K02432]
105294552  FZD1; frizzled-1 [KO:K02432]
105303480  FZD2; frizzled-2 [KO:K02235]
105291512  FZD3; frizzled-3 isoform X1 [KO:K02329]
105294187  FZD4; frizzled-4 [KO:K02354]
105307149  FZD8; frizzled-8 [KO:K02375]
105298400  FZD5; frizzled-5 [KO:K02375]
105300873  FZD6; frizzled-6 isoform X1 [KO:K02376]
105299568  FZD10; frizzled-10 [KO:K02842]
105299684  FZD9; frizzled-9 [KO:K02842]
105306578  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105302799  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105288320  casein kinase I [KO:K08960] [EC:2.7.11.1]
105291733  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105307126  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105303599  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105301374  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105305378  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105305487  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105305340  CSNK2B; casein kinase II subunit beta [KO:K03115]
105303252  AXIN1; axin-1 isoform X1 [KO:K02157]
105297749  AXIN2; axin-2 [KO:K04385]
105295478  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
105302259  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105299427  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
105298309  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
105291670  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
105288463  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105304445  KLC1; kinesin light chain 1 [KO:K10407]
105297346  KLC3; kinesin light chain 3 [KO:K10407]
105297932  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105297234  TUBA8; tubulin alpha-8 chain [KO:K07374]
105297536  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
105297537  tubulin alpha-1B chain-like [KO:K07374]
105297584  tubulin alpha-1C chain-like [KO:K07374]
105291036  tubulin alpha-4A chain [KO:K07374]
105291037  tubulin alpha-1B chain-like [KO:K07374]
105296776  tubulin beta-2A chain [KO:K07375]
105304852  TUBB3; tubulin beta-3 chain [KO:K07375]
105298557  TUBB4B; tubulin beta-4B chain [KO:K07375]
105306353  TUBB6; tubulin beta-6 chain [KO:K07375]
105308138  TUBB; tubulin beta chain [KO:K07375]
105301083  TUBB4A; tubulin beta-4A chain [KO:K07375]
105310590  LOW QUALITY PROTEIN: tubulin beta-1 chain-like [KO:K07375]
105296085  TUBB1; tubulin beta-1 chain [KO:K07375]
105305278  AGER; advanced glycosylation end product-specific receptor isoform X9 [KO:K19722]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105305459  ARAF; serine/threonine-protein kinase A-Raf isoform X8 [KO:K08845] [EC:2.7.11.1]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105308064  NOX1; NADPH oxidase 1 isoform X2 [KO:K08008]
105308561  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105294193  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
105297999  RELA; transcription factor p65 [KO:K04735]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105291934  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105295029  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105305325  TNF; tumor necrosis factor [KO:K03156]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105303981  IL1A; interleukin-1 alpha [KO:K04383]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105297143  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105289553  SNCA; alpha-synuclein [KO:K04528]
105292967  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105301327  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
105301581  IRS4; insulin receptor substrate 4 isoform X1 [KO:K17446]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105299561  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105291380  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105307010  ATG101; autophagy-related protein 101 [KO:K19730]
105290020  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
105291422  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
105290018  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105305404  BECN2; beclin-2 [KO:K08334]
105306274  BECN1; beclin-1 isoform X1 [KO:K08334]
105307906  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
105310149  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105298814  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105292883  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
105297863  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
105298800  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105294564  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
pvp00190  Oxidative phosphorylation
pvp03050  Proteasome
pvp04020  Calcium signaling pathway
pvp04140  Autophagy - animal
pvp04141  Protein processing in endoplasmic reticulum
pvp04210  Apoptosis
pvp04310  Wnt signaling pathway
pvp04910  Insulin signaling pathway
pvp04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system