KEGG   PATHWAY: pps05161
Entry
pps05161                    Pathway                                
Name
Hepatitis B - Pan paniscus (bonobo)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pps05161  Hepatitis B
pps05161

Disease
H00412  Hepatitis B
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967426  [KO:K16197]
100967539  [KO:K05414]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100967985  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
100968191  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100968231  [KO:K05414]
100968673  FADD; FAS-associated death domain protein [KO:K02373]
100969025  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X6 [KO:K06255]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100969275  [KO:K05414]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100969624  [KO:K05414]
100969626  [KO:K08738]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100970296  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100970300  [KO:K05414]
100970360  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100970420  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
100970465  NRAS; GTPase NRas isoform X2 [KO:K07828]
100970658  [KO:K05414]
100971620  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
100971666  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100972005  [KO:K05414]
100972035  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100972085  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100972202  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100972354  [KO:K05414]
100972365  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100972424  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100972863  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
100972867  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100972895  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100973049  [KO:K05414]
100973232  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
100973837  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100973941  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
100974002  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100974026  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100974073  DDB1; DNA damage-binding protein 1 [KO:K10610]
100974281  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100974592  EGR3; early growth response protein 3 isoform X3 [KO:K12497]
100974672  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100974722  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100974934  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100975020  [KO:K04432] [EC:2.7.12.2]
100975220  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100977025  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X3 [KO:K04369] [EC:2.7.12.2]
100977114  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
100977358  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
100977477  YWHAZ; 14-3-3 protein zeta/delta isoform X2 [KO:K16197]
100977674  TNF; tumor necrosis factor [KO:K03156]
100977804  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100978369  CXCL8; interleukin-8 [KO:K10030]
100978497  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100979090  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100979542  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100979730  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100980038  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100980286  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100980532  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
100980644  TLR4; toll-like receptor 4 precursor [KO:K10160]
100980724  [KO:K04374]
100980798  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100980908  JUN; transcription factor Jun [KO:K04448]
100980937  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100980947  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100981063  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100981268  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100981559  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100981695  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100981891  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
100982480  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100982481  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X6 [KO:K17334]
100982544  MAPK13; mitogen-activated protein kinase 13 isoform X4 [KO:K04441] [EC:2.7.11.24]
100982783  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100983073  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
100983118  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100983141  YWHAB; 14-3-3 protein beta/alpha isoform X4 [KO:K16197]
100983185  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100983649  MAPK14; mitogen-activated protein kinase 14 isoform X4 [KO:K04441] [EC:2.7.11.24]
100983938  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
100983960  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100984173  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100984258  TLR3; toll-like receptor 3 precursor [KO:K05401]
100984393  E2F2; transcription factor E2F2 [KO:K09389]
100984463  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100984888  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100985128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100985481  SLC10A1; hepatic sodium/bile acid cotransporter [KO:K14341]
100985497  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100985706  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100985755  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100986032  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100986194  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100986423  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100986481  [KO:K08738]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100987711  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100987766  STAT3; signal transducer and activator of transcription 3 isoform X7 [KO:K04692]
100987805  PCNA; proliferating cell nuclear antigen [KO:K04802]
100987900  CCNA2; cyclin-A2 [KO:K06627]
100987957  FOS; protein c-Fos [KO:K04379]
100988212  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100988437  [KO:K04369] [EC:2.7.12.2]
100988487  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100988526  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
100988550  [KO:K11223]
100988665  BAD; bcl2-associated agonist of cell death [KO:K02158]
100989105  [KO:K11224]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100989537  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100989555  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100989680  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990080  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990211  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100990245  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100990362  EGR2; E3 SUMO-protein ligase EGR2 isoform X3 [KO:K12496]
100990590  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100990801  KRAS; GTPase KRas isoform X1 [KO:K07827]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990987  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100991126  YWHAQ; 14-3-3 protein theta [KO:K16197]
100991127  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100991447  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100991495  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100991705  [KO:K04741] [EC:3.4.22.-]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100991820  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
100991936  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100992480  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100992567  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100992569  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100992951  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100993322  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100993334  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100994768  TLR2; toll-like receptor 2 precursor [KO:K10159]
100994796  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100995446  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100995524  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100995734  [KO:K05414]
100995851  IFNB1; interferon beta [KO:K05415]
100996159  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103782996  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
103785895  [KO:K08738]
103786410  MYC; myc proto-oncogene protein [KO:K04377]
103786771  [KO:K16197]
106634335  [KO:K08738]
106634558  [KO:K08738]
106635123  [KO:K08738]
106635415  [KO:K08738]
117975808  [KO:K08738]
117976221  [KO:K08738]
117977099  [KO:K16197]
117977645  [KO:K07210]
117981650  [KO:K05414]
117981652  [KO:K05414]
117981750  [KO:K08738]
129393331  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
129393500  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
129397948  [KO:K08738]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
pps04010  MAPK signaling pathway
pps04064  NF-kappa B signaling pathway
pps04110  Cell cycle
pps04115  p53 signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04210  Apoptosis
pps04620  Toll-like receptor signaling pathway
pps04622  RIG-I-like receptor signaling pathway
pps04630  JAK-STAT signaling pathway
KO pathway
ko05161   

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