KEGG   PATHWAY: lcat05166
Entry
lcat05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Lemur catta (Ring-tailed lemur)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
lcat05166  Human T-cell leukemia virus 1 infection
lcat05166

Disease
H00009  Adult T-cell leukemia
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620570  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123620590  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123620780  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
123620951  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
123620957  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
123620959  [KO:K11223]
123621038  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
123621224  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123621580  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621810  CANX; calnexin [KO:K08054]
123621890  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
123621953  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
123622070  MSX1; homeobox protein MSX-1 [KO:K09341]
123622080  B2M; beta-2-microglobulin [KO:K08055]
123622328  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
123622430  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
123622732  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123623027  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
123623028  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
123623354  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
123623846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123623971  RELB; transcription factor RelB isoform X1 [KO:K09253]
123624079  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123624096  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624345  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
123624519  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
123625176  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123625456  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
123625466  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123625769  RAN; GTP-binding nuclear protein Ran [KO:K07936]
123625798  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
123626066  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
123626076  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
123626162  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123626606  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123626608  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123626667  NRP1; neuropilin-1 isoform X1 [KO:K06724]
123626839  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123627110  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627668  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
123627989  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123628071  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123628379  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123628616  [KO:K04725] [EC:2.3.2.27]
123628633  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123628744  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
123628780  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123629236  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630128  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630419  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123630651  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
123630743  ETS2; protein C-ets-2 [KO:K21932]
123630775  [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123631567  [KO:K08874]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631673  [KO:K06751]
123631675  [KO:K06751]
123631677  [KO:K06751]
123631693  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
123631716  [KO:K06751]
123631723  LTA; lymphotoxin-alpha [KO:K05468]
123631724  TNF; tumor necrosis factor [KO:K03156]
123631772  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
123631796  [KO:K06752]
123631797  [KO:K06752]
123631798  [KO:K06752]
123631799  [KO:K06752]
123631804  [KO:K06752]
123631807  [KO:K06752]
123631808  [KO:K06752]
123631809  [KO:K06752]
123631812  [KO:K06752]
123631813  [KO:K06752]
123631814  [KO:K06752]
123631868  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123631905  SRF; serum response factor [KO:K04378]
123632318  [KO:K04498] [EC:2.3.1.48]
123632319  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123632552  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
123632560  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
123632733  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632883  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123633292  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
123633474  [KO:K03120]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123633885  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123634005  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123634008  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
123634070  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
123634153  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123634187  [KO:K02649]
123634247  CDC20; cell division cycle protein 20 homolog [KO:K03363]
123634267  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
123634427  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123635081  NRAS; GTPase NRas [KO:K07828]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635562  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123635592  JUN; transcription factor AP-1 [KO:K04448]
123635667  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
123635834  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
123636306  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
123636670  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123636809  [KO:K08057]
123636948  XPO1; exportin-1 isoform X1 [KO:K14290]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123637179  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
123637265  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
123637267  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
123637304  CALR; calreticulin [KO:K08057]
123637344  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
123637707  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123637712  IL2; interleukin-2 [KO:K05429]
123637744  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123637815  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
123637822  EGR1; early growth response protein 1 [KO:K09203]
123638000  PTTG1; securin [KO:K06635]
123638325  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
123638458  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
123638542  IL15; interleukin-15 [KO:K05433]
123638564  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
123638601  CCNA2; cyclin-A2 [KO:K06627]
123638639  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123638903  MSX2; homeobox protein MSX-2 [KO:K09341]
123639296  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123639359  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
123639564  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123639589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123639673  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123639770  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
123639921  KRAS; GTPase KRas [KO:K07827]
123640106  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
123640133  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
123640135  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123640152  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123640263  TSPO; translocator protein isoform X1 [KO:K05770]
123640292  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
123640316  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123640442  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
123640990  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
123641082  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
123641207  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
123641318  FOSL1; fos-related antigen 1 [KO:K04502]
123641351  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641519  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
123641520  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
123641521  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
123641731  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
123641894  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
123642645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
123642675  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
123642799  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123643408  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123643661  [KO:K12456]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123644073  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123644339  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
123644579  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123644625  MYC; myc proto-oncogene protein [KO:K04377]
123645106  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
123645577  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
123645633  [KO:K06621]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123645745  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123646043  CDKN2B; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
123646154  TLN1; talin-1 isoform X1 [KO:K06271]
123646158  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123646462  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
123646521  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
123646534  FOS; proto-oncogene c-Fos [KO:K04379]
123646908  IL6; interleukin-6 [KO:K05405]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123647634  [KO:K09047]
123647675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
123647994  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
123648063  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123648188  [KO:K03363]
123648234  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123648833  CDC16; cell division cycle protein 16 homolog [KO:K03353]
123649215  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
123649357  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
123649935  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
123650084  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123650127  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123650270  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650328  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123650380  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
123650390  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650673  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
123650680  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123650708  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
123650863  GPS2; G protein pathway suppressor 2 [KO:K15307]
123650900  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
lcat03013  Nucleocytoplasmic transport
lcat04010  MAPK signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04110  Cell cycle
lcat04115  p53 signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04210  Apoptosis
lcat04350  TGF-beta signaling pathway
lcat04612  Antigen processing and presentation
lcat04660  T cell receptor signaling pathway
lcat04668  TNF signaling pathway
KO pathway
ko05166   

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