KEGG   PATHWAY: zca05010
Entry
zca05010                    Pathway                                
Name
Alzheimer disease - Zalophus californianus (California sea lion)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
zca05010  Alzheimer disease
zca05010

Disease
H00056  Alzheimer disease
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113907948  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
113907950  BECN1; beclin-1 isoform X1 [KO:K08334]
113907956  WNT9B; protein Wnt-9b [KO:K01064]
113908025  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
113908035  AXIN2; axin-2 isoform X1 [KO:K04385]
113908037  [KO:K03945]
113908104  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
113908192  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
113908211  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
113908589  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
113908612  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
113908627  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
113908652  FZD6; frizzled-6 isoform X1 [KO:K02376]
113908731  [KO:K00235] [EC:1.3.5.1]
113908736  RYR3; ryanodine receptor 3 [KO:K04963]
113908738  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
113908798  CALM1; calmodulin-1 [KO:K02183]
113908853  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
113908866  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
113908893  [KO:K02272]
113908939  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
113908954  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
113908979  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113909034  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
113909095  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
113909121  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113909127  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
113909155  [KO:K03948]
113909169  [KO:K00134] [EC:1.2.1.12]
113909205  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
113909577  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
113909591  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
113909655  [KO:K03945]
113909911  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
113909952  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910035  [KO:K02264]
113910090  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
113910197  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
113910274  [KO:K02137]
113910347  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
113910465  CHRNA7; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
113910511  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
113910547  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
113910552  [KO:K02131]
113910988  [KO:K02268]
113911009  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113911031  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
113911035  [KO:K00134] [EC:1.2.1.12]
113911261  [KO:K08738]
113911305  [KO:K02137]
113911329  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
113911381  [KO:K03948]
113911411  [KO:K02266]
113911464  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
113911578  WNT2; protein Wnt-2 [KO:K00182]
113911583  [KO:K03947]
113911619  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
113911645  [KO:K03937]
113911646  FZD1; frizzled-1 [KO:K02432]
113911688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113911734  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
113911785  [KO:K02128]
113911795  [KO:K03957]
113911872  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
113911895  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
113911910  IL6; interleukin-6 [KO:K05405]
113911953  WNT16; protein Wnt-16 [KO:K01558]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113912409  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
113912413  [KO:K02128]
113912425  SLC39A6; zinc transporter ZIP6 [KO:K14712]
113912479  [KO:K03957]
113912583  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
113912591  [KO:K02127]
113912650  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
113912698  [KO:K02266]
113912785  [KO:K02266]
113912886  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
113912908  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
113912962  [KO:K00419]
113913021  XBP1; X-box-binding protein 1 [KO:K09027]
113913086  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
113913107  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
113913115  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113913119  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
113913122  FZD10; frizzled-10 [KO:K02842]
113913597  [KO:K00134] [EC:1.2.1.12]
113913722  [KO:K00134] [EC:1.2.1.12]
113913769  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
113913785  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
113913831  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
113913901  [KO:K02272]
113913911  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
113913921  FZD4; frizzled-4 isoform X1 [KO:K02354]
113913999  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
113914077  [KO:K02183]
113914078  [KO:K03945]
113914236  FRAT1; proto-oncogene FRAT1 [KO:K03069]
113914243  [KO:K02271]
113914353  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
113914357  [KO:K03947]
113914445  CALML6; calmodulin-like protein 6 [KO:K02183]
113914462  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
113914497  WNT11; protein Wnt-11 [KO:K01384]
113914501  [KO:K02273]
113914539  BAD; bcl2-associated agonist of cell death [KO:K02158]
113914580  INS; insulin [KO:K04526]
113914678  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
113914679  [KO:K02270]
113914701  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
113914728  [KO:K00411] [EC:7.1.1.8]
113914747  FADD; FAS-associated death domain protein [KO:K02373]
113914779  [KO:K03943] [EC:7.1.1.2]
113914790  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
113914802  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113914893  [KO:K03947]
113914896  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
113914948  RELA; transcription factor p65 [KO:K04735]
113915003  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
113915039  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
113915131  [KO:K02271]
113915204  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
113915210  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
113915225  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
113915273  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
113915286  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113915330  [KO:K00417]
113915368  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
113915373  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
113915392  RTN3; reticulon-3 isoform X1 [KO:K20723]
113915400  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
113915657  [KO:K03948]
113915839  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
113915905  [KO:K00236]
113916044  [KO:K00134] [EC:1.2.1.12]
113916148  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
113916151  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
113916205  [KO:K03957]
113916244  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113916286  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
113916377  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
113916393  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
113916433  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
113916473  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
113916517  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113916546  [KO:K02128]
113916636  TUBB4A; tubulin beta-4A chain [KO:K07375]
113916653  [KO:K00420]
113916664  [KO:K02136]
113916725  [KO:K00417]
113916759  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
113916785  [KO:K04520]
113916795  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
113917006  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
113917022  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113917088  ATP5F1D; LOW QUALITY PROTEIN: ATP synthase subunit delta, mitochondrial [KO:K02134]
113917167  MME; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
113917179  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113917199  [KO:K03945]
113917309  [KO:K00414]
113917354  [KO:K00134] [EC:1.2.1.12]
113917379  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113917509  WNT7A; protein Wnt-7a [KO:K00572]
113917598  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
113917705  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
113917714  CTNNB1; catenin beta-1 [KO:K02105]
113917812  [KO:K02272]
113917862  [KO:K03945]
113917893  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
113917957  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
113918049  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
113918159  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
113918169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113918208  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
113918479  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
113918500  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
113918509  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113918544  ATP5PO; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
113918704  [KO:K03948]
113918892  [KO:K03945]
113918898  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113918932  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
113919175  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
113919207  FZD5; frizzled-5 [KO:K02375]
113919327  [KO:K03946]
113919432  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
113919467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113919493  [KO:K02267]
113919563  [KO:K02271]
113919632  KIF5C; kinesin heavy chain [KO:K10396]
113919696  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
113919721  [KO:K02138]
113919723  IRS2; insulin receptor substrate 2 [KO:K07187]
113919871  [KO:K00134] [EC:1.2.1.12]
113919925  [KO:K03949]
113919926  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
113919936  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
113919983  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113920032  IRS1; insulin receptor substrate 1 [KO:K16172]
113920123  [KO:K00420]
113920227  WNT10A; protein Wnt-10a [KO:K01357]
113920384  [KO:K02183]
113920393  [KO:K03943] [EC:7.1.1.2]
113920563  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
113920580  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
113920583  [KO:K03945]
113920600  FZD7; frizzled-7 [KO:K02432]
113920624  [KO:K00134] [EC:1.2.1.12]
113920632  WNT6; protein Wnt-6 [KO:K00445]
113920673  [KO:K02138]
113920690  [KO:K03945]
113920765  [KO:K00134] [EC:1.2.1.12]
113920768  [KO:K00134] [EC:1.2.1.12]
113920876  [KO:K07374]
113920877  [KO:K02267]
113920996  [KO:K00417]
113921409  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113921428  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
113921493  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
113921503  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
113921591  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
113921668  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
113921728  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
113921757  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113921779  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113921804  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113921815  SLC39A5; zinc transporter ZIP5 [KO:K14711]
113921843  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
113921855  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
113921883  [KO:K08960] [EC:2.7.11.1]
113921886  [KO:K02138]
113921922  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
113921955  WNT10B; protein Wnt-10b [KO:K01357]
113921956  WNT1; proto-oncogene Wnt-1 [KO:K03209]
113921994  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
113922015  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113922046  [KO:K15041]
113922064  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
113922087  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
113922091  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
113922162  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
113922192  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
113922330  [KO:K07374]
113922331  [KO:K07374]
113922345  WNT8B; protein Wnt-8b [KO:K00714]
113922403  [KO:K02270]
113922447  WNT7B; protein Wnt-7b [KO:K00572]
113922486  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
113922505  [KO:K02183]
113922573  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113922694  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
113922724  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
113922735  [KO:K02268]
113922775  [KO:K02138]
113922790  [KO:K03947]
113922818  [KO:K03945]
113922861  [KO:K02267]
113922885  [KO:K02266]
113922888  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
113922904  [KO:K00417]
113922940  [KO:K00134] [EC:1.2.1.12]
113922954  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
113922975  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113922995  [KO:K02183]
113923011  CALML3; LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
113923043  ATG101; autophagy-related protein 101 [KO:K19730]
113923054  FZD8; frizzled-8 [KO:K02375]
113923369  [KO:K00134] [EC:1.2.1.12]
113923387  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113923463  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
113923487  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
113923550  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
113923573  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
113923631  DKK1; dickkopf-related protein 1 [KO:K02165]
113923759  [KO:K02263]
113923771  [KO:K02273]
113923802  [KO:K03949]
113923899  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
113923921  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
113924059  [KO:K03967]
113924066  [KO:K02273]
113924135  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
113924138  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924139  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113924279  [KO:K02138]
113924334  [KO:K02131]
113924373  [KO:K02265]
113924410  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
113924414  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924501  [KO:K05863]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113924510  [KO:K02128]
113924761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113924769  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
113924798  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
113924817  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
113924844  [KO:K02272]
113924949  [KO:K00416]
113924993  [KO:K02127]
113925060  FZD3; frizzled-3 [KO:K02329]
113925088  [KO:K02271]
113925168  [KO:K02131]
113925208  DKK2; dickkopf-related protein 2 [KO:K02165]
113925227  [KO:K02270]
113925277  SNCA; LOW QUALITY PROTEIN: alpha-synuclein [KO:K04528]
113925439  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1 [KO:K03967]
113925460  [KO:K03115]
113925640  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
113925679  [KO:K03957]
113925738  [KO:K00235] [EC:1.3.5.1]
113925822  [KO:K02183]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113925883  DKK4; dickkopf-related protein 4 [KO:K02165]
113925953  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
113925955  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
113926255  [KO:K10881]
113926313  [KO:K00413]
113926430  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
113926528  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
113926974  [KO:K08738]
113927034  [KO:K05862]
113927035  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
113927124  [KO:K07375]
113927125  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
113927199  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
113927218  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113927231  [KO:K00237]
113927239  [KO:K03949]
113927275  [KO:K02730] [EC:3.4.25.1]
113927342  [KO:K03115]
113927447  PSMB1; proteasome subunit beta type-1 isoform X1 [KO:K02732] [EC:3.4.25.1]
113927572  [KO:K02273]
113927616  [KO:K02270]
113927740  TNF; tumor necrosis factor [KO:K03156]
113927749  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
113927778  [KO:K03938]
113927801  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
113927996  TUBB; tubulin beta chain isoform X1 [KO:K07375]
113928413  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
113928501  [KO:K03944]
113928550  [KO:K00134] [EC:1.2.1.12]
113928600  WNT8A; protein Wnt-8a [KO:K00714]
113928748  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113928873  [KO:K02267]
113928897  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113928925  [KO:K03949]
113928933  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
113928989  [KO:K00418]
113929024  [KO:K00134] [EC:1.2.1.12]
113929025  [KO:K03097] [EC:2.7.11.1]
113929103  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
113929105  [KO:K02138]
113929195  [KO:K02183]
113929199  [KO:K02128]
113929477  [KO:K00417]
113929507  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
113929521  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
113929533  [KO:K03945]
113929550  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
113929658  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
113929739  [KO:K02183]
113929839  [KO:K02127]
113929849  [KO:K02272]
113929909  [KO:K00417]
113930205  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113930220  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
113930268  [KO:K21421] [EC:1.-.-.-]
113930597  [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930718  [KO:K02263]
113930739  [KO:K00134] [EC:1.2.1.12]
113930829  [KO:K02138]
113930850  IRS4; insulin receptor substrate 4 [KO:K17446]
113930946  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
113931031  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
113931143  [KO:K07374]
113931151  [KO:K02373]
113931189  [KO:K03937]
113931211  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
113931221  [KO:K03035]
113931264  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
113931319  [KO:K03947]
113931398  [KO:K03948]
113931401  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113931446  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
113931478  [KO:K02138]
113931482  [KO:K02272]
113931503  [KO:K02271]
113931507  [KO:K00134] [EC:1.2.1.12]
113931520  [KO:K02136]
113931879  NRAS; GTPase NRas [KO:K07828]
113931880  NCSTN; nicastrin [KO:K06171]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932138  [KO:K02266]
113932201  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
113932292  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
113932312  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
113932320  BECN2; beclin-2 [KO:K08334]
113932406  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
113932454  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
113932475  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
113932530  [KO:K00415]
113932642  [KO:K17445]
113932654  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
113932759  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
113932787  [KO:K02267]
113932824  [KO:K03115]
113932830  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
113932864  [KO:K07374]
113932917  [KO:K02131]
113932958  [KO:K02273]
113932963  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
113932986  AXIN1; axin-1 isoform X1 [KO:K02157]
113933001  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
113933086  [KO:K02131]
113933111  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
113933138  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113933268  [KO:K05862]
113933286  [KO:K02266]
113933515  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
113933533  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
113933552  SLC39A1; zinc transporter ZIP1 [KO:K14709]
113933553  [KO:K05863]
113933567  [KO:K03948]
113933690  [KO:K02267]
113933996  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
113934048  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
113934578  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
113934602  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113934604  TUBB4B; tubulin beta-4B chain [KO:K07375]
113934691  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113934784  [KO:K03945]
113934839  [KO:K02131]
113934908  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
113935070  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
113935276  [KO:K07374]
113935471  [KO:K07375]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113935588  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
113935658  [KO:K02267]
113935661  [KO:K02270]
113935665  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
113935893  [KO:K02267]
113935895  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
113935939  [KO:K02263]
113935942  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
113936086  CALM3; calmodulin-3 [KO:K02183]
113936090  [KO:K00411] [EC:7.1.1.8]
113936123  [KO:K02267]
113936171  [KO:K08957] [EC:2.7.11.1]
113936225  [KO:K02131]
113936249  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
113936426  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
113936493  APOE; apolipoprotein E [KO:K04524]
113936546  KLC3; kinesin light chain 3 isoform X2 [KO:K10407]
113936636  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
113936647  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
113936650  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
113936745  [KO:K02270]
113936755  [KO:K02128]
113936867  [KO:K07374]
113936929  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
113936988  [KO:K02263]
113937005  [KO:K03938]
113937056  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
113937102  [KO:K02138]
113937245  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
113937313  [KO:K02266]
113937385  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113937386  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
113937435  [KO:K03945]
113937504  [KO:K03948]
113937506  [KO:K02265]
113937538  CALM2; calmodulin-2 [KO:K02183]
113937551  [KO:K02725] [EC:3.4.25.1]
113937669  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
113937717  [KO:K02128]
113937743  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
113937833  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
113937839  IL1B; interleukin-1 beta [KO:K04519]
113937908  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
113937989  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113938009  [KO:K02272]
113938051  [KO:K03948]
113938273  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
113938326  RTN4; reticulon-4 isoform X1 [KO:K20720]
113938347  [KO:K02270]
113938352  [KO:K03948]
113938488  [KO:K07374]
113938523  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
113938644  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
113938649  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
113938694  [KO:K02273]
113938904  WNT9A; protein Wnt-9a [KO:K01064]
113938914  WNT3A; protein Wnt-3a [KO:K00312]
113938999  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113939099  [KO:K00134] [EC:1.2.1.12]
113939180  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113939295  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
113939369  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
113939436  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
113939439  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
113939471  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
113939515  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
113939560  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
113939602  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
113939696  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
113939727  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
113939732  FZD2; frizzled-2 [KO:K02235]
113939784  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113939837  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
113939860  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118355935  [KO:K04741] [EC:3.4.22.-]
118356054  [KO:K02270]
118356080  [KO:K00134] [EC:1.2.1.12]
118356088  [KO:K00134] [EC:1.2.1.12]
118356158  [KO:K07374]
118356194  [KO:K02270]
118356210  [KO:K02183]
118356237  [KO:K07374]
118356266  [KO:K07374]
118356289  [KO:K02138]
118356418  [KO:K02138]
118356511  [KO:K00134] [EC:1.2.1.12]
118356554  [KO:K07210]
118356633  [KO:K03945]
118356768  [KO:K02726] [EC:3.4.25.1]
118356769  [KO:K02268]
118356796  [KO:K03965]
118356834  [KO:K02127]
118356882  [KO:K03945]
118356894  [KO:K02271]
118356917  [KO:K03960]
118357011  [KO:K02138]
118357023  [KO:K00134] [EC:1.2.1.12]
118357105  [KO:K02138]
118357243  [KO:K02138]
118357304  [KO:K07374]
118357322  [KO:K07374]
4355788  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
4355789  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
4355790  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355791  COX2; cytochrome c oxidase subunit II [KO:K02261]
4355792  COX3; cytochrome c oxidase subunit III [KO:K02262]
4355793  CYTB; cytochrome b [KO:K00412]
4355794  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355795  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355796  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355797  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355798  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355799  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355800  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
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Related
pathway
zca00190  Oxidative phosphorylation
zca03050  Proteasome
zca04020  Calcium signaling pathway
zca04140  Autophagy - animal
zca04141  Protein processing in endoplasmic reticulum
zca04210  Apoptosis
zca04310  Wnt signaling pathway
zca04910  Insulin signaling pathway
zca04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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