KEGG   PATHWAY: qlo03040
Entry
qlo03040                    Pathway                                
Name
Spliceosome - Quercus lobata (valley oak)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
qlo03040  Spliceosome
qlo03040

Other DBs
GO: 0005681
Organism
Quercus lobata (valley oak) [GN:qlo]
Gene
115983095  U1 spliceosomal RNA [KO:K14276]
115983071  U1 spliceosomal RNA [KO:K14276]
115954356  U1 spliceosomal RNA [KO:K14276]
115983065  U1 spliceosomal RNA [KO:K14276]
115983083  U1 spliceosomal RNA [KO:K14276]
115969668  U1 spliceosomal RNA [KO:K14276]
115983049  U1 spliceosomal RNA [KO:K14276]
115951040  U2 spliceosomal RNA [KO:K14277]
115978470  U2 spliceosomal RNA [KO:K14277]
115958759  U2 spliceosomal RNA [KO:K14277]
115951081  U2 spliceosomal RNA [KO:K14277]
115951085  U2 spliceosomal RNA [KO:K14277]
115951102  U4 spliceosomal RNA [KO:K14278]
115983077  U4 spliceosomal RNA [KO:K14278]
115969673  U4 spliceosomal RNA [KO:K14278]
115958639  U5 spliceosomal RNA [KO:K14279]
115978496  U6 spliceosomal RNA [KO:K14280]
115973197  U6 spliceosomal RNA [KO:K14280]
115954339  U6 spliceosomal RNA [KO:K14280]
115983089  U6 spliceosomal RNA [KO:K14280]
115974718  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
115951570  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
115991532  DEAD-box ATP-dependent RNA helicase 56-like isoform X1 [KO:K12812] [EC:5.6.2.7]
115974963  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
115963086  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like [KO:K12813] [EC:5.6.2.6]
115963510  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like isoform X1 [KO:K12813] [EC:5.6.2.6]
115982254  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
115954317  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7-like [KO:K12815] [EC:5.6.2.6]
115982638  pre-mRNA-processing factor 17-like isoform X1 [KO:K12816]
115952670  pre-mRNA-processing factor 17-like isoform X1 [KO:K12816]
115982299  pre-mRNA-splicing factor 18-like [KO:K12817]
115971883  pre-mRNA-splicing factor 18 [KO:K12817]
115979066  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 isoform X1 [KO:K12818] [EC:5.6.2.6]
115982274  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 [KO:K12818] [EC:5.6.2.6]
115974462  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
115993569  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
115951028  pre-mRNA-splicing factor SLU7-like isoform X1 [KO:K12819]
115974644  pre-mRNA-splicing factor SLU7-A [KO:K12819]
115971186  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
115981854  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
115950615  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
115972015  small nuclear ribonucleoprotein SmD1b [KO:K11087]
115982389  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
115969776  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
115974630  small nuclear ribonucleoprotein SmD3b [KO:K11088]
115977376  small nuclear ribonucleoprotein E-like [KO:K11097]
115955110  small nuclear ribonucleoprotein E-like [KO:K11097]
115977431  probable small nuclear ribonucleoprotein F [KO:K11098]
115972616  probable small nuclear ribonucleoprotein F [KO:K11098]
115951181  probable small nuclear ribonucleoprotein G [KO:K11099]
115994133  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
115971462  U1 small nuclear ribonucleoprotein A [KO:K11091]
115986695  U1 small nuclear ribonucleoprotein C-like isoform X1 [KO:K11095]
115971201  U1 small nuclear ribonucleoprotein C [KO:K11095]
115954296  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
115973682  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
115973683  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
115969203  uncharacterized protein LOC115969203 isoform X1 [KO:K12821]
115969378  pre-mRNA-processing protein 40A-like [KO:K12821]
115969893  pre-mRNA-processing protein 40A [KO:K12821]
115982655  RNA-binding protein 25 isoform X1 [KO:K12822]
115976631  DEAD-box ATP-dependent RNA helicase 14 [KO:K12823] [EC:5.6.2.7]
115962981  DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [KO:K12823] [EC:5.6.2.7]
115950986  DEAD-box ATP-dependent RNA helicase 46 [KO:K12823] [EC:5.6.2.7]
115988317  DEAD-box ATP-dependent RNA helicase 20 isoform X1 [KO:K12823] [EC:5.6.2.7]
115981853  pre-mRNA-processing protein 40C isoform X1 [KO:K12824]
115990054  transcription initiation factor TFIID subunit 15b [KO:K13098]
115981961  U2 small nuclear ribonucleoprotein A' [KO:K11092]
115984925  U2 small nuclear ribonucleoprotein B'' 2-like [KO:K11094]
115985142  U2 small nuclear ribonucleoprotein B'' 2-like [KO:K11094]
115959654  probable splicing factor 3A subunit 1 [KO:K12825]
115979894  splicing factor 3A subunit 2 [KO:K12826]
115960382  splicing factor SF3a60 homolog [KO:K12827]
115970069  splicing factor 3B subunit 1 [KO:K12828]
115991678  splicing factor 3B subunit 2 [KO:K12829]
115954023  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
115954524  spliceosome-associated protein 130 A [KO:K12830]
115960633  protein HSH49 isoform X1 [KO:K12831]
115949594  splicing factor 3B subunit 4 [KO:K12831]
115950527  uncharacterized protein At4g14342 [KO:K12832]
115982768  splicing factor 3B subunit 6-like protein [KO:K12833]
115983842  PHD finger-like domain-containing protein 5B [KO:K12834]
115984182  PHD finger-like domain-containing protein 5B [KO:K12834]
115984624  PHD finger-like domain-containing protein 5B [KO:K12834]
115986482  PHD finger-like domain-containing protein 5B [KO:K12834]
115986483  PHD finger-like domain-containing protein 5B [KO:K12834]
115986484  PHD finger-like domain-containing protein 5B [KO:K12834]
115989723  PHD finger-like domain-containing protein 5B [KO:K12834]
115971348  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
115963623  splicing factor U2af small subunit B-like [KO:K12836]
115952839  splicing factor U2af small subunit B-like [KO:K12836]
115974725  splicing factor U2af small subunit B-like [KO:K12836]
115994048  splicing factor U2af large subunit B [KO:K12837]
115994350  splicing factor U2af large subunit B isoform X1 [KO:K12837]
115989626  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
115977650  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
115992187  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
115974824  protein RRC1 isoform X1 [KO:K12842]
115971977  sm-like protein LSM2 [KO:K12621]
115960380  sm-like protein LSM3A [KO:K12622]
115975037  sm-like protein LSM3B [KO:K12622]
115978624  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115970818  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115971826  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115962102  sm-like protein LSM5 [KO:K12624]
115959429  sm-like protein LSM5 [KO:K12624]
115951346  sm-like protein LSM36B [KO:K12625]
115977947  sm-like protein LSM7 [KO:K12626]
115983163  sm-like protein LSM7 [KO:K12626]
115974791  sm-like protein LSM7 [KO:K12626]
115963058  sm-like protein LSM8 [KO:K12627]
115965470  sm-like protein LSM8 [KO:K12627]
115957500  protein RDM16 isoform X1 [KO:K12843]
115953186  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
115988136  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
115950724  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
115982667  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
115977057  NHP2-like protein 1 [KO:K12845]
115977437  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
115991992  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
115994487  SART-1 family protein DOT2-like [KO:K11984]
115994535  SART-1 family protein DOT2-like [KO:K11984]
115966895  SART-1 family protein DOT2-like [KO:K11984]
115982320  zinc finger matrin-type protein 2-like isoform X1 [KO:K12848]
115979399  zinc finger matrin-type protein 2-like [KO:K12848]
115981520  pre-mRNA-splicing factor 38 isoform X1 [KO:K12849]
115976016  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
115977162  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
115975501  110 kDa U5 small nuclear ribonucleoprotein component CLO-like [KO:K12852]
115984391  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
115963029  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
115956063  protein STABILIZED1 [KO:K12855]
115989805  pre-mRNA-processing-splicing factor 8A [KO:K12856]
115964055  U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
115969979  DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
115987025  DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
115995022  thioredoxin-like protein YLS8 [KO:K12859]
115994751  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
115981480  cell division cycle 5-like protein [KO:K12860]
115965754  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
115993916  protein pleiotropic regulatory locus 1 [KO:K12862]
115955411  protein CWC15 homolog [KO:K12863]
115975882  beta-catenin-like protein 1 isoform X1 [KO:K12864]
115977277  heat shock 70 kDa protein [KO:K03283]
115994774  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115994775  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115977564  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
115981901  heat shock cognate 70 kDa protein-like [KO:K03283]
115984127  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
115987279  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115987286  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115987291  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115987312  heat shock cognate 70 kDa protein 2-like isoform X1 [KO:K03283]
115954580  heat shock cognate 70 kDa protein-like [KO:K03283]
115955371  heat shock cognate 70 kDa protein-like [KO:K03283]
115955595  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
115955617  heat shock cognate 70 kDa protein-like [KO:K03283]
115955880  heat shock cognate 70 kDa protein 2 [KO:K03283]
115956006  heat shock cognate 70 kDa protein-like [KO:K03283]
115957266  heat shock cognate 70 kDa protein-like [KO:K03283]
115957458  heat shock cognate 70 kDa protein-like [KO:K03283]
115957507  heat shock cognate 70 kDa protein-like [KO:K03283]
115957751  heat shock cognate 70 kDa protein 2-like [KO:K03283]
115957752  heat shock cognate 70 kDa protein-like [KO:K03283]
115958032  heat shock cognate 70 kDa protein-like [KO:K03283]
115958045  heat shock cognate 70 kDa protein-like [KO:K03283]
115992612  heat shock cognate 70 kDa protein-like [KO:K03283]
115952443  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
115952857  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
115952920  uncharacterized protein LOC115952920 [KO:K12865]
115953221  SNW/SKI-interacting protein A [KO:K06063]
115989721  pre-mRNA-splicing factor SYF1 [KO:K12867]
115969322  pre-mRNA-splicing factor syf2 [KO:K12868]
115969548  pre-mRNA-splicing factor syf2-like isoform X1 [KO:K12868]
115987084  crooked neck-like protein 1 [KO:K12869]
115955833  crooked neck-like protein 1 [KO:K12869]
115959180  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
115952208  peptidyl-prolyl cis-trans isomerase CYP18-2 isoform X1 [KO:K12733] [EC:5.2.1.8]
115966002  coiled-coil domain-containing protein 12 [KO:K12871]
115985410  zinc finger CCCH domain-containing protein 49-like [KO:K12872]
115979884  protein BUD31 homolog 1-like [KO:K12873]
115951365  protein BUD31 homolog 2 [KO:K12873]
115986371  RNA helicase aquarius isoform X1 [KO:K12874]
115994357  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
115967662  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
115953930  RNA-binding protein Y14B-like [KO:K12876]
115975079  RNA-binding protein Y14 [KO:K12876]
115952841  protein mago nashi homolog [KO:K12877]
115987565  protein mago nashi homolog [KO:K12877]
115953380  THO complex subunit 1-like isoform X1 [KO:K12878]
115986951  THO complex subunit 1-like isoform X1 [KO:K12878]
115981650  THO complex subunit 2 [KO:K12879]
115955740  THO complex subunit 3 [KO:K12880]
115979148  THO complex subunit 4D-like [KO:K12881]
115987577  THO complex subunit 4A [KO:K12881]
115972931  THO complex subunit 4D-like [KO:K12881]
115958132  THO complex subunit 4A-like [KO:K12881]
115975963  THO complex subunit 4D-like [KO:K12881]
115981732  nuclear cap-binding protein subunit 1 [KO:K12882]
115957586  nuclear cap-binding protein subunit 2 [KO:K12883]
115976727  UBP1-associated protein 2B-like [KO:K12741]
115976737  UBP1-associated protein 2A-like [KO:K12741]
115994858  UBP1-associated protein 2B-like [KO:K12741]
115963595  glycine-rich RNA-binding protein 3, mitochondrial [KO:K12741]
115983215  heterogeneous nuclear ribonucleoprotein A2 homolog 1-like [KO:K12741]
115952749  UBP1-associated protein 2A-like [KO:K12741]
115952817  UBP1-associated protein 2A-like [KO:K12741]
115953284  UBP1-associated protein 2C-like isoform X1 [KO:K12741]
115988023  heterogeneous nuclear ribonucleoprotein A2 homolog 1-like [KO:K12741]
115988358  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
115955840  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
115991990  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
115958395  UBP1-associated protein 2C [KO:K12741]
115960005  serine/arginine-rich splicing factor SR34A [KO:K12890]
115979898  serine/arginine-rich splicing factor SR30-like [KO:K12890]
115970736  serine/arginine-rich-splicing factor SR34 isoform X1 [KO:K12890]
115968562  serine/arginine-rich splicing factor SC35 isoform X1 [KO:K12891]
115971736  serine/arginine-rich splicing factor SC35-like isoform X1 [KO:K12891]
115955588  serine/arginine-rich splicing factor RS41-like isoform X1 [KO:K12893]
115957284  serine/arginine-rich splicing factor RS31-like [KO:K12893]
115959659  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
115982672  serine/arginine-rich splicing factor RSZ21 [KO:K12896]
115953053  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
115971178  serine/arginine-rich splicing factor RSZ22A [KO:K12896]
115958533  serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896]
115995115  serine/arginine-rich splicing factor SR45a [KO:K12897]
115971630  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
115994399  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
115977263  serine/arginine-rich SC35-like splicing factor SCL30A isoform X1 [KO:K12900]
115953364  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
115957259  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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